Risk of Psychiatric Disorders Following Primary Sjögren Syndrome: A Nationwide Population-based Retrospective Cohort Study

Objective.Primary Sjögren syndrome (pSS) is a chronic autoimmune disease. A clear temporal causal relationship between pSS and psychiatric disorders has not been well established. We used a nationwide population-based retrospective cohort study to explore the relationship between pSS and the subsequent development of psychiatric disorders.Methods.We identified subjects who were newly diagnosed with pSS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database. A comparison cohort was constructed for patients without pSS. There were 2686 patients with pSS and 10,744 matched controls observed until diagnosed with psychiatric disorders or until death, withdrawal from the NHI system, or December 31, 2009. The Institutional Review Board of Taipei Veterans General Hospital approved this study (2012-12-013BC).Results.The adjusted HR of depressive disorder, anxiety disorder, and sleep disorder in subjects with pSS were significantly higher at 1.829, 1.856, and 1.967 than those of the controls during the followup. We found that pSS might increase the risk of subsequent newly diagnosed depressive disorder, anxiety disorder, and sleep disorder that may impair life quality.Conclusion.Our findings highlight the need for psychiatric evaluation and intervention for patients with pSS.

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Risk of Psychiatric Disorders following Ankylosing Spondylitis: A Nationwide Population-based Retrospective Cohort Study

The Journal of Rheumatology ◽

10.3899/jrheum.150388 ◽

2016 ◽

Vol 43 (3) ◽

pp. 625-631 ◽

Cited By ~ 32

Author(s):

Cheng-Che Shen ◽

Li-Yu Hu ◽

Albert C. Yang ◽

Benjamin Ing-Tiau Kuo ◽

Yung-Yen Chiang ◽

...

Keyword(s):

Bipolar Disorder ◽

Cohort Study ◽

Ankylosing Spondylitis ◽

Depressive Disorder ◽

Psychiatric Disorders ◽

Retrospective Cohort ◽

Depressive Disorders ◽

Population Based ◽

Newly Diagnosed ◽

Comparison Cohort

Objective.Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease. A higher prevalence of psychiatric comorbidities, including depressive disorder, has been proven in patients with AS. However, a clear temporal causal relationship between AS and psychiatric disorders has not been well established. We performed a nationwide population-based retrospective cohort study to analyze the relationship between AS and the subsequent development of psychiatric disorders, including schizophrenia, bipolar disorder, depressive disorders, anxiety disorders, and sleep disorders.Methods.We identified subjects who were newly diagnosed with AS between January 1, 2000, and December 31, 2008, in the Taiwan National Health Insurance (NHI) Research Database. A comparison cohort was constructed of patients without AS who were matched according to age and sex. All patients with AS and control patients were observed until diagnosed with psychiatric disorders, or until death or withdrawal from the NHI system, or until December 31, 2009.Results.The AS cohort consisted of 2331 patients and the comparison cohort consisted of 9324 matched control patients without AS. The adjusted HR for depressive disorders, anxiety disorders, and sleep disorders in subjects with AS were higher than those of the controls during followup (HR 1.718, 95% CI 1.303–2.265; HR 1.848, 95% CI 1.369–2.494; and HR 1.494, 95% CI 1.031–2.162, respectively).Conclusion.AS might increase the risk of a subsequent newly diagnosed depressive disorder, anxiety disorder, or sleep disorder, but not schizophrenia or bipolar disorder. These observations highlight the need for psychiatric evaluation and intervention for patients with AS.

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Healthcare utilization and mortality outcomes in patients with pre-existing psychiatric disorders after intensive care unit discharge: A population-based retrospective cohort study

Journal of Critical Care ◽

10.1016/j.jcrc.2021.08.009 ◽

2021 ◽

Vol 66 ◽

pp. 67-74

Author(s):

Brianna K. Rosgen ◽

Stephana J. Moss ◽

Andrea Soo ◽

Henry T. Stelfox ◽

Scott B. Patten ◽

...

Keyword(s):

Intensive Care Unit ◽

Cohort Study ◽

Intensive Care ◽

Psychiatric Disorders ◽

Healthcare Utilization ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Intensive Care Unit Discharge ◽

Population Based ◽

Unit Discharge

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Incidence of osteoporosis and ambient air pollution in South Korea: a population-based retrospective cohort study

BMC Public Health ◽

10.1186/s12889-021-11866-7 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Jinyoung Shin ◽

Hyuk Jung Kweon ◽

Kyoung Ja Kwon ◽

Seol-Heui Han

Keyword(s):

Air Pollution ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Ambient Air ◽

Population Based ◽

Cox Proportional Hazards ◽

Ambient Air Pollution ◽

Newly Diagnosed ◽

Residential Areas

Abstract Background This study investigated the associations between exposure to ambient air pollutants and the incidence of osteoporosis using the Korean National Insurance Service–National Sample Cohort. Methods This nationwide, population-based, retrospective cohort study included 237,149 adults aged ≥40 years that did not have a diagnosis of osteoporosis at baseline between January 1, 2003, and December 31, 2015. Osteoporosis was defined as claim codes and prescriptions of bisphosphonates or selective estrogen receptor modulators at least twice annually. After matching values for PM10, NO2, CO, and SO2 during the 2002–2015 time period and PM2.5 in 2015 with residential areas, the incidence of osteoporosis was analyzed using a Cox proportional hazards regression model according to the quartile of average yearly concentrations of pollutants. Results Overall 22.2% of the study subjects, 52,601 (male: 5.6%, female: 37.6%) adults in total, were newly diagnosed with osteoporosis and treated. Exposure to PM10 was positively associated with incidence of osteoporosis (Q4: 1798 per 100,000 person-years vs. Q1: 1655 per 100,000 person-years). The adjusted hazard ratio (HR) with 95% confidence interval (CI) of Q4 in PM10 was 1.034 (1.009–1.062). The effect of PM10 on osteoporosis incidence was distinct in females (adjusted sub-HR: 1.065, 95% CI: 1.003–1.129), subjects aged < 65 years (adjusted sub-HR: 1.040, 95% CI: 1.010–1.072), and for residents in areas with low urbanization (adjusted sub-HR: 1.052, 95% CI: 1.019–1.087). However, there was no increase in osteoporosis based on exposure to NO2, CO, SO2, or PM2.5. Conclusions Long-term exposure to PM10 was associated with newly diagnosed osteoporosis in Korean adults aged ≥40 years. This finding can aid in policy-making that is directed to control air pollution as a risk factor for bone health.

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