scholarly journals Thiamine Responsive Poli-oencephalomalacia in a Swan Goose- A Case Report

2017 ◽  
Vol 13 (01) ◽  
Author(s):  
S. U. Digraskar ◽  
S. T. Borikar ◽  
A. S. Tawheed ◽  
B. S. Nithin ◽  
S. Neelam ◽  
...  
Keyword(s):  
Amino Acids ◽  
Case Report ◽  
Freshwater Fish ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Cellular Processes ◽  
Neuronal Membranes ◽  
Water Soluble Vitamin ◽  
General Weakness ◽  
Vitamin B1 Deficiency

Thiamine (vitamin B1) deficiency in birds is caused by malnutrition or thiaminase-rich foods (raw freshwater fish) or foods high in anti-thiamine factors (betel nuts).Thiamine is an essential water soluble vitamin contributing phosphate derivatives that are involved in many cellular processes as coenzymes in the catabolism of sugars and amino acids. Also thiamine triphosphate (TTP) helps in proper functioning of neuronal membranes (Cooper and Pincus, 1979) and its deficiency leads to polyneuritis which is manifested as lethargy, head tremors, impaired digestion, general weakness, star-gazing and frequent convulsions

An Improved Method for the Quantification of Thiamine (Vitamin B1) in Cocoa-Containing Beverage Powders

2017 ◽  
Vol 100 (5) ◽  
pp. 1511-1515
Author(s):  
Frédéric Martin ◽  
Liliane Meyer ◽  
Konstantinos Zelianos ◽  
Esther Campos Gimenez
Keyword(s):  
Ph Value ◽  
Solid Phase ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Local Market ◽  
Improved Method ◽  
Test Portion ◽  
Beverage Samples ◽  
Water Soluble Vitamin ◽  
Thiamine Content

Abstract The purpose of this work was to understand low recoveries of thiamine (vitamin B1) when extracted from cocoa-containing beverage powders fortified with water-soluble vitamin B1, and to develop and validate a new procedure to improve these results. Based on the literature, previous trials have focused on two main factors: pH value prior to paper filtration and the need for solid-phase extraction (SPE) clean up. We demonstrate that by following European Standard EN 14122, recovery of thiaminein cocoa-containing beverage powders is low and dependent on the test portion (86 and 72% for 0.5 and 1.5 g test portions, respectively). Our improved method resolved this problem by keeping the pH low (around 1) prior to paper filtration, leading to a 96.3% recovery and high precision (RSDr of 3.5%). The use of strong cation-exchange SPE cartridges for cleanup prior to the thiamine oxidation reaction proved to be essential. A comparison between our improved method and EN 14122 on nine cocoa-containing beverage samples available on local market from different manufacturers showed a systematic increase in thiamine content (up to 70%) when the improved methodwas applied. The highest difference was observed forthe sample that contained the highest amount of cocoa. However, for beverage powders that contained bothcocoa and milk, no difference was observed.

scholarly journals The composite nature of the water-soluble vitamin B1

1930 ◽  
Vol 24 (6) ◽  
pp. 1764-1779 ◽  
Author(s):  
Harriette Chick ◽  
Alice Mary Copping
Keyword(s):  
Vitamin B1 ◽  
Water Soluble ◽  
Water Soluble Vitamin ◽  
Composite Nature

A case series of rare neurological and cardio-pulmonary manifestations of thiamine deficiency in pregnancy and lactation

2020 ◽  
pp. 1753495X2096090
Author(s):  
Nivedita Hegde ◽  
AJ Ashwal ◽  
Shrayva Deekonda ◽  
KK Suresh
Keyword(s):  
Thiamine Deficiency ◽  
Tricarboxylic Acid Cycle ◽  
Vitamin B1 ◽  
Case Series ◽  
Right Heart Failure ◽  
Water Soluble ◽  
Water Soluble Vitamin ◽  
Pulmonary Manifestations ◽  
Pregnancy And Lactation ◽  
In Pregnancy

Thiamine (vitamin B1) is a sulfur-containing, water-soluble vitamin that plays an essential role in energy metabolism and the tricarboxylic acid cycle. There is an increased need for vitamin B1 (1–1.2 mg daily) during pregnancy and lactation. Hyperemesis during pregnancy can cause severe polyneuropathy (Wernicke’s encephalopathy) as a result of thiamine deficiency. Thiamine deficiency has also been associated with beriberi. A number of atypical cases with reversible right heart failure and severe pulmonary hypertension have also been reported in non-pregnant individuals, but have never been reported in pregnancy. Here we present five such cases of thiamine deficiency with neurological and cardio-pulmonary manifestations.

Study on Synthesis of Tert-Butyl(4R)-4-(Methoxymethylcarbamoyl)-2,2-Dimethylthiazolidine-3- Carboxylate

2014 ◽  
Vol 1033-1034 ◽  
pp. 555-557
Author(s):  
Shuang Lin Qin ◽  
Lin Jun Tang ◽  
Gao Peng Wang ◽  
Li Ping Wang ◽  
Fei Fei Huang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Natural Product ◽  
Water Soluble ◽  
Tert Butyl ◽  
Water Soluble Vitamin ◽  
Fixation Of Carbon Dioxide ◽  
Metabolic Cycle

Tert-butyl (4R)-4-(methoxymethylcarbamoyl)-2,2-dimethylthiazolidine-3-carboxylate, an key intermediate of the natural product Biotin which is a water-soluble vitamin, involved in an essential part of the metabolic cycle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 54% through three steps. The study including acetonization, Boc protection, N-methoxy-N-methyl amidation.

scholarly journals The role of thiamine as a resuscitator in patients with nonalcoholic medical and CNS disorders

2017 ◽  
Vol 5 (19) ◽  
pp. 11 ◽  
Author(s):  
Mohamed Shehab-Eldin
Keyword(s):  
Septic Shock ◽  
Side Effects ◽  
Thiamine Deficiency ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Essential Factor ◽  
Cns Disorders ◽  
Water Soluble Vitamin

Thiamine (vitamin B1), a water-soluble vitamin, is an essential factor in cellular metabolismand fundamental cofactor in important biochemical cycles. Thiamine deficiency is a wellknowncause of neurological and cardiologic disorders, especially in patients with alcoholdependence. Recently, several researchers have studied the role of thiamine deficiency incritically ill patients and the link between thiamine supplementation and changes in lactatelevels in septic shock patients. The role of thiamine in this group of patients is still unclear;however, thiamine supplementation does not cause toxic side effects or increase morbidityor mortality. In this review, we discuss the most common conditions associated with thiaminedeficiency and the limited literature available on thiamine supplementation in critically illpatients.

Study on Synthesis of (R)-Methyl 2-((Tert-Butoxycarbonyl)Amino)-3-((Tert-Butyldimethylsilyl)Thio)Propanoate

2014 ◽  
Vol 1033-1034 ◽  
pp. 596-598
Author(s):  
Shuang Lin Qin ◽  
Lin Jun Tang ◽  
Li Ping Wang ◽  
Gao Peng Wang ◽  
Fei Fei Huang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Amino Acids ◽  
Fatty Acids ◽  
Natural Product ◽  
Water Soluble ◽  
Water Soluble Vitamin ◽  
Fixation Of Carbon Dioxide ◽  
Metabolic Cycle

(R)-methyl 2-((tert-butoxycarbonyl) amino)-3-((tert-butyldimethylsilyl) thio) propanoate, an key intermediate of the natural product Biotin which is a water-soluble vitamin, involved in an essential part of the metabolic cycle causing catalytic fixation of carbon dioxide in the biosynthesis of fatty acids, sugars, and α-amino acids, was synthesized from L-cystine in overall yield 67% through three steps, which synthesis included esterification, protection of amine and thiol.

scholarly journals Testing many keys in one lock: an unsuccessful yet fruitful quest for the cure of beri-beri

2017 ◽  
Vol 39 (2) ◽  
pp. 44-47
Author(s):  
Megumi Takashima ◽  
Chiaki Sano ◽  
Motonari Uesugi
Keyword(s):  
Amino Acids ◽  
Vitamin B1 ◽  
Early 20Th Century ◽  
Major Protein ◽  
Plant Seed ◽  
Seed Biology ◽  
Comprehensive Knowledge ◽  
The World ◽  
Essential Nutrient ◽  
Vitamin B1 Deficiency

Sutematsu Kajiura found himself in the early 20th century where the known essential nutrients only consisted of amino acids, carbohydrates, fats, minerals and water. Therefore, scientists and doctors were navigating a battlefield without comprehensive knowledge of the terrain, being completely unaware of the essential sector of vitamins. This is the world in which our story was published and Kajiura was on a mission to find the cause of the ‘national disease,’ beriberi, now known to be caused primarily by thiamine (vitamin B1) deficiency. Though Kajiura discovered neither the cause nor the cure, he made major contributions to plant seed biology by identifying and isolating the major protein in rice, oryzenin, which was later studied indepth. In addition, he was unknowingly a part of the massive movement toward the discovery of vitamins, the newest member of the essential nutrient family.

scholarly journals Investigation of Water-Soluble Vitamin (B1, B2, B3, and B7) Contents in Beverages and Confectionery

2021 ◽  
Vol 50 (6) ◽  
pp. 551-561
Author(s):  
Chang-Guk Boo ◽  
Sung Min Cho ◽  
Hyang Yun Jeong ◽  
So Jeong Yoon ◽  
Seong Jun Hong ◽  
...  
Keyword(s):  
Vitamin B1 ◽  
Water Soluble ◽  
Water Soluble Vitamin

Spectrophotometric determination of vitamin B1 in dosage forms using drugs compounds as reagents by normal and reverse flow injection methods

2021 ◽  
Vol 17 ◽  
Author(s):  
Rana Amir ◽  
Hind Hadi
Keyword(s):  
Flow Injection ◽  
Reverse Flow ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Thiamine Hydrochloride ◽  
Accuracy And Precision ◽  
Water Soluble Vitamin ◽  
Injection Methods ◽  
Injection Modes ◽  
Reverse Flow Injection

Background: Thiamine hydrochloride (THY), also known as vitamin B1, is a water soluble vitamin usually found in food, and considered as a dietary supplement and treatment in case of vitamin deficiency for example in malabsorption and chronic diarrhea. Objective: Rapid, green and sensitive methods for the assay of vitamin B1 (thiamine hydrochloride, THY) in pharmaceutical forms, using normal and reverse flow injection manifolds and sulfonamide drugs as green and safe reagents were reported. Sulfamethoxazole and sulfadimidine drugs were used rather than toxic and expensive reagents. Methods: nFIA and rFIA manifolds were used for automated the reaction of THY with diazotized sulfamethoxazole (DSMZ) and diazotized sulfadimidine (DSDM) in alkaline medium respectively. The absorbance of the resultant red-orange azo dyes was monitored spectrophotometrically at λmax 494 and 496 nm for both methods respectively. Results: The linearity of the suggested methods was in the ranges 2–80 µg/mL (LOD 0.69 µg/mL, % RSD 0.32, n=6) for nFIA method and 0.5-70 µg/mL (LOD 0.29 µg/mL, %RSD 0.85, n=6) for rFIA. Sampling frequency was 84 and 51 injections per hour for nFIA and rFIA methods respectively. Chemical and physical variables for both methods were studied carefully. Conclusion: Both flow injection modes were effectively applied in assay of THY in its pharmaceutical forms. The results were compared with those of standard pharmacopeia method and the statistical analysis indicated insignificant differences in accuracy and precision between the methods.

scholarly journals Developmental maturation of the colonic uptake process of the microbiota-generated thiamin pyrophosphate

2021 ◽  
Author(s):  
Subrata Sabui ◽  
Jose M Romero ◽  
Hamid M Said
Keyword(s):  
Developmental Regulation ◽  
Cell Metabolism ◽  
Active Form ◽  
Vitamin B1 ◽  
Water Soluble ◽  
Biologically Active ◽  
Nuclear Factors ◽  
Water Soluble Vitamin ◽  
Uptake Process ◽  
Thiamin Pyrophosphate

The water-soluble vitamin B1 is essential for normal human health and physiology. In its main biologically active form, i.e., thiamin pyrophosphate (TPP), the vitamin plays many critical roles in cell metabolism; thus, its deficiency leads to a variety of adverse effects. Humans/mammals obtain vitamin B1 from two exogenous sources: diet and gut microbiota. Considerable amount of the microbiota-generated vitamin B1 exists in the form of TPP, and colonocytes can efficiently absorb this TPP via a high-affinity and specific carrier-mediated mechanism that involves the recently cloned colonic TPP transporter (cTPPT; product of SLC44A4 gene). There is nothing currently known about colonic uptake of TPP during early stages of life, and whether the process undergoes developmental regulation. We addressed this issue using the mouse as animal model. Our results showed that colonic uptake of TPP undergoes developmental up-regulation as the animal moves from the suckling period to weanling and adulthood. This up-regulation in uptake was found to be associated with a parallel induction in level of expression of the cTPPT protein, mRNA and heterologous nuclear RNA (hnRNA), suggesting possible involvement of transcriptional mechanism(s). We also found a parallel up-regulation in level of expression of the two nuclear factors that drive activity of the SLC44A4 promoter (i. e., CREB-1 and Elf-3) with maturation. These results demonstrate, for the first time, that colonic TPP uptake process and cTPPT expression are developmentally up-regulated, and that this up-regulation is likely driven via transcriptional mechanism(s).

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