Age, Gender, and Number of Atherosclerotic Risk Factors are the Independent Factor of Endothelial Dysfunction in Patients with Coronary Atherosclerosis

2005 ◽  
Vol 35 (4) ◽  
pp. 302 ◽  
Author(s):  
Hyun Ju Yoon ◽  
Jang Ho Bae ◽  
Ki Young Kim ◽  
Jung Kyu Kim
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Coronary Atherosclerosis ◽  
Independent Factor ◽  
Atherosclerotic Risk Factors

scholarly journals Functionally Defective High-Density Lipoprotein and Paraoxonase: A Couple for Endothelial Dysfunction in Atherosclerosis

Cholesterol ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Esin Eren ◽  
Necat Yilmaz ◽  
Ozgur Aydin
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Density Lipoprotein ◽  
Paraoxonase 1 ◽  
Oxidized Lipids ◽  
No Production ◽  
Inductive Effects ◽  
Near Future ◽  
Atherosclerotic Risk Factors ◽  
Dysfunctional Hdl

The endothelium is the primary target for biochemical or mechanical injuries caused by the putative risk factors of atherosclerosis. Endothelial dysfunction represents the ultimate link between atherosclerotic risk factors that promote atherosclerosis. HDL-C is thought to exert at least some parts of its antiatherogenic facilities via stimulating endothelial NO production, nearby inhibiting oxidative stress and inflammation. HDL-C is capable of opposing LDL’s inductive effects and avoiding the ox-LDL’s inhibition of eNOS. Paraoxonase 1 (PON1) is an HDL-associated enzyme esterase which appears to contribute to the antioxidant and antiatherosclerotic capabilities of HDL-C. “Healthy HDL,” namely the particle that contains the active Paraoxonase 1, has the power to suppress the formation of oxidized lipids. “Dysfunctional HDL,” on the contrary, has reduced Paraoxonase 1 enzyme activity and not only fails in its mission but also potentially leads to greater formation of oxidized lipids/lipoproteins to cause endothelial dysfunction. The association of HDL-C PON1 and endothelial dysfunction depends largely on the molecules with exact damaging effect on NO synthase coupling. Loss of nitric oxide bioavailability has a pivotal role in endothelial dysfunction preceding the appearance of atherosclerosis. Analyses of HDL-C and Paraoxonase1 would be more important in the diagnosis and treatment of atherosclerosis in the very near future.

Nontraditional atherosclerotic risk factors and extent of coronary atherosclerosis in patients with combined impaired fasting glucose and impaired glucose tolerance

Metabolism ◽  
2007 ◽  
Vol 56 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Andrzej Surdacki ◽  
Ewa Stochmal ◽  
Magdalena Szurkowska ◽  
Stefanie M. Bode-Böger ◽  
Jens Martens-Lobenhoffer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Coronary Atherosclerosis ◽  
Fasting Glucose ◽  
Atherosclerotic Risk Factors

MARKERS OF OXIDATIVE STRESS, INFLAMMATION, AND ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE WITH CONCOMITANT DYSLIPIDEMIA

2021 ◽  
pp. 39-43
Author(s):  
Юлия Александровна Котова ◽  
Анна Александровна Зуйкова ◽  
Ольга Николаевна Красноруцкая ◽  
Вероника Ивановна Шевцова
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Coronary Atherosclerosis ◽  
Oxidative Modification ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Markers Of Oxidative Stress

На сегодняшний день одним из значимых факторов риска развития ИБС является дислипидемия. На основании имеющихся исследований можно сделать вывод, что среди пациентов с корорнарным атеросклерозом во всех возрастных группах большинство случаев развития ИБС обусловлено именно дислипидемией. Целью исследования стало изучение изменения маркеров окислительного стресса, воспаления и эндотелиальной дисфункции у больных коронарной болезнью сердца в зависимости от наличия дислипидемии. Материалы и методы: мы обследовали 336 пациентов с диагнозом коронарная болезнь сердца, верифицированной стандартизированными валидизированными критериями и клинико-функциональными методами, в возрасте от 47 до 75 лет. Наличие коронарного атеросклероза подтверждали проведением коронароангиографии с последующим расчетом индекса Gensini. По наличию дислипидемии пациенты были разделены на 2 группы: 1 группа - имевшие дислипидемию - 168 человек, 2 группа - не имевшие дислипидемию - 168 человек. Статистическая обработка результатов исследования проводилась с помощью пакетов программ SPSS Statistics 20. Результаты: В исследовании показаны особенности выраженности коронарного атеросклероза, рассчитанного по индексу Gensini, в зависимости от дислипидемии. Выявлены достоверные различия по показателям окислительной модификации белков, супероксиддисмутазы, С-реактивного белка и гомоцистеина. Кроме того, установлены взаимосвязи между наличием дислипидемии и изучаемыми биомаркерами, а также клинико-антропометрическими показателями. Установлена взаимосвязь между дислипидемией, выраженностью коронарного атеросклероза и изучаемыми факторами риска. Таким образом, коррекция факторов риска КБС остается на субоптимальном уровне, и значительная часть пациентов не привержена к их коррекции. Отмечена низкая приверженность к гиполипидемической терапии у пациентов с признаками коронарного атеросклероза. В связи с этим сохраняется необходимость поиска маркеров остаточного риска, принимая во внимание значимость факторов риска To date, one of the most significant risk factors for the development of CHD is dyslipidemia. Based on the available studies, it can be concluded that among patients with coronary atherosclerosis in all age groups, the majority of cases of CHD development are caused by dyslipidemia. The aim of the study was to study the changes in markers of oxidative stress, inflammation and endothelial dysfunction in patients with coronary heart disease, depending on the presence of dyslipidemia. Materials and methods: we examined 336 patients with a diagnosis of coronary heart disease, verified by standardized validated criteria and clinical and functional methods, aged 47 to 75 years. The presence of coronary atherosclerosis was confirmed by coronary angiography with subsequent calculation of the Gensini index. According to the presence of dyslipidemia, the patients were divided into 2 groups: group 1 - those who had dyslipidemia - 168 people, group 2 - those who did not have dyslipidemia - 168 people. Statistical processing of the study results was carried out using the SPSS Statistics 20 software packages. Results: The study shows the features of the severity of coronary atherosclerosis, calculated by the Gensini index, depending on dyslipidemia. Significant differences in the parameters of oxidative modification of proteins, superoxide dismutase, C-reactive protein, and homocysteine were revealed. In addition, the relationships between the presence of dyslipidemia and the studied biomarkers, as well as clinical and anthropometric indicators, were established. The relationship between dyslipidemia, the severity of coronary atherosclerosis and the studied risk factors was established. Thus, the correction of CBS risk factors remains at a suboptimal level, and a significant proportion of patients are not committed to their correction. Low adherence to lipid-lowering therapy was noted in patients with signs of coronary atherosclerosis. In this regard, it remains necessary to search for markers of residual risk, taking into account the significance of risk factors

Popliteal entrapment syndrome and age

VASA ◽  
2012 ◽  
Vol 41 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Schweizer ◽  
Hügli ◽  
Koella ◽  
Jeanneret
Keyword(s):  
Risk Factors ◽  
Leg Pain ◽  
Walking Distance ◽  
Therapeutic Approaches ◽  
Long Distance ◽  
Entrapment Syndrome ◽  
Long Distance Running ◽  
Popliteal Entrapment ◽  
Popliteal Entrapment Syndrome ◽  
Atherosclerotic Risk Factors

On the occasion of diagnosing a popliteal entrapment syndrome in a 59-year old man with no cardiovascular risk factors, who developed acute ischemic leg pain during long distance running, we give an overview on this entity with emphasis on patients’age. The different types of the popliteal artery compression syndrome are summarized. The diagnostic and therapeutic approaches are discussed. The most important clinical sign of a popliteal entrapment syndrome is the lack of atherosclerotic risk factors in patients with limited walking distance. Not only in young athletes but also in patients more than 50 years old the popliteal entrapment syndrome has to be taken into account.

Atherosclerotic risk factors in adolescence

2001 ◽  
Vol 77 (8) ◽  
pp. 153-164 ◽  
Author(s):  
Lísia Marcílio Rabelo
Keyword(s):  
Risk Factors ◽  
Atherosclerotic Risk Factors

Impact of age and sex on subclinical coronary atherosclerosis in a healthy asian population

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
M Wong ◽  
J Yap ◽  
KK Yeo
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Ldl Cholesterol ◽  
Multivariable Analysis ◽  
Asian Population ◽  
Atherosclerotic Cardiovascular Disease ◽  
Age And Gender ◽  
And Gender

Abstract Funding Acknowledgements Type of funding sources: None. Background and Aims The influence of age and gender on clinical atherosclerotic cardiovascular disease is well reported, but literature remains sparse on whether these extend to the disease in its preclinical stage. We aim to report the prevalence, risk-factors and impact of age and gender on the burden of subclinical coronary atherosclerosis in a healthy Asian population. Methods Healthy subjects aged 30-69 years old, with no history of cardiovascular disease or diabetes were recruited from the general population. Subclinical coronary atherosclerosis was quantified via the Coronary Artery Calcium Score (CACS) with CACS of 0 indicating the absence of calcified plaque, 1 to 10 minimal plaque, 11 to 100 mild plaque, and >100 moderate to severe plaque. Results A total of 663 individuals (mean age 49.4 ± 9.2 years, 44.8% male) were included. The prevalence of any CAC was 29.3% with 9% having CAC > 100.  The prevalence was significantly higher in males than females (43.1 vs 18.0%, p < 0.001). These gender differences became increasingly pronounced with increasing age, especially in those with moderate-severe CAC. Multivariable analysis revealed significant associations between increasing age, male, higher blood pressure, increased glucose levels and higher LDL cholesterol levels with the presence of any CAC. LDL cholesterol was more significantly associated with CAC in females compared to males (Pinteraction = 0.022). Conclusions The prevalence of preclinical atherosclerosis increased with age, and was higher in males than females, with gender-specific differences in associated risk factors. These results will better inform individualised future risk management strategies to prevent the development and progression of coronary artery disease within healthy individuals.

scholarly journals Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case–control study

2021 ◽  
Vol 8 (1) ◽  
pp. e000515
Author(s):  
Isak Samuelsson ◽  
Ioannis Parodis ◽  
Iva Gunnarsson ◽  
Agneta Zickert ◽  
Claes Hofman-Bang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Atherosclerosis ◽  
Great Majority ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Medical File ◽  
Similar Frequency ◽  
Ventricular Ejection Fraction ◽  
Increased Risk

ObjectivePatients with SLE have increased risk of myocardial infarction (MI). Few studies have investigated the characteristics of SLE-related MIs. We compared characteristics of and risk factors for MI between SLE patients with MI (MI-SLE), MI patients without SLE (MI-non-SLE) and SLE patients without MI (non-MI-SLE) to understand underlying mechanisms.MethodsWe identified patients with a first-time MI in the Karolinska SLE cohort. These patients were individually matched for age and gender with MI-non-SLE and non-MI-SLE controls in a ratio of 1:1:1. Retrospective medical file review was performed. Paired statistics were used as appropriate.ResultsThirty-four MI-SLE patients (88% females) with a median age of 61 years were included. These patients had increased number of coronary arteries involved (p=0.04), and ≥50% coronary atherosclerosis/occlusion was numerically more common compared with MI-non-SLE controls (88% vs 66%; p=0.07). The left anterior descending artery was most commonly involved (73% vs 59%; p=0.11) and decreased (<50%) left ventricular ejection fraction occurred with similar frequency in MI-SLE and MI-non-SLE patients (45% vs 36%; p=0.79). Cardiovascular disease (44%, 5.9%, 12%; p<0.001) and coronary artery disease (32%, 2.9%, 0%; p<0.001), excluding MI, preceded MI/inclusion more commonly in MI-SLE than in MI-non-SLE and non-MI-SLE patients, respectively. MI-SLE patients had lower plasma albumin levels than non-MI-SLE patients (35 (29–37) vs 40 (37–42) g/L; p=0.002).ConclusionIn the great majority of cases, MIs in SLE are associated with coronary atherosclerosis. Furthermore, MIs in SLE are commonly preceded by symptomatic vascular disease, calling for attentive surveillance of cardiovascular disease and its risk factors and early atheroprotective treatment.

Atherosclerotic risk factors and carotid stiffness in elderly asymptomatic HD patients

2006 ◽  
Vol 38 (3-4) ◽  
pp. 801-809 ◽  
Author(s):  
Paraskevi Tseke ◽  
Eirini Grapsa ◽  
Kimon Stamatelopoulos ◽  
Elisabeth Samouilidou ◽  
Athanasios Protogerou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carotid Stiffness ◽  
Atherosclerotic Risk Factors
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