Performance and Loads of a Lift Offset Rotor, Part II: Prediction Validations with Measurements

2021 ◽  
Author(s):  
Joseph H. Schmaus ◽  
Inderjit Chopra
Keyword(s):  
Experimental Model ◽  
Comprehensive Analysis ◽  
Rotor Part ◽  
Pitch Bearing ◽  
The Impact

The predictions of an upgraded UMARC comprehensive analysis are compared to experimental lift offset rotor results. The experiments cover a range of collective pitch angles (θ°) from 2° to 10°, advance ratios (μ) from 0.21 to 0.53, and lift offset from 0% to 20%. The experimental model rotors are from a system of coaxial hingeless rotors, with two blades each, and a first flap frequency of approximately 1.6/rev. The simulation is compared with isolated rotor performance and controls with lift offset, loads, and pitch link forces. Increasing efficiency with increasing lift offset, the impact of lift offset on different loads, and the dependence of pitch link loads on pitch bearing damping are identified in the experiment and correlated with the simulation.

Comprehensive Effects of Short-Term Rental Platforms Across Hotel Types in U.S. and International Destinations

2021 ◽  
pp. 193896552110335
Author(s):  
John W. O’Neill ◽  
Jihwan Yeon
Keyword(s):  
Service Providers ◽  
Comprehensive Analysis ◽  
Competitive Market ◽  
Substitution Effects ◽  
Short Term ◽  
Hotel Performance ◽  
The World ◽  
Different Types ◽  
Location Type ◽  
The Impact

In recent years, short-term rental platforms in the lodging sector, including Airbnb, VRBO, and HomeAway, have received extensive attention and emerged as potentially alternative suppliers of services traditionally provided by established commercial accommodation providers, that is, hotels. Short-term rentals have dramatically increased the available supply of rooms for visitors to multiple international destinations, potentially siphoning demand away from hotels to short-term rental businesses. In a competitive market, an increase in supply with constant demand would negatively influence incumbent service providers. In this article, we examine the substitution effects of short-term rental supply on hotel performance in different cities around the world. Specifically, we comprehensively investigate the substitution effects of short-term rental supply on hotel performance based on hotel class, location type, and region. Furthermore, we segment the short-term rental supply based on its types of accommodations, that is, shared rooms, private rooms, and entire homes, and both examine and quantify the differential effects of these types of short-term rentals on different types of hotels. This study offers a comprehensive analysis regarding the impact of multiple short-term rental platforms on hotel performance and offers both conceptual and practical insights regarding the nature and extent of the effects that were identified.

scholarly journals Deletion of arginase 2 attenuates neuroinflammation in an experimental model of optic neuritis

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247901
Author(s):  
Amritha A. Candadai ◽  
Fang Liu ◽  
Abdelrahman Y. Fouda ◽  
Moaddey Alfarhan ◽  
Chithra D. Palani ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Experimental Model ◽  
Axonal Degeneration ◽  
Wild Type ◽  
Autoimmune Encephalomyelitis ◽  
Optic Nerves ◽  
Clinical Presentations ◽  
Retinal Neurodegeneration ◽  
The Impact ◽  
Experimental Autoimmune

Vision impairment due to optic neuritis (ON) is one of the major clinical presentations in Multiple Sclerosis (MS) and is characterized by inflammation and degeneration of the optic nerve and retina. Currently available treatments are only partially effective and have a limited impact on the neuroinflammatory pathology of the disease. A recent study from our laboratory highlighted the beneficial effect of arginase 2 (A2) deletion in suppressing retinal neurodegeneration and inflammation in an experimental model of MS. Utilizing the same model, the present study investigated the impact of A2 deficiency on MS-induced optic neuritis. Experimental autoimmune encephalomyelitis (EAE) was induced in wild-type (WT) and A2 knockout (A2-/-) mice. EAE-induced cellular infiltration, as well as activation of microglia and macrophages, were reduced in A2-/- optic nerves. Axonal degeneration and demyelination seen in EAE optic nerves were observed to be reduced with A2 deletion. Further, the lack of A2 significantly ameliorated astrogliosis induced by EAE. In conclusion, our findings demonstrate a critical involvement of arginase 2 in mediating neuroinflammation in optic neuritis and suggest the potential of A2 blockade as a targeted therapy for MS-induced optic neuritis.

scholarly journals Administrative and Legal Principles of the Activities of the National Police of Ukraine in Preventing and Counteracting Bullying

2020 ◽  
Vol 79 (4) ◽  
pp. 48-53
Author(s):  
Д. А. Сорочан
Keyword(s):  
Comprehensive Analysis ◽  
Educational Institutions ◽  
Main Task ◽  
Legal Principles ◽  
Ethical Education ◽  
Preventive Activity ◽  
Close Cooperation ◽  
National Police ◽  
The Impact

The negative socio-economic situation and large gaps in the moral and ethical education of the younger generation have led to an increase in the number of cases of deliberate abuse of older and stronger to the smaller and weaker members of educational institutions. The author has studied administrative and legal principles of the activity of the National Police of Ukraine on preventing and counteracting bullying. Based on a comprehensive analysis of national legislation on preventing and combating bullying in Ukraine, the author has determined perspective areas for improving administrative and legal principles in this area. It has been emphasized that the role of the National Police in this area cannot be limited to the preventive registration of a child. It is necessary to develop a set of preventive and educational measures aimed at preventing bullying manifestations among minors. It has been found out that there are no tools to assess the effectiveness of the impact of existing strategies to combat bullying in Ukraine, which necessitates further research in this area. It has been determined that it is necessary to fight not with individual facts of bullying, but to enshrine in the legislation the system of counteraction to harassment in educational institutions, which can be preventive in nature. It has been established that the legislator has introduced a number of amendments over the last few years, which are characterized by the strengthening of the component of protection of children’s rights. A positive novelty is that the main task of the juvenile police was preventive activity instead of punitive one. In general, the regulatory basis for the activities of the National Police of Ukraine to prevent and combat bullying can be divided into two parts: general legislative acts and departmental regulatory acts. It has been noted that the prevention of bullying and the prevention and combating of domestic violence are different aspects of the same problem, which are in constant close cooperation, and then the measures to overcome them should be common.

The impact of naloxegol treatment on gastrointestinal transit and colonic volume

2017 ◽  
Vol 16 (1) ◽  
pp. 172-172
Author(s):  
D. Grønlund ◽  
A.E. Olesen ◽  
J.L. Poulsen ◽  
C. Brock ◽  
A.M. Drewes
Keyword(s):  
Experimental Model ◽  
Transit Time ◽  
Gastrointestinal Transit ◽  
Receptor Activation ◽  
Opioid Antagonist ◽  
Imaging Method ◽  
Transit System ◽  
Gi Symptoms ◽  
Gi Transit ◽  
The Impact

Abstract Aims Opioid treatment is associated with gastrointestinal (GI) side effects, known as opioid-induced bowel dysfunction (OIBD). Symptoms of OIBD are caused by opioid receptor activation in the enteric nervous system, which results in increased GI transit time and increased faecal volume in the colon. OIBD can be experimentally induced in healthy participants through oral oxycodone treatment. The aim of this study was to investigate whether administration of naloxegol, a peripherally restricted opioid antagonist, could reduce GI symptoms, GI transit time, and colorectal volume, using an experimental model of OIBD. Methods In a double blind crossover trial, twenty-five healthy males were randomly assigned to a six day treatment of oral oxycodone in combination with either oral naloxegol or placebo. At baseline and at day six, participants filled in the Patient Assessment of Constipation Symptom questionnaire, and colorectal volume was quantified with a magnetic resonance imaging method. Participants swallowed a small electromagnetic capsule, which allowed determination of total and segmental GI transit times, using the 3D-Transit system. Results In the established model of oxycodone induced OIBD, fewer GI symptoms were observed during naloxegol treatment, compared to placebo (P <0.01). Naloxegol decreased median total transit time by 27% (56 vs 71 h, P < 0.05) and decreased colorectal transit time by 33% (45 vs 59 h, P < 0.01), compared to placebo. No difference in colorectal volume was found between the two treatments. Conclusions In an experimental model of OIBD, GI symptoms and GI transit time were reduced during treatment with naloxegol, compared to placebo. However, naloxegol treatment did not reduce colorectal volume. These findings add information on the potential of naloxegol to be used in prevention and treatment of OIBD.

Abstract 401: Experimental Aneurysm in Rats Excluded by Stent Graft: A New Model to Assess the Impact of Endovascular Aneurysm Repair on the Pathophysiology of Abdominal Aortic Aneurysm.

2012 ◽  
Vol 32 (suppl_1) ◽  
Author(s):  
Martin Rouer ◽  
Martin Rouer ◽  
Jean-Marc Alsac ◽  
Jean-Baptiste Michel
Keyword(s):  
Experimental Model ◽  
Ex Vivo ◽  
Endovascular Aneurysm Repair ◽  
Small Animal ◽  
Normal Diet ◽  
Biological Study ◽  
Experimental Aneurysm ◽  
Midline Laparotomy ◽  
The Impact

Introduction Biological study of the impact of endovascular aortic repair (EVAR) on pathophysiology of aortic abdominal aneurysms (AAA) can only be performed indirectly in humans, by imaging or search for peripheral biomarkers in the circulating blood. Therefore biological mechanism’s modifications into the aneurismal wall related to its endovascular exclusion are still to be elucidated, and small animal models should bring a valuable help in this field. We describe a new experimental model of stentgraft implantation for the exclusion of AAA in rats. Methods Aneurysms were induced as previously described by intra-aortic elastase injection in Wistar rats, or by aortic decellularized xenograft transplantation in Lewis rats. At least 15 days later, the midline laparotomy was reopened, and 3mm covered stentgraft were inserted and deployed in the AAA to obtain its exclusion. The patency of the graft and the AAA exclusion could be assessed by a global arteriogram through the carotid artery. After closure of the laparotomy, the rats were awakened and returned to a normal diet. Results This experimental model of AAA exclusion by a stentgraft allows many in vivo and ex vivo studies of the pathophysiology of AAA after EVAR. Histological modifications of the aortic wall and the intra-luminal thrombus could be assessed. The impact of EVAR on the adventitial immuno-inflammatory activity could be studied by different imaging such as MRI, scintigraphy or PET-scan. In situ biological and enzymatic activities could be evaluated to better understand the local mechanisms leading to AAA shrinkage or expansion after EVAR. Conclusion Exclusion by stentgraft of experimental AAA in rats is the first described model of EVAR in small animals. It is feasible and reproducible for both elastase and xenograft experimental AAA models. This model will definitely help to a better analysis and understanding of the impact of stentgrafting on biological mechanisms in the aneurismal wall, that lead to EVAR success with shrinkage of aneurismal sac or EVAR failure with its continuing expansion.

Methods for Comprehensive Analysis of Heat Supply Reliability

2013 ◽  
Vol 2 (4) ◽  
pp. 120-142
Author(s):  
V. A. Stennikov ◽  
I. V. Postnikov
Keyword(s):  
Heat Supply ◽  
Methodological Approach ◽  
Flow Distribution ◽  
Heat Supply System ◽  
Short Review ◽  
Comprehensive Analysis ◽  
Heat Energy ◽  
Production And Distribution ◽  
The Impact ◽  
Supply Reliability

The paper deals with the problem of comprehensive analysis of heat supply reliability for consumers. It implies a quantitative assessment of the impact of all stages of heat energy production and distribution on heat supply reliability for each consumer of the heat supply system. A short review of existing methods for the analysis of fuel and heat supply reliability is presented that substantiates the key approaches to solving the problem of comprehensive analysis of heat supply reliability. A methodological approach is suggested, in which mathematical models and methods for nodal evaluation of heat supply reliability for consumers are developed and the studies on the impact of different elements of fuel and heat supply systems on its level are described. Mathematical modeling is based on the Markov random processes, models of flow distribution in a heat network, deterministic dependences of thermal processes of heat energy consumption and some other models.

scholarly journals The Impact of Rotavirus Vaccines on Genotype Diversity: A Comprehensive Analysis of 2 Decades of Australian Surveillance Data

2018 ◽  
Vol 218 (4) ◽  
pp. 546-554 ◽  
Author(s):  
Susie Roczo-Farkas ◽  
Carl D Kirkwood ◽  
Daniel Cowley ◽  
Graeme L Barnes ◽  
Ruth F Bishop ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Surveillance Data ◽  
Rotavirus Vaccines ◽  
Genotype Diversity ◽  
The Impact

scholarly journals Development of methodology for evaluation of innovative IT-projects

2019 ◽  
Vol 110 ◽  
pp. 02092
Author(s):  
Lisienkova Tatiana ◽  
Liubov Lisienkova ◽  
Ekaterina Baranova ◽  
Lyudmila Nosova ◽  
Inna Tursukova
Keyword(s):  
Comprehensive Analysis ◽  
Business Development ◽  
Digital Transformation ◽  
Innovation Strategy ◽  
Financial Indicators ◽  
It Projects ◽  
Urgent Task ◽  
Methodological Approaches ◽  
The Impact ◽  
Selection And Ranking

Innovative business development based on a digital transformation is the urgent task for companies. It is able to ensure the implementation of innovation strategy and digital transformation of business. Due to the high development speed and the IT-market updating, the problem is lack of methods of rational choice of the IT-project. In practice, companies often implement IT-projects without reasonable selection and ranking, which leads to a high proportion of failed innovative IT-projects. As a result, the company does not receive a commercially successful product or service that stands out to the consumer among competitors. The evaluation of innovative IT-projects is based on the financial indicators analysis of the expected results from the implementation. The evaluation of the strategic coherence of the project is ignored. The research approaches the methodical of ranking innovative IT-projects in companies. The method consists in a comprehensive analysis of the impact of the proposed project results in various aspects of the company (strategic, environmental, organizational and technological). The study highlights the features of innovative projects in the field of information technology, a comparative analysis of methodological approaches to the evaluation of innovative projects, modified the model of acceptance of IT-innovations.

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