scholarly journals Protective Role of Natural Antioxidants Against the Formation and Harmful Effects of Acrylamide in Food

2019 ◽  
Vol 14 (1) ◽  
pp. 41-55 ◽  
Author(s):  
Rehab Mohamed Ibrahim ◽  
Isis Nawar ◽  
Mokhtar Ibrahim Yousef ◽  
Mahmoud Ibrahim El-Sayed ◽  
Amal Hassanein
Keyword(s):  
Natural Antioxidants ◽  
Protective Role ◽  
Harmful Effects

scholarly journals Protective Role of Flavonoids against Intestinal Pro-Inflammatory Effects of Silver Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6610
Author(s):  
Ana T. Rufino ◽  
Ana Ramalho ◽  
Adelaide Sousa ◽  
José Miguel P. Ferreira de Oliveira ◽  
Paulo Freitas ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Protective Action ◽  
Cell Types ◽  
Protective Role ◽  
Toxic Effects ◽  
Oral Exposure ◽  
Dietary Flavonoids ◽  
Harmful Effects ◽  
Human Intestinal Cells

Silver nanoparticles (AgNP) have been increasingly incorporated into food-related and hygiene products for their unique antimicrobial and preservative properties. The consequent oral exposure may then result in unpredicted harmful effects in the gastrointestinal tract (GIT), which should be considered in the risk assessment and risk management of these materials. In the present study, the toxic effects of polyethyleneimine (PEI)-coated AgNP (4 and 19 nm) were evaluated in GIT-relevant cells (Caco-2 cell line as a model of human intestinal cells, and neutrophils as a model of the intestinal inflammatory response). This study also evaluated the putative protective action of dietary flavonoids against such harmful effects. The obtained results showed that AgNP of 4 and 19 nm effectively induced Caco-2 cell death by apoptosis with concomitant production of nitric oxide, irrespective of the size. It was also observed that AgNP induced human neutrophil oxidative burst. Interestingly, some flavonoids, namely quercetin and quercetagetin, prevented the deleterious effects of AgNP in both cell types. Overall, the data of the present study provide a first insight into the promising protective role of flavonoids against the potentially toxic effects of AgNP at the intestinal level.

scholarly journals Radio-protective role of antioxidant agents

2012 ◽  
pp. e16
Author(s):  
Alireza Shirazi ◽  
Ehsan Mihandoost ◽  
Seied Rabie Mahdavi ◽  
Mehran Mohseni
Keyword(s):  
Therapeutic Index ◽  
Past Research ◽  
Protective Role ◽  
Herbal Products ◽  
Antioxidant Agents ◽  
Effects Of Radiation ◽  
Cellular Components ◽  
Harmful Effects ◽  
Research Show

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

scholarly journals Protective Role of Trigonella hamosa Saponins Against Diabetic Perturbations and Complications in Rats

2007 ◽  
Vol 2 (8) ◽  
pp. 1934578X0700200
Author(s):  
Alaa-Eldin Salah-Eldin ◽  
Usama Ahmed Mahalel ◽  
Arafa I. Hamed
Keyword(s):  
Oxidative Stress ◽  
Glucose Homeostasis ◽  
Protein Metabolism ◽  
Protective Role ◽  
Lipid Profiles ◽  
Insulin Synthesis ◽  
Harmful Effects

Trigonella hamosa saponins (SS) were purified using Sephadex LH-20. The effects of SS on diabetes, lipid profiles and glucose homeostasis were investigated by supplementation of the diet of rats with SS, which countered the adverse, harmful effects of chronic diabetes by improving insulin synthesis, secretion and action, enhancing lipid and protein metabolism, and removing the oxidative stress concomitant with glucose homeostasis.

scholarly journals The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

2021 ◽  
Vol 11 ◽  
Author(s):  
Liuqing Yang ◽  
Yun Chen ◽  
Yan Liu ◽  
Yu Xing ◽  
Chenyun Miao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reproductive Potential ◽  
Natural Antioxidants ◽  
Protective Role ◽  
Therapeutic Interventions ◽  
Telomere Shortening ◽  
Ovarian Aging ◽  
Promising Strategy ◽  
Apoptosis And Inflammation

The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.

scholarly journals Radio-protective role of antioxidant agents

2012 ◽  
Vol 6 (2) ◽  
pp. 16 ◽  
Author(s):  
Alireza Shirazi ◽  
Ehsan Mihandoost ◽  
Seied Rabie Mahdavi ◽  
Mehran Mohseni
Keyword(s):  
Therapeutic Index ◽  
Past Research ◽  
Protective Role ◽  
Herbal Products ◽  
Antioxidant Agents ◽  
Effects Of Radiation ◽  
Cellular Components ◽  
Harmful Effects ◽  
Research Show

Ionizing radiation interacts with biological systems to produce reactive oxygen species and reactive nitrogen species which attack various cellular components. Radio-protectors act as prophylactic agents to shield healthy cells and tissues from the harmful effects of radiation. Past research on synthetic radio-protectors has brought little success, primarily due to the various toxicity-related problems. Results of experimental research show that antioxidant nutrients, such as vitamin E and herbal products and melatonin, are protective against the damaging effects of radiation, with less toxicity and side effects. Therefore, we propose that in the future, antioxidant radio-protective agents may improve the therapeutic index in radiation oncology treatments.

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Parenting Behaviors and Anxiety in Young Adults

2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock
Keyword(s):  
Effortful Control ◽  
Parenting Behaviors ◽  
Protective Role ◽  
Anxiety Symptoms ◽  
Interactive Effects ◽  
Parental Overprotection ◽  
High Control ◽  
Development Of Anxiety ◽  
The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

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