An Evaluation of the Potential for Pharmacokinetic Interaction between Tramadol and Cytochrome P450 2D6 Inhibitor Promethazine
2014 ◽
Vol 989-994
◽
pp. 1041-1043
Keyword(s):
In this single-center, randomized, open-label, 3-way crossover study, subjects received each of the following: a single dose of Tramadol Hydrochloride Injection (THI) 35 mg, a single dose of Promethazine Hydrochloride Injection (PHI) 45 mg, and single dose of Compound Tramadol Hydrochloride Injection (CTHI) 80mg. Blood was collected and plasma was analyzed for the pharmacokinetic parameters (maximum plasma concentration [Cmax], time to Cmax [Tmax], area under the plasma concentration-time curve, plasma elimination half-life, clearance, and apparent volume of distribution) of Tramadol and Promethazine. In general, several pharmacokinetic interactions were observed between Tramadol and Promethazine in the present study.
2020 ◽
2013 ◽
Vol 31
(15_suppl)
◽
pp. e13512-e13512
◽
2013 ◽
Vol 57
(5)
◽
pp. 2304-2309
◽
2013 ◽
Vol 57
(12)
◽
pp. 6158-6164
◽
Keyword(s):