scholarly journals Inhibition of lymphocyte function associated antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/phosphatidylinositol 3 kinase/Akt pathway

2007 ◽  
Author(s):  
Ralf Schmidmaier ◽  
Sonja Mandl-Weber ◽  
Leander Gaul ◽  
Philipp Baumann ◽  
Irmgard Bumeder ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Akt Pathway ◽  
Lymphocyte Function ◽  
Phosphatidylinositol 3 Kinase ◽  
Myeloma Cells ◽  
Phosphatidylinositol 3

scholarly journals Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Tao Zeng ◽  
Yongqing Cao ◽  
Tiantian Gu ◽  
Li Chen ◽  
Yong Tian ◽  
...  
Keyword(s):  
Heat Stress ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Messenger Rna ◽  
Akt Pathway ◽  
Phosphatidylinositol 3 Kinase ◽  
Regulatory Pathways ◽  
Phosphatidylinositol 3

Accumulating pieces of evidence showed that α-enolase (ENO1) is a multifunctional protein that plays a crucial role in a variety of pathophysiological processes. In our previous study, differential expression of ENO1 was observed in different heat-tolerance duck breeds. Here, we examined in vitro expression level of ENO1 in hepatocytes against heat stress. The mechanisms of ENO1 on cell glycolysis, growth, and its potential regulatory pathways were also analyzed. The results showed that ENO1 expression in messenger RNA and protein levels were both greatly increased in heat-treated cells compared with non-treated cells. ENO1-overexpressed cells significantly elevated cell viability and glycolysis levels. It was further shown that stably upregulated ENO1 activated focal adhesion kinase-phosphatidylinositol 3-kinase/Akt and its downstream signals. In addition, the interaction between ENO1 and 70-kDa heat shock protein was detected using co-immunoprecipitation. Our research suggests that ENO1 may interact with 70-kDa heat shock protein to protect hepatocyte against heat stress through focal adhesion kinase-mediated phosphatidylinositol 3-kinase/Akt pathway.

Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis

Cytoskeleton ◽  
2010 ◽  
pp. NA-NA ◽  
Author(s):  
Norimichi Itoh ◽  
Masanori Nakayama ◽  
Takashi Nishimura ◽  
Shin Fujisue ◽  
Tomoki Nishioka ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Proteomic Analysis ◽  
Pi3 Kinase ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3
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