Peculiarities of the Gingiva Cellular Composition and Functional Activity of the Epithelial Cells among the Children Patients with Chronic Gastritis and Duodenitis

2016 ◽  
Vol 29 ◽  
pp. 54-60
Author(s):  
Y.G. Romanenko ◽  
A.D. Matveeva
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Functional Properties ◽  
Chronic Gastritis ◽  
Functional Property ◽  
Functional Activity ◽  
Polymorphonuclear Leukocytes ◽  
Epithelial Layer ◽  
Cellular Composition ◽  
Skin Cells

At the children with chronic gastritis and duodenitis was revealed destroyed of morphological - functional property of gums with prevalence of degenerative component, which is manifested by appearance of basal and parabasal cells (0.3%), increasing of intermediate epithelial cells (84.7%), decreasing amount of surface nucleated epithelial cells (11.7%), and nuclear-free dead skin cells (4.3%). Majority of cells was with cytopathology shifts (18.2%), polymorphonuclear leukocytes (92.3%) and lymphocytes (20.5%). The data obtained in the research showed that 23 (21.5%) of samples, taken from children with chronic gastritis and duodenitis revealed cells in the early stages of differentiation, accumulation of leukocytes and fibrin, which demonstrates erosions of the gums in the epithelial layer. Adhesion of epithelial cells with Candida albicans at the children with chronic gastritis and duodenitis indicates about changes functional properties of the epithelial cells, growing on a background of the somatic pathology.

Electron Microscopic Study of the Epithelium of the Seminal Vesicle of Aging Rats

1974 ◽  
Vol 32 ◽  
pp. 138-139
Author(s):  
V. F. Allison ◽  
G. C. Fink ◽  
G. W. Cearley
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Seminal Vesicle ◽  
Seminal Vesicles ◽  
Epithelial Layer ◽  
Epithelial Hyperplasia ◽  
Electron Microscopic ◽  
Aging Rats ◽  
Pseudostratified Epithelium

It is well known that epithelial hyperplasia (benign hypertrophy) is common in the aging prostate of dogs and man. In contrast, little evidence is available for abnormal epithelial cell growth in seminal vesicles of aging animals. Recently, enlarged seminal vesicles were reported in senescent mice, however, that enlargement resulted from increased storage of secretion in the lumen and occurred concomitant to epithelial hypoplasia in that species.The present study is concerned with electron microscopic observations of changes occurring in the pseudostratified epithelium of the seminal vescles of aging rats. Special attention is given to certain non-epithelial cells which have entered the epithelial layer.

scholarly journals Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis

2015 ◽  
Vol 83 (7) ◽  
pp. 2614-2626 ◽  
Author(s):  
Rohitashw Kumar ◽  
Darpan Saraswat ◽  
Swetha Tati ◽  
Mira Edgerton
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Oral Candidiasis ◽  
Oral Microbiome ◽  
Proteinase Activity ◽  
Adhesion Properties ◽  
Content Type ◽  
Oral Epithelial Cells ◽  
Oral Epithelial ◽  
Cell Cell

Candida albicans, a commensal fungus of the oral microbiome, causes oral candidiasis in humans with localized or systemic immune deficiencies. Secreted aspartic proteinases (Saps) are a family of 10 related proteases and are virulence factors due to their proteolytic activity, as well as their roles in adherence and colonization of host tissues. We found that mice infected sublingually withC. albicanscells overexpressing Sap6 (SAP6OE and a Δsap8strain) had thicker fungal plaques and more severe oral infection, while infection with the Δsap6strain was attenuated. These hypervirulent strains had highly aggregative colony structurein vitroand higher secreted proteinase activity; however, the levels of proteinase activity ofC. albicansSaps did not uniformly match their abilities to damage cultured oral epithelial cells (SCC-15 cells). Hyphal induction in cells overexpressing Sap6 (SAP6OE and Δsap8cells) resulted in formation of large cell-cell aggregates. These aggregates could be produced in germinated wild-type cells by addition of native or heat-inactivated Sap6. Sap6 bound only to germinated cells and increasedC. albicansadhesion to oral epithelial cells. The adhesion properties of Sap6 were lost upon deletion of its integrin-binding motif (RGD) and could be inhibited by addition of RGD peptide or anti-integrin antibodies. Thus, Sap6 (but not Sap5) has an alternative novel function in cell-cell aggregation, independent of its proteinase activity, to promote infection and virulence in oral candidiasis.

scholarly journals A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells

2010 ◽  
Vol 8 (3) ◽  
pp. 225-235 ◽  
Author(s):  
David L. Moyes ◽  
Manohursingh Runglall ◽  
Celia Murciano ◽  
Chengguo Shen ◽  
Deepa Nayar ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Innate Immune

scholarly journals Functional activity of L-carnitine transporters in human airway epithelial cells

2016 ◽  
Vol 1858 (2) ◽  
pp. 210-219 ◽  
Author(s):  
Filippo Ingoglia ◽  
Rossana Visigalli ◽  
Bianca Maria Rotoli ◽  
Amelia Barilli ◽  
Benedetta Riccardi ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Functional Activity ◽  
Airway Epithelial Cells ◽  
Airway Epithelial ◽  
Human Airway ◽  
Human Airway Epithelial Cells

scholarly journals Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates

2018 ◽  
Vol 160 ◽  
pp. 82-93 ◽  
Author(s):  
Harlei Martin ◽  
Mairead Mc Govern ◽  
Lorna Abbey ◽  
Aisling Gilroy ◽  
Stephanie Mullins ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Buccal Epithelial Cells

Equilibrium analysis of binding of Candida albicans to human buccal epithelial cells

1990 ◽  
Vol 36 (5) ◽  
pp. 336-340 ◽  
Author(s):  
William Staddon ◽  
Tom Todd ◽  
Randall T. Irvin
Keyword(s):  
Candida Albicans ◽  
Epithelial Cells ◽  
Copy Number ◽  
Incubation Temperature ◽  
Temperature Shift ◽  
Equilibrium Analysis ◽  
High Copy Number ◽  
Buccal Epithelial Cells ◽  
Low Copy Number ◽  
Receptor Interactions

The effect of growth temperature on the binding of Candida albicans to human buccal epithelial cells (BECs) was examined using an equilibrium of binding analysis. Candida albicans was cultured in M9 medium either for 12 h at 25 °C or for 9 h at 25 °C and then shifted to 37 °C for 3 h. The temperature shift did not result in germ tube formation; however, the adherence of C. albicans to BECs was altered. Shifting temperature increased the yeast's ability to bind to BECs. A Langmuir adsorption isotherm was used to calculate the maximum number of available binding sites (N) and the apparent association constants of binding (Ka) for all resolvable adhesin–receptor interactions. Three classes of adhesin–receptor interactions were resolved when the yeast was cultured at 25 °C and included a low copy number site (N = 3.0 cfu/BEC; Ka = 2.11 × 10−6 mL/cfu), a medium copy number site (N = 23.6 cfu/BEC, Ka = 8.21 × 10−7 mL/cfu), and a high copy number site (N = 91.7 cfu/BEC, Ka = 3.35 × 10−8 mL/cfu). Two classes of adhesin–receptor interactions were resolved when the incubation temperature was shifted to 37 °C: a low copy number site (N = 4.5 cfu/BEC, Ka = 3.98 × 10−6 mL/cfu) and a high copy number site (N = 150.5 cfu/BEC, Ka = 8.47 × 10−8 mL/cfu). Augmented C. albicans adherence to BECs due to the elevated growth temperatures appears to result from a temperature-regulated alteration in the C. albicans adhesin that recognizes a high copy number receptor site with relatively low affinity.

scholarly journals Verbal Monomials in English for Audit and Accounting

2021 ◽  
Vol 04 (03) ◽  
Author(s):  
Oksana Chaika ◽  
Keyword(s):  
Functional Properties ◽  
Functional Property ◽  
The Other ◽  
Discussion Section ◽  
Work In Progress ◽  
The One

The paper research is work in progress and makes part of a publication set devoted the study of the English monomials and polynomials in the professional domain of audit and accounting, on the one hand. On the other, the research can be treated as a standalone piece for the study into the nature of verbal monomials as set term clusters in English for Audit and Accounting. The scope of research arrives at the following objectives. One objective is to give an overview of the term ‘monomial’ in English for Audit and Accounting, or English for A&A, which leads to understanding of the verbal monomial in English for A&A, correspondingly. The other objective refers to the classification introduced earlier as attributable to the analysis of the structure of the mentioned monomials and polynomials in English for A&A from a morphological perspective of the head term in a monomial, i.e. nounal, verbal, adjectival and adverbial. The said classification in this work associates with verbal monomials in English for A&A only, and provides a relevant sub-classification of the relevant verbal monomials through the lens of their functional properties and roles in a sentence, under the professional language framework. The results and discussion section presents five distinct groups of verbal monomials in English for Audit and Accounting, each corresponding to a specific syntactical role and functional property in a sentence. A variety of the examples helps see and identify the type of the English verbal monomial in the area of audit and accounting.

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