Microwave-Assisted Anomeric Deacetylation of Ribofuranoses with Fe(III) Reagents

2013 ◽  
Vol 859 ◽  
pp. 337-340
Author(s):  
Qiang Wang ◽  
Guo Dong Liu ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Product Yield ◽  
Experimental Results ◽  
Heating Condition ◽  
Thermal Heating ◽  
Microwave Assisted ◽  
Acetyl Group ◽  
Cost Efficient ◽  
High Yields

Treatment of protected furanoses with FeCl3·6H2O in acetonitrile with microwave irradiation provides an efficient and mild protocol for regioselective removal of anomeric O-acetyl group. This method features cost efficient reagents, simple procedures, and high yields. The experimental results proved that microwave irradiation could notably shorten the reaction time and increase the product yield compared to the conventional thermal heating condition.

Microwave-Assisted FeCl3·6H2O-Catalyzed Regioselective Deprotection of Pyranose Anomeric O-Acetyl Group

2013 ◽  
Vol 830 ◽  
pp. 155-158 ◽  
Author(s):  
Qiang Wang ◽  
Guo Dong Liu ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Experimental Results ◽  
Conventional Heating ◽  
Heating Condition ◽  
Microwave Assisted ◽  
Acetyl Group

Treatment of peracetylated pyranoses with FeCl3·6H2O in acetonitrile under microwave conditions provides an efficient and mild method for regioselective deprotection of anomeric O-acetyl group. The experimental results indicated that the employment of microwave could notably improve the reaction efficacy compared with the conventional heating condition.

scholarly journals Microwave Assisted Synthesis of 1,5-Benzothiazepines Using Greener Reaction Medium

2019 ◽  
Vol 31 (5) ◽  
pp. 993-996 ◽  
Author(s):  
Sanjay S. Kotalwar ◽  
Amol D. Kale ◽  
Ram B. Kohire ◽  
Vasant B. Jagrut
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Reaction Medium ◽  
Microwave Assisted Synthesis ◽  
Reaction Conditions ◽  
Renewable Sources ◽  
Microwave Assisted ◽  
High Yields

An efficient and eco-friendly synthesis of 1,5-benzothiazepines has been developed by the reaction of various 2-propen-1-ones with 2-aminothiophenol using microwave irradiation in greener reaction medium, glycerol. The clean reaction conditions, shorter reaction time, high yields and non-toxic, biodegradable reaction medium manufactured from renewable sources are unique features of this method.

Microwave-assisted expeditious O-alkylation of meso-hydroxyphenylporphyrins

2009 ◽  
Vol 13 (08n09) ◽  
pp. 888-892 ◽  
Author(s):  
Vincent Chaleix ◽  
Pierre Couleaud ◽  
Vincent Sol ◽  
Rachida Zerrouki ◽  
Sandra Alves ◽  
...  
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Reaction Yield ◽  
Thermal Heating ◽  
Dramatic Decrease ◽  
Microwave Assisted

A mild method for O-alkylation of meso-hydroxyphenylporphyrin has been developed using microwave irradiation. This method is clean and efficient for many substrates and results in significant improvement in reaction yield and in a dramatic decrease in reaction time in comparison to thermal heating.

scholarly journals An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2501 ◽  
Author(s):  
Tarek S. Ibrahim ◽  
Israa A. Seliem ◽  
Siva S. Panda ◽  
Amany M. M. Al-Mahmoudy ◽  
Zakaria K. M. Abdel-Samii ◽  
...  
Keyword(s):  
Amino Acid ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Short Reaction Time ◽  
Mild Conditions ◽  
Drug Conjugates ◽  
Cost Efficient ◽  
High Yields

A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.

Ultrasonic-Assisted Deprotection of tert-Butyldimethylsilyl Ethers with Bromotrichloromethane in Methanol

2013 ◽  
Vol 830 ◽  
pp. 230-233 ◽  
Author(s):  
Jian Sun ◽  
Shan Shan Gong ◽  
Qi Sun
Keyword(s):  
Efficient Method ◽  
Experimental Results ◽  
Heating Condition ◽  
Thermal Heating ◽  
Reaction Efficiency ◽  
Ultrasonic Assisted ◽  
Ultrasonic Conditions

Treatment of tert-butyldimethylsilyl (TBDMS) ethers of nucleosides with bromo-trichloromethane (CBrCl3) in methanol under ultrasonic conditions provides a mild and efficient method for desilylation. The experimental results showed that the employment of ultrasonic could notably improve the reaction efficiency compared with thermal heating condition.

scholarly journals Microwave assisted synthesis of five membered nitrogen heterocycles

RSC Advances ◽  
2020 ◽  
Vol 10 (59) ◽  
pp. 36031-36041
Author(s):  
Gopinadh Meera ◽  
K. R. Rohit ◽  
Salim Saranya ◽  
Gopinathan Anilkumar
Keyword(s):  
Reaction Time ◽  
Nitrogen Heterocycles ◽  
Product Formation ◽  
Microwave Assisted Synthesis ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
High Yields

Microwave assisted synthesis of N-heterocycles with short reaction time, high yields and high product purities along with a decrease in the rate of by-product formation.

Microwave-assisted regioselective synthesis of acyclic nucleosides through an alkylating reaction with 2-oxa-1,4-butanediol diacetate

2006 ◽  
Vol 84 (5) ◽  
pp. 819-824 ◽  
Author(s):  
Guirong Qu ◽  
Suhui Han ◽  
Zhiguang Zhang ◽  
Mingwei Geng ◽  
Feng Xue
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Regioselective Synthesis ◽  
Environmental Friendliness ◽  
Short Reaction Time ◽  
Microwave Assisted ◽  
Acyclic Nucleosides ◽  
Green Procedure ◽  
Simple Manipulation

An efficient and green procedure for the synthesis of purine acyclic nucleosides through microwave-assisted alkylation of various purine nucleobases with 2-oxa-1,4-butanediol diacetate in the absence of solvent and catalyst is described. The advantages of using this method include its environmental friendliness, simple manipulation, short reaction time, high regioselectivity, and good yields.Key words: acyclic nucleosides, microwave irradiation, regioselectivity, alkylation, 2-oxa-1,4-butanediol diacetate.

Synthesis of Butanone 1,2 - Propanediol Ketal by Sulfamic Acid as Catalyzed

2013 ◽  
Vol 781-784 ◽  
pp. 276-279
Author(s):  
Yu Hang Zhao ◽  
Li Cui ◽  
Da Zhi Wang ◽  
Tong Kuan Xu ◽  
Yong Peng Li
Keyword(s):  
Reaction Time ◽  
Reaction Temperature ◽  
Raw Materials ◽  
Sulfamic Acid ◽  
Product Yield ◽  
Experimental Results ◽  
Reaction Conditions ◽  
Optimal Reaction

Butanone 1,2-propanediol ketal was synthesized by butanone and 1,2-propanediol as raw materials and sulfamic acid as catalyst. The effects of the mole ratio of raw materials agent, the dosage of the water-carrying agent and catalyst, reaction time on the product yield were discussed separately. Experimental results showed that sulfamic acid was a suitable catalyst for synthesizing of butanone 1,2-propanediol ketal. And the optimal reaction conditions are as follows: the mole ratio of butanone to 1,2-propanediol is 1:1.5, the amount of the catalyst is 2.2%, the water-carrying agent is 25ml, the reaction temperature is 358-378K and reaction time 3h. In this condition, the yield of production could reach 93.8%.

Synthesis of anti-inflammatory 2,3-unsaturated O-glycosides using conventional and microwave heating techniques

2017 ◽  
Vol 23 (3) ◽  
pp. 205-211
Author(s):  
Adriana Cristina N. de Melo ◽  
Ronaldo N. de Oliveira ◽  
João R. de Freitas Filho ◽  
Teresinha G. da Silva ◽  
Rajendra M. Srivastava
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Microwave Heating ◽  
Acid Catalyst ◽  
Conventional Heating ◽  
Microwave Exposure ◽  
Ferrier Rearrangement ◽  
Acetyl Group ◽  
Anti Inflammatory

AbstractThe preparation of eight 2,3-unsaturated O-glycosides from D-glycals and alcohols, using montmorillonite K-10 as an acid catalyst, is described. The Ferrier rearrangement products were obtained in good yields using conventional heating and microwave irradiation but the reaction time was substantially reduced employing the latter procedure. The yields were slightly lower under microwave exposure. Five of the di-O-acetylated products were deacetylated to the glycosides in excellent yields. The acetylated products possess good anti-inflammatory property suggesting that the acetyl group plays an important role in reducing the inflammation. Among the compounds tested, glycosides containing thiophene as an aglycone present much better inflammation reducing characteristics than the analogues without this function.

Microwave assisted synthesis of substituted metallophthalocyanines and their catalytic activity in epoxidation reaction

2005 ◽  
Vol 09 (03) ◽  
pp. 163-169 ◽  
Author(s):  
Farzad Bahadoran ◽  
Solmaz Dialameh
Keyword(s):  
Catalytic Activity ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
Microwave Assisted Synthesis ◽  
Free Condition ◽  
Catalytic Activities ◽  
Microwave Assisted ◽  
Solvent Free Condition ◽  
Epoxidation Reaction ◽  
Phthalocyanine Ring

Substituted iron and cobalt phthalocyanines are easily prepared by microwave irradiation of the starting materials under solvent free condition, which reduced reaction time considerably. The synthesized metallophthalocyanines (octachloro-, tetranitro-, tetracarboxy- or polyphthalocyanine) are used as epoxidation catalysts of cyclooctene in homogeneous and heterogeneous conditions by iodosylbenzene as an oxidant. Their catalytic activities have shown that the electron withdrawing groups on the phthalocyanine ring have a very small effect on stability of the catalyst during the reactions.

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