scholarly journals The Results of Well-conducted Negative Clinical Trials Should Be Reported in a Peer-reviewed Journal

2021 ◽  
pp. jrheum.201622
Author(s):  
Roy Fleischmann
Keyword(s):  
Clinical Trials ◽  
Positive Result ◽  
Medical Literature ◽  
Successful Management

We expect that the pathogenesis, manifestations, and successful management of disease will be fully reported in peer-reviewed journals. However, there are multiple publications addressing the likelihood that clinical trials that do not report a positive result are underreported in the medical literature, with a maximum of 50% of negative studies published, even after 5 years of availability of their results1,2.

scholarly journals Influence of EPs 7630 on Antipyretic Comedication and Recovery from Acute Tonsillopharyngitis in Children: A Meta-analysis of Randomized, Placebo-Controlled, Clinical Trials

2021 ◽  
Author(s):  
Georg Seifert ◽  
Petra Funk ◽  
Thorsten Reineke ◽  
Walter Lehmacher
Keyword(s):  
Clinical Trials ◽  
Medical Literature ◽  
Meta Analysis ◽  
Controlled Clinical Trials ◽  
Viral Origin ◽  
Treatment Risk ◽  
Pelargonium Sidoides ◽  
Clinical Trial Registries ◽  
End Of Treatment ◽  
Seasonal Infection

Abstract Objective Acute tonsillopharyngitis (ATP) is a common, seasonal infection of predominantly viral origin. Management is aimed at shortening the course of the disease and restoring the comfort of the patient. We performed a meta-analysis to investigate whether treatment with the Pelargonium sidoides extract EPs 7630 reduces the use of antipyretic comedication (i.e., acetaminophen) in children suffering from ATP. Methods Studies were identified from clinical trial registries and medical literature. Randomized, placebo-controlled, clinical trials investigating EPs 7630 in children with ATP and reporting the coadministration of paracetamol were eligible. Based on the raw data of eligible trials, we analyzed cumulative paracetamol use, as well as the ability to attend school at the end of treatment. Three trials including a total of 345 children aged 6 to 10 years and suffering from non-β-hemolytic streptococcal ATP were identified and eligible. Children were administered EPs 7630 or placebo for 6 days. Results Compared with placebo, EPs 7630 reduced the cumulative paracetamol dose by an average of 449 mg (95% confidence interval [CI]: 252–646 mg; p < 0.001). A total of 19.1% (EPs 7630) and 71.5% (placebo) of children were still unable to attend school at the end of the treatment (risk ratio = 0.28; 95% CI: 0.16–0.48; p < 0.001). Conclusion Our meta-analysis demonstrates that EPs 7630 reduced the use of antipyretic comedication and accelerated recovery.

scholarly journals Hypothyroidism with special reference to kaphavruta udana vayu – an overview study.

2020 ◽  
Vol 8 (03) ◽  
Author(s):  
Pragati Dwivedi
Keyword(s):  
Clinical Trials ◽  
Differential Diagnosis ◽  
Positive Result ◽  
Special Reference ◽  
Prevalence Rate ◽  
Signs And Symptoms ◽  
Autoimmune Disorder ◽  
Modern Medicine ◽  
Clinical Correlation ◽  
Health Issues

Hypothyroidism is one of the fastest rising health issues in India, with the prevalence rate of 10.95% ~1 in 10 adults. Thus, it is of great need to deal with this ever-emerging disease. In Ayurveda, Hypothyroidism is often taken as Rasa - pradoshaja vyadhi and treated accordingly but the outcome is not as expected always. So, there is a need to find out other conditions which shows similar signs and symptoms as hypothyroidism and that can be considered in differential diagnosis. In Modern medicine the causes of Hypothyroidism are differentiated in deficiency, insufficiency of hormone, inefficiency of gland, autoimmune disorder, Cancer etc. In our study we will refer it with Kaphavruta udana vayu vikriti with the help of classical textual references which will be helpful in the treatment precisely. Aims & objective – 1. To evaluate co-relation between hypothyroidism with kaphavruta udana vayu vikruti 2. To evaluate action of erand sneh in kaphavruta udana vayu vikruti Methodology – All classical texts were referred like Bruhtrayi & Laghutrayi and others to evaluate the clinical correlation of hypothyroidism and kaphavruta udana vayu vikruti. Whether line of treatment mentioned in kaphavruta udana vayu vikruti shows the positive result in hypothyroidism. Conclusion –It was observed that the signs and symptoms of hypothyroidism were very much similar with kapha vruta udana vayu vikruti. Hypothyroidism can successes fully be referred as Kaphavruta udana yavu vikruti. According to textual references we can utilize Eranda Sneha Nasya & Paan in the management of hypothyroidism. Thus, it has significant role in reducing the signs and Symptoms of Hypothyroidism because of its Vata - kaphhara, srotovishodhan, Anulomana, vrushya actions. Further studies and clinical trials are essential to evaluate the efficacy of erand sneha and correlation between hypothyroidism & kaphavruta udana vayu vikriti.

Trials and Tribulations

1959 ◽  
Vol 105 (441) ◽  
pp. 1082-1087 ◽  
Author(s):  
A. A. Baker ◽  
J. G. Thorpe
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Positive Result ◽  
New Method ◽  
Medical Statistics ◽  
Control Groups ◽  
Therapeutic Success ◽  
Sixth Edition ◽  
Bradford Hill ◽  
Physical Therapies

With the advent of effective physical therapies, psychiatrists have become increasingly interested in the problems posed by clinical trials. Professor Bradford Hill, in the Preface to the Sixth Edition of his Principles of Medical Statistics (1) noted that “… passage of time has … brought clinical trials into prominence and fashion …”. More recently Professor Pickering has described the clinical trial as “the most important new method introduced into clinical science in recent years” (2). Some interesting differences between controlled and uncontrolled trials are well brought out in the paper by Foulds (3) in which he found that therapeutic success was claimed in 85 per cent. of studies not using control groups. Among those studies using control groups, however, only 25 per cent. obtained a positive result. He concluded that “claims for the success of a treatment are closely associated with absence of the means whereby these claims can be scientifically substantiated”.

Identifying Clinical Trials in the Medical Literature with Electronic Databases

2000 ◽  
Vol 21 (5) ◽  
pp. 476-487 ◽  
Author(s):  
Maria E Suarez-Almazor ◽  
Elaine Belseck ◽  
Joanne Homik ◽  
Marlene Dorgan ◽  
Cesar Ramos-Remus
Keyword(s):  
Clinical Trials ◽  
Medical Literature

scholarly journals Maintaining the Trust of Physicians and the Public in the Medical Literature: Report of a Task Force on Scientific Publishing of Clinical Trials

2007 ◽  
Vol 22 (11) ◽  
pp. 1661-1667 ◽  
Author(s):  
Elizabeth Shane ◽  
Roberto Civitelli ◽  
Pierre D Delmas ◽  
Marc Drezner ◽  
John A Eisman ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Medical Literature ◽  
Task Force ◽  
Scientific Publishing ◽  
Literature Report ◽  
The Public

scholarly journals Erythema chronicum migrans like- T cell lymphoma: First description in the medical literature. Successful management with methotrexate and methylprednisolone aceponate!

2019 ◽  
Vol 6 (4) ◽  
pp. 1-4
Author(s):  
Ivanka Temelkova ◽  
Georgi Tchernev
Keyword(s):  
T Cell ◽  
Mycosis Fungoides ◽  
Medical Literature ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Skin Disorders ◽  
Successful Management ◽  
T Cell Lymphomas ◽  
Methylprednisolone Aceponate ◽  
Inflammatory Skin

The group of cutaneous T-cell lymphomas (CTCL) or the so-called Mycosis fungoides (MF) is also referred to as a “great imitator" and in some cases may be misinterpreted as benign inflammatory skin disorders. Difficulties could arise both clinically and histopathologically, especially in the early stages of the disease. For this reason, it is recommended that the diagnosis of MF to follow a three-stage pattern of behavior and be performed on the basis of clinic, histopathology and immunohistochemistry.

Sign in / Sign up

Export Citation Format

Share Document