Acute Toxicity and Hepatoprotective Effect of Methanolic Extract of Tephrosia calophylla

2011 ◽  
Vol 5 (3) ◽  
pp. 266-273 ◽  
Author(s):  
K. Adinarayan ◽  
K.N. Jayaveera ◽  
P. Mallikarjuna Rao ◽  
C. Madhusudhana Chetty ◽  
D.K. Sandeep ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Hepatoprotective Effect

Acute and sub-acute toxicity methanolic extract from Brickellia cavanillesii in mice

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
GM Avila-Villarreal ◽  
DE Giles-Rivas ◽  
B Aguilar-Guadarrama ◽  
P Castillo-España ◽  
S Estrada-Soto
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract

scholarly journals Acute and Sub-Acute Toxicity Evaluation of the Methanolic Extract of Alstonia scholaris Stem Bark

2016 ◽  
Vol 4 (1) ◽  
pp. 4 ◽  
Author(s):  
Idris Bello ◽  
Abdulmenem Bakkouri ◽  
Yasser Tabana ◽  
Bassel Al-Hindi ◽  
Majed Al-Mansoub ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Stem Bark ◽  
Toxicity Evaluation ◽  
Alstonia Scholaris

scholarly journals Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves

2011 ◽  
Vol 3 (1) ◽  
pp. 40 ◽  
Author(s):  
PSuresh Babu ◽  
V Krishna ◽  
KR Maruthi ◽  
K Shankarmurthy ◽  
RameshK Babu
Keyword(s):  
Acute Toxicity ◽  
Methanolic Extract ◽  
Hepatoprotective Activity ◽  
Dichrostachys Cinerea

scholarly journals Acute and Subacute Toxicity Profiles of the Methanol Extract of Lycopersicon esculentum L. Leaves (Tomato), a Botanical with Promising In Vitro Anticancer Potential

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Gaëlle S. Nguenang ◽  
Arsène S. M. Ntyam ◽  
Victor Kuete
Keyword(s):  
Single Dose ◽  
Acute Toxicity ◽  
Lycopersicon Esculentum ◽  
Methanolic Extract ◽  
Female Rats ◽  
Male Rats ◽  
Total Serum ◽  
Subacute Toxicity ◽  
Tomato Extract ◽  
Long Term Treatment

Lycopersicon esculentum (tomato) is a plant widely used in Africa like food and to solve many health problems. The methanol crude extract of tomato recently demonstrated a good antiproliferative effect on many human cancer cell lines. The aim of this research was to evaluate the acute toxicity and subacute oral toxicity of methanolic extract from leaves of this plant. These toxicities were evaluated based on the OECD (Organization for Economic Cooperation and Development) guidelines. The assay of acute toxicity was performed using a total of 3 female rats, which received a single dose of 5000 mg/kg of methanolic extract via oral gavage. For the subacute toxicity study, 32 Wistar rats (males and females) were used. The groups were treated with three different doses of Lycopersicon esculentum methanolic extract (250, 500, and 1000 mg/kg b.w.) for 28 days and the control group received distilled water. The hematological, biochemical, and histopathological studies were performed after the sacrifice. Single dose of tomato extract caused no toxicity up to a dose of 5000 mg/kg body weight; hence, the median lethal dose (DL50) of leaves of this plant was greater than this value. However, lower toxic effects could be manifested in the long-term treatment at the highest dose (1000 mg/kg) because urea level and total serum proteins significantly increased at a dose of 1000 mg/kg with respect to control. The microscopic observation showed no remarkable pathological changes on all organs in the treated groups compared with the control groups of female and male rats. These results demonstrate that single dose of tomato extract leaves is relatively nontoxic at a dose of 5000 mg/kg b.w. and prolonged use of lower doses (250 and 500 mg/kg) of L. esculentum orally should be encouraged, whereas highest dose (1000 mg/kg) should be avoided.

Antioxidant and Analgesic Activity of Acer laevigatum Wall, a Traditional Mizo-tribe Medicine

2020 ◽  
Vol 13 (6) ◽  
pp. 5200-5207
Author(s):  
Andrew Lalthasanga Ralte ◽  
Phaibiang Lapasam ◽  
Freddy Teilang Nongkhlaw ◽  
Pdiangmon Kyndait ◽  
Zothanpuia
Keyword(s):  
Antioxidant Activity ◽  
Acute Toxicity ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Bark Extract ◽  
Total Phenolic ◽  
Phytochemical Screening ◽  
External Application ◽  
Soxhlet Apparatus

Acer laevigatum is an evergreen tree growing to a height of 10–15 m or more, with a trunk up to 50 cm diameter belonging to the family Sapindaceae. In Mizoram, the decoction of the leaves is used as an external application in sprains. Extraction was carried out by drying the leaves and barks and extracted by using methanol as solvent using the Soxhlet apparatus. Preliminary phytochemical screening was carried out by methanolic extract of both leaves and barks to determine the chemical constituents present in the plant using a different phytochemical test, acute toxicity for leave and bark extract, in-vitro antioxidant activity and in-vivo analgesic activity of barks extract. Phytochemical screening was performed for both extract and it contains glycoside, saponin, phenol, tannin, flavonoid, and steroid. The antioxidant activity test of the methanolic extract of bark extract was performed successfully. In acute toxicity, the LD50 was found that for more than 2000 mg/kg body weight was safe for further uses. The total phenolic content of the bark extract contains 493 ± 0.23 mg of GAE/g and the total flavonoids content of the bark extract was 220 ± 0.034 mg of QE/g. The IC50 value of DPPH free radical scavenging activity was found to be 86.1211 µg/ml and nitric oxide was 75.9 µg/ml. Whereas, in reducing power it was found that the percentage inhibition was increased with an increase in concentration (increase in concen-tration, percentage inhibition was also increased) and reduced Fe3+ (ferricyanide complex) to Fe2+ (ferrous form). Finally, for in-vivo analgesic activity, 4000 mg/kg was more effective than 2000 mg/kg of the bark extract. These results confirm that the methanolic extract of bark of Acer laevigatum possesses antioxidant activity and non-significant or less analgesic activity.

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