Solutions in Limit Deviations for Optimum Dimensional Structures of Technological Processes of Machining

2014 ◽  
Vol 657 ◽  
pp. 936-940
Author(s):  
Alexei Toca ◽  
Ion Stingaci
Keyword(s):  
Manufacturing Process ◽  
Machine Tools ◽  
Dimensional Structure ◽  
Dimensional Chain ◽  
Linear Dimensions ◽  
Adaptability To Manufacture ◽  
Machining Allowance ◽  
Structural Nature ◽  
Two Phases ◽  
Definition Of

In the paper the analysis of the dimensional structure of different manufacturing process is made. There are shown that the different schemes of the designer sizes result in a different level of an optimality of a dimensional structure. At definition of number of the technological sizes as criterium of a optimality it is necessary to allow both formation of the intermediate sizes and the effect of errors compensation. The effect of errors compensation is the reason for the change of the sizes nominals and its limit deviations. The detail subjected to machining, is characterized by constructive dimensional links which reflect, eventually, its functionality. The character of the constructive dimensional links is defined by the designer who takes into account the technological features of machine tools, but not in detriment of functionality. Therefore, carrying out of the dimensional analysis on a joint of these two phases is very important with the purpose of improvement of dimensional adaptability to manufacture of made details. One of criterions of this optimality has the structural nature. The manufacturing process is considered optimum, if in the structure of all technological dimensional chaines number of the technological sizes is minimum. This condition executes if to each designer size there corresponds in a technological dimensional chain the unique technological size, and in dimensional circuits for machining allowances, each machining allowance is determined by two technological sizes or one technological size and one size on blank. For different variants of the linear dimensions are shown the way in which are changing the limit deviations of technological sizes and respectively of the constructive sizes of the equivalent details.

scholarly journals A Reliable Turning Process by the Early Use of a Deep Simulation Model at Several Manufacturing Stages

2017 ◽  
Author(s):  
Gorka Urbikain ◽  
Luis Norberto López De Lacalle ◽  
Mikel Arsuaga ◽  
Alvaro Alvarez ◽  
Miguel A. Alonso
Keyword(s):  
Machine Tools ◽  
Manufacturing Companies ◽  
Machining Processes ◽  
Knowledge Based ◽  
Direct Benefits ◽  
Definition Of ◽  
The Right ◽  
Machining Operations ◽  
Physical Laws ◽  
Manufacturing Problems

The future of machine tools will be dominated by highly flexible and interconnected systems, in order to achieve the required productivity, accuracy and reliability. Nowadays, distortion and vibration problems are easily solved in labs for the most common machining operations by using models based on equations describing the physical laws of the machining processes; however additional efforts are needed to overcome the gap between scientific research and the real manufacturing problems. In fact, there is an increasing interest in developing simulation packages based on “deep-knowledge and models” that aid machine designers, production engineers or machinists to get the best of the machine-tools. This article proposes a methodology to reduce problems in machining by means of a simulation utility, which uses the main variables of the system&process as input data, and generates results that help in the proper decision-making and machining planification. Direct benefits can be found in a) the fixture/clamping optimal design, b) the machine tool configuration, c) the definition of chatter-free optimum cutting conditions and d) the right programming of cutting toolpaths at the Computer Aided Manufacturing (CAM) stage. The information and knowledge-based approach showed successful results in several local manufacturing companies and are explained in the paper.

scholarly journals Systema Temporis: A Time-Based Dimensional Framework for Consciousness and Cognition

2019 ◽  
Author(s):  
Lachlan Kent ◽  
George Van Doorn ◽  
Britt Klein
Keyword(s):  
Time Perception ◽  
Dimensional Structure ◽  
Two Dimensional ◽  
Dimensional Approach ◽  
Short Term ◽  
Hierarchical Framework ◽  
Time Consciousness ◽  
Emotion And Memory ◽  
Definition Of

This study uses a combined categorical-dimensional approach to depict a hierarchical framework for consciousness similar to, and contiguous with, factorial models of cognition (cf., intelligence). On the basis of the longstanding definition of time consciousness, the analysis employs a dimension of temporal extension, in the same manner that psychology has temporally organised memory (i.e., short-term, long-term, and long-lasting memories). By defining temporal extension in terms of the structure of time perception at short timescales (< 100 s), memory and time consciousness are proposed to fit along the same logarithmic dimension. This suggests that different forms of time consciousness (e.g., experience, wakefulness, and self-consciousness) are embedded within, or supported by, the ascending timescales of different modes of memory (i.e., short-term, long-term, etc.). A secondary dimension is also proposed to integrate higher-order forms of consciousness/emotion and memory/cognition. The resulting two-dimensional structure accords with existing theories of cognitive and emotional intelligence.

A Temporal Process Specification Language for Virtual Manufacturing Engineering

1998 ◽  
Author(s):  
David E. Lee ◽  
H. Thomas Hahn
Keyword(s):  
Manufacturing Process ◽  
Specification Language ◽  
Virtual Manufacturing ◽  
Process Definition ◽  
Virtual Factory ◽  
Process Specification ◽  
Temporal Relationships ◽  
Temporal Process ◽  
Definition Of ◽  
Virtual Process

Abstract A process specification language is being developed for virtual manufacturing that provides a structured portable definition of a given manufacturing process as well as the ability to specify the temporal relationships between individual operation steps that compose a process. Based on the concepts embodied in markup languages such as HTML, SGML and XML, a portable process definition structure is defined. This structure provides a template from which virtual process specifications can be created. Subsequently, these structures can be exchanged between development environments for virtual process engineering and the actualized manufacturing facilities where processes are implemented. In addition, dependencies in time between the operation steps of a process such as common start times and operation serialization can be represented to allow for a complete specification of temporal behavior of a given manufacturing process. By providing this explicit mechanism for representing temporal constraints, a virtual manufacturing process can be viewed and utilized both in a localized application on a single virtual factory floor as well as distributed across multiple, interlinked virtual environments.

scholarly journals Interprofessional Practice in the Emergency Service: specific and shared assignments of nurses

2019 ◽  
Vol 72 (suppl 1) ◽  
pp. 213-220
Author(s):  
Ruth Ester Assayag Batista ◽  
Marina Peduzzi
Keyword(s):  
Exploratory Study ◽  
Delphi Technique ◽  
Emergency Service ◽  
Nursing Interventions ◽  
Interprofessional Practice ◽  
Potential Factor ◽  
Two Phases ◽  
Definition Of

ABSTRACT Objective: To map and categorize, according to the Nursing Interventions Classification (NIC), the specific assignments of the nurses and to identify the assignments shared with doctors and physiotherapists in the Emergency Service. Method: Descriptive exploratory study, carried out in two phases: first, the analysis of dissertations /theses from the database of the Center for Studies and Research of the Brazilian Nursing Association; Second, the use of the Delphi Technique to reach the consensus about which assignments were specific to the nurse and which were shared with physiotherapists and doctors. Results: The results were 45.7% for specific to the nurses, 14.2% for shared with physiotherapists and/or doctors, and in 40% (n=42) there was no consensus about the sharing of assignments. Conclusion: The sharing of actions among professionals shows an increase in the scope of the practice of professions and the constitution of a common sphere of work, but the high number of assignments with no consensus among specialists can be a potential factor in conflicts due to the lack of definition of these assignments.

scholarly journals Automation of optimization of discrete technological processes

2018 ◽  
Vol 196 ◽  
pp. 04067
Author(s):  
Evgeniy Kudryavtsev
Keyword(s):  
Technological Process ◽  
Second Phase ◽  
Recurrent Equation ◽  
Technological Processes ◽  
Labour Costs ◽  
Two Phases ◽  
Definition Of

The article describes the procedure automation of optimization discrete technological processes with using of Bellman’s functional (recurrent) equation and system Mathcad. As rule the technological processes includes n of operations and each operation can be executed by various types of equipment. Expenses (cost, time, …) on execution of i operation by k equipment after execution by j equipment (i-1) operation are known - c (i, j, k). Expenses for execution by k equipment i operation can depend on the equipment - j, which executed previous (i-1) operation. It is necessary to execute automation of optimization technological process with the minimum expenses. The algorithm of the decision of a problem by Bellman’s method includes two phases. The first phase is calculations of the minimum expenses for execution of all partial technological processes, from last operation of process to the first. The second phase is definition of the required optimum set of equipment which is carrying out all technological process with the minimum expenses. The proposed procedure of automation of optimization technological process using Bellman’s method and system Mathcad significantly decreases time and labour costs on execution of such calculations and efficiently to execute investigations related with change of equipment parameters.

Shrinkage of lung after chemical fixation for analysis of pulmonary structure-function relations

1980 ◽  
Vol 48 (2) ◽  
pp. 382-385 ◽  
Author(s):  
R. W. Mazzone ◽  
S. Kornblau ◽  
C. M. Durand
Keyword(s):  
Structure Function ◽  
Freeze Substitution ◽  
Transpulmonary Pressure ◽  
Vascular Perfusion ◽  
Fixed Tissue ◽  
Linear Dimensions ◽  
Schiff Reagent ◽  
Tissue Shrinkage ◽  
Series Of Experiments ◽  
Definition Of

Glutaraldehyde is widely used to chemically fix lungs for analysis of pulmonary structure-function relations. Accurate interpretation of observations on fixed tissue requires a clear definition of any artifacts, such as tissue shrinkage, resulting from fixation with glutaraldehyde. Two experimental procedures were used in this study to examine possible shrinkage artifacts resulting from fixation of lung by glutaraldehyde. In the first, isolated perfused dog lungs were rapidly frozen at different transpulmonary pressures. Samples were then freeze substituted at -50 degrees C using 70% ethylene glycol with and without fixatives present. In the second series of experiments, the left lungs of mongrel dogs were fixed by vascular perfusion with glutaraldehyde at different transpulmonary pressures. In both series of experiments any changes in linear dimensions resulting from the fixation procedure were measured. Also, the presence of aldehyde was demonstrated by a positive reaction with Schiff reagent. The results demonstrate that lung tissue fixed either by vascular perfusion or freeze substitution tends to shrink to about the same extent. This shrinkage is reasonably constant at about 9% for transpulmonary pressures of 5 and 15 cmH2O and increases to about 15% when the transpulmonary pressure reaches 25 cmH20.

The Life Cycle Assessment of a Polypropylene Product, Part A: Raw Materials, Manufacturing and Disposal Scenario

2014 ◽  
Vol 535 ◽  
pp. 515-518
Author(s):  
Karin Kandananond
Keyword(s):  
Life Cycle Assessment ◽  
Life Cycle ◽  
Environmental Impact ◽  
Manufacturing Process ◽  
Fossil Fuel ◽  
Raw Materials ◽  
Injection Molding Process ◽  
Molding Process ◽  
Two Phases ◽  
Product Part

The life cycle of a polypropylene stacking chair is assessed in order to represent the environmental impact of a plastic product. The analysis is categorized into two phases, manufacturing and disposing. The manufacturing process of a chair concerns a prime material, polypropylene (PP) granulate, an injection molding process and a resource, electricity. According to the assessment, the PP granulate seems to contribute the highest impact on the environment in term of the fossil fuel used. Afterwards, the landfill method is used in the disposal scenario of waste, and the analysis shows that the highest impact comes in the form of carcinogens followed by ecotoxicity.

Structural Characterization of BAX 855, a PEGylated Recombinant FVIII

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4356-4356 ◽  
Author(s):  
Martin Kaliwoda ◽  
Michael Graninger ◽  
Peter Matthiessen ◽  
Gerald Schrenk ◽  
Peter L Turecek ◽  
...  
Keyword(s):  
Primary Structure ◽  
Manufacturing Process ◽  
Three Dimensional ◽  
Electrophoretic Pattern ◽  
Dimensional Structure ◽  
Ionization Mass ◽  
Site Distribution ◽  
Rp Hplc ◽  
Good Consistency ◽  
Recombinant Fviii

Abstract Abstract 4356 Baxter and Nektar have developed a longer acting recombinant FVIII (BAX 855), which is manufactured by coupling stable PEG using Nektar technology to Baxter’s full-length rFVIII bulk drug substance from the protein-free ADVATE™ manufacturing process. BAX 855 was characterized by a number of analytical methods, focusing on the elucidation of the primary structure, posttranslational modifications, PEGylation site distribution and three-dimensional structure. The primary structure of BAX 855 was investigated using a peptide mapping approach. Samples were digested with trypsin and the resulting peptides were separated by reversed phase chromatography and detected with on-line electrospray ionization mass spectrometry. This approach resulted in a sequence coverage of 94% with good consistency demonstrated between different BAX 855 batches. Protein-bound oligosaccharides were determined by normal phase HPLC of fluorescence labeled N-glycans released by PNGase F treatment. The composition of the N-linked oligosaccharides showed a similar pattern between BAX 855 and unmodified rFVIII, confirming that the N-glycosylation pattern remained intact during the PEGylation process. PEGylation site distribution and detailed analysis of the consistency of PEGylation was investigated by activating BAX 855 with thrombin. The resulting PEGylated and non-PEGylated fragments were separated using a RP-HPLC approach and the bound PEG was measured for each thrombin fragment. The distribution of PEG among the different thrombin fragments of rFVIII was shown to be consistent between several BAX 855 batches. Moreover, RP-HPLC of native BAX 855 showed reproducible subunit composition and PEGylation. SDS-PAGE and Western blot analysis of BAX 855 revealed changes in the electrophoretic pattern due to PEGylation without the appearance of any relevant degradation products. The random PEGylation of rFVIII was shown using antibodies with different epitope specificities. Dynamic light scattering and Fourier-transformed infrared spectroscopy (FTIR) were used to monitor the consistency of three dimensional structures. The mean hydrodynamic diameter of BAX 855 was between 30 and 40 nm, which is a characteristic size for a ∼300-kDa protein. Several BAX 855 batches showed almost overlapping FTIR absorbance spectra, especially in the conformationally susceptible amide I and amide II peak at 1650 and 1550 cm−1, respectively, indicative for good consistency of the manufacturing process. In summary, BAX 855, a PEGylated rFVIII derivative, can be manufactured reproducibly without changes to the protein structure characteristic for a fully functional FVIII molecule. Disclosures: Kaliwoda: Baxter Innovations GmbH: Employment. Graninger:Baxter Innovations GmbH: Employment. Matthiessen:Baxter Innovations GmbH: Employment. Schrenk:Baxter Innovations GmbH: Employment. Turecek:Baxter Innovations GmbH: Employment. Mitterer:Baxter Innovations GmbH: Employment. Ehrlich:Baxter Innovations GmbH: Employment. Scheiflinger:Baxter Innovations GmbH: Employment.

scholarly journals IAPSO Standard Seawater: Definition of the Uncertainty in the Calibration Procedure, and Stability of Recent Batches

2007 ◽  
Vol 24 (10) ◽  
pp. 1785-1799 ◽  
Author(s):  
Sheldon Bacon ◽  
Fred Culkin ◽  
Nigel Higgs ◽  
Paul Ridout
Keyword(s):  
Reference Material ◽  
Potassium Chloride ◽  
Manufacturing Process ◽  
Calibration Procedure ◽  
Conductivity Ratio ◽  
Coverage Factor ◽  
Expanded Uncertainty ◽  
Significant Variability ◽  
Definition Of

Abstract Standard seawater (SSW) has been employed by oceanographers as a reference material in the determination of salinity for over a century. In all that time, this is the first study to determine the uncertainty of the SSW manufacturing process. SSW is calibrated in reference to carefully prepared solutions of potassium chloride (KCl). All uncertainties in the preparation and measurement of KCl solutions and of new SSW are calculated. The expanded uncertainty of the SSW conductivity ratio is found to be 1 × 10−5, based on a coverage factor of 2, at the time of manufacture. There is no discernible “within batch” variability. No significant variability of quality within or between batches of KCl is found. Measurement of SSW “offsets” from the label conductivity ratio as long as 5 yr after the SSW batch manufacture are reported, and no significant change in label conductivity ratio for SSW batches P130 through P144 outside the expanded uncertainty of 1 × 10−5 is found. This last result is in contrast to some other studies, and herein are suggestions as to why this may be the case.

An Approach to Science in the Qurʾān

2015 ◽  
Vol 95 (1-2) ◽  
pp. 32-66 ◽  
Author(s):  
Majid Daneshgar
Keyword(s):  
Analytical Study ◽  
Essential Question ◽  
Two Phases ◽  
Definition Of

The purpose of this analytical study is to re-examine Ṭanṭāwī Ǧawharī’s (1862-1940) so-called scientific exegesis of the Qurʾān. Some academics have praised him, while others critiqued or even called him a dreamer. However, this study takes into account Ṭanṭāwī’s view concerning science and explores his true motives for invoking science. The main purpose for analyzing his view in the course of this article is to further explore his definition of science. Nonetheless, the essential question is: Was science a tool he employed to help comprehend the Qurʾān or a vehicle by which to convey his personal messages? In this regard, two phases will be considered: (a) Ṭanṭāwī and his exegesis; and (b) Ṭanṭāwī’s definition of science in his exegesis, which will be achieved through an investigation of his viewpoints about different Qurʾānic verses.

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