Cellulose nanofibrils/chitosan based transdermal drug delivery vehicle for controlled release of ketorolac tromethamine

2017 ◽  
Vol 41 (24) ◽  
pp. 15312-15319 ◽  
Author(s):  
Gunjan Sarkar ◽  
Jonathan T. Orasugh ◽  
Nayan R. Saha ◽  
Indranil Roy ◽  
Amartya Bhattacharyya ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Transdermal Drug Delivery ◽  
High Surface ◽  
Cellulose Nanofibrils ◽  
High Surface Area ◽  
Ketorolac Tromethamine ◽  
Delivery Vehicle ◽  
Biomedical Field

Cellulose nanofibrils (CNFs) have attracted attention as a promising material in the biomedical field because of their outstanding properties such as hydrophilicity, biocompatibility, biodegradability, and high surface area.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

scholarly journals Use of natural diatoms for drug delivery

Bionatura ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 1275-1279
Author(s):  
Dario Castro ◽  
Joselyn Cuasquer ◽  
Eva Chavez
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
Pore Structure ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Processing Cost ◽  
Silica Materials ◽  
Different Characteristics ◽  
Ordered Porous

Diatoms are microalgae organisms that have a cover of silica, with a fascinating ordered porous structure that varies in size, giving them some different characteristics. Because of their different size, shape, and structure, it has incredible properties, letting them be capable of been functionalized with other particles. Therefore, due to the ordered pore structure, the high surface area, biocompatibility, availability, and low processing cost, they present a growing potential for drug delivery when talking about silica materials, natural and synthetic, not to mention that is less expensive and a green alternative.

Fabrication of high surface area mesoporous silicon via magnesiothermic reduction for drug delivery

2011 ◽  
Vol 142 (1) ◽  
pp. 194-201 ◽  
Author(s):  
Mingyi Guo ◽  
Xiaoqin Zou ◽  
Hao Ren ◽  
Faheem Muhammad ◽  
Caixia Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Magnesiothermic Reduction ◽  
Mesoporous Silicon

scholarly journals Anodic TiO2 Nanotubes: Tailoring Osteoinduction via Drug Delivery

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2359
Author(s):  
Jung Park ◽  
Anisoara Cimpean ◽  
Alexander B. Tesler ◽  
Anca Mazare
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Tio2 Nanotubes ◽  
Synergistic Effects ◽  
High Surface ◽  
High Surface Area ◽  
Bioactive Molecules ◽  
Electrochemical Anodization ◽  
Drug Delivery Applications

TiO2 nanostructures and more specifically nanotubes have gained significant attention in biomedical applications, due to their controlled nanoscale topography in the sub-100 nm range, high surface area, chemical resistance, and biocompatibility. Here we review the crucial aspects related to morphology and properties of TiO2 nanotubes obtained by electrochemical anodization of titanium for the biomedical field. Following the discussion of TiO2 nanotopographical characterization, the advantages of anodic TiO2 nanotubes will be introduced, such as their high surface area controlled by the morphological parameters (diameter and length), which provides better adsorption/linkage of bioactive molecules. We further discuss the key interactions with bone-related cells including osteoblast and stem cells in in vitro cell culture conditions, thus evaluating the cell response on various nanotubular structures. In addition, the synergistic effects of electrical stimulation on cells for enhancing bone formation combining with the nanoscale environmental cues from nanotopography will be further discussed. The present review also overviews the current state of drug delivery applications using TiO2 nanotubes for increased osseointegration and discusses the advantages, drawbacks, and prospects of drug delivery applications via these anodic TiO2 nanotubes.

The Effect of Surfactant Extraction Method on Pore Characteristics of Mesoporous Carbonated Hydroxyapatite

2013 ◽  
Vol 858 ◽  
pp. 190-198 ◽  
Author(s):  
Nur Farahiyah Mohammad ◽  
Radzali Othman ◽  
Fei Yee Yeoh
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Synthesis Process ◽  
Ionic Surfactant ◽  
Pore Characteristics ◽  
Carbonated Hydroxyapatite ◽  
Different Types ◽  
Surfactant Removal

Incorporated with pore sizes of 2-50 nm, CHA was found to be a promising drug delivery agent for disease treatment and could be a carrier for different types of proteins. A desired drug delivery system should consist of an ordered pore network, optimum pore size, and volume, as well as a high surface area, to allow a high drug adsorption rate, controllable drug loading, and release. However, until now, most results are still not up to expectation; since the BET surface area and pore volume obtained has been rather low, compared to the existing mesoporous silica. The objective of this work was to investigate the effect of surfactant washing on the pore characteristics and the importance of this step in the synthesis process of mesoporous carbonated hydroxyapatite (CHA). In this study, mesostructured CHA particles were prepared, via a self-assembly mechanism, between CHA and non-ionic surfactant (P123), using the co-precipitation synthesis method. The synthesized mesoporous CHA samples were washed five times using different types of solvents for surfactant removal. A sphere-like particle shape of CHA was observed under SEM for all samples; regardless of the type of solvent used. The formation of CHA was confirmed by FTIR analysis, where the carbonate ion peaks were observed in the spectrums. It was found that the mesoporous CHA with a high surface area was synthesized when high polarity solvents were used during surfactant washing. These results imply that high surface area mesoporous CHA can be obtained through surfactant washing, without applying calcination for surfactant removal, which may change the structure of the CHA during heat treatment.

High surface area polypyrrole scaffolds for tunable drug delivery

2013 ◽  
Vol 443 (1-2) ◽  
pp. 163-168 ◽  
Author(s):  
Manisha Sharma ◽  
Geoffrey I.N. Waterhouse ◽  
Samuel W.C. Loader ◽  
Sanjay Garg ◽  
Darren Svirskis
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
High Surface ◽  
High Surface Area

Novel catalytic micromotor of porous zeolitic imidazolate framework-67 for precise drug delivery

Nanoscale ◽  
2018 ◽  
Vol 10 (24) ◽  
pp. 11384-11391 ◽  
Author(s):  
Linlin Wang ◽  
Hongli Zhu ◽  
Ying Shi ◽  
You Ge ◽  
Xiaomiao Feng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
Zeolitic Imidazolate Framework ◽  
High Drug ◽  
High Drug Loading

Novel catalytic micromotors based on porous ZIF-67 were used as efficient fluorescence drug (DOX) carriers. Benefiting from the porous nature and high surface area, these micromotors display effective motion, long durable movement life and high drug loading capacity.

Tenacious Mass Transfer Limitations Drive Catalytic Selectivity during Electrochemical Carbon Dioxide Reduction

2019 ◽  
Author(s):  
Kailun Yang ◽  
Recep Kas ◽  
Wilson A. Smith
Keyword(s):  
Surface Area ◽  
High Surface ◽  
High Surface Area ◽  
Catalyst Layer ◽  
Active Surface ◽  
Active Surface Area ◽  
High Concentration ◽  
Copper Electrodes ◽  
Surface Enhanced ◽  
Local Current

<p>This study evaluated the performance of the commonly used strong buffer electrolytes, i.e. phosphate buffers, during CO<sub>2</sub> electroreduction in neutral pH conditions by using in-situ surface enhanced infrared absorption spectroscopy (SEIRAS). Unfortunately, the buffers break down a lot faster than anticipated which has serious implications on many studies in the literature such as selectivity and kinetic analysis of the electrocatalysts. Increasing electrolyte concentration, surprisingly, did not extend the potential window of the phosphate buffers due to dramatic increase in hydrogen evolution reaction. Even high concentration phosphate buffers (1 M) break down within the potentials (-1 V vs RHE) where hydrocarbons are formed on copper electrodes. We have extended the discussion to high surface area electrodes by evaluating electrodes composed of copper nanowires. We would like highlight that it is not possible to cope with high local current densities on these high surface area electrodes by using high buffer capacity solutions and the CO<sub>2</sub> electrocatalysts are needed to be evaluated by casting thin nanoparticle films onto inert substrates as commonly employed in fuel cell reactions and up to now scarcely employed in CO<sub>2</sub> electroreduction. In addition, we underscore that normalization of the electrocatalytic activity to the electrochemical active surface area is not the ultimate solution due to concentration gradient along the catalyst layer.This will “underestimate” the activity of high surface electrocatalyst and the degree of underestimation will depend on the thickness, porosity and morphology of the catalyst layer. </p> <p> </p>

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