Study on Synthesis of (R)-Methyl 2-((Tert-Butoxycarbonyl)Amino)-3-((Tert-Butyldimethylsilyl)Thio)Propanoate

2014 ◽  
Vol 1033-1034 ◽  
pp. 596-598
Author(s):  
Shuang Lin Qin ◽  
Lin Jun Tang ◽  
Li Ping Wang ◽  
Gao Peng Wang ◽  
Fei Fei Huang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Natural Product ◽  
Water Soluble ◽  
Water Soluble Vitamin ◽  
Fixation Of Carbon Dioxide ◽  
Metabolic Cycle

(R)-methyl 2-((tert-butoxycarbonyl) amino)-3-((tert-butyldimethylsilyl) thio) propanoate, an key intermediate of the natural product Biotin which is a water-soluble vitamin, involved in an essential part of the metabolic cycle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 67% through three steps, which synthesis included esterification, protection of amine and thiol.

Study on Synthesis of Tert-Butyl(4R)-4-(Methoxymethylcarbamoyl)-2,2-Dimethylthiazolidine-3- Carboxylate

2014 ◽  
Vol 1033-1034 ◽  
pp. 555-557
Author(s):  
Shuang Lin Qin ◽  
Lin Jun Tang ◽  
Gao Peng Wang ◽  
Li Ping Wang ◽  
Fei Fei Huang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Natural Product ◽  
Water Soluble ◽  
Tert Butyl ◽  
Water Soluble Vitamin ◽  
Fixation Of Carbon Dioxide ◽  
Metabolic Cycle

Tert-butyl (4R)-4-(methoxymethylcarbamoyl)-2,2-dimethylthiazolidine-3-carboxylate, an key intermediate of the natural product Biotin which is a water-soluble vitamin, involved in an essential part of the metabolic cycle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 54% through three steps. The study including acetonization, Boc protection, N-methoxy-N-methyl amidation.

scholarly journals Metabolism of saturated and polyunsaturated fatty acids by normal and Zellweger syndrome skin fibroblasts

1989 ◽  
Vol 260 (3) ◽  
pp. 647-655 ◽  
Author(s):  
J M Street ◽  
D W Johnson ◽  
H Singh ◽  
A Poulos
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
De Novo ◽  
Zellweger Syndrome ◽  
Normal Skin ◽  
Product Formation ◽  
Water Soluble ◽  
Skin Fibroblasts

The metabolism of 1-11C-labelled derivatives of palmitic (C16:0), arachidonic (C20:4,n-6) lignoceric (C21:0) and tetracosatetraenoic (C24:4,n-6) acids was studied in normal skin fibroblast cultures and in cultures of fibroblasts from peroxisome-deficient (Zellweger's syndrome) patients. Radiolabelled products of the fatty acids included carbon dioxide. C14-24 saturated and mono-unsaturated fatty acids formed from released acetate either by synthesis de novo or by elongation of endogenous fatty acids, fatty acids formed by 2-6-carbon elongation of added substrates, and a number of water-soluble compounds, some of which were tentatively identified as the amino acids glutamine, glutamic acid and asparagine. The labelled amino acids were found predominantly in the culture medium. Zellweger's syndrome fibroblasts showed a marked decrease in radiolabelled carbon dioxide and water-soluble-product formation from (I-14C)-labelled arachidonic, tetracosatetraenoic and lignoceric acids but not from [I-14C]palmitic acid, and the production of radiolabelled C14-18 fatty acids was also diminished. However, the elongation of individual fatty acids was either normal or above normal. Our data support the view that the oxidation of 20:4, 24:4 and 24:0 fatty acids in cultured skin fibroblasts takes place largely in peroxisomes, and further that the acetyl-CoA released by the beta-oxidation process is available for the synthesis of fatty acids and amino acids. We speculate that the generation of C2 units used for synthesis is a major peroxisomal function and that this function is absent or greatly impaired in Zellweger's syndrome cells.

scholarly journals Compositional Features and Nutritional Value of Pig Brain: Potential and Challenges as a Sustainable Source of Nutrients

Foods ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2943
Author(s):  
Jaruwan Chanted ◽  
Worawan Panpipat ◽  
Atikorn Panya ◽  
Natthaporn Phonsatta ◽  
Ling-Zhi Cheong ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Soluble Protein ◽  
Nutritional Value ◽  
Saturated Fatty Acids ◽  
Water Soluble ◽  
Meat Industry ◽  
High Iron Content ◽  
Protein Nitrogen ◽  
Pig Brain

The goal of this study was to establish the nutritional value and compositional properties of the brains of crossbred pigs (Landrace–Large white–Duroc (LLD)), in order to realize the zero-waste concept and increase the use of by-products in the sustainable meat industry. Fat (9.25% fresh weight (fw)) and protein (7.25% fw) were the principal dry matters of pig brain, followed by carbohydrate and ash. Phospholipid and cholesterol had a 3:1 ratio. Pig brain had a red tone (L* = 63.88, a* = 5.60, and b* = 15.43) and a high iron content (66 mg/kg) due to a total heme protein concentration of 1.31 g/100 g fw. The most prevalent macro-element was phosphorus (14 g/kg), followed by potassium, sodium, calcium, and magnesium. Zinc, copper, and manganese were among the other trace elements discovered. The most prevalent nitrogenous constituents were alkali-soluble protein, followed by water-soluble protein, stromal protein, salt-soluble protein, and non-protein nitrogen. Essential amino acids were abundant in pig brain (44% of total amino acids), particularly leucine (28.57 mg/g protein), threonine, valine, and lysine. The total lipid, neutral, and polar lipid fractions of the pig brain had different fatty acid compositions. The largest amount was observed in saturated fatty acids (SFA), followed by monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA). Stearic acid and palmitic acid were the most common SFA. Oleic acid was the most prevalent MUFA, while docosahexaenoic acid was the most common PUFA. Thus, the pig brain can be used in food formulations as a source of nutrients.

scholarly journals Thiamine Responsive Poli-oencephalomalacia in a Swan Goose- A Case Report

2017 ◽  
Vol 13 (01) ◽  
Author(s):  
S. U. Digraskar ◽  
S. T. Borikar ◽  
A. S. Tawheed ◽  
B. S. Nithin ◽  
S. Neelam ◽  
...  
Keyword(s):  
Amino Acids ◽  
Case Report ◽  
Freshwater Fish ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Cellular Processes ◽  
Neuronal Membranes ◽  
Water Soluble Vitamin ◽  
General Weakness ◽  
Vitamin B1 Deficiency

Thiamine (vitamin B1) deficiency in birds is caused by malnutrition or thiaminase-rich foods (raw freshwater fish) or foods high in anti-thiamine factors (betel nuts).Thiamine is an essential water soluble vitamin contributing phosphate derivatives that are involved in many cellular processes as coenzymes in the catabolism of sugars and amino acids. Also thiamine triphosphate (TTP) helps in proper functioning of neuronal membranes (Cooper and Pincus, 1979) and its deficiency leads to polyneuritis which is manifested as lethargy, head tremors, impaired digestion, general weakness, star-gazing and frequent convulsions

UTILIZATION OF ADDED SUBSTRATES BY UREDOSPORES OF WHEAT STEM RUST

1956 ◽  
Vol 2 (6) ◽  
pp. 559-563 ◽  
Author(s):  
P. Shu ◽  
A. C. Neish ◽  
G. A. Ledingham
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Glutamic Acid ◽  
Metabolic Activity ◽  
Stem Rust ◽  
Volatile Fatty Acids ◽  
The Other ◽  
Wheat Stem Rust ◽  
Better Than

Uredospores of wheat stem rust utilized a number of externally-supplied, labelled carbohydrates, amino acids, and volatile fatty acids. The carbon of these substrates appeared in the spore materials and in the carbon dioxide. This metabolic activity, though very weak, is definite. D-Mannose, D-mannitol, D-glucose, sucrose, and D-fructose were utilized better than the other carbohydrates. Glutamic acid gave the highest yield of carbon dioxide while the basic amino acids, L-arginine and L-lysine, were more efficiently incorporated into the spore material.

scholarly journals Pharmacognostic and Physico-chemical Standardization of Monotheca buxifolia (Falc.) A. DC.

2020 ◽  
Vol 63 (2) ◽  
pp. 77-85
Author(s):  
Maryam Ehsan ◽  
Muhammad Ibrar ◽  
Fazal Hadi ◽  
Barkatullah Khan
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Stem Bark ◽  
Water Soluble ◽  
Root Bark ◽  
Fruit Pulp ◽  
Moisture Contents ◽  
Physico Chemical ◽  
Monotheca Buxifolia ◽  
Phytochemical Profile

Monotheca buxifolia is an ethno-medicinally important plant of Pak-Afghan regions. The pharmacognostic standards of fruit, leaf, seed, barks of stem and root were set in present study. Microscopy revealed characteristic distinguishable powder drug fragments. Each part showed certain unique florescence behaviour with various reagents under light of various wavelengths. It has a broad spectrum phytochemical profile including amino acids and proteins, fats (fixed oils), sugars (both non reducing and reducing), alkaloids, flavonoids, glycosides, tannins, triterpenoids, phenolics, saponins, phytosterols and anthocyanins. The fruit had 15.5% moisture contents seed and leaf had 8.5% each and stem and root bark had 9.5% each. The values of total ash were 7.0, 6.0, 4.5, 8.25 and 11.75%; values of water soluble ash were 4.9, 3.5, 0.5, 4.2 and 6.75%, while the values of acid insoluble ash 1.5, 1.75, 4.0, 3.75 and 4.25% in fruit pulp, leaf, stem bark, root bark and seeds, respectively. The fixed oil yield of M. buxifolia was measured to be 8.33, 10.62 and 0.56% in fruit pulp, seeds and leaves, respectively. Palmitic acid, Oleic acid, Linolenic acid, Stearic acid and Myristic acid were the most frequently found fatty acids in each part. The plant is a rich source of phosphorus, nitrogen and potassium. The plant contained safe amounts of tested trace elements as directed by WHO except for cobalt in root bark (10.7±0.01) and lead in stem bark (22.48±0.33).  

Polystyrene‐Supported Amino Acids as Efficient Catalyst for Chemical Fixation of Carbon Dioxide

2010 ◽  
Vol 352 (11‐12) ◽  
pp. 1925-1933 ◽  
Author(s):  
Chaorong Qi ◽  
Jinwu Ye ◽  
Wei Zeng ◽  
Huanfeng Jiang
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Chemical Fixation ◽  
Efficient Catalyst ◽  
Fixation Of Carbon Dioxide

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1010-P
Author(s):  
VICTORIA E. PARKER ◽  
DARREN ROBERTSON ◽  
TAO WANG ◽  
DAVID C. HORNIGOLD ◽  
MAXIMILIAN G. POSCH ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Receptor Activity ◽  
Glucagon Receptor
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