Effect of 1-week Calendula officinalis consumption before high-intensity interval exercise on some delayed onset muscle soreness (DOMS) elements in male rowers

Previous studies showed that some medicinal herbs can prevent delayed onset muscle soreness (DOMS). The present study investigates the effect of Calendula officinalis supplementation on DOMS elements on male rowers. Thirty healthy adult male rowers were randomly chosen and equally divided into experimental and control groups. Blood samples, Sargent jumps (SJ), and pain perception tests were measured at the starting point. The experimental group consumed (twice a day, 200 μl each time) C. officinalis extract for a week while the control group received a placebo. After consuming the supplementations for a week, the second samples and tests were taken. All the athletes participated in the high-intensity interval exercise (HIIE – a muscle soreness protocol). Third, fourth, and fifth samples/tests were executed immediately, 24 and 48 h after HIIE. Statistical analysis was conducted and P≤0.05 was considered as the significant level. The results showed that HIIE induced a significant increase in the serum tumour necrosis factor-alpha (TNF-α) and creatine kinase-MB (CK-MB) values as well as the pain perception in both groups. TNF-α and pain perception were significantly lower in the experimental group immediately, 24 and 48 h after HIIE. CK-MB activity was significantly decreased in the experimental group during next 24 and 48 h after HIIE. The muscle soreness protocol and its preceding supplementation had no significant effect on SJ. The present study suggests that the consumption of C. officinalis based on the present study dose and timespan may be effective to attenuate inflammation and pain induced by HIIE in male rowers and probably has no functional impact on muscle.

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Effect of Low-Volume High-Intensity Interval Exercise and Continuous Exercise on Delayed-Onset Muscle Soreness in Untrained Healthy Males

The Journal of Strength and Conditioning Research ◽

10.1519/jsc.0000000000002059 ◽

2019 ◽

Vol 33 (3) ◽

pp. 774-782 ◽

Cited By ~ 2

Author(s):

Luiz F. Farias Junior ◽

Rodrigo A.V. Browne ◽

Danniel T. Frazão ◽

Teresa C.B. Dantas ◽

Paulo H.M. Silva ◽

...

Keyword(s):

High Intensity ◽

Muscle Soreness ◽

Delayed Onset Muscle Soreness ◽

Interval Exercise ◽

Continuous Exercise ◽

Delayed Onset ◽

Low Volume ◽

High Intensity Interval ◽

Healthy Males

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Psychological responses, muscle damage, inflammation, and delayed onset muscle soreness to high-intensity interval and moderate-intensity continuous exercise in overweight men

Physiology & Behavior ◽

10.1016/j.physbeh.2018.11.028 ◽

2019 ◽

Vol 199 ◽

pp. 200-209 ◽

Cited By ~ 8

Author(s):

Luiz Fernando Farias-Junior ◽

Rodrigo Alberto Vieira Browne ◽

Yuri Alberto Freire ◽

Filipe Fernandes Oliveira-Dantas ◽

Telma Maria Araújo Moura Lemos ◽

...

Keyword(s):

Muscle Damage ◽

High Intensity ◽

Muscle Soreness ◽

Delayed Onset Muscle Soreness ◽

Moderate Intensity ◽

Psychological Responses ◽

Continuous Exercise ◽

Delayed Onset ◽

High Intensity Interval

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Establishment of an animal model for delayed-onset muscle soreness after high-intensity eccentric exercise and its application for investigating the efficacy of low-load eccentric training

Journal of Orthopaedic Science ◽

10.1007/s00776-012-0212-1 ◽

2012 ◽

Vol 17 (3) ◽

pp. 244-252 ◽

Cited By ~ 8

Author(s):

Teppei Munehiro ◽

Katsuhiko Kitaoka ◽

Yoshinobu Maruhashi ◽

Hiroyuki Tsuchiya ◽

Yoshimichi Ueda

Keyword(s):

Animal Model ◽

Eccentric Exercise ◽

High Intensity ◽

Muscle Soreness ◽

Delayed Onset Muscle Soreness ◽

Eccentric Training ◽

Delayed Onset ◽

Low Load

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Effect of curcumin supplement or placebo in delayed onset muscle soreness: a systematic review and meta-analysis

Bulletin of the National Research Centre ◽

10.1186/s42269-021-00664-1 ◽

2021 ◽

Vol 45 (1) ◽

Author(s):

Natthanichar Rattanaseth ◽

Patteera Panyarapeepat ◽

Janisa Andrea Muljadi ◽

Kornkit Chaijenkij ◽

Jatupon Kongtharvonskul

Keyword(s):

Muscle Soreness ◽

Meta Analysis ◽

Delayed Onset Muscle Soreness ◽

Main Body ◽

Level Of Evidence ◽

Post Exercise ◽

Multiple Strategies ◽

Delayed Onset ◽

Tnf Α ◽

Exercise Induced

Abstract Background There are multiple strategies that have been suggested to attenuate delayed onset muscle soreness (DOMS). Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. However, currently, there is still controversy. Main body of the abstract We conduct this meta-analysis according to the PRISMA guidelines. Relevant studies were included from Medline and Scopus from the date of inception to May 04th, 2021 that reported VAS score, blood markers (creatinine kinese (CK), tumor necrotic factor (TNF)-α and interleukin (IL)-6) and range of motion of either group. There were total of 13 studies including 202 and 176 persons in curcumin and placebo group. The unstandardized mean difference (UMD) of VAS muscle soreness in post-exercise, 1, 2, 3 and 4 days was − 0.12 (95% CI − 0.46, 0.22), − 0.38 (− 0.83, 0.08), − 0.67 (− 1.19, − 0.16), − 0.86 (− 1.38, − 0.34), − 0.81 (− 1.27, − 036) and − 1.24 (− 1.50, − 0.99) scores lower in curcumin when compared to placebo. The UMD of CK was − 11.07 (95% CI − 24, 1.86), − 37.51 (− 68.04, − 6.97), − 45.40 (− 95.67, 4.86), − 53.33 (− 128.11, 21.45), − 90.98 (− 173.45, − 8.51) and 117.84 (− 338.69, 574.37) lower in curcumin when compared to placebo. No statistically significantly differences were noted for IL-6, TNF-α and ROM between two groups. Short conclusion This meta-analysis suggested that curcumin supplement reduced delayed onset muscle soreness and CK after exercise in 1, 2, 3, and 4 days when compared to placebo. However, TNF and IL were not affected by curcumin ingestion. Level of evidence I.

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Purslane supplementation lowers oxidative stress, inflammatory and muscle damage biomarkers after high-intensity intermittent exercise in female runners

Baltic Journal of Health and Physical Activity ◽

10.29359/bjhpa.13.1.03 ◽

2021 ◽

Vol 13 (1) ◽

pp. 17-27

Author(s):

ANIS CHARKHI SAHL ABAD ◽

AMINE GRAM ◽

RAHMAN SOORI ◽

ALI AKBARNEJAD ◽

FATEMEH AZIZI GHUCHAN ◽

...

Keyword(s):

Oxidative Stress ◽

Muscle Damage ◽

High Intensity ◽

Intermittent Exercise ◽

Interval Exercise ◽

Tnf Α ◽

Healthy Female ◽

High Intensity Interval ◽

Treadmill Protocol ◽

Biomarkers Of Oxidative Stress

Background: The aim of this study was to determine the effect of purslane supplementation on oxidative stress, inflammation and muscle damage biomarkers after completing high-intensity interval exercise (HIIE). Methods: Nine healthy female runners completed a HIIE treadmill protocol comprising 1 min at 100% of the peak treadmill velocity attained in a preliminary exhaustive incremental treadmill test, interspersed by 1 min of passive recovery, until they had run for 2.5 km. Athletes repeated this test following 10 days of supplementation with 1000 mg per day of purslane. Results: At baseline (i.e., absence of purslane supplementation) the HIIE protocol increased 9-HODE (p < 0.001), 13-HODE (p < 0.001), IL-17 (p < 0.001), TNF-α (p < 0.001), and LDH (p < 0.001). After purslane consumption, resting 9-HODE, 13-HODE, IL-17, TNF-α, and LDH were lowered (p < 0.001) and IL-10 was increased (p < 0.001) compared to before purslane supplementation. After purslane consumption and following the HIIE protocol, the responses of these biomarkers were lower compared to baseline (p < 0.001). Conclusion: Ten days of purslane supplementation blunted the perturbation to biomarkers of oxidative stress, inflammation and muscle damage in female runners completing a HIIE protocol.

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Intense Acute Swimming Induces Delayed-Onset Muscle Soreness Dependent on Spinal Cord Neuroinflammation

Frontiers in Pharmacology ◽

10.3389/fphar.2021.734091 ◽

2022 ◽

Vol 12 ◽

Author(s):

Sergio M. Borghi ◽

Sylvia K. D. Bussulo ◽

Felipe A. Pinho-Ribeiro ◽

Victor Fattori ◽

Thacyana T. Carvalho ◽

...

Keyword(s):

Oxidative Stress ◽

Spinal Cord ◽

Muscle Soreness ◽

Nuclear Factor Κb ◽

Delayed Onset Muscle Soreness ◽

Pyrrolidine Dithiocarbamate ◽

Peripheral Tissues ◽

Delayed Onset ◽

Tnf Α ◽

And Oxidative Stress

Unaccustomed exercise involving eccentric contractions, high intensity, or long duration are recognized to induce delayed-onset muscle soreness (DOMS). Myocyte damage and inflammation in affected peripheral tissues contribute to sensitize muscle nociceptors leading to muscle pain. However, despite the essential role of the spinal cord in the regulation of pain, spinal cord neuroinflammatory mechanisms in intense swimming-induced DOMS remain to be investigated. We hypothesized that spinal cord neuroinflammation contributes to DOMS. C57BL/6 mice swam for 2 h to induce DOMS, and nociceptive spinal cord mechanisms were evaluated. DOMS triggered the activation of astrocytes and microglia in the spinal cord 24 h after exercise compared to the sham group. DOMS and DOMS-induced spinal cord nuclear factor κB (NFκB) activation were reduced by intrathecal treatments with glial inhibitors (fluorocitrate, α-aminoadipate, and minocycline) and NFκB inhibitor [pyrrolidine dithiocarbamate (PDTC)]. Moreover, DOMS was also reduced by intrathecal treatments targeting C-X3-C motif chemokine ligand 1 (CX3CL1), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β or with recombinant IL-10. In agreement, DOMS induced the mRNA and protein expressions of CX3CR1, TNF-α, IL-1β, IL-10, c-Fos, and oxidative stress in the spinal cord. All these immune and cellular alterations triggered by DOMS were amenable by intrathecal treatments with glial and NFκB inhibitors. These results support a role for spinal cord glial cells, via NFκB, cytokines/chemokines, and oxidative stress, in DOMS. Thus, unveiling neuroinflammatory mechanisms by which unaccustomed exercise induces central sensitization and consequently DOMS.

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