scholarly journals Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease

2019 ◽  
Vol 15 (3) ◽  
pp. 292 ◽  
Author(s):  
Jae-Won Jang ◽  
Yeshin Kim ◽  
Yong-Ho Choi ◽  
Jong-Min Lee ◽  
Bora Yoon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Nutritional Status ◽  
Brain Aging ◽  
The Elderly ◽  
Korean Population ◽  
Aging Study

scholarly journals Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer’s Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD

2019 ◽  
Vol 8 (3) ◽  
pp. 341 ◽  
Author(s):  
Jihye Hwang ◽  
Jee Jeong ◽  
Soo Yoon ◽  
Kyung Park ◽  
Eun-Joo Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Validation Cohort ◽  
Brain Aging ◽  
Hippocampal Volume ◽  
Clinical Spectrum ◽  
Subjective Cognitive Decline ◽  
Significant Difference ◽  
Aging Study

We aimed to present the study design of an independent validation cohort from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s disease (AD) (KBASE-V) and to investigate the baseline characteristics of the participants according to the AD clinical spectrum. We recruited 71 cognitively normal (CN) participants, 96 with subjective cognitive decline (SCD), 72 with mild cognitive impairment (MCI), and 56 with AD dementia (ADD). The participants are followed for three years. The Consortium to Establish a Registry for AD scores was significantly different between all of the groups. The logical memory delayed recall scores were significantly different between all groups, except between the MCI and ADD groups. The Mini-Mental State Examination score, hippocampal volume, and cerebrospinal fluid (CSF) amyloid-β42 level were significant difference among the SCD, MCI, and ADD groups. The frequencies of participants with amyloid pathology according to PET or CSF studies were 8.9%, 25.6%, 48.3%, and 90.0% in the CN, SCD, MCI, and ADD groups, respectively. According to ATN classification, A+/T+/N+ or A+/T+/N− was observed in 0%, 15.5%, 31.0%, and 78.3% in the CN, SCD, MCI, and ADD groups, respectively. The KBASE-V showed a clear difference according to the AD clinical spectrum in neuropsychological tests and AD biomarkers.

Molecular Imaging and Magnetic Resonance Imaging in Early Diagnosis of Alzheimer's Disease

2008 ◽  
Vol 21 (6) ◽  
pp. 755-771
Author(s):  
O. Schillaci ◽  
L. Travascio ◽  
C. Bruni ◽  
G. Bazzocchi ◽  
A. Testa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Early Diagnosis ◽  
Neurodegenerative Disorder ◽  
The Elderly ◽  
Resonance Imaging ◽  
New Techniques ◽  
Molecular Imaging Agents

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Magnetic resonance (MR) or computed tomography (CT) imaging is recommended for routine evaluation of dementias. The development of molecular imaging agents and the new techniques of MR for AD are critically important for early diagnosis, neuropathogenesis studies and assessing treatment efficacy in AD. Neuroimaging using nuclear medicine techniques such as SPECT, PET and MR spectroscopy has the potential to characterize the biomarkers for Alzheimer's disease. The present review summarizes the results of radionuclide imaging and MR imaging in AD.

Flavonoids with Potential Anti-Amyloidogenic Effects as Therapeutic Drugs for Treating Alzheimer’s Disease

2021 ◽  
pp. 1-29
Author(s):  
Qixin Wang ◽  
Xiaofang Dong ◽  
Ran Zhang ◽  
Changqi Zhao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Positive Impact ◽  
Amyloid Β ◽  
The Elderly ◽  
Favorable Effect ◽  
Amyloid Β Protein ◽  
Physical And Mental Health ◽  
Dementia Patients

Alzheimer’s disease (AD) is a central neurodegenerative disease generally among the elderly; it accounts for approximately 50–75%of total cases of dementia patients and poses a serious threat to physical and mental health. Currently available treatments for AD mainly relieves its symptoms, and effective therapy is urgently needed. Deposition of amyloid-β protein in the brain is an early and invariant neuropathological feature of AD. Currently the main efforts in developing anti-AD drugs focus on anti-amyloidogenic therapeutics that prevent amyloid-β production or aggregation and decrease the occurrence of neurotoxic events. The results of an increasing number of studies suggest that natural extracts and phytochemicals have a positive impact on brain aging. Flavonoids belong to the broad group of polyphenols and recent data indicate a favorable effect of flavonoids on brain aging. In this review, we collect relevant discoveries from 1999 to 2021, discuss 75 flavonoids that effectively influence AD pathogenesis, and summarize their functional mechanisms in detail. The data we have reviewed show that, these flavonoids belong to various subclasses, including flavone, flavanone, biflavone, etc. Our results provide a reference for further study of the effects of flavonoids on AD and the progress of anti-AD therapy.

scholarly journals Influence of Alzheimer’s disease on the relationship between nutritional status and risk of fall

2021 ◽  
Vol 43 ◽  
pp. e48747
Author(s):  
Maria Vaitsa Loch Haskel ◽  
Sara Carolina Scremin Souza ◽  
Danilo Fernandes da Silva ◽  
Weber Cláudio Francisco Nunes da Silva ◽  
Juliana Sartori Bonini
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Body Composition ◽  
Nutritional Status ◽  
Elderly Population ◽  
Mini Nutritional Assessment ◽  
The Elderly ◽  
Metabolic Condition ◽  
Risk Of Falls ◽  
Risk Of Fall

Although malnutrition and risk of falls in the elderly have increased in recent years, uncertainties exist as to whether these conditions are associated after controlling for sociodemographic variables, body composition, metabolic condition, and Alzheimer’s disease (AD). This study aimed to analyze the association between nutritional status and risk of fall in the elderly population. Participants were matched by gender and age, after they had been grouped on the basis of diagnosis of AD. The risk of falls, nutritional status, and mental status were assessed using the Downton Fall Risk Score (FRS), Mini Nutritional Assessment (MNA), and Mini Mental State Evaluation (MMSE), respectively. Logistic regression models adjusted for the main confounders were used in the analyses. Among the 68 elderly individuals studied, participants who were malnourished or at risk of malnutrition were more likely to fall (odds ratio = 8.29; 95% confidence interval = 1.49-46.04) than those with normal nutritional status, regardless of gender, age, education, body composition, and metabolic condition. This association did not remain significant after adjustment for AD, a potential confounder in this association. Malnutrition or its risk was independently associated with high risk of fall; thus, malnutrition should be considered in the prevention of falls among the elderly population.

scholarly journals Alzheimer’s Disease – Future Therapy Based on Dendrimers

2019 ◽  
Vol 17 (3) ◽  
pp. 288-294 ◽  
Author(s):  
Gjumrakch Aliev ◽  
Ghulam Md Ashraf ◽  
Vadim V. Tarasov ◽  
Vladimir N. Chubarev ◽  
Jerzy Leszek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Molecular Mechanisms ◽  
Senile Plaques ◽  
The Elderly ◽  
Gamma Secretase ◽  
Radical Generation ◽  
Future Therapy

Alzheimer’s disease (AD) is characterized by the loss of neurons. It is the most common cause of dementia in the elderly population accompanied by pathological degeneration of neurofibrillary tangles. Senile plaques are formed with beta-amyloid, hyperphosphoryled tau protein, apolipoprotein E and presenilin associated with protease activity [amyloid beta (Aβ), gamma-secretase (γS)]. The molecular mechanisms of neurodegeneration include apoptosis, oxidative stress (free radical generation), inflammation, immune activation, and others. The lack of effective treatments for AD stems mainly from the incomplete understanding the causes of AD. Currently, there are several hypotheses explaining the early mechanisms of AD pathogenesis. Recent years witnessed an unprecedented research growth in the area of nanotechnology, which uses atomic, molecular and macromolecular methods to create products in microscale (nanoscale) dimensions. In this article, we have discussed the role of nanotechnology in the development and improvement of techniques for early diagnosis and effective treatment of AD. Since AD pathology is practically irreversible, applications of disease-modifying treatments could be successful only if early diagnosis of AD is available. This review highlights various possibilities for the early diagnosis and therapy of AD and investigates potential adaptation of nanoparticles-dendrimers as a class of well-defined branched polymers that are chemically synthesized with a well-defined shape, size and nanoscopic physicochemical properties reminiscent of the proteins for the treatment of neurodegenerative diseases.

scholarly journals Vascular cognitive impairment and Alzheimer's disease: Is there a relationship between them?

2019 ◽  
Vol 11 (3) ◽  
pp. 110-115
Author(s):  
G. R. Tabeeva ◽  
E. A. Kirjanova
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Brain Aging ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Vascular Cognitive Impairment ◽  
Close Relationship ◽  
Neuroimaging Biomarkers ◽  
Relationship Of

Cognitive impairment (CI) associated with brain aging is a consequence of disorders varying in etiology and pathogenesis, which often coexist in elderly patients and can have a mutual impact on the clinical manifestation, severity, and rate of progression of CI. Alzheimer's disease (AD) and vascular CI are the most common forms of dementia in the elderly. In recent decades, there has been increasing evidence that there is a close relationship between these forms due to a substantial overlap of their risk factors, clinical manifestations, neuromorphological changes, as well as genetic and neuroimaging biomarkers. The complex multicomponent relationship of these disorders also makes it difficult to elaborate effective preventive and therapeutic approaches in these patients.

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