scholarly journals Classification of Parkinson Disease Based on Analysis and Synthesis of Voice Signal

2021 ◽  
Vol 16 (4) ◽  
pp. 1-22
Author(s):  
Vikas Mittal ◽  
R. K. Sharma
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Vocal Tract ◽  
Acoustic Parameter ◽  
Physical Parameters ◽  
Voice Signal ◽  
Analysis And Synthesis ◽  
The Central Nervous System ◽  
Pitch Ratio

The most important application of voice profiling is pathological voice detection. Parkinson's disease is a chronic neurological degenerative disease affecting the central nervous system responsible for essentially progressive evolution movement disorders. 70% to 90% of Parkinson’s disease (PD) patients show an affected voice. This paper proposes a methodology for PD based on acoustic, glottal, physical, and electrical parameters. The results show that the acoustic parameter is more important in the case of Parkinson’s disease as compared to glottal and physical parameters. The authors achieved 97.2% accuracy to differentiate Parkinson and healthy voice using jitter to pitch ratio proposed algorithm. The Authors also proposed an algorithm of poles calculation of the vocal tract to find formants of the vocal tract. Further, formants are used for finding the transfer function of vocal tract filter. In the end, the authors suggested parameters of the electrical vocal tract model are also changed in the case of PD voices.

Multiclass machine learning classification of functional brain images for Parkinson's disease stage prediction

2020 ◽  
Vol 13 (5) ◽  
pp. 508-523 ◽  
Author(s):  
Guan‐Hua Huang ◽  
Chih‐Hsuan Lin ◽  
Yu‐Ren Cai ◽  
Tai‐Been Chen ◽  
Shih‐Yen Hsu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Stage ◽  
Brain Images ◽  
Functional Brain ◽  
Machine Learning Classification

scholarly journals The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 732
Author(s):  
Gianfranco Natale ◽  
Larisa Ryskalin ◽  
Gabriele Morucci ◽  
Gloria Lazzeri ◽  
Alessandro Frati ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Enteric Nervous System ◽  
Gi Tract ◽  
Multiple Control ◽  
Fine Control ◽  
The Central Nervous System ◽  
Degenerative Alterations ◽  
Comprehensive Classification

The gastrointestinal (GI) tract is provided with a peculiar nervous network, known as the enteric nervous system (ENS), which is dedicated to the fine control of digestive functions. This forms a complex network, which includes several types of neurons, as well as glial cells. Despite extensive studies, a comprehensive classification of these neurons is still lacking. The complexity of ENS is magnified by a multiple control of the central nervous system, and bidirectional communication between various central nervous areas and the gut occurs. This lends substance to the complexity of the microbiota–gut–brain axis, which represents the network governing homeostasis through nervous, endocrine, immune, and metabolic pathways. The present manuscript is dedicated to identifying various neuronal cytotypes belonging to ENS in baseline conditions. The second part of the study provides evidence on how these very same neurons are altered during Parkinson’s disease. In fact, although being defined as a movement disorder, Parkinson’s disease features a number of degenerative alterations, which often anticipate motor symptoms. Among these, the GI tract is often involved, and for this reason, it is important to assess its normal and pathological structure. A deeper knowledge of the ENS is expected to improve the understanding of diagnosis and treatment of Parkinson’s disease.

Inflammatory Mechanisms in Parkinson’s Disease: From Pathogenesis to Targeted Therapies

2021 ◽  
pp. 107385842199226
Author(s):  
Stellina Y. H. Lee ◽  
Nathanael J. Yates ◽  
Susannah J. Tye
Keyword(s):  
Parkinson’S Disease ◽  
Central Nervous System ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Immune Cells ◽  
Critical Factor ◽  
Neurodegenerative Process ◽  
Inflammatory Processes ◽  
The Central Nervous System ◽  
Novel Target

Inflammation is a critical factor contributing to the progressive neurodegenerative process observed in Parkinson’s disease (PD). Microglia, the immune cells of the central nervous system, are activated early in PD pathogenesis and can both trigger and propagate early disease processes via innate and adaptive immune mechanisms such as upregulated immune cells and antibody-mediated inflammation. Downstream cytokines and gene regulators such as microRNA (miRNA) coordinate later disease course and mediate disease progression. Biomarkers signifying the inflammatory and neurodegenerative processes at play within the central nervous system are of increasing interest to clinical teams. To be effective, such biomarkers must achieve the highest sensitivity and specificity for predicting PD risk, confirming diagnosis, or monitoring disease severity. The aim of this review was to summarize the current preclinical and clinical evidence that suggests that inflammatory processes contribute to the initiation and progression of neurodegenerative processes in PD. In this article, we further summarize the data about main inflammatory biomarkers described in PD to date and their potential for regulation as a novel target for disease-modifying pharmacological strategies.

scholarly journals 3D convolutional neural networks for classification of Alzheimer’s and Parkinson’s disease with T1-weighted brain MRI

2021 ◽  
Author(s):  
Nikhil J. Dhinagar ◽  
Sophia I. Thomopoulos ◽  
Conor Owens-Walton ◽  
Dimitris Stripelis ◽  
Jose Luis Ambite ◽  
...  
Keyword(s):  
Neural Networks ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Convolutional Neural Networks ◽  
Brain Mri

scholarly journals Astaxanthin attenuates neurotoxicity in a mouse model of Parkinson’s disease

2017 ◽  
Vol 7 (8) ◽  
pp. 562 ◽  
Author(s):  
B. Grimmig ◽  
L. Daly ◽  
C. Hudson ◽  
K.R. Nash ◽  
P.C. Bickford
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Microglial Activation ◽  
Biological Activities ◽  
Control Diet ◽  
Dietary Supplementation ◽  
Mechanisms Of Action ◽  
Immunohistochemical Detection ◽  
Dopaminergic Cell ◽  
The Central Nervous System

Background: Astaxanthin (AXT) is a natural carotenoid with diverse biological activities. Although it is best known as a potent antioxidant, recent work suggests additional mechanisms of action that have the potential to oppose the ongoing pathophysiology of Parkinson’s disease (PD). For example, AXT has a putative role in modulating microglial activity and preserving mitochondrial function, thereby implicating this compound as a neuroprotective agent. Both oxidative stress and inflammation are involved in the progression of many neurodegenerative diseases. Therefore, we examined the efficacy for AXT to reduced neurotoxicity in a toxic model of PD in mice. Methods: In this study, we used a 4-week dietary supplementation of algae derived AXT to reduce 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopaminergic cell death.Results: AXT treated mice were protected against the loss of tyrosine hydroxylase (TH) staining in the substantia nigra (SN) after MPTP exposure compared to the control diet. This effect of preserved TH immunoreactivity was also observed in the striatum. Furthermore, AXT administration was able to interrupt the neuroinflammatory process known to contribute to neurodegeneration in this model.Conclusions: We demonstrate that AXT neuroprotection was associated with attenuated microglial activation as indicated by reduced immunohistochemical detection of IBA-1 in the SN and striatum of AXT treated mice. Altogether, these studies suggest that AXT has neuroprotective property in the central nervous system against MPTP neurodegeneration.Keywords: Astaxanthin, Neuroprotection, Neurodegeneration, Neuroinflammation, Parkinson’s disease

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