Prospective association between alcohol intake and hormone-dependent cancer risk: modulation by dietary fiber intake

Abstract Dietary fiber intake has been implicated as a protective factor for several human cancers in multiple epidemiologic studies. However, little is known about the effect of fiber intake on bladder cancer. This study examines the association between dietary fiber intake and bladder cancer risk among participants in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. A total of 101 721 participants were included in this study as they completed both the baseline questionnaire and the diet history questionnaire (cancer free before completion of the diet history questionnaire). Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were estimated using the Cox proportional hazards regression model. After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Higher intake of total fiber, insoluble fiber and soluble fiber were not significantly associated with a reduced risk of bladder cancer. The multi-adjusted HRs (95 CIs) of highest versus lowest tertile of intake were 0.83 (0.66–1.04) for total fiber (P for trend = 0.098), 0.83 (95% CI: 0.67–1.03) for insoluble fiber (P for trend = 0.092) and 0.86 (95% CI: 0.68–1.08) for soluble fiber (P for trend = 0.168), respectively. There was no significant interaction of potential confounders, including education, body mass index and smoking status, with total fiber intake on bladder cancer risk. In summary, the findings of this prospective study show that there is no obvious evidence for a link between dietary fiber consumption and bladder cancer risk. Further large cohort studies are warranted to confirm these findings.

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Dietary fiber intake and ovarian cancer risk: a prospective cohort study

Cancer Causes & Control ◽

10.1007/s10552-006-0107-6 ◽

2007 ◽

Vol 18 (3) ◽

pp. 335-341 ◽

Cited By ~ 11

Author(s):

Stephanie A. N. Silvera ◽

Meera Jain ◽

Geoffrey R. Howe ◽

Anthony B. Miller ◽

Thomas E. Rohan

Keyword(s):

Ovarian Cancer ◽

Cohort Study ◽

Cancer Risk ◽

Dietary Fiber ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Ovarian Cancer Risk ◽

Fiber Intake ◽

Dietary Fiber Intake

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Dietary Fiber Intake Modifies the Positive Association between n–3 PUFA Intake and Colorectal Cancer Risk in a Caucasian Population

Journal of Nutrition ◽

10.3945/jn.114.208462 ◽

2015 ◽

Vol 145 (8) ◽

pp. 1709-1716 ◽

Cited By ~ 17

Author(s):

Bledar Kraja ◽

Taulant Muka ◽

Rikje Ruiter ◽

Catherine E de Keyser ◽

Albert Hofman ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Positive Association ◽

Caucasian Population ◽

Colorectal Cancer Risk ◽

Fiber Intake ◽

Pufa Intake ◽

Dietary Fiber Intake

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Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

International Journal of Cancer ◽

10.1002/ijc.30886 ◽

2017 ◽

Vol 141 (9) ◽

pp. 1811-1821 ◽

Cited By ~ 12

Author(s):

Daisuke Kawakita ◽

Yuan-Chin Amy Lee ◽

Federica Turati ◽

Maria Parpinel ◽

Adriano Decarli ◽

...

Keyword(s):

Head And Neck Cancer ◽

Cancer Risk ◽

Head And Neck ◽

Dietary Fiber ◽

Neck Cancer ◽

Pooled Analysis ◽

Cancer Epidemiology ◽

Fiber Intake ◽

Dietary Fiber Intake

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Association between dietary fiber intake and risk of ovarian cancer: a meta-analysis of observational studies

Journal of International Medical Research ◽

10.1177/0300060518792801 ◽

2018 ◽

Vol 46 (10) ◽

pp. 3995-4005 ◽

Cited By ~ 8

Author(s):

Xiumin Huang ◽

Xuelian Wang ◽

Jing Shang ◽

Yanzhen Lin ◽

Ying Yang ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Meta Analysis ◽

Ovarian Cancer Risk ◽

Fiber Intake ◽

Case Control Studies ◽

Relative Risks ◽

Dietary Fiber Intake ◽

Study Heterogeneity

Objective To evaluate the associations between dietary fiber intake and ovarian cancer risk. Methods A literature survey was conducted by searching the PubMed, Web of Science, and Wanfang Med Online databases up to March 1st, 2018. The effect of dietary fiber intake on ovarian cancer risk was evaluated by calculating relative risks with 95% confidence intervals (95%CI) using Stata 12.0 software. Results A total of 17 articles with 149,177 participants including 7609 ovarian cancer patients were included in this analysis. The summarized relative risk for ovarian cancer in participants with the highest compared with the lowest fiber intake was 0.760 (95%CI=0.702–0.823), with no significant between-study heterogeneity ( I2=12.4%). Subgroup analysis according to study design demonstrated positive associations in both cohort studies and case-control studies. Moreover, the results were consistent among populations from America, Europe, and Asia. No publication bias was found by Egger’s test or funnel plots. Conclusion This meta-analysis concluded that a high intake of dietary fiber could significantly reduce the risk of ovarian cancer compared with a low fiber intake.

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Dietary fiber intake and pancreatic cancer risk: a meta-analysis of epidemiologic studies

Scientific Reports ◽

10.1038/srep10834 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 18

Author(s):

Chun-Hui Wang ◽

Chong Qiao ◽

Ruo-Chen Wang ◽

Wen-Ping Zhou

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Meta Analysis ◽

Epidemiologic Studies ◽

Fiber Intake ◽

Pancreatic Cancer Risk ◽

Dietary Fiber Intake

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Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

Nutrients ◽

10.3390/nu10070945 ◽

2018 ◽

Vol 10 (7) ◽

pp. 945 ◽

Cited By ~ 4

Author(s):

Kangning Chen ◽

Qianyu Zhao ◽

Xiaofan Li ◽

Jing Zhao ◽

Peiqin Li ◽

...

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Meta Analysis ◽

Case Control ◽

Negative Association ◽

Fiber Intake ◽

Case Control Studies ◽

Endometrial Cancer Risk ◽

Dietary Fiber Intake

Epidemiological studies are inconclusive regarding the association between dietary fiber intake and endometrial cancer risk. Thus, we aimed to conduct a meta-analysis to clarify the association between dietary fiber and endometrial cancer risk. We searched the PubMed and ISI Web databases for relevant studies through March 2018. The association between dietary fiber and endometrial cancer risk was evaluated by conducting a meta-analysis including 3 cohort and 12 case–control studies. A significant negative association was observed between total dietary fiber intake and endometrial cancer risk in 11 case–control studies (odds ratios (OR) 0.76, 95% confidence interval (CI): 0.64–0.89, I2 = 35.2%, p = 0.117), but a marginal positive association was observed in three cohort studies (relative risk (RR) 1.22, 95% CI: 1.00–1.49, I2 = 0.0%, p = 0.995). Particularly, a negative association was observed in North America (OR = 0.70, 95% CI: 0.59–0.83, I2 = 8.9%, p = 0.362). In addition, a positive association was observed in cereal fiber (RR = 1.26, 95% CI: 1.03–1.52, I2 = 0.0%, p = 0.530, 3 cohort studies) and a negative association was observed in vegetable fiber (OR = 0.74, 95% CI: 0.58–0.94, I2 = 0.0%, p = 0.445, 3 case–control studies). In conclusion, negative associations with endometrial cancer risk were observed for higher total dietary fiber intake and higher vegetable fiber intake in the case–control studies. However, results from the cohort studies suggested positive relationships of higher total fiber intake and higher cereal fiber intake with endometrial cancer risk.

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