Self-Degradable Bioadhesive

2007 ◽  
Vol 342-343 ◽  
pp. 713-716 ◽  
Author(s):  
Naoki Nakajima ◽  
Hajime Sugai ◽  
Sadami Tsutsumi ◽  
Suong Hyu Hyon
Keyword(s):  
Acetic Anhydride ◽  
Fibrin Glue ◽  
Bonding Strength ◽  
Sodium Periodate ◽  
Aqueous Media ◽  
Food Additives ◽  
In Vitro Degradation ◽  
Aldehyde Groups

To improve the conventional and commercially-available medical adhesives such as cyanoacrylate, aldehyde-based, and fibrin glue, new bioadhesive has been prepared using medical and food additives as starting materials. Aldehyde groups could be easily introduced in dextran in the presence of sodium periodate in aqueous media, and the extent of the introduction could also be controlled. In vitro degradation speed of the hydrogel prepared by mixing of aldehyded dextran with ε-poly(L-lysine) at 37oC significantly varied by acetic anhydride concentration added to ε-poly(L-lysine) from < 5h to > 5 weeks. Bonding strength of the glue was 4 times higher than that of commercial fibrin glue and almost no cytotoxicity was observed, suggesting the development of novel self-degradable bioadhesive.

Presence of Angiotensin Peptides in Human Urine

1992 ◽  
Vol 38 (9) ◽  
pp. 1768-1772 ◽  
Author(s):  
K Hermann ◽  
R Rittweger ◽  
M I Phillips ◽  
J Ring
Keyword(s):  
Circadian Rhythm ◽  
Angiotensin Ii ◽  
Human Urine ◽  
Food Additives ◽  
Angiotensin I ◽  
In Vitro Degradation ◽  
Angiotensin Peptides ◽  
Daily Excretion ◽  
Anaphylactoid Reactions

Abstract Immunoreactive angiotensin I and angiotensin II were found in human urine that was purified on octadecasilylsilica cartridges. The daily excretion of angiotensin I and II in healthy volunteers was 189.00 (SE 38.36) and 17.54 (SE 3.07) pmol/24 h or 148.09 (SE 32.22) and 12.82 (SE 2.34) pmol/L, respectively (n = 12). No circadian rhythm was observed in the excretion patterns of angiotensin I and II. In vitro degradation of angiotensin I or II could not be detected in acidified urine samples. A marked increase in the excretion of angiotensin I and II could be demonstrated in patients with anaphylactoid reactions to drugs and food additives after oral challenge. Immunoreactive angiotensin I and II could be characterized by HPLC as Ile5-angiotensin I, Ile5-angiotensin II, and angiotensin II metabolites.

In vitro degradation of insoluble lignin in aqueous media by lignin peroxidase and manganese peroxidase

1998 ◽  
Vol 70-72 (1) ◽  
pp. 967-982 ◽  
Author(s):  
David N. Thompson ◽  
Bonnie R. Hames ◽  
C. A. Reddy ◽  
Hans E. Grethlein
Keyword(s):  
Lignin Peroxidase ◽  
Manganese Peroxidase ◽  
Aqueous Media ◽  
In Vitro Degradation

In Vitro Degradation Of beta-Amyloid[25-35] Peptide

2001 ◽  
Vol 8 (6) ◽  
pp. 423-428 ◽  
Author(s):  
Krisztina Jost ◽  
Jozsef Varga ◽  
Botond Pence ◽  
Marta Zarandi
Keyword(s):  
Beta Amyloid ◽  
In Vitro Degradation

In-vitro bactericidal activity of a novel plant source Plumeria pudica against some human and fish pathogenic bacteria

2020 ◽  
Vol 17 ◽  
Author(s):  
Shubhaisi Das ◽  
Sunanda Burman ◽  
Goutam Chandra
Keyword(s):  
Ethyl Acetate ◽  
Bioactive Compounds ◽  
Pathogenic Bacteria ◽  
Ethyl Acetate Extract ◽  
Positive Control ◽  
Leaf Extracts ◽  
Ms Analysis ◽  
Ft Ir ◽  
Aldehyde Groups

Background: The only remedy for up surging problem of antibiotic resistance is the discovery of antibacterial agents of natural origin. Objective: The present study was aimed at finding antibacterial potential of crude and solvent extracts of mature leaves of Plumeria pudica. Methods: Antibacterial activity of three different solvent extracts were evaluated in four human and four fish pathogenic bacteria by measuring the zone of inhibition and determining Minimum Inhibitory Concentration and Minimum Bactericidal Concentration values. Standard antibiotics were used as positive control. Preliminary phytochemical screening of most effective extract i.e., ethyl acetate extract, Fourier Transform Infra Red analysis and GC-MS analysis of the Thin Layer Chromatographic (TLC) fraction of ethyl acetate extract were done meticulously. All experiments were done thrice and analyzed statistically. Results: Crude leaf extracts and solvent extracts caused good inhibition of bacterial growth in all selected bacteria. Ethyl acetate extract showed highest inhibition zones in all tested strains with maximum inhibition (19.50±0.29 mm) in Escherichia coli (MTCC 739). MBC/MIC of the extracts indicated that all three solvent extracts were bactericidal. Preliminary phytochemical tests revealed the presence of tannins, steroids and alkaloids and FT-IR analysis revealed presence of many functional groups namely alcoholic, amide, amine salt and aldehyde groups. From the GC-MS analysis of TLC fraction of ethyl acetate extract five different bioactive compounds e.g., 2,4-ditert –butylphenyl 5-hydroxypentanoate, Oxalic acid; allyl nonyl ester, 7,9-Ditert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, Dibutyl phthalate and 2,3,5,8-tetramethyl-decane were identified. Conclusion: Leaf extracts of P. pudica contain bioactive compounds that can be used as broad spectrum bactericidal agent.

scholarly journals In Vitro Degradation of Absorbable Zinc Alloys in Artificial Urine

Materials ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 295 ◽  
Author(s):  
Sébastien Champagne ◽  
Ehsan Mostaed ◽  
Fariba Safizadeh ◽  
Edward Ghali ◽  
Maurizio Vedani ◽  
...  
Keyword(s):  
Surface Characterization ◽  
Urinary Tract Obstruction ◽  
Calcium Content ◽  
Corrosion Layer ◽  
Uniform Corrosion ◽  
In Vitro Degradation ◽  
Pure Zinc ◽  
Zinc Alloys ◽  
Artificial Urine

Absorbable metals have potential for making in-demand rigid temporary stents for the treatment of urinary tract obstruction, where polymers have reached their limits. In this work, in vitro degradation behavior of absorbable zinc alloys in artificial urine was studied using electrochemical methods and advanced surface characterization techniques with a comparison to a magnesium alloy. The results showed that pure zinc and its alloys (Zn–0.5Mg, Zn–1Mg, Zn–0.5Al) exhibited slower corrosion than pure magnesium and an Mg–2Zn–1Mn alloy. The corrosion layer was composed mostly of hydroxide, carbonate, and phosphate, without calcium content for the zinc group. Among all tested metals, the Zn–0.5Al alloy exhibited a uniform corrosion layer with low affinity with the ions in artificial urine.

scholarly journals Improved Antioxidant Capacity of Black Tea Waste Utilizing PlantCrystals

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 592 ◽  
Author(s):  
Abraham M. Abraham ◽  
Reem M. Alnemari ◽  
Jana Brüßler ◽  
Cornelia M. Keck
Keyword(s):  
Antioxidant Capacity ◽  
Aqueous Media ◽  
Natural Antioxidants ◽  
Black Tea ◽  
Pharmaceutical Products ◽  
Small Scale ◽  
Alternative Source ◽  
Significant Difference ◽  
Plant Waste

Antioxidants are recommended to prevent and treat oxidative stress diseases. Plants are a balanced source of natural antioxidants, but the poor solubility of plant active molecules in aqueous media can be a problem for the formulation of pharmaceutical products. The potential of PlantCrystal technology is known to improve the extraction efficacy and antioxidant capacity (AOC) of different plants. However, it is not yet proved for plant waste. Black tea (BT) infusion is consumed worldwide and thus a huge amount of waste occurs as a result. Therefore, BT waste was recycled into PlantCrystals using small-scale bead milling. Their characteristics were compared with the bulk-materials and tea infusion, including particle size and antioxidant capacity (AOC) in-vitro. Waste PlantCrystals possessed a size of about 280 nm. Their AOC increased with decreasing size according to the DPPH (1,1-diphenyl-2-picrylhydrazyl) and ORAC (oxygen radical absorbance capacity) assays. The AOC of the waste increased about nine-fold upon nanonization, leading to a significantly higher AOC than the bulk-waste and showed no significant difference to the infusion and the used standard according to DPPH assay. Based on the results, it is confirmed that the PlantCrystal technology represents a natural, cost-effective plant-waste recycling method and presents an alternative source of antioxidant phenolic compounds.

Effects of Mn-doping on the structure and in vitro degradation of β-tricalcium phosphate

2021 ◽  
Author(s):  
Junjian Che ◽  
Hubiao Wang ◽  
Yunhai Ma ◽  
Feipeng Cao ◽  
Guoqin Liu ◽  
...  
Keyword(s):  
Tricalcium Phosphate ◽  
In Vitro Degradation ◽  
Mn Doping
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