Anti-spermatogenic Activity of Leptadenia hastata (Pers.) Decne Leaf Stems Aqueous Extracts in Male Wistar Rats

2011 ◽  
Vol 6 (4) ◽  
pp. 391-399 ◽  
Author(s):  
B. Bayala ◽  
P.B. Telefo ◽  
I.H.N. Bassole ◽  
H.H. Tamboura ◽  
R.G. Belemtougr ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Aqueous Extracts ◽  
Male Wistar Rats

Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

2021 ◽  
Vol 18 ◽  
Author(s):  
Kehinde S. Olaniyi ◽  
Isaiah W. Sabinari ◽  
Adesola A. Oniyide ◽  
Nifesimi T. Akinnagbe ◽  
Toluwani B. Agunbiade ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Wistar Rats ◽  
Concomitant Administration ◽  
Energy Regulation ◽  
Aqueous Extracts ◽  
Garcinia Kola ◽  
Or Management ◽  
Male Wistar Rats ◽  
Susceptible Populations ◽  
Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

scholarly journals Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.

2016 ◽  
Vol 3 ◽  
pp. 76-83
Author(s):  
Olanrewaju Roland Akinseye
Keyword(s):  
Wistar Rats ◽  
Moringa Oleifera ◽  
Glycyrrhiza Glabra ◽  
Atherogenic Index ◽  
Simultaneous Increase ◽  
Hypolipidemic Effect ◽  
Aqueous Extracts ◽  
Water Control ◽  
Beneficial Effects ◽  
Male Wistar Rats

Herbal teas ofMoringa oleifera(Moringa) andGlycyrrhiza glabra(Licorice)were known to have many beneficial effects, their possible hypolipidemic effects were investigated in this paper. Albino wistar rats were fed with aqueous extracts ofM. oleifera,G. glabraand their blend teas(10, 30 and 50 mg/kg.BW/ml). The teas were found to lower the serum cholesterol, triglycerides, VLDL, LDL, and atherogenic index at their higher concentration, but were found to slightly increase the HDL as compared to the corresponding normal healthy rats fed with clean water (control). The phytochemicals screening of the teas aqueous extract were also investigated, the chemicals (tannins, saponins, flavonoids, terpenoids and glycosides) which were known to exhibit cholesterol lowering effect by inhibiting its absorption and simultaneous increase its excretion were found to be present in the teas extract. Thus, the study demonstrates and validates thatM.oleifera,G. glabraand their blend possess hypolipidemic effect at higher concentration.

Hypertensive and Sympathomimetic Effects of the Methanol and Aqueous Extracts of Scoparia dulcis in Anaesthetized Male Wistar Rats

2011 ◽  
Vol 4 (1) ◽  
pp. 11-19
Author(s):  
C.O. Esume ◽  
A.O. Opajobi ◽  
A. Osasuyi ◽  
O.O. Ebong ◽  
A.K. Osakwe
Keyword(s):  
Wistar Rats ◽  
Aqueous Extracts ◽  
Scoparia Dulcis ◽  
Male Wistar Rats

Effect of Aqueous Extracts of Mangifera indica linn. on the Testes of Adult Male Wistar Rats

2016 ◽  
Vol 56 (1-2) ◽  
pp. 135-138 ◽  
Author(s):  
Oluwadara Pelumi Alamu ◽  
Olusola A. Adeeyo ◽  
Olubukola Oluranti Babalola
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Mangifera Indica ◽  
Aqueous Extracts ◽  
Male Wistar Rats

scholarly journals Evaluation of Quantitative Phytochemicals, Liver Enzymes and Histological Changes in Isoniazid Induced Hepatotoxicity in Adult Male Wistar Rats Treated with Aqueous Extracts of <i>Brysocarpus coccineus</i>

2017 ◽  
Vol 05 (03) ◽  
pp. 33-44
Author(s):  
Kashini Andrew ◽  
Nachamada Solomon Emmanuel ◽  
Deborah Chioma Ejiogu ◽  
Chinonso Nicodemus Chima ◽  
Fatima Mohammed Yahuza ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
Aqueous Extracts ◽  
Histological Changes ◽  
Male Wistar Rats

scholarly journals Preliminary Phytochemical Screening of Plumbagozeylanica L. Roots and Its Aphrodisiac Effect in Male Rats

2021 ◽  
pp. 24-31
Author(s):  
Patrick Onen ◽  
Daniel Ocira ◽  
Timothy Omara ◽  
Jacob Nyeko ◽  
Augastine Okwir
Keyword(s):  
Erectile Dysfunction ◽  
Wistar Rats ◽  
Research Work ◽  
Male Rats ◽  
Aqueous Extracts ◽  
Phytochemical Screening ◽  
Plumbago Zeylanica ◽  
Root Extracts ◽  
Methanolic Extracts ◽  
Male Wistar Rats

Aim: To perform phytochemical screening of Plumbago zeylanica L. root extracts and assess the claim of its use in traditional management of erectile dysfunction in Uganda through evaluation of the aphrodisiac effect of its aqueous extracts in male Wistar rats. Study Design: This study employed both qualitative and quantitative research designs. Place and Duration of Study: All research work were performed at the Department of Biological Sciences, Gulu University, Gulu, Uganda between August 2019 and December 2019. Methodology: Classical phytochemical screening of aqueous and methanolic extracts of Plumbago zeylanica roots were performed following standard methods. Aqueous extracts were administered to Male Wistar rats and the effect of the extracts on the mounting and intromission frequencies were determined. Results: Glycosides, phenols, saponins, quinones, terpenoids and steroids were present in both methanolic and aqueous extracts. Alkaloids were present in methanolic extracts only while tannins and phlobatannins were only present in aqueous extracts. Flavonoids, coumarins and anthraquinones were not detected in both extracts. Aqueous root extracts of Plumbago zeylanica produced pro-sexual stimulatory effects in male rats when administered at 150, 300 and 450 mg/kg body weight. Conclusion: The results support the use of Plumbago zeylanicaroots by indigenous people in Uganda to increase libido, treat premature ejaculation and erectile dysfunction. The extracts had low sexual enhancement in sexually inexperienced male rats and therefore, further studies using experienced animal models are needed to better apprehend the prosexual effects of P. zeylanica roots. The toxicity of the extracts as well as structural elucidation and pharmacological evaluation of the responsible bioactive compounds merit further studies.

Pro-sexual effects of aqueous extracts of Massularia acuminata root in male Wistar rats

Andrologia ◽  
2011 ◽  
Vol 43 (5) ◽  
pp. 334-340 ◽  
Author(s):  
M. T. Yakubu ◽  
O. S. Awotunde ◽  
T. O. Ajiboye ◽  
A. T. Oladiji ◽  
M. A. Akanji
Keyword(s):  
Wistar Rats ◽  
Aqueous Extracts ◽  
Male Wistar Rats ◽  
Massularia Acuminata

scholarly journals Effect of aqueous extract of Allium sativum (Garlic) on fertility in male Wistar rats

2020 ◽  
pp. 100-107
Author(s):  
IO Osonuga ◽  
AS Faponle ◽  
EN Ezima ◽  
TK Adenowo ◽  
AA Adelegan
Keyword(s):  
Wistar Rats ◽  
Allium Sativum ◽  
Oral Route ◽  
Male Rats ◽  
Control Group ◽  
High Dose ◽  
Aqueous Extracts ◽  
Beneficial Effects ◽  
Male Wistar Rats ◽  
Recovery Groups

Background: Allium sativum (Garlic) is widely used as a food flavour and it has antimicrobial medicinal purposes. It has other beneficial effects such as improving the cardiovascular and immune systems. The likely effect of garlic on the testicular functions remains controversial. Objective: To investigate the effects of fresh garlic on the fertility of male Wistar rats by quantitative determination of testosterone, follicle-stimulating hormone (FSH), and Luteinizing hormone (LH) levels, as well as the sperm properties. Methods: The aqueous extracts of garlic were administered to the animals through the oral route. Thirty-five male rats were categorized into seven groups, with five rats each distributed as follows: high-dose, medium-dose, low-dose that were administered 750, 500, and 250 mg/kg body weight dosages of the aqueous extracts, respectively. Others were the control group, which received no extract, and the recovery groups received the same doses of the extract. The recovery groups were left for additional twenty-one days without receiving the extract. Results: The results showed an increase in testosterone levels at medium to high-doses of the extract including sustained high levels in recovery groups. Also, there were increases in sperm motility and sperm viability. Conclusions: These findings suggest garlic may play beneficial roles in the reproductive functions of male Wistar rats. The mechanisms for these effects may involve the interplay of many currently unknown factors.

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