Natural Antioxidants Effect of Mulberry Fruits (Morus nigra and Morus alba L.) On Lipids Profile and Oxidative Stress in Hypercholestrolemic Rats

2013 ◽  
Vol 12 (7) ◽  
pp. 665-672 ◽  
Author(s):  
Mohamed Y. Mahmoud
Author(s):  
Bin Wang ◽  
Gaurav Gupta ◽  
Mahaveer Singh ◽  
Kasturi Vishwanatha Setty Veerabhadrappa ◽  
Anurag Mishra ◽  
...  

Cosmetics ◽  
2021 ◽  
Vol 8 (4) ◽  
pp. 111
Author(s):  
Punniamoorthy Thiviya ◽  
Ashoka Gamage ◽  
Dinushika Piumali ◽  
Othmane Merah ◽  
Terrence Madhujith

The excess level of reactive oxygen species (ROS) disturbs the oxidative balance leading to oxidative stress, which, in turn, causes diabetes mellites, cancer, and cardiovascular diseases. These effects of ROS and oxidative stress can be balanced by dietary antioxidants. In recent years, there has been an increasing trend in the use of herbal products for personal and beauty care. The Apiaceae (previously Umbelliferae) family is a good source of antioxidants, predominantly phenolic compounds, therefore, widely used in the pharmaceutical, cosmetic, cosmeceutical, flavor, and perfumery industries. These natural antioxidants include polyphenolic acids, flavonoids, carotenoids, tocopherols, and ascorbic acids, and exhibit a wide range of biological effects, including anti-inflammatory, anti-aging, anti-atherosclerosis, and anticancer. This review discusses the Apiaceae family plants as an important source of antioxidants their therapeutic value and the use in cosmetics.


2015 ◽  
Vol 54 (6) ◽  
pp. 1052-1064 ◽  
Author(s):  
Nergiz Hacer Turgut ◽  
Derya Guliz Mert ◽  
Haki Kara ◽  
Hatice Reyhan Egilmez ◽  
Emre Arslanbas ◽  
...  

Author(s):  
A. D. Kadam ◽  
D. M. Khopade ◽  
A. V. Sontakke ◽  
S. A. Abhang

Objective: In several countries including India, leprosy is an older disease & until now continuous to be an important health issue. Leprosy is a chronic granulomatous disease, the causative agent for which is mycobacterium leprae. Due to imbalance between natural antioxidants and oxidative stress is significant event occurs that influences the pathogenesis of leprosy. Considering this the study was carried out to find, what type of relationship between MDA, Protein carbonyl and thiols as disease advances. Methods: 50 diagnosed leprosy patients & 50 healthy controls were included in this study. In leprosy group, 16 were Paucibacillary (PB) and 34 were Multibacillary (MB) type leprosy patients. Results: Serum Protein carbonyl and serum Malondialdehyde increased in leprosy patients than controlling. Further analysis reveals that the serum malondialdehyde was significantly increased in MB leprosy patients than PB leprosy patients. On the other hand, our proposed system significantly lowers the total thiols in leprosy patients when compared with controls. Serum total thiols were lower in MB leprosy than PB leprosy patients. Among leprosy patients the negative correlation of Malondialdehyde with total thiol and Protein carbonyl with total thiols was observed. Conclusion: Thus, as protein oxidation and lipid per oxidation in leprosy increases, the total thiols decreases which may lead to modifications of protein and lipids that are responsible for severity of disease hence therapy aimed at reducing generation of free radicals that can result in oxidative stress and as a result a modification of proteins and lipids.


Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 223 ◽  
Author(s):  
Carmine Negro ◽  
Alessio Aprile ◽  
Luigi De Bellis ◽  
Antonio Miceli

In this work, for the first time, were analyzed mulberry genotypes grown in Apulia (Southern Italy, Salento region) were analyzed. Two local varieties of Morus alba (cv. Legittimo nero and cv. Nello) and one of Morus nigra were characterized for content in simple sugars, organic acids, phenols, anthocyanins; fruit antioxidant activity (AA) was also evaluated by three different methods (2,2-Diphenyl-1-picrylhydrazyl, DPPH; 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ABTS; and Ferric reducing antioxidant potential, FRAP test). The results showed that the sugars amount ranged between 6.29 and 7.66 g/100 g fresh weight (FW) while the malic and citric acids content was low, at about 0.1–1 g/100 g FW. Mulberries are a good source of phenols which are present in higher values in M. nigra and M. alba cv. Legittimo nero (485 and 424 mg Gallic Acid Equivalent (GAE)/ 100 g FW, respectively). The high performance liquid chromatography/diode array detector/mass spectrometry (HPLC/DAD/MS) analysis identified 5 main anthocyanin compounds present in different concentrations in each variety of mulberry: cyanidin 3-sophoroside, cyanidin 3-glucoside, cyanidin 3-rutinoside, pelargonidin 3-glucoside, pelargonidin 3-rutinoside. The highest concentration of anthocyanins was determined in Morus alba Legittimo (about 300 mg/100 g FW) while the lowest content (about 25 mg/100 g FW) was measured in M. alba cv. Nello. Morus nigra showed a good AA in comparison with the different M. alba genotypes with all the used methods; its AA was equal to 33, 26 and 21 μmols Trolox/g FW when using DPPH, ABTS and FRAP tests, respectively. All genotypes showed an anti-inflammatory activity (measured by cyclooxygenase (COX) inhibitory assay) which was also compared with two commercial anti-inflammatory drugs. The data obtained support the high biological qualities of mulberry fruits and their diffusion in human nutrition.


2014 ◽  
Vol 5 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Hemdan Ibrahem Mahmoud ◽  
Said Mnaa Gad ElRab ◽  
Ayman Fathey Khalil ◽  
Samah Mohamed Ismael

2015 ◽  
Vol 12 ◽  
pp. 399-408 ◽  
Author(s):  
Eva M. Sánchez-Salcedo ◽  
Pedro Mena ◽  
Cristina García-Viguera ◽  
Juan José Martínez ◽  
Francisca Hernández

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2757
Author(s):  
Alexandra Usuga ◽  
Irene Tejera ◽  
Jorge Gómez ◽  
Oliver Restrepo ◽  
Benjamín Rojano ◽  
...  

Sperm undergo oxidative stress due to excessive production of reactive oxygen species (ROS) during cryopreservation. Some unconventional natural antioxidants can reduce ROS-induced changes in cryopreserved canine sperm. This study aimed to identify the cryoprotective effects of ergothioneine and isoespintanol on the quality of thawed canine semen. Twelve ejaculates from six dogs were cryopreserved in a tris-yolk extender without (control) or with 50 (E50), 100 (E100), or 150 (E150) µM ergothioneine or 20 (I20), 40 (I40), or 60 (I60) µM isoespintanol. We evaluated the motility and kinetics of thawed sperm using computerized analysis; determined morphology by eosin-nigrosin staining; functional membrane integrity using hypoosmotic tests, and structural membrane and acrosome integrity; mitochondrial membrane potential by fluorescence microscopy; and ROS production by spectrophotometry. Data were statistically analyzed using mixed models and Tukey tests. E100 increased total (60.6% vs. 49.6%) and progressive (26.4% vs. 20.1%) motility, straight line velocity (41.3 vs. 35.9 µm/s), and rapid sperm (17.6% vs. 12.3%) compared with controls. However, E150 reduced the numbers of hyperactive sperm. E100, I40, and I60 reduced the abnormal morphology and ROS production, and all concentrations of both antioxidants increased acrosomal integrity. We concluded that ergothioneine and isoespintanol reduce deleterious sperm alterations and oxidative stress in thawed canine semen.


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