Analysing the Hypolipidemic Activities of the Tea Extracts of Moringa oleifera, Glycyrrhiza glabra and their Blend at Different Concentrations, Orally Induced on Adult Male Wistar Rats.

Herbal teas ofMoringa oleifera(Moringa) andGlycyrrhiza glabra(Licorice)were known to have many beneficial effects, their possible hypolipidemic effects were investigated in this paper. Albino wistar rats were fed with aqueous extracts ofM. oleifera,G. glabraand their blend teas(10, 30 and 50 mg/kg.BW/ml). The teas were found to lower the serum cholesterol, triglycerides, VLDL, LDL, and atherogenic index at their higher concentration, but were found to slightly increase the HDL as compared to the corresponding normal healthy rats fed with clean water (control). The phytochemicals screening of the teas aqueous extract were also investigated, the chemicals (tannins, saponins, flavonoids, terpenoids and glycosides) which were known to exhibit cholesterol lowering effect by inhibiting its absorption and simultaneous increase its excretion were found to be present in the teas extract. Thus, the study demonstrates and validates thatM.oleifera,G. glabraand their blend possess hypolipidemic effect at higher concentration.

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Effects of Licorice (Glycyrrhiza glabra) on testicular oxidative stress in sleep-deprived male Wistar rats

Annals of Clinical and Experimental Medicine ◽

10.47838/acem.26011977.127122020.asmeda.1.8 ◽

2020 ◽

Vol 1 (2) ◽

Author(s):

Ayodeji J Ajibare ◽

Olabode O Akintoye ◽

Oyesanmi A Fabunmi ◽

Luqman A Olayak ◽

Babatunde A Olofinbiyi ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Medicinal Plant ◽

Sleep Deprivation ◽

Wistar Rats ◽

Glycyrrhiza Glabra ◽

Simultaneous Increase ◽

Distilled Water ◽

Stress Injury ◽

Male Wistar Rats

Background: Sleep deprivation is a public health problem that causes oxidative stress injury. Research evidence agrees that oxidative stress serves as an underlying factor in many chronic debilitating diseases. This study investigated the effect of aqueous Licorice extract (Glycyrrhiza glabra) a medicinal plant with known antioxidant activity on testicular oxidative stress parameters. Methods Twenty-five male Wistar rats were randomly allocated to and administered one of the following treatment regimens daily for five days: CONTROL – Distilled water, Sleep – Deprived (SD) – Distilled water, Sleep Deprived +Sleep Recovery (SD+SR) – Distilled Water, SD+LICORICE (SD+LICORICE) – 150 mg/kg bodyweight of Licorice and Sleep – Deprivation + Sleep-Recovery + Licorice (SD+SR+LICORICE) – 150 mg/kg bodyweight of Licorice. The rats in Sleep – Recovery groups were allowed to sleep in their cages after sleep deprivation protocol for 5 days each treatment regimen had ad libitum access to standard rat chow. After the experiment, the rats were sacrificed and blood was collected. Serum cortisol and testosterone were taken alongside testicular Glutathione, Catalase, and Malondialdehyde. Results Sleep deprivation significantly raised cortisol level and decreased testosterone levels both of which were reversed by licorice administration. Significant reduction in Malondialdehyde (MDA) in rats treated with licorice with a simultaneous increase in both GSH and CAT was also observed. Conclusions The antioxidant activity of licorice (Glycyrrhiza glabra) aqueous extract on the testis of rats exposed to oxidative stress suggests the potential of using this traditional medicinal plant in preventing oxidative injury caused by sleep deprivation.

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Effect of aqueous extract of Allium sativum (Garlic) on fertility in male Wistar rats

Annals of Health Research ◽

10.30442/ahr.0601-11-71 ◽

2020 ◽

pp. 100-107

Author(s):

IO Osonuga ◽

AS Faponle ◽

EN Ezima ◽

TK Adenowo ◽

AA Adelegan

Keyword(s):

Wistar Rats ◽

Allium Sativum ◽

Oral Route ◽

Male Rats ◽

Control Group ◽

High Dose ◽

Aqueous Extracts ◽

Beneficial Effects ◽

Male Wistar Rats ◽

Recovery Groups

Background: Allium sativum (Garlic) is widely used as a food flavour and it has antimicrobial medicinal purposes. It has other beneficial effects such as improving the cardiovascular and immune systems. The likely effect of garlic on the testicular functions remains controversial. Objective: To investigate the effects of fresh garlic on the fertility of male Wistar rats by quantitative determination of testosterone, follicle-stimulating hormone (FSH), and Luteinizing hormone (LH) levels, as well as the sperm properties. Methods: The aqueous extracts of garlic were administered to the animals through the oral route. Thirty-five male rats were categorized into seven groups, with five rats each distributed as follows: high-dose, medium-dose, low-dose that were administered 750, 500, and 250 mg/kg body weight dosages of the aqueous extracts, respectively. Others were the control group, which received no extract, and the recovery groups received the same doses of the extract. The recovery groups were left for additional twenty-one days without receiving the extract. Results: The results showed an increase in testosterone levels at medium to high-doses of the extract including sustained high levels in recovery groups. Also, there were increases in sperm motility and sperm viability. Conclusions: These findings suggest garlic may play beneficial roles in the reproductive functions of male Wistar rats. The mechanisms for these effects may involve the interplay of many currently unknown factors.

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Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male wistar rats

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2020-0246 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Tosan Peter Omayone ◽

Samuel Babafemi Olaleye

Keyword(s):

Acetic Acid ◽

Untreated Control ◽

Wistar Rats ◽

Low Dose ◽

Healing Process ◽

Beneficial Effects ◽

Male Wistar Rats ◽

Haematological Changes ◽

Therapeutic Properties ◽

Histopathological Effects

Abstract Objectives Vanadium has been reported to possess relevant therapeutic properties such as anti-diabetic and anti-tumoral. This study aimed at determining the effects of vanadium on experimentally induced colitis in rats. Methods Forty-five male Wistar rats (103 ± 3.90 g, n=15) were used for this study and were divided into three groups. Group 1 (Untreated control) had nothing added to their drinking, while groups 2 and 3 received sodium metavanadate at a dose of 50 and 200 mg/L respectively in their drinking water for 10 weeks. Colitis was thereafter induced by intra colonic administration of 1.50 mL of 6% acetic acid. Animals were sacrificed on day 0 (pre-induction), three- and seven-days post induction. Blood samples were collected for haematological variables and the distal 8 cm of the colon was collected for macroscopic, histological and biochemical (malondialdehyde-MDA, superoxide dismutase-SOD, catalase-CAT, glutathione peroxidase- GPx and nitrite concentration- NO) assessment. Results Low dose vanadium proved beneficial in ameliorating acetic acid-induced colitis by improving both histopathological and haematological changes. Gross observation showed a faster healing rate in vanadium treated groups (50 and 200 mg/L) compared with untreated control at day 3 (40 and 26.20 vs. 2.50%) and day 7 (80 and 66.70 vs. 42%) respectively. Vanadium also appears to exert its beneficial effects on acetic acid-induced colitis via up regulation of antioxidant enzymes (SOD, CAT, GPx) and NO while decreasing the over production of MDA. Conclusions Vanadium at small concentration functions as an essential trace element and may be able to promote healing process during ulcerative colitis.

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Aqueous extract of Cola nitida and Garcinia kola synergistically enhances hippocampal-hypothalamic glutamate and Na+/K+-ATPase activity in male Wistar rats

Current Drug Discovery Technologies ◽

10.2174/1570163818666210329102207 ◽

2021 ◽

Vol 18 ◽

Author(s):

Kehinde S. Olaniyi ◽

Isaiah W. Sabinari ◽

Adesola A. Oniyide ◽

Nifesimi T. Akinnagbe ◽

Toluwani B. Agunbiade ◽

...

Keyword(s):

Atpase Activity ◽

Wistar Rats ◽

Concomitant Administration ◽

Energy Regulation ◽

Aqueous Extracts ◽

Garcinia Kola ◽

Or Management ◽

Male Wistar Rats ◽

Susceptible Populations ◽

Cola Nitida

Background: The incidence of cognitive decline has been proposed to rise exponentially in coming years. Therapies targeting molecular pathways involved in enhancement of memory and energy regulation could be a major breakthrough in prevention or management of dementia in susceptible populations. Objectives: This study investigated the effects of aqueous extracts of Cola nitida (AECONS) and Garcinia kola (AEGAK) on glutamate level and Na+/K+-ATPase activity in the hippocampus and hypothalamus of male Wistar rats. Methods: Adult male Wistar rats (170-200) were randomly allotted into groups (n=5/group); control (distilled water p.o.), AECONS1 (200 mg/kg), AECONS2 (400 mg/kg), AEGAK1 (200 mg/kg), AEGAK2 (400 mg/kg), AECONS1+AEGAK1 and AECONS2+AEGAK2. The extract was prepared and the administration was done daily for 6 weeks. Results and Discussion: Administration of AECONS or AEGAK increased plasma, hippocampal and hypothalamic glutamate, Na+/K+-ATPase activity, NO, SOD except hippocampal glutamate in AECONS1/AEGAK1, Na+/K+-ATPase activity and SOD in AEGAK1, hypothalamic glutamate and SOD in AECONS1 when compared with control. Besides, MDA level decreased in AEGAK2 and hippocampal but not hypothalamic MDA decreased in AEGAK1 compared with control. However, concomitant administration of AECONS and AEGAK enhanced plasma, hippocampal and hypothalamic biomarkers except hypothalamic MDA level. The present study demonstrates that AECONS and AEGAK synergistically enhances hippocampal and hypothalamic glutamate and Na+/K+-ATPase activity, which are accompanied by NO and SOD-dependent antioxidant enrichment. Conclusion: These findings therefore suggest that AECONS+AEGAK could be a better therapeutic candidate in hippocampal-hypothalamic-related neurodegenerative diseases.

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Nutraceutical values of hot water infusions of moringa leaf (Moringa oleifera) and licorice root (Glycyrrhiza glabra) and their effects on liver biomarkers in Wistar rats

Journal of Food Measurement & Characterization ◽

10.1007/s11694-018-9973-3 ◽

2018 ◽

Vol 13 (1) ◽

pp. 602-613

Author(s):

Sule O. Salawu ◽

Emmanuel O. Ibukun ◽

Israel A. Esan

Keyword(s):

Wistar Rats ◽

Moringa Oleifera ◽

Hot Water ◽

Glycyrrhiza Glabra ◽

Licorice Root

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Effects of aqueous extract of Moringa oleifera seed on cadmium-induced reproductive toxicity in male Wistar rats

African Health Sciences ◽

10.4314/ahs.v18i3.23 ◽

2018 ◽

Vol 18 (3) ◽

pp. 653 ◽

Cited By ~ 3

Author(s):

Olawale O Obembe ◽

Yunus Raji

Keyword(s):

Aqueous Extract ◽

Wistar Rats ◽

Moringa Oleifera ◽

Reproductive Toxicity ◽

Male Wistar Rats ◽

Moringa Oleifera Seed

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The hypolipidemic action of a diet supplemented withp,p’-methoxyl-diphenyl diselenide is not directly related to its antioxidant property

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2015-0411 ◽

2016 ◽

Vol 94 (6) ◽

pp. 662-668 ◽

Cited By ~ 3

Author(s):

Carla Elena Sartori Oliveira ◽

Simone Pinton ◽

Juliana Trevisan da Rocha ◽

Bibiana Mozzaquatro Gai ◽

Cristina Wayne Nogueira

Keyword(s):

Oxidative Stress ◽

Lipid Profile ◽

Wistar Rats ◽

Antioxidant Property ◽

Atherogenic Index ◽

Hypolipidemic Effect ◽

Diphenyl Diselenide ◽

Hypolipidemic Action ◽

Triton Wr 1339 ◽

Rule Out

The present study investigated whether a p,p’-methoxyl-diphenyl diselenide (MeOPhSe)2-supplemented diet causes toxicity in rats. A second aim of this study was to determine whether a 10 ppm (MeOPhSe)2-supplemented diet has hypolipidemic effect on Triton WR-1339-induced hyperlipidemia in rats. To rule out the antioxidant property of (MeOPhSe)2in its hypolipidemic action, parameters of oxidative stress were carried out. Wistar rats were fed with 3, 10, or 30 ppm of (MeOPhSe)2-supplemented diet for 30 days. None of (MeOPhSe)2-supplemented diets caused alteration in general parameters of toxicity and lipid profile of rats. The hypolipidemic effect of 10 ppm of (MeOPhSe)2-supplemented diet on rats treated with Triton WR-1339 (400 mg/kg, intraperitoneal) was investigated. The (MeOPhSe)2-supplemented diet partially protected against the levels of total cholesterol (TC) and non-HDL-C and reduced the atherogenic index (AI) increased by Triton WR-1339 in rats. A positive correlation between TC and triglyceride levels (r = 0.679) and non-HDL-C levels (r = 0.929) and AI (r = 0.889) was demonstrated. Triton WR-1339 altered parameters of oxidative stress in livers of rats but (MeOPhSe)2-supplemented diet did not protect against these alterations. The results demonstrated that the hypolipidemic action of (MeOPhSe)2-supplemented diet is not directly related to its antioxidant property and devoid of systemic toxicity in rats at the parameters analyzed.

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