Simultaneous and sequential micro-porous semi-interpenetrating polymer network hydrogel films for drug delivery and wound dressing applications

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

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Synthesis and characterization of a novel wound dressing by PVP/ PAANa/chitosan with semi-interpenetrating polymer network structure

e-Polymers ◽

10.1515/epoly.2012.12.1.674 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 1

Author(s):

Ying Wu ◽

Qing Yang ◽

Yali Gi ◽

Yueting Zhang

Keyword(s):

Network Structure ◽

Wound Dressing ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Wound Dressings ◽

Synthesis And Characterization ◽

Cross Linking ◽

Mass Ratio ◽

Scanning Electron

AbstractA novel hydrogel wound dressing with semi-interpenetrating polymer network structure (semi-IPN) was prepared by radical polymerization of acrylic acid with potassium persulfate (K2S2O8) as initiator and N, N'-methylenebisacrylamide (MBA) as cross-linking agent in the presence of chitosan (CTS) and polyvinyl pyrrolidone (PVP). Hydrogels were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). SEM displayed semi- IPN hydrogels' creased surface with some scale-like wrinkles, thus improving the absorptive capability which has been considered as a most important characteristic of wound dressings. It was found that the content of cross-linking agent and the mass ratio of PVP and CTS had much influence on the mechanical properties of the hydrogel, varying from brittle plastics to elastomer due to the different degrees of cross linking. Since tensile strength is partly in inverse ratio to the hydrogel absorbent capability, the article offers an analysis of varying material proportion in order to obtain an optimum properties of the hydrogel wound dressing .

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Ionically Gelled Polysaccharide-Based Interpenetrating Polymer Network Systems for Drug Delivery

Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery - Gels Horizons: From Science to Smart Materials ◽

10.1007/978-981-16-2271-7_7 ◽

2021 ◽

pp. 121-133

Author(s):

Mohsen Khodadadi Yazdi ◽

Mohammad Reza Ganjali ◽

Morteza Rezapour ◽

Payam Zarrintaj ◽

Sajjad Habibzadeh ◽

...

Keyword(s):

Drug Delivery ◽

Polymer Network ◽

Interpenetrating Polymer Network ◽

Network Systems

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A pH/Temperature-Sensitive Semi-IPN Bead for Drug Release Carrier

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.148-149.1449 ◽

2010 ◽

Vol 148-149 ◽

pp. 1449-1452 ◽

Cited By ~ 1

Author(s):

Kui Lin Deng ◽

Yu Bo Gou ◽

Jian Zuo ◽

Li Rong Dong ◽

Qian Li ◽

...

Keyword(s):

Drug Delivery ◽

Polymer Network ◽

Phosphate Buffer Solution ◽

Interpenetrating Polymer Network ◽

Temperature Sensitive ◽

Buffer Solution ◽

Hydrogel Beads ◽

Drug Delivery Carrier ◽

Temperature Sensitive Hydrogel ◽

Stimuli Sensitive

A series of pH/temperature sensitive hydrogel beads with semi-interpenetrating polymer network (semi-IPN), composed of sodium alginate and poly(N-acryloylglycinate) were prepared as drug delivery carrier. In pH=2.3 phosphate buffer solution (PBS), the release amount of indomethacin incorporated into the beads was about 9% within 610 min, while this value approached to 68% in pH=7.4 PBS. The release rate of indomethacin was higher at 37 than that at 20 . In addition, the release amount of indomethacin was increased with increasing poly(N-acryloylglycinate) content. These results suggest that the stimuli-sensitive beads have the potential to be used as an effective pH/temperature delivery system in bio-medical fields.

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