Administration of Antiretroviral Drugs(Lamivudine, Nevirapine and Stavudine) has no Untoward Effect on Haematological Profile in Albino Rats

2007 ◽  
Vol 2 (2) ◽  
pp. 147-151 ◽  
Author(s):  
R.A. Umar ◽  
M.J. Ladan ◽  
S.W. Hassan ◽  
Y. Sa`id ◽  
A.Y. Abbas ◽  
...  
Keyword(s):  
Antiretroviral Drugs ◽  
Albino Rats ◽  
Untoward Effect ◽  
Haematological Profile

scholarly journals Bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on haematological profile in paracetamol-induced Wistar rats

2019 ◽  
Vol 6 (14) ◽  
pp. 521-533
Author(s):  
C. U. Ogunka-Nnoka ◽  
B. W. Abbey
Keyword(s):  
Blood Cells ◽  
Leaf Extract ◽  
White Blood Cells ◽  
Appreciable Amount ◽  
Albino Rats ◽  
Bioactive Components ◽  
Sample Extract ◽  
Significant Difference ◽  
Haematological Profile ◽  
Aqueous Leaf Extract

The study evaluates the bioactive components and the effect of aqueous leaf extract of Maesobotrya barteri (Baill.) Hutch. (Euphorbiaceae) on the haematological profile of paracetamol-induced Wistar albino rats. Standard methods were used in the proximate, phytochemical and haematological profile analysis. The results of the proximate composition revealed high values for crude fiber (49.13%), carbohydrates (16.33%) and protein (10.94%). Phytochemical studies showed the presence of alkaloids, flavonoids, saponins, phenols and tannins within the concentration range of 0.0003-94.68 µg/mL. Twenty-four hours after the last oral administration, the rats were sacrificed. Blood was obtained by cardiac puncture. Results of the haematological profile at different dose levels (200 mg/kg, 300 mg/kg and 500 mg/kg body weight) did not show any significant difference (p > 0.05) when compared with the control. A slight increase was observed in the erythrocytes (red blood cells, haemoglobin, packed cell volume and platelets). Meanwhile, a significant increase (p <= 0.05) was observed in the WBC and platelets of the groups induced with paracetamol only. However, administration of ascorbic and the sample extract reduced the white blood cells and platelet levels. The study revealed that M. barteri leaves contain an appreciable amount of nutrients, bioactive constituents and may serve as a blood booster.

scholarly journals Haematological profile of albino rats exposed to polar leaf extracts of Portulaca oleracea Linn.

2019 ◽  
Vol 7 (1) ◽  
pp. 075-085 ◽  
Author(s):  
Victoria Chinenye Obinna ◽  
Hope Delesi Kagbo ◽  
Ozadheoghene Eriarie Afieroho ◽  
Gabriel Ogaba Agu
Keyword(s):  
Portulaca Oleracea ◽  
Albino Rats ◽  
Leaf Extracts ◽  
Haematological Profile

scholarly journals The influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol

2020 ◽  
Vol 12 (4) ◽  
pp. 773-780
Author(s):  
Martins S. AKOGWU ◽  
Chukwuka N. UCHENDU ◽  
Rita I. ODO
Keyword(s):  
Oral Administration ◽  
Chorionic Gonadotropin ◽  
Human Chorionic Gonadotropin ◽  
Haemoglobin Concentration ◽  
Albino Rats ◽  
Haematological Profile ◽  
Group A ◽  
Group B ◽  
Male Hormones ◽  
Group D

This study evaluated the influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol. Twenty-four mature male albino rats were assigned to four groups (n=6). Group A was the control, given distilled water, Group B was given 30% ethanol (8 ml/kg) orally 3 times a week, Group C was given human chorionic gonadotropin (HcG) (50 IU/kg) subcutaneously 3 times a week and Group D was given HcG (50 IU/kg) subcutaneously + 30% ethanol (8 ml/kg) orally 3 times a week. The study was for 10 weeks, and hormonal profile and haematology were determined. The follicle stimulating hormone of Group B decreased significantly (P<0.05) when compared to Groups A, C and D. The luteinizing hormone was significantly lower (P<0.05) in Group B when compared to Groups A, C and D. The testosterone level was significantly higher (P<0.05) in Group D when compared to Groups A, B and C. The results obtained from haematology indicated that haemoglobin concentration of Group B was significantly lower (P<0.05) when compared to Groups A, C and D. Ethanol significantly reduced (P<0.05) platelets when compared to Groups A, C and D. There was a significant reduction (P<0.05) in the neutrophils and lymphocytes in Group B when compared to Groups A, C and D. The study showed that HcG improves the level of male hormones and haematology in postpubertal albino rats exposed to chronic alcohol administration.

EFFECT OF KAEMPFERIA GALANGA RHIZOME EXTRACT ON HAEMATOLOGICAL PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS

2020 ◽  
pp. 255-259
Author(s):  
Subbaian Kokila ◽  
Balliah RAGAVAN
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Albino Rats ◽  
Weight Changes ◽  
Reduced Body ◽  
Kaempferia Galanga ◽  
Wistar Strain ◽  
Haematological Profile

Diabetes mellitus is a metabolic disorder that is characterized by elevated blood glucose level, altered lipids, carbohydrates and protein metabolism. The present investigation was undertaken to determine the hypoglycemic potential of hydroethanolic extract of Kaempferia galanga rhizome and to assess haematological profile in diabetic rats. Adult male albino rats of Wistar strain were induced with diabetes by intraperitoneal injection of streptozotocin (STZ) (60 mg/kg body weight). Changes in haematological profile reported by STZ induced diabetic rats were found to be restored to normal condition upon administration of K. galanga extract in treated groups indicating hematoprotective effect of the extract. Diabetic rats exhibited increased level of serum glucose and reduced body weight compared to normal control rats. The K. galanga rhizome extract treated animals exhibited significant increase in body weight and reduced level of blood glucose thereby restoring to near normal levels. The present findings indicate that K. galanga rhizome can be considered for treating diabetes induced complications.

scholarly journals Introduction pages

2020 ◽  
Vol 12 (4) ◽  
pp. I-VIII
Author(s):  
Radu E. SESTRAS
Keyword(s):  
Pennisetum Glaucum ◽  
Mangifera Indica ◽  
Western Himalaya ◽  
Hot Water ◽  
Coi Gene ◽  
Albino Rats ◽  
Cucumis Sativus L ◽  
Coniesta Ignefusalis ◽  
Cornus Mas ◽  
Haematological Profile

Notulae Scientia Biologicae (http://www.notulaebiologicae.ro), Issue 4, Volume 12, 2020: The papers published in this issue represent interesting novelties in different topics of life science. Among the exciting researches or reviews, we invite readers to find news about: The influence of human chorionic gonadotropin on hormonal and haematological profile of postpubertal male albino rats exposed to chronic oral administration of alcohol; Phylogenetic observation in Ariidae, Bagridae and Plotosidae catfishes by COI gene sequence analysis; A preliminary study and new distributional records of family Erebidae (Leach, [1815]) (Lepidoptera: Noctuoidea) from Aligarh, Uttar Pradesh, India; Evaluation of pearl millet (Pennisetum glaucum L. (R. Br.)) landraces for resistance to stem borer (Coniesta ignefusalis Hampson.) infestation; Photochemical responses of cucumber (Cucumis sativus L.) plants to heat stress; Vegetative propagation of cornelian cherry (Cornus mas L.) selections; Effect of pre-storage hot air and hot water treatments on post-harvest quality of mango (Mangifera indica Linn.) fruit; Effect of snowmelt regime on phenology of herbaceous species at and around treeline in Western Himalaya, India etc.

scholarly journals Evaluation of Associated Changes on Haematological Profile of Wistar Rats Fed Curcuma longa (Turmeric) Rhizome Powder

2020 ◽  
pp. 25-29
Author(s):  
A. V. Iwueke ◽  
E. C. Chukwu ◽  
J. N. Ejekwummadu ◽  
J. A. Nwodu
Keyword(s):  
Body Weight ◽  
Blood Cells ◽  
Biological Activities ◽  
Curcuma Longa ◽  
Well Being ◽  
The Body ◽  
Albino Rats ◽  
Mean Corpuscular Hemoglobin ◽  
Study Results ◽  
Haematological Profile

Turmeric spice has a diverse array of biological activities. The present study evaluated body weight and haematological impact of Curcuma longa (Turmeric) in male albino rats using  standard analytical methods. Twenty four healthy male albino rats were used for the study.  Results shows no significant increase in body weight in the first week of dieting while a gradual increase     was observed with increasing weeks of dieting.  Treatment with the powder did not significantly (P ≥ 0.05) alter the levels of hemoglobin (Hb), red blood cells (RBC) and means corpuscular volume (MCV) of the rats. The result also showed a significant (p ≤ 0.05) increase in the platelets and mean corpuscular hemoglobin concentrations (MCHC). However, the white blood cells (WBC) and the packed cell volume (PCV) concentrations were slightly reduced. This study   suggests that adding Curcuma longa (Turmeric) at 50, 100, 200 mg/kg body weight within the duration of study could positively affect the hematological parameters and general well being of the body.

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