scholarly journals Evaluation of Quantitative Phytochemicals, Liver Enzymes and Histological Changes in Isoniazid Induced Hepatotoxicity in Adult Male Wistar Rats Treated with Aqueous Extracts of <i>Brysocarpus coccineus</i>

2017 ◽  
Vol 05 (03) ◽  
pp. 33-44
Author(s):  
Kashini Andrew ◽  
Nachamada Solomon Emmanuel ◽  
Deborah Chioma Ejiogu ◽  
Chinonso Nicodemus Chima ◽  
Fatima Mohammed Yahuza ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
Aqueous Extracts ◽  
Histological Changes ◽  
Male Wistar Rats

scholarly journals The Protective Effects of Turmeric on Liver Enzymes of Metronidazole-Treated Adult Male Wistar Rats

2015 ◽  
Vol 1 (6) ◽  
pp. 255
Author(s):  
Akudike C. J. ◽  
Chukwu V. O. ◽  
Ezejindu D. N. ◽  
Ihim A. C.
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Liver Enzymes ◽  
Antimicrobial Effect ◽  
The Body ◽  
Protective Effects ◽  
Negative Effects ◽  
Serum Samples ◽  
Male Wistar Rats ◽  
Anti Oxidant

Over the years, research works on the different liver enzymes has proven to be very helpful to man. This study evaluates the protective effects of turmeric on the liver enzymes of metronidazole-treated adult male wistar rats. With previous researches, metronidazole has been found to exert some negative effects on some organs of the body like the testis, kidney etc but the turmeric on its own part, has been found to have no side effects with a host of beneficial functions such as its anti-oxidant and antimicrobial effect amongst a host of other functions. In this study, twenty wistar rats with weight range of between 165-180g were assigned into four groups A, B, C and D of 5 each. The experimental groups A, B and C were orally administered 200mg of metronidazole, 400mg of metronidazole and 400mg of metronidazole as well as 400mg of turmeric respectively for duration of twenty-eight days while the group D served as control and were orally administered water and feed only. Twenty four hours after the last administration, the animals were anaesthetized under chloroform inhalation and dissected for organ collection. Blood for serum preparation was collected into sterile plain tubes and stored in the refrigerator for analysis. Serum samples from the bloods were analyzed for liver enzymes activities using randox kit method. The study revealed that turmeric helped reduced the effects of metronidazole on the serum activities of ALT, AST and ALP on the liver. This present study suggests that metronidazole could have negative effects on the liver and so advises that turmeric be added when on metronidazole administration.

Effect of Aqueous Extracts of Mangifera indica linn. on the Testes of Adult Male Wistar Rats

2016 ◽  
Vol 56 (1-2) ◽  
pp. 135-138 ◽  
Author(s):  
Oluwadara Pelumi Alamu ◽  
Olusola A. Adeeyo ◽  
Olubukola Oluranti Babalola
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Mangifera Indica ◽  
Aqueous Extracts ◽  
Male Wistar Rats

Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

2021 ◽  
Vol 18 ◽  
Author(s):  
Kehinde S. Olaniyi ◽  
Isaiah W. Sabinari ◽  
Adesola A. Oniyide ◽  
Nifesimi T. Akinnagbe ◽  
Toluwani B. Agunbiade ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Wistar Rats ◽  
Concomitant Administration ◽  
Energy Regulation ◽  
Aqueous Extracts ◽  
Garcinia Kola ◽  
Or Management ◽  
Male Wistar Rats ◽  
Susceptible Populations ◽  
Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

scholarly journals Effects of Long-Term Administration of Lithium and Hydrochlorothiazide in Rats

1999 ◽  
Vol 6 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Felicia Loghin ◽  
Adriana Olinic ◽  
Daniela-Saveta Popa ◽  
Carmen Socaciu ◽  
Sorin E. Leucuta
Keyword(s):  
Wistar Rats ◽  
Histopathological Examination ◽  
Concomitant Administration ◽  
Histological Changes ◽  
Association Group ◽  
Term Administration ◽  
Male Wistar Rats ◽  
Kidney Liver ◽  
Lithium Lactate

The biochemical and histological changes following 60 days administration of daily doses equivalent to 1/20 LD50 of lithium lactate and hydrochlorothiazide, as such and in association, were studied in male Wistar rats. No mortality or overt signs of toxicity were observed during the experiment and the serum activities of transaminases, alkaline phosphatase and cholinesterase were not significantly modified compared to controls. The histopathological examination of all the investigated organs: kidney, liver, brain and spleen, revealed significant lesions which were time-dependant and more pronounced in the association group. Although the changes were mostly inflammatory and conqestive, it was proved that the concomitant administration of lithium and hydrochlorothiazid is potentially dangerous, increasing lithium’s nephrotoxicity and the thiazide diuretic's hepatotoxicity.

scholarly journals Anti‐Fertility Effects of Amlodipine in Adult Male Wistar Rats

2011 ◽  
Vol 25 (S1) ◽  
Author(s):  
Adelaja Abdulazeez Akinlolu ◽  
Olaide Ghazali ◽  
Adebayo Kehinde Adefule
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Azathioprine and Methotrexate impaired the morphology and functions of the testes in adult wistar rats

2014 ◽  
Vol 31 (02) ◽  
pp. 075-081
Author(s):  
A. Akinlolu ◽  
O. Akinola ◽  
P. Khobe ◽  
K. Obasi ◽  
O. Dada
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Follicle Stimulating Hormone ◽  
Physiological Saline ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Connective Tissues ◽  
Group I ◽  
Male Wistar Rats ◽  
Dose Dependent

Abstract Introduction: AAzathioprine and Methotrexate are both used in the treatment of cancer; and are classified as cytotoxic drugs with reported adverse effects such as oxidative damage to the DNA/RNA, the testes and sperm cells. This study, therefore, tested the hypothesis that AAzathioprine and Methotrexate administrations impair the morphology and functions of the testes in adult male wistar rats. Methods: AAzathioprine (50-150mg per day) and Methotrexate (2.5mg per week) are used in the treatment of cancer in adult Man. We tested the hypothesis that AAzathioprine and Methotrexate impair the morphology and functions of testes in rats. Forty adult male wistar rats (150-230g) were employed in the study: Control Group I received physiological saline while Experimental Groups II - V received oral administrations of 5mg/kg/bodyweight of AAzathioprine per day, 15mg/kg/bodyweight of AAzathioprine per day, 8mg/kg/bodyweight of Methotrexate per week and 20mg/kg/bodyweight of Methotrexate per week respectively for 35 days. Results: Histological examinations of the testes of rats of Groups II - V showed dose-dependent morphological anomalies such as fewer collagen ibers of connective tissues, disrupted seminiferous tubules and scanty spermatozoa when compared to rats of Group I. Statistical analyses showed dose-dependent elevated levels (P≤0.05) of superoxide dismutase and malondialdehyde in testes homogenates of rats of Groups II - V when compared to rats of Group I. This implied increased oxidative stress in rats of Groups II - V. Evaluations of Follicle Stimulating Hormone and Testosterone showed dose-dependent significantly elevated levels (P≤0.05) in rats of Groups II - V when compared to rats of Group I. Conclusions: Our findings are consistent with the stated hypothesis.

scholarly journals Avoidance memory requires CaMKII activity to persist after recall

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Andressa Radiske ◽  
Maria Carolina Gonzalez ◽  
Janine I. Rossato ◽  
Gênedy Apolinário ◽  
João R. de Oliveira ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Adult Male ◽  
Wistar Rats ◽  
Memory Reconsolidation ◽  
Memory Processing ◽  
Conflicting Information ◽  
Male Wistar Rats ◽  
Avoidance Memory ◽  
Avoidance Responses

AbstractAvoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses.

Chronic consumption of Hypericum humifusum leaf extracts impairs epididymis spermatozoa characters in association with oxidative stress in adult male Wistar rats

2017 ◽  
Vol 93 ◽  
pp. 616-625 ◽  
Author(s):  
Imen Hammami ◽  
Ridha Ben Ali ◽  
Afef Nahdi ◽  
Olfa Kallech-Ziri ◽  
Marwa Boussada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adult Male ◽  
Wistar Rats ◽  
Leaf Extracts ◽  
Male Wistar Rats
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