Dietary Fiber Intake and Endometrial Cancer Risk: A Systematic Review and Meta-Analysis

Epidemiological studies are inconclusive regarding the association between dietary fiber intake and endometrial cancer risk. Thus, we aimed to conduct a meta-analysis to clarify the association between dietary fiber and endometrial cancer risk. We searched the PubMed and ISI Web databases for relevant studies through March 2018. The association between dietary fiber and endometrial cancer risk was evaluated by conducting a meta-analysis including 3 cohort and 12 case–control studies. A significant negative association was observed between total dietary fiber intake and endometrial cancer risk in 11 case–control studies (odds ratios (OR) 0.76, 95% confidence interval (CI): 0.64–0.89, I2 = 35.2%, p = 0.117), but a marginal positive association was observed in three cohort studies (relative risk (RR) 1.22, 95% CI: 1.00–1.49, I2 = 0.0%, p = 0.995). Particularly, a negative association was observed in North America (OR = 0.70, 95% CI: 0.59–0.83, I2 = 8.9%, p = 0.362). In addition, a positive association was observed in cereal fiber (RR = 1.26, 95% CI: 1.03–1.52, I2 = 0.0%, p = 0.530, 3 cohort studies) and a negative association was observed in vegetable fiber (OR = 0.74, 95% CI: 0.58–0.94, I2 = 0.0%, p = 0.445, 3 case–control studies). In conclusion, negative associations with endometrial cancer risk were observed for higher total dietary fiber intake and higher vegetable fiber intake in the case–control studies. However, results from the cohort studies suggested positive relationships of higher total fiber intake and higher cereal fiber intake with endometrial cancer risk.

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Association between dietary fiber intake and risk of ovarian cancer: a meta-analysis of observational studies

Journal of International Medical Research ◽

10.1177/0300060518792801 ◽

2018 ◽

Vol 46 (10) ◽

pp. 3995-4005 ◽

Cited By ~ 8

Author(s):

Xiumin Huang ◽

Xuelian Wang ◽

Jing Shang ◽

Yanzhen Lin ◽

Ying Yang ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Meta Analysis ◽

Ovarian Cancer Risk ◽

Fiber Intake ◽

Case Control Studies ◽

Relative Risks ◽

Dietary Fiber Intake ◽

Study Heterogeneity

Objective To evaluate the associations between dietary fiber intake and ovarian cancer risk. Methods A literature survey was conducted by searching the PubMed, Web of Science, and Wanfang Med Online databases up to March 1st, 2018. The effect of dietary fiber intake on ovarian cancer risk was evaluated by calculating relative risks with 95% confidence intervals (95%CI) using Stata 12.0 software. Results A total of 17 articles with 149,177 participants including 7609 ovarian cancer patients were included in this analysis. The summarized relative risk for ovarian cancer in participants with the highest compared with the lowest fiber intake was 0.760 (95%CI=0.702–0.823), with no significant between-study heterogeneity ( I2=12.4%). Subgroup analysis according to study design demonstrated positive associations in both cohort studies and case-control studies. Moreover, the results were consistent among populations from America, Europe, and Asia. No publication bias was found by Egger’s test or funnel plots. Conclusion This meta-analysis concluded that a high intake of dietary fiber could significantly reduce the risk of ovarian cancer compared with a low fiber intake.

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Dietary fiber intake and pancreatic cancer risk: a meta-analysis of epidemiologic studies

Scientific Reports ◽

10.1038/srep10834 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 18

Author(s):

Chun-Hui Wang ◽

Chong Qiao ◽

Ruo-Chen Wang ◽

Wen-Ping Zhou

Keyword(s):

Pancreatic Cancer ◽

Cancer Risk ◽

Dietary Fiber ◽

Meta Analysis ◽

Epidemiologic Studies ◽

Fiber Intake ◽

Pancreatic Cancer Risk ◽

Dietary Fiber Intake

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Modelling body mass index and endometrial cancer risk in a pooled-analysis of three case-control studies

BJOG An International Journal of Obstetrics & Gynaecology ◽

10.1111/1471-0528.13717 ◽

2015 ◽

Vol 123 (2) ◽

pp. 285-292 ◽

Cited By ~ 6

Author(s):

M Rota ◽

F Rumi ◽

V Bagnardi ◽

L Dal Maso ◽

A Zucchetto ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Cancer Risk ◽

Body Mass ◽

Pooled Analysis ◽

Case Control ◽

Case Control Studies ◽

Endometrial Cancer Risk

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Association of dietary fiber intake and gut microbiota in healthy adults.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.1569 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. 1569-1569 ◽

Cited By ~ 1

Author(s):

Daniel Lin ◽

Brandilyn Peters ◽

Rashmi Sinha ◽

James J. Goedert ◽

Richard Hayes ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Risk ◽

Gut Microbiota ◽

Dietary Fiber ◽

Community Composition ◽

Meta Analysis ◽

Healthy Adults ◽

Fiber Intake ◽

Dietary Fiber Intake ◽

The Relationship

1569 Background: Increasing evidence has shown that gut microbiota alterations may play a role in colorectal cancer risk. Diet, particularly fiber intake, may modify gut microbiota composition, which may consequently impact cancer risk development. We investigated the relationship between dietary fiber intake and gut microbiota in healthy humans. Methods: Using 16S rRNA gene sequencing, we assessed gut microbiota in fecal samples from 151 healthy adults in two independent study populations: Study A, n = 75 (healthy controls from a colorectal cancer case-control study), and Study B, n = 76 (polyp-free subjects from a cross-sectional colonoscopy study). We calculated energy-adjusted total dietary fiber intake of participants based on food frequency questionnaires. For each study population, we evaluated the relationship between quartiles of higher fiber intake as a continuous ordinal variable, and global gut microbiota community composition (via PERMANOVA of weighted UniFrac distance) and specific taxon abundance (via DESeq2). Results: We found that fiber intake was significantly associated with overall microbial community composition in Study B (p = 0.003) but not Study A (p = 0.68), after adjustment for age, sex, race, body mass index, and cigarette smoking. In a taxonomy-based meta-analysis of these two study populations, higher fiber intake was associated with lower abundance of genus Actinomyces (fold change [FC] = 0.769, p = 0.003), and higher abundance of genera Faecalibacterium (FC = 1.153, p = 0.03), Lachnospira (FC = 1.167, p = 0.04), and SMB53 (FC = 1.201, p = 0.05). A species-level meta-analysis showed an association between higher fiber intake and higher abundance of Faecalibacterium prausnitzii (FC = 1.165, p = 0.03) and lower abundance of Ruminococcus bromii (FC = 0.828, p = 0.08). Conclusions: Our results suggest that higher intake of dietary fiber may alter gut microbiota in healthy adults. Given the potentially modifiable nature of the gut microbiota through diet, these findings warrant further study of diet-microbiota based colorectal cancer prevention strategies.

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Metformin and endometrial cancer risk: A Meta-analysis

10.21203/rs.2.19317/v1 ◽

2019 ◽

Author(s):

Weimin Xie ◽

Dan Wen

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Fixed Effects ◽

Controlled Trial ◽

Meta Analysis ◽

Case Control Studies ◽

Eligibility Criteria ◽

Endometrial Cancer Risk ◽

Patients With Diabetes ◽

Comprehensive Search

Abstract Objective: To assess the association between metformin and endometrial cancer risk by conducting a meta-analysis.Methods: A comprehensive search of electronic databases, conference abstracts, and clinical trial registers was performed to identify available evidence. Studies that evaluated the association between metformin use and endometrial cancer risk were considered. We pooled relative risk (RR) estimates with 95% confidence intervals (CIs) by using either a fixed-effects or a random-effects model.Results: Nine studies (1 randomized controlled trial, 5 cohort studies, and 3 case-control studies) involving more than 1.20 million participants and 7,762 cases of endometrial cancer met eligibility criteria. There was no evidence of an association between metformin use and endometrial cancer risk (RR, 0.96; 95% CI, 0.80 to 1.16). Similarly, the pooled data showed that metformin use was not significantly associated with endometrial cancer risk in patients with diabetes (RR, 0.93; 95% CI, 0.78 to 1.11). In subgroup analyses, the results were stable across different study designs and comparisons, and remained unchanged after adjusting for age and BMI or obesity.Conclusions: The current meta-analysis suggests that metformin has no chemopreventive effect against endometrial cancer.

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Cytochrome P450 1A1 Gene Polymorphisms and Endometrial Cancer Risk: A Meta-Analysis

International Journal of Gynecological Cancer ◽

10.1097/igc.0b013e31820575c0 ◽

2011 ◽

Vol 21 (2) ◽

pp. 323-331 ◽

Cited By ~ 12

Author(s):

Theodoros N. Sergentanis ◽

Konstantinos P. Economopoulos ◽

Souzana Choussein ◽

Nikos F. Vlahos

Keyword(s):

Cytochrome P450 ◽

Endometrial Cancer ◽

Cancer Risk ◽

Random Effects ◽

Fixed Effects ◽

Meta Analysis ◽

Cytochrome P450 1A1 ◽

Case Control Studies ◽

Endometrial Cancer Risk ◽

Random Effects Models

Introduction:This meta-analysis aims to examine whether the genotype status of Msp1, Ile462Val, and Thr461Asn polymorphisms in cytochrome P450 1A1 (CYP1A1) is associated with endometrial cancer risk.Methods:Eligible case-control studies were identified through search in MEDLINE (end of search: August 2010). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models.Results:ConcerningMspI polymorphism, 8 studies were eligible (1456 cases and 2371 controls); 9 studies were eligible (1889 cases and 3662 controls) for Ile462Val and 6 studies were eligible (1272 cases and 2122 controls) for Thr461Asn.MspI polymorphism was not associated with endometrial cancer risk (for heterozygous TC vs TT carriers: OR = 0.83, 95% confidence interval [CI], 0.59-1.15, random effects; for homozygous CC vs TT carriers: OR = 1.00, 95% CI, 0.55-1.82, fixed effects). Similarly, Ile462Val polymorphism was not associated with endometrial cancer risk (for heterozygous Ile/Val vs Ile/Ile carriers: OR = 1.27, 95% CI, 0.78-2.06, random effects; for homozygous Val/Val vs Ile/Ile carriers: OR = 1.16, 95% CI, 0.48-2.81, fixed effects). Accordingly, Thr461Asn status was not significantly associated with endometrial cancer risk. The same results were reproduced in Caucasians.Conclusions:The 3 examined CYP1A1 genotype polymorphisms do not seem to confer any additional risk for endometrial cancer in Caucasians. Accumulation of further data seems mandatory for future race-specific analyses.

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