Magneto-Structural and Antimicrobial Properties of Sodium Doped Lanthanum Manganite Magnetic Nanoparticles for Biomedical Applications: Influence of Silica Coating

2018 ◽  
Vol 37 ◽  
pp. 117-127 ◽  
Author(s):  
Cyril O. Ehi-Eromosele ◽  
J.A.O. Olugbuyiro ◽  
A. Edobor-Osoh ◽  
A.A. Adebisi ◽  
O.A. Bamgboye ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Magnetic Nanoparticles ◽  
Structural Properties ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Antimicrobial Properties ◽  
Silica Coating ◽  
Coated Sample ◽  
Lanthanum Manganites ◽  
Doped Lanthanum Manganites

Coating of magnetic nanoparticles (MNPs) is usually a requirement prior to their utilization in biomedical applications. However, coating can influence the magneto-structural properties of MNPs thereby imparting their applications. The present work highlights the combustion synthesis of Na-doped lanthanum manganites (LNMO) and the influence of silica coatings on the magneto-structural properties, colloidal stability and antimicrobial properties of LNMO MNPs with their biomedical applications in mind. The crystalline perovskite structure was the same both for the bare and silica coated LNMO samples while there was a slight increase in crystallite size after coating. The FTIR spectral analysis, reduction in agglomeration of the particles and the elemental composition of the coated nanoparticles confirmed the presence of silica. The magnetization values of 34 emu/g and 29 emu/g recorded for bare and coated LNMO samples, respectively show that LNMO MNPs retained its ferromagnetic behaviour after silica coating. The pH dependent zeta potentials of the coated sample is-22.20 mV at pH 7.4 (physiological pH) and-18 mV at pH 5.0 (cell endosomal pH). Generally, silica coating reduced the antibacterial activity of the sample except forBacillussppwhere the antibacterial activity was the same with the bare sample. These results showed that while silica coating had marginal effect on the crystalline structure, size and magnetization of LNMO MNPs, it reduced the antibacterial activity of LNMO MNPs and enhanced greatly the colloidal stability of LNMO nanoparticles. Keywords: Na-doped lanthanum manganites, Silica coating, magnetic nanoparticles, biomedical applications, antimicrobial properties, colloidal stability

Magnetorelaxometry procedures for quantitative imaging and characterization of magnetic nanoparticles in biomedical applications

2015 ◽  
Vol 60 (5) ◽  
Author(s):  
Maik Liebl ◽  
Frank Wiekhorst ◽  
Dietmar Eberbeck ◽  
Patricia Radon ◽  
Dirk Gutkelch ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Quantitative Imaging ◽  
Local Environment ◽  
Quantitative Information ◽  
Magnetic Drug Targeting ◽  
Spatially Resolved ◽  
Fast Change

AbstractQuantitative knowledge about the spatial distribution and local environment of magnetic nanoparticles (MNPs) inside an organism is essential for guidance and improvement of biomedical applications such as magnetic hyperthermia and magnetic drug targeting. Magnetorelaxometry (MRX) provides such quantitative information by detecting the magnetic response of MNPs following a fast change in the applied magnetic field.In this article, we review our MRX based procedures that enable both the characterization and the quantitative imaging of MNPs in a biomedical environment.MRX characterization supported the selection of an MNP system with colloidal stability and suitable cellular MNP uptake. Spatially resolved MRX, a procedure employing multi-channel MRX measurements allowed forThese MRX based measurement and analysis procedures have substantially supported the development of MNP based biomedical applications.

scholarly journals Silica Coating of Ferromagnetic Iron Oxide Magnetic Nanoparticles Significantly Enhances Their Hyperthermia Performances for Efficiently Inducing Cancer Cells Death In Vitro

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2026
Author(s):  
Cristian Iacoviță ◽  
Ionel Fizeșan ◽  
Stefan Nitica ◽  
Adrian Florea ◽  
Lucian Barbu-Tudoran ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Colloidal Stability ◽  
Silica Coating ◽  
Neutral Red ◽  
Heating Performance ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Ferromagnetic Iron

Increasing the biocompatibility, cellular uptake, and magnetic heating performance of ferromagnetic iron-oxide magnetic nanoparticles (F-MNPs) is clearly required to efficiently induce apoptosis of cancer cells by magnetic hyperthermia (MH). Thus, F-MNPs were coated with silica layers of different thicknesses via a reverse microemulsion method, and their morphological, structural, and magnetic properties were evaluated by multiple techniques. The presence of a SiO2 layer significantly increased the colloidal stability of F-MNPs, which also enhanced their heating performance in water with almost 1000 W/gFe as compared to bare F-MNPs. The silica-coated F-MNPs exhibited biocompatibility of up to 250 μg/cm2 as assessed by Alamar Blues and Neutral Red assays on two cancer cell lines and one normal cell line. The cancer cells were found to internalize a higher quantity of silica-coated F-MNPs, in large endosomes, dispersed in the cytoplasm or inside lysosomes, and hence were more sensitive to in vitro MH treatment compared to the normal ones. Cellular death of more than 50% of the malignant cells was reached starting at a dose of 31.25 μg/cm2 and an amplitude of alternating magnetic field of 30 kA/m at 355 kHz.

Structural Properties Of Potassium Doped Lanthanum Manganites

2011 ◽  
Author(s):  
Dinesh Varshney ◽  
M. W. Shaikh ◽  
N. Dodiya ◽  
I. Mansuri ◽  
Alka B. Garg ◽  
...  
Keyword(s):  
Structural Properties ◽  
Lanthanum Manganites ◽  
Doped Lanthanum Manganites

scholarly journals Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

2020 ◽  
Vol 21 (6) ◽  
pp. 1979 ◽  
Author(s):  
Katarzyna Niemirowicz-Laskowska ◽  
Joanna Mystkowska ◽  
Dawid Łysik ◽  
Sylwia Chmielewska ◽  
Grażyna Tokajuk ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Artificial Saliva ◽  
Antimicrobial Properties ◽  
Core Shell ◽  
Oral Microbiota ◽  
Oral Dryness ◽  
Systemic Factors ◽  
Saliva Substitutes

Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects.

scholarly journals Luminomagnetic Silica-Coated Heterodimers of Core/Shell FePt/Fe3O4 and CdSe Quantum Dots as Potential Biomedical Sensor

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Caio Guilherme Secco de Souza ◽  
João Batista Souza ◽  
Watson Beck ◽  
Laudemir Carlos Varanda
Keyword(s):  
Quantum Dots ◽  
Saturation Magnetization ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Silica Coating ◽  
Magnetic Core ◽  
Superparamagnetic Nanoparticles ◽  
Cdse Quantum Dots ◽  
Water Dispersible ◽  
Growth Method

We report the synthesis of a new multifunctional nanomaterial based on silica-coated FePt/Fe3O4-CdSe heteronanostructures, combining luminescent and magnetic properties in a promising bifunctional sensor for biomedical applications. Spherical Fe3O4-coated FePt (FePt/Fe3O4) superparamagnetic nanoparticles (10.8 ± 1.5 nm) with high saturation magnetization and controlled size and shape were obtained using thermal decomposition coupled with seed-mediated growth method. Luminescent property was added to the nanomaterial by using the FePt/Fe3O4 magnetic core as seed and growing the CdSe quantum dots (2.7 ± 0.6 nm) onto its surface in a heterodimer-like structure using the hot-injection approach. The FePt/Fe3O4-CdSe luminomagnetic heteronanostructures were coated with silica shell using the reverse-micelle microemulsion route to avoid solvent-quenching effects. After silica coating, the water-dispersible heteronanostructures showed a diameter of 25.3 ± 2 nm, high colloidal stability, magnetic saturation of around 11 emu g−1, and photoluminescence in the blue-green region, as expected for potential bifunctional platform in biomedical applications. The saturation magnetization of heteronanostructures can be increased to 28 emu g−1 by annealing at 550°C due to the presence of the FePt phase.

scholarly journals Graphene for Antimicrobial and Coating Application

2022 ◽  
Vol 23 (1) ◽  
pp. 499
Author(s):  
Viritpon Srimaneepong ◽  
Hans Erling Skallevold ◽  
Zohaib Khurshid ◽  
Muhammad Sohail Zafar ◽  
Dinesh Rokaya ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Biomedical Applications ◽  
Medical Technology ◽  
Graphene Layer ◽  
Web Of Science ◽  
Antimicrobial Properties ◽  
High Strength ◽  
Corrosion Prevention ◽  
Coating Application ◽  
Thermal And Electrical Properties

Graphene is a versatile compound with several outstanding properties, providing a combination of impressive surface area, high strength, thermal and electrical properties, with a wide array of functionalization possibilities. This review aims to present an introduction of graphene and presents a comprehensive up-to-date review of graphene as an antimicrobial and coating application in medicine and dentistry. Available articles on graphene for biomedical applications were reviewed from January 1957 to August 2020) using MEDLINE/PubMed, Web of Science, and ScienceDirect. The selected articles were included in this study. Extensive research on graphene in several fields exists. However, the available literature on graphene-based coatings in dentistry and medical implant technology is limited. Graphene exhibits high biocompatibility, corrosion prevention, antimicrobial properties to prevent the colonization of bacteria. Graphene coatings enhance adhesion of cells, osteogenic differentiation, and promote antibacterial activity to parts of titanium unaffected by the thermal treatment. Furthermore, the graphene layer can improve the surface properties of implants which can be used for biomedical applications. Hence, graphene and its derivatives may hold the key for the next revolution in dental and medical technology.

Silica Functionalized Magnesium Ferrite Nanocomposites for Potential Biomedical Applications: Preparation, Characterization and Enhanced Colloidal Stability Studies

2016 ◽  
Vol 40 ◽  
pp. 146-157 ◽  
Author(s):  
Cyril O. Ehi-Eromosele ◽  
Benedict I. Ita ◽  
Emeka E.J. Iweala ◽  
Kehinde O. Ogunniran ◽  
Joseph A. Adekoya ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Biomedical Applications ◽  
Colloidal Stability ◽  
Spinel Phase ◽  
Aqueous Media ◽  
Physiological Saline ◽  
Silica Coating ◽  
Solution Combustion ◽  
X Ray ◽  
Silica Coatings

Magnetic nanocomposite material composed of silica coated MgFe2O4 for potential biomedical applications were synthesized by a two-step chemical method including solution combustion synthesis, followed by silica coatings of the ferrite nanoparticles. The effects of silica coatings on the structural, morphological and magnetic properties were comprehensively investigated using powder X-ray diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), energy dispersive absorption x-ray (EDAX), Fourier Transform Infrared spectroscopy (FTIR), thermogravimetric analysis and differential thermal analysis (TG–DTA) and vibrating sample magnetometer (VSM). The colloidal behaviour of coated MNPs in physiological saline medium like water or phosphate buffer saline (PBS) was also studied by zeta potential measurements. The XRD patterns indicate that the crystalline structure is single cubic spinel phase and the spinel structure is retained after silica coating. Also, after silica coating, the crystallite size (from Scherrer formula) decreases from 53 to 47 nm. The magnetic results show that MgFe2O4 MNPs (bare and silica coated) is ferrimagnetic at room temperature. Zeta potential studies revealed that there is enhanced colloidal stability of MgFe2O4 MNPs after silica coating in aqueous media which is an applicable potential in biomedical applications.

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