MMonoclonal outbreak of Ralstonia solanacearum catheter-related bloodstream infection associated with contaminated package of normal saline solution in a tertiary care hospital

Catheter-related bloodstream infection (CRBSI) is an important healthcare-associated infection caused by various nosocomial pathogens. Candida parapsilosis has emerged as a crucial causative agent for the CRBSI in the last two decades. Many factors have been associated with the development of CRBSI including, demography, pre-maturity, comorbidities (diabetes mellitus, hypertension, heart diseases, neuropathy, respiratory diseases, renal dysfunction, hematological and solid organ malignancies, and intestinal dysfunction), intensive care unit (ICU) admission, mechanical ventilation (MV), total parenteral nutrition (TPN), prior antibiotic and/or antifungal therapy, neutropenia, prior surgery, immunosuppressant, and type, site, number, and duration of catheters. This study aims to determine C. parapsilosis CRBSI risk factors. A retrospective study has been performed in an 853-bedded tertiary-care hospital in north-eastern Malaysia. All inpatients with C. parapsilosis positive blood cultures from January 2006 to December 2018 were included, and their medical records were reviewed using a standardized checklist. Out of 208 candidemia episodes, 177 had at least one catheter during admission, and 31 cases had not been catheterized and were excluded. Among the 177 cases, 30 CRBSI cases were compared to 147 non-CRBSI cases [81 bloodstream infections (BSIs), 66 catheter colonizers]. The significance of different risk factors was calculated using multivariate analysis. Multivariate analysis of potential risk factors shows that ICU admission was significantly associated with non-CRBSI as compared to CRBSI [OR, 0.242; 95% CI (0.080–0.734); p = 0.012], and TPN was significantly positively associated with CRBSI than non-CRBSI [OR, 3.079; 95%CI (1.125–8.429); p = 0.029], while other risk factors were not associated significantly. Patients admitted in ICU were less likely to develop C. parapsilosis CRBSI while patients receiving TPN were more likely to have C. parapsilosis CRBSI when compared to the non-CRBSI group.

Download Full-text

Antimicrobial surveillance associated with bloodstream infection in children: A tertiary care hospital-based observation

Current Medical Issues ◽

10.4103/0973-4651.194489 ◽

2016 ◽

Vol 14 (4) ◽

pp. 142

Author(s):

Partha Bhattacharjee

Keyword(s):

Bloodstream Infection ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Antimicrobial Surveillance

Download Full-text

PROPORTION OF ESBL AND CARBAPENEMASE PRODUCING ENTEROBACTERIACEAE CAUSING BLOODSTREAM INFECTIONS AND SHOWING MULTI DRUG RESISTANCE IN INFECTED PATIENTS IN TERTIARY CARE HOSPITAL AT AGARTALA, TRIPURA

10.36106/gjra/8603638 ◽

2021 ◽

pp. 28-30

Author(s):

Lija Ghosh ◽

Arun B ◽

Puja Ghosh ◽

Tapan Majumdar

Keyword(s):

Drug Resistance ◽

Bloodstream Infection ◽

Tertiary Care Hospital ◽

Culture Media ◽

Tertiary Care ◽

Bloodstream Infections ◽

Multi Drug Resistance ◽

Care Hospital ◽

Biochemical Tests ◽

North East

BACKGROUND: Enrerobacteriaceae species are the major leading cause of bloodstream infections in many developing countries. Moreover, ESBL and Carbapenemase-producing Enterobacteriaceae species are often associated with high resistance to a wide class of antibiotics. There are few studies regarding the bloodstream infections causing by Enterobacteriaceae with the production of Extended-spectrum β-lactamases and Carbapenemase enzymes in Tripura, North-East India. This study aimed to determine the “ proportion of ESBL and carbapenemase-producing Enterobacteriaceae causing bloodstream infection and showing Multi-drug resistance (MDR) in infected patients'' in Tertiary care Hospital at Agartala, Tripura. METHOD: Blood samples were collected from all indoor and outdoor patients suspected of Bloodstream infection. Then specimens were inoculated in various culture media after that with this culture isolates we performed gram staining and many biochemical tests (as per CLSI guidelines) to identies the Enterobacteriaceae species. And the production of β-lactamases and Carbapenemase was conrmed by the combined disk test and Modied Hodge method. RESULTS: In this study out of 760 samples processed in the laboratory 77 (10.13%) was tested positive for bacteremia from which 42 (54.54%) blood specimens were infected by Enterobacteriaceae. The members of the Enterobacteriaceae family isolated in patient samples are E.coli (22/42, 52.38%), K. pneumoniae (11/42, 52.38%) others are Enterobacter spp. (8/42, 52.38%) and S.typhi(1/42, 2.38%). In all 42 Enterobacteriaceae species, 17 (40.47%) isolates were found ESBL positive on antibiotic screening which is conrmed by Combined disc diffusion test, and out of 17 Beta-lactamase producers 8 (47.05%) were E. coli, 5 (29.41%) were K. pneumoniae and 4 (23.52%) were Enterobacter spp. And among 42 isolates of Enterobacteriaceae 16 (38.09%) isolates showed Carbapenemase producers, in that 8 (50%) were E.coli, 5 (31.25%) were K. pneumoniae, and 3 (18.75%) were Enterobacter spp. CONCLUSION: This study aims to provide an early, rapid, and effective phenotypic method for identifying Multi-drug resistant (MDR) Bloodstream infections (BSIs) causing by the species of the Enterobacteriaceae family

Download Full-text

Clinical Characteristics of Bacillus cereus Bloodstream Infection in a Tertiary Care Hospital in Japan: the Rate of True Bloodstream Infections and Mortality Are Much Higher Than Previously Reported

Open Forum Infectious Diseases ◽

10.1093/ofid/ofx163.1425 ◽

2017 ◽

Vol 4 (suppl_1) ◽

pp. S548-S548

Author(s):

Akihiro Anma ◽

Ryota Hase ◽

Yoshihito Otsuka ◽

Naoto Hosokawa

Keyword(s):

Bacillus Cereus ◽

Bloodstream Infection ◽

Clinical Characteristics ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Bloodstream Infections ◽

Care Hospital

Download Full-text

Effectiveness and Safety of Heparinized Saline versus Normal Saline in Maintaining Patency of Peripheral Intravenous Locks in Neonates at a Tertiary Care Hospital

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2017/26797.10736 ◽

2017 ◽

Author(s):

Treasa Mathews ◽

Leelavathi D Acharya ◽

Leslie Edward Simon Lewis ◽

Rayapudi Udaya Bhaskar ◽

Alsha Abdul Rahim ◽

...

Keyword(s):

Normal Saline ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Heparinized Saline

Download Full-text

Long-Term Silicone Central Venous Catheters Impregnated With Minocycline and Rifampin Decrease Rates of Catheter-Related Bloodstream Infection in Cancer Patients: A Prospective Randomized Clinical Trial

Journal of Clinical Oncology ◽

10.1200/jco.2004.04.124 ◽

2004 ◽

Vol 22 (15) ◽

pp. 3163-3171 ◽

Cited By ~ 140

Author(s):

Hend Hanna ◽

Robert Benjamin ◽

Ioannis Chatzinikolaou ◽

Badie Alakech ◽

Deborah Richardson ◽

...

Keyword(s):

Clinical Trial ◽

Cancer Patients ◽

Bloodstream Infection ◽

Tertiary Care ◽

Bloodstream Infections ◽

Central Venous Catheters ◽

Care Hospital ◽

Central Venous ◽

Catheter Related Bloodstream Infection

PurposeTo evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections.Patients and MethodsThis prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy.ResultsBetween September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (± standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 ± 30.88 v 63.01 ± 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters.ConclusionLong-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.

Download Full-text