scholarly journals The Impact of Rotavirus Vaccines on Genotype Diversity: A Comprehensive Analysis of 2 Decades of Australian Surveillance Data

2018 ◽  
Vol 218 (4) ◽  
pp. 546-554 ◽  
Author(s):  
Susie Roczo-Farkas ◽  
Carl D Kirkwood ◽  
Daniel Cowley ◽  
Graeme L Barnes ◽  
Ruth F Bishop ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Surveillance Data ◽  
Rotavirus Vaccines ◽  
Genotype Diversity ◽  
The Impact

scholarly journals Clinical laboratory practices for the detection of rotavirus in England and Wales: can surveillance based on routine laboratory testing data be used to evaluate the impact of vaccination?

2009 ◽  
Vol 14 (20) ◽  
Author(s):  
C J Atchison ◽  
B A Lopman ◽  
C J Harris ◽  
C C Tam ◽  
M Iturriza Gómara ◽  
...  
Keyword(s):  
Laboratory Testing ◽  
Clinical Laboratory ◽  
Age Groups ◽  
Surveillance Data ◽  
Enzyme Linked Immunosorbent Assay ◽  
Routine Laboratory ◽  
England And Wales ◽  
Rotavirus Vaccines ◽  
Testing Data ◽  
The Impact

Two rotavirus vaccines have recently been licensed in Europe. Rotavirus surveillance data in many European countries are based on reports of laboratory-confirmed rotavirus infections. If surveillance data based on routine laboratory testing data are to be used to evaluate the impact of vaccination programmes, it is important to determine how the data are influenced by differences in testing practices, and how these practices are likely to affect the ability of the surveillance data to represent trends in rotavirus disease in the community. We conducted a survey of laboratory testing polices for rotavirus gastroenteritis in England and Wales in 2008. 60% (94/156) of laboratories responded to the survey. 91% of reporting laboratories offered routine testing for rotavirus all year round and 89% of laboratories offered routine rotavirus testing of all stool specimens from children under the age of five years. In 96% of laboratories, rotavirus detection was presently done either by rapid immunochromatographic tests or by enzyme-linked immunosorbent assay. Currently, rotavirus testing policies among laboratories in England and Wales are relatively homogenous. Therefore, surveillance based on laboratory testing data is likely to be representative of rotavirus disease trends in the community in the most frequently affected age groups (children under the age of five years) and could be used to help determine the impact of a rotavirus vaccine.

Identifying signatures of the impact of rotavirus vaccines on hospitalizations using sentinel surveillance data from Latin American countries

Vaccine ◽  
2020 ◽  
Vol 38 (2) ◽  
pp. 323-329 ◽  
Author(s):  
Kayoko Shioda ◽  
Lucia Helena de Oliveira ◽  
Jennifer Sanwogou ◽  
Gloria Rey-Benito ◽  
Diana Nuñez Azzad ◽  
...  
Keyword(s):  
Latin American ◽  
Sentinel Surveillance ◽  
Surveillance Data ◽  
Rotavirus Vaccines ◽  
The Impact ◽  
Latin American Countries

scholarly journals Detection of diarrhoea associated rotavirus and co-infection with diarrhoeagenic pathogens in the Littoral region of Cameroon using ELISA, RT-PCR and Luminex xTAG GPP assays

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rahinatou N. Ghapoutsa ◽  
Maurice Boda ◽  
Rashi Gautam ◽  
Valantine Ngum Ndze ◽  
Akongnwi E. Mugyia ◽  
...  
Keyword(s):  
Demographic Data ◽  
Laboratory Diagnosis ◽  
Epidemiological Studies ◽  
Sub Saharan Africa ◽  
Rt Pcr ◽  
Mortality And Morbidity ◽  
Vaccine Introduction ◽  
Littoral Region ◽  
Rotavirus Vaccines ◽  
The Impact

Abstract Background Despite the global roll-out of rotavirus vaccines (RotaTeq/Rotarix / ROTAVAC/Rotasiil), mortality and morbidity due to group A rotavirus (RVA) remains high in sub-Saharan Africa, causing 104,000 deaths and 600,000 hospitalizations yearly. In Cameroon, Rotarix™ was introduced in March 2014, but, routine laboratory diagnosis of rotavirus infection is not yet a common practice, and vaccine effectiveness studies to determine the impact of vaccine introduction have not been done. Thus, studies examining RVA prevalence post vaccine introduction are needed. The study aim was to determine RVA prevalence in severe diarrhoea cases in Littoral region, Cameroon and investigate the role of other diarrheagenic pathogens in RVA-positive cases. Methods We carried out a study among hospitalized children < 5 years of age, presenting with acute gastroenteritis in selected hospitals of the Littoral region of Cameroon, from May 2015 to April 2016. Diarrheic stool samples and socio-demographic data including immunization and breastfeeding status were collected from these participating children. Samples were screened by ELISA (ProSpecT™ Rotavirus) for detection of RVA antigen and by gel-based RT-PCR for detection of the VP6 gene. Co-infection was assessed by multiplexed molecular detection of diarrheal pathogens using the Luminex xTAG GPP assay. Results The ELISA assay detected RVA antigen in 54.6% (71/130) of specimens, with 45, positive by VP6 RT-PCR and 54, positive using Luminex xTAG GPP. Luminex GPP was able to detect all 45 VP6 RT-PCR positive samples. Co-infections were found in 63.0% (34/54) of Luminex positive RVA infections, with Shigella (35.3%; 12/34) and ETEC (29.4%; 10/34) detected frequently. Of the 71 ELISA positive RVA cases, 57.8% (41/71) were fully vaccinated, receiving two doses of Rotarix. Conclusion This study provides insight on RVA prevalence in Cameroon, which could be useful for post-vaccine epidemiological studies, highlights higher than expected RVA prevalence in vaccinated children hospitalized for diarrhoea and provides the trend of RVA co-infection with other enteric pathogens. RVA genotyping is needed to determine circulating rotavirus genotypes in Cameroon, including those causing disease in vaccinated children.

Comprehensive Effects of Short-Term Rental Platforms Across Hotel Types in U.S. and International Destinations

2021 ◽  
pp. 193896552110335
Author(s):  
John W. O’Neill ◽  
Jihwan Yeon
Keyword(s):  
Service Providers ◽  
Comprehensive Analysis ◽  
Competitive Market ◽  
Substitution Effects ◽  
Short Term ◽  
Hotel Performance ◽  
The World ◽  
Different Types ◽  
Location Type ◽  
The Impact

In recent years, short-term rental platforms in the lodging sector, including Airbnb, VRBO, and HomeAway, have received extensive attention and emerged as potentially alternative suppliers of services traditionally provided by established commercial accommodation providers, that is, hotels. Short-term rentals have dramatically increased the available supply of rooms for visitors to multiple international destinations, potentially siphoning demand away from hotels to short-term rental businesses. In a competitive market, an increase in supply with constant demand would negatively influence incumbent service providers. In this article, we examine the substitution effects of short-term rental supply on hotel performance in different cities around the world. Specifically, we comprehensively investigate the substitution effects of short-term rental supply on hotel performance based on hotel class, location type, and region. Furthermore, we segment the short-term rental supply based on its types of accommodations, that is, shared rooms, private rooms, and entire homes, and both examine and quantify the differential effects of these types of short-term rentals on different types of hotels. This study offers a comprehensive analysis regarding the impact of multiple short-term rental platforms on hotel performance and offers both conceptual and practical insights regarding the nature and extent of the effects that were identified.

Performance and Loads of a Lift Offset Rotor, Part II: Prediction Validations with Measurements

2021 ◽  
Author(s):  
Joseph H. Schmaus ◽  
Inderjit Chopra
Keyword(s):  
Experimental Model ◽  
Comprehensive Analysis ◽  
Rotor Part ◽  
Pitch Bearing ◽  
The Impact

The predictions of an upgraded UMARC comprehensive analysis are compared to experimental lift offset rotor results. The experiments cover a range of collective pitch angles (θ°) from 2° to 10°, advance ratios (μ) from 0.21 to 0.53, and lift offset from 0% to 20%. The experimental model rotors are from a system of coaxial hingeless rotors, with two blades each, and a first flap frequency of approximately 1.6/rev. The simulation is compared with isolated rotor performance and controls with lift offset, loads, and pitch link forces. Increasing efficiency with increasing lift offset, the impact of lift offset on different loads, and the dependence of pitch link loads on pitch bearing damping are identified in the experiment and correlated with the simulation.

scholarly journals Tuberculosis in Saudi Arabia: Prevalence between Saudis and Non-Saudis from 2013 to 2018 with a special concern about regions of the KSA

2019 ◽  
Vol 4 (6) ◽  
Keyword(s):  
Saudi Arabia ◽  
Migrant Workers ◽  
Action Plan ◽  
Age Groups ◽  
Incidence Rates ◽  
Arab Countries ◽  
Surveillance Data ◽  
Significance Level ◽  
Chi Squared ◽  
The Impact

The Kingdom of Saudi Arabia is one of the largest Arab countries with a moderate annual problem of tuberculosis that is either pulmonary or extra-pulmonary. TB is still one of the most significant health troubles in the KSA, affecting different nationalities (Saudis, non-Saudis), ages, provinces, and genders. The control of TB still faces some challenges in different provinces of the KSA. Data were collected, arranged, analyzed and presented in tables and figures. In this retrospective study, we appraised TB surveillance data for the period between 2013 (1434H) and 2018 (1439H). Data were handled using Microsoft Excel and SPSS version 23. Data were checked for normality using Shapiro-Wilk normality test at 0.05 levels to determine whether they are parametric or nonparametric. Chi-squared, Kruskal Wallis, and analysis of variance tests were used to evaluate trends at a significance level of p< 0.05. Statistical analyses were performed using IBM-SPSS version 23 for Mac OS. We appraised TB surveillance data for the period between 2013 (1434H) and 2018 (1439H). The data included the region of the country (province), age, sex, and nationality (Saudis, non-Saudis). The study evaluated the impact of TB on various nationalities (Saudis and non-Saudis), age groups (0-14, 15-34, 35-55, more than 55 years old), and genders (males and females). Non-Saudis had a higher incidence rate than Saudis in 2013-2018. The number of cases and incidence rates of TB recorded in males between 2013 to 2018 were about two to three times greater than estimates for females. The Makkah, Riyadh, and Jeddah regions attract enormous numbers of non-Saudi migrant workers, who account for ~60% of all TB cases in the KSA. Assessing the main TB risk factors contributing to high TB rates in non-Saudi workers is essential. Furthermore, periodical accurate studies, including evidence-based studies for optimum surveillance, avoidance, spread risk, inspection, control procedures and treatment of TB, should be conducted. These assessments would lead to evaluating the strengths and weaknesses of KSA-NTP’s TB action plan.

scholarly journals Administrative and Legal Principles of the Activities of the National Police of Ukraine in Preventing and Counteracting Bullying

2020 ◽  
Vol 79 (4) ◽  
pp. 48-53
Author(s):  
Д. А. Сорочан
Keyword(s):  
Comprehensive Analysis ◽  
Educational Institutions ◽  
Main Task ◽  
Legal Principles ◽  
Ethical Education ◽  
Preventive Activity ◽  
Close Cooperation ◽  
National Police ◽  
The Impact

The negative socio-economic situation and large gaps in the moral and ethical education of the younger generation have led to an increase in the number of cases of deliberate abuse of older and stronger to the smaller and weaker members of educational institutions. The author has studied administrative and legal principles of the activity of the National Police of Ukraine on preventing and counteracting bullying. Based on a comprehensive analysis of national legislation on preventing and combating bullying in Ukraine, the author has determined perspective areas for improving administrative and legal principles in this area. It has been emphasized that the role of the National Police in this area cannot be limited to the preventive registration of a child. It is necessary to develop a set of preventive and educational measures aimed at preventing bullying manifestations among minors. It has been found out that there are no tools to assess the effectiveness of the impact of existing strategies to combat bullying in Ukraine, which necessitates further research in this area. It has been determined that it is necessary to fight not with individual facts of bullying, but to enshrine in the legislation the system of counteraction to harassment in educational institutions, which can be preventive in nature. It has been established that the legislator has introduced a number of amendments over the last few years, which are characterized by the strengthening of the component of protection of children’s rights. A positive novelty is that the main task of the juvenile police was preventive activity instead of punitive one. In general, the regulatory basis for the activities of the National Police of Ukraine to prevent and combat bullying can be divided into two parts: general legislative acts and departmental regulatory acts. It has been noted that the prevention of bullying and the prevention and combating of domestic violence are different aspects of the same problem, which are in constant close cooperation, and then the measures to overcome them should be common.

Methods for Comprehensive Analysis of Heat Supply Reliability

2013 ◽  
Vol 2 (4) ◽  
pp. 120-142
Author(s):  
V. A. Stennikov ◽  
I. V. Postnikov
Keyword(s):  
Heat Supply ◽  
Methodological Approach ◽  
Flow Distribution ◽  
Heat Supply System ◽  
Short Review ◽  
Comprehensive Analysis ◽  
Heat Energy ◽  
Production And Distribution ◽  
The Impact ◽  
Supply Reliability

The paper deals with the problem of comprehensive analysis of heat supply reliability for consumers. It implies a quantitative assessment of the impact of all stages of heat energy production and distribution on heat supply reliability for each consumer of the heat supply system. A short review of existing methods for the analysis of fuel and heat supply reliability is presented that substantiates the key approaches to solving the problem of comprehensive analysis of heat supply reliability. A methodological approach is suggested, in which mathematical models and methods for nodal evaluation of heat supply reliability for consumers are developed and the studies on the impact of different elements of fuel and heat supply systems on its level are described. Mathematical modeling is based on the Markov random processes, models of flow distribution in a heat network, deterministic dependences of thermal processes of heat energy consumption and some other models.

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