scholarly journals Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Rufai Abdu Dachi ◽  
Falmata Grema Mustapha ◽  
Saleh Yuguda ◽  
Modu Baba Kagu ◽  
Ali Adamu Gwaram ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Megaloblastic Anemia ◽  
Bone Marrow Aspiration ◽  
University Teaching ◽  
Anatomical Site ◽  
Diagnostic Utility ◽  
Monitoring Tool ◽  
Aspiration Cytology ◽  
Hematological Diseases

Bone Marrow Aspiration (BMA) cytology is an important diagnostic and monitoring tool where cytological details of the marrow elements are examined using light microscopy. Various hematological diseases are diagnosed and monitored by using BMA. This study aimed at reporting a 3-year BMA experience of Department of Hematology and Blood Transfusion of Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) Bauchi. This was a retrospective study that involved the use of records of the bone marrow aspirates done from January 1st, 2016 to December 31st, 2018. The age, sex, indications for BMA, anatomical site and final bone marrow diagnosis were collated. The data was analyzed using SPSS Version 23.0 software. One hundred and three (103) bone marrow aspirations were performed during the period under review. Two third of the participants were males, with the median age of 40.0 years and a range of 5 months to 92 years. The commonest indication for BMA was recurrent anemia 45.6%, followed by splenomegaly, fever and lymphadenopathy with 11.7% each. While, the commonest diagnosis by BMA was megaloblastic anemia (28.2%). Mixed nutritional deficiency and Bone Marrow (BM) metastasis are the commoner BMA diagnoses with 12.6% each. Recurrent anemia is the commonest indication for BMA and nutritional anemias (megaloblastic and combined nutrients deficiency) are the commonest BMA diagnoses in Bauchi. Proper evaluation of patients by the clinicians before referral is recommended to ensure that only those that really need the procedure are subjected to it.

scholarly journals Bone Marrow Examination in Cases of Pancytopenia

2008 ◽  
Vol 47 (169) ◽  
Author(s):  
Abhimanyu Jha ◽  
G Sayami ◽  
R C Adhikari ◽  
A D Panta ◽  
R Jha
Keyword(s):  
Bone Marrow ◽  
Megaloblastic Anemia ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Pure Red Cell Aplasia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Cross Sectional ◽  
Erythroid Hyperplasia ◽  
Niemann Pick

This study was carried to identify the causes of pancytopenia and to fi nd out the bone marrowmorphology in cases of pancytopenia.It was a cross sectional study conducted over a period of two years in the Department of Pathology,Tribhuvan University Teaching Hospital. Bone marrow aspiration smears of patients fulfi lling thecriteria of pancytopenia were examined. The data obtained were analyzed using measures of centraltendency.One hundred and forty eight cases underwent bone marrow aspiration and it constituted 15.74% oftotal cases. Mean age was 30 years (range, 1-79 years). 42 cases were children (28.37%). Male: femaleratio was 1.5:1. The commonest cause was hypoplastic bone marrow seen in 43 cases (29%) followedby megaloblastic anemia in 35 cases (23.64%), and hematological malignancy in 32 cases (21.62%).Erythroid hyperplasia was seen in 29 cases (19.6%) and normal bone marrow was seen in 5 cases(3.38%). There was one case each of Niemann-Pick disease and metastatic neuroblastoma in childrenand chronic pure red cell aplasia and leishmaniasis in adults. Acute leukemia was the commonesthematological malignancy. In children, commonest fi nding was hypoplastic bone marrow (38.1%)while in adults megaloblastic anemia (30.18%) was commonest fi nding followed by hypoplasticanemia (25.47%).In present study bone marrow examination was able to establish diagnosis in 77% of cases. Hypoplasticmarrow was the commonest diagnosis, followed by megaloblastic anemia, and hematologicalmalignancies.Key Words: Bone marrow aspiration, hypoplastic anemia, leukemia, megaloblastic anemia,pancytopenia

MORPHOLOGICAL FEATURES OF BONE MARROW ASPIRATES IN VARIOUS TYPES OF CYTOPENIA(S) AT SAIDU TEACHING HOSPITAL, SWAT

1969 ◽  
Vol 4 (2) ◽  
pp. 550-554
Author(s):  
SAADIA HAROON DURRANI ◽  
AMREEK LAL ◽  
ZUFISHAN BATOOL ◽  
MUHAMMAD SAYYAR ◽  
ASHHAD HALIMI
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Megaloblastic Anemia ◽  
Age Groups ◽  
Bone Marrow Aspiration ◽  
Sampling Procedure ◽  
Morphological Features ◽  
Teaching Hospitals ◽  
Deficiency Anemia ◽  
Malignant Neoplasms

OBJECTIVES: To find and document clinico-hematological features of bone marrow aspirates inpatients presenting with various forms of cytopenia(s) at Saidu Teaching Hospitals Swat.STUDY DESIGN: Descriptive study.PLACE AND DURATION OF STUDY: This study was carried out over a period of one year (1stJanuary 2013 to 31st December 2013) at Pathology department, Saidu Medical College, Saidu Sharif,Swat.METHODS AND MATERIALS: Total 200 patients of both genders and all age groups withcytopenias referred from Saidu Teaching Hospital for bone marrow cytology were included for bonemarrow aspiration and assessment.RESULTS: Two hundred patients underwent bone marrow sampling procedure. Patient’s age rangedfrom 6 months to 90 years. There were 56% male and 44% female at the ratio of 1.5:1. The mostcommon non malignant hematological condition was megaloblastic anemia 28%, mixed nutritionaldeficiency anemia 16%, hypoplasia 8%, hemolytic anemia 7%, iron deficiency anemia was present in6% cases, visceral leishmaniasis 4%, thrombocytopenia due to any cause (immune thrombocytopenicpurpura (ITP)) 2%, anemia of chronic illness was present in 2% cases, malaria and sepsis leading tocytopenia were 1% each. Malignant neoplasms in our study were 50 cases (25%), which were comprisedof; ALL 10%, AML 5%, CML 4%, MDS 3%, multiple myeloma 1.5% and lymphoproliferativedisorders in 1% cases.CONCLUSION: This study showed the pattern of morphological features on bone marrow aspiration,which was found to be different from pattern seen in European and Middle East regions and similar tothat found in Asian subcontinent.KEY WORDS: Cytopenias, pancytopenia, bicytopenia, anemia, thrombocytopenia, megaloblasticanemia, acute leukemia, myelodysplastic syndrome.

scholarly journals Correlation of bone marrow aspiration and biopsy findings in diagnosing hematological disorders - a study of 89 cases

2014 ◽  
Vol 4 (7) ◽  
pp. 534-538 ◽  
Author(s):  
S Parajuli ◽  
A Tuladhar
Keyword(s):  
Bone Marrow ◽  
Diagnostic Accuracy ◽  
Wide Spectrum ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Histopathological Study ◽  
Trephine Biopsy ◽  
Aspiration Cytology ◽  
Serological Tests ◽  
Hematological Diseases

Background: Bone marrow examination is an important diagnostic tool to evaluate various disorders which includes both neoplastic and non- neoplastic hematological diseases. Few studies have compared the relative value of aspirate with trephine biopsy. The present study was conducted to compare the role of bone marrow aspirate and trephine biopsy to formulate an effective and rapid method for diagnosing wide spectrum of hematological diseases. Materials and Methods: This is a three year retrospective study done from July 2010 to June 2013. A total of 95 cases presented with clinical haematological disorders; of which only 89 were biopsied and the correlation done. All the smears and sections were reviewed for morphological details and findings on aspirate and biopsy and compared to each other. Results: Out of the 89 cases selected for study; bone marrow aspiration revealed diagnostic materials in 75 cases and 14 cases were inconclusive for a definite diagnosis. The diagnostic accuracy of the bone marrow aspiration cytology was 84.26%. Eighty eight cases were diagnosed on trephine biopsy of bone marrow with diagnostic accuracy of 98.87%. Conclusion: Both the aspiration cytology and trephine biopsy complement each other for evaluating any haematological disorder. Though cellular morphology is better understood in marrow aspirates and is equally effective to biopsy in diagnosing various anemias and leukemias; however it is the histopathological study of trephine biopsy that gives well preserved marrow architecture with its all cellular and stromal components. modalities including radiological, microbiological and serological tests. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10294 Journal of Pathology of Nepal (2014) Vol. 4, 534-538

Bone marrow aspiration diagnostic findings in adults at the Lagos University Teaching Hospital: A 10-year review (2005-2014).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e18563-e18563
Author(s):  
Yusuf Adetomiwa Adelabu ◽  
Uche Maureen Amaechi ◽  
Sampson Omagbemi Owhin ◽  
Folasade Adebisi Adelekan ◽  
Oluwole Olugbenga Banjoko ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Bone Marrow Aspiration ◽  
University Teaching

scholarly journals Bone marrow aspiration cytology in the diagnosis of hematologic and non-hematologic diseases in a multi-specialty hospital in Nepal

2017 ◽  
Vol 5 (3) ◽  
pp. 922 ◽  
Author(s):  
Sabin Ranabhat ◽  
Sushna Maharjan ◽  
Mamata Tiwari ◽  
Anita Bhandari ◽  
Bidur Prasad Osti
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Biopsy ◽  
Megaloblastic Anemia ◽  
Univariate Analysis ◽  
College Teaching ◽  
Bone Marrow Aspiration ◽  
Invasive Technique ◽  
Aspiration Cytology ◽  
Cross Sectional ◽  
Hematologic Diseases

Background: Peripheral blood smear examination and other routine laboratory assays are not always sufficient to diagnose various diseases which affect the blood and bone marrow. A bone marrow aspirate examination is essential in most of the cases.Methods: This work was a hospital-based cross sectional analytical observational study carried out in the department of pathology at the Chitwan Medical College, Teaching Hospital, Nepal, over a period of 3 years from January, 2013 to December 2015. Bone marrow was aspirated from posterior superior iliac crest under local anesthesia; sternum was the alternative site in obese patients. Univariate analysis was performed for each variable using frequency distribution and means with the help of Statistical Package for Social Sciences 20.0 (SPSS 20.0) software.Results: One hundred and fifty-nine patients were included in the study. Eight cases of 'dry tap' were excluded, for whom bone marrow biopsy was advised. Anemia was the largest group followed by malignancy, infection and miscellaneous diseases. Among anemia, megaloblastic anemia was the most common, followed by aplastic anemia, dyserythropoietic anemia and myelopthisic anemia. The category 'malignancy' consisted of leukemia, multiple myeloma and myelodysplastic syndrome. Regarding individual diseases, megaloblastic anemia was the most common haematological disorder followed by immune thrombocytopenic purpura, leukemia and aplastic anemia.Conclusions: Bone marrow aspiration cytology is a mildly invasive technique which can diagnose many haematological and non-hematologic diseases that can be confirmed by more advanced investigations, if needed: serological, biochemical or molecular. However, bone marrow sample cannot be obtained (dry tap) in a proportion of cases. In such cases, a bone marrow biopsy needs to be performed.

scholarly journals Clinico-hematological study of pancytopenia

1970 ◽  
Vol 2 (3) ◽  
pp. 207-210 ◽  
Author(s):  
A Lakhey ◽  
OP Talwar ◽  
VK Singh ◽  
Shiva Raj KC
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Myeloid Leukemia ◽  
Hematological Malignancies ◽  
Hematological Malignancy ◽  
Complete Blood Count ◽  
Megaloblastic Anemia ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Erythroid Hyperplasia

Background: Pancytopenia refers to a reduction in all the three cellular elements of blood. The aim of this study was to identify the various causes of pancytopenia in patients attending to Manipal teaching hospital in Pokhara. Materials and Methods: This was a cross-sectional study, carried out in Manipal teaching hospital from August 2008 to August 2010. Fifty-four patients with pancytopenia were included in the study. Complete blood count, bone marrow aspirations and trephine biopsies were performed. Data were analyzed using SPSS 11.0 version. Results: Out of 54 cases, there were 16 cases (29.60%) of hypoplastic bone marrow, 15 cases (27.78%) of hematological malignancies, 13 cases (24.10%) of megaloblastic anemia, 4 cases (11.11%) of erythroid hyperplasia and 6 cases (7.41%) of normcellular bone marrow. Acute myeloid leukemia was the commonest hematological malignancy. Conclusion: The commonest cause of pancytopenia in our study was hypoplastic bone marrow followed by hematological malignancies and megaloblastic anemia. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6023 JPN 2012; 2(3): 207-210

scholarly journals DIAGNOSTIC IMPORTANCE OF BONE MARROW ASPIRATION IN HEMATOLOGICAL DISORDERS – TERTIARY CARE CENTRE BASED STUDY.

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Seema Meena ◽  
Sukriti . ◽  
Sonal Bhati ◽  
Abha Patni
Keyword(s):  
Bone Marrow ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Aspiration ◽  
Deficiency Anemia ◽  
Invasive Technique ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Female Ratio ◽  
Hematological Disorders

Background: Bone marrow aspiration (BMA) is a minimally invasive technique performed in a variety of hematological disorders. It is considered essential for the diagnosis and management of haematological disorders. BMA is usually sufficient to diagnose nutritional anemia and most of the leukemias. Aims & Objectives: To study the spectrum of hematological disorders diagnosed on BMA in a tertiary care centre, Udaipur. Material & Methods:  The present study was conducted in the hematology section of department of Pathology, RNT Medical College & MB Hospital, Udaipur for a period of one year from June 2018 to May 2019. A total of 123 cases of suspected hematological disorders underwent the process of BMA from posterior superior iliac spine under local anesthesia. Exclusion criteria of our study included aspirates of dry tap. BMA smears were stained with Giemsa stain for morphologic examination. Result: The present study included 123 cases. Male to female ratio in our study was 1.6:1. Anemia (45.5%) was the most common hematological disorder in our study, iron deficiency anemia being the most common followed by megaloblastic anemia. Chronic myeloid leukemia (26.01%) was the most common hematological malignancy in our study. Conclusion: Bone marrow aspiration is a useful diagnostic procedure in hematological practice for the diagnosis of both hematological and non-hematological conditions. Rapid and early diagnosis of malignancies are critical for proper initiation of treatment and to control the disease. Keywords: Bone Marrow Aspiration, Hematological disorders, Leukemias

scholarly journals Adrenal incidentaloma: prevalence and referral patterns from routine practice in a large UK university teaching hospital

2021 ◽  
Author(s):  
Fahmy W F Hanna ◽  
Sarah Hancock ◽  
Cherian George ◽  
Alexander Clark ◽  
Julius Sim ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
Imaging Modality ◽  
Temporal Trends ◽  
Adrenal Incidentaloma ◽  
University Teaching ◽  
Routine Practice ◽  
Anatomical Site ◽  
Referral Patterns ◽  
Referral Rates ◽  
Abdomen Ct

Abstract Context Adrenal incidentalomas are increasingly being identified during unrelated imaging. Unlike AI clinical management, data on referral patterns in routine practice are lacking. Objective To identify factors associated with AI referral Design We linked data from imaging reports and outpatient bookings from a large UK teaching hospital. We examined; (i) AI prevalence and (ii) pattern of referral to endocrinology, stratified by age, imaging modality, scan anatomical site, requesting clinical specialty and temporal trends. Patients Utilising key radiology phrases to identify scans reporting potential AI, we identified 4,097 individuals from 479,945 scan reports (2015-19). Main Outcome Measures Prevalence of AI and referral rates Results Overall, AI lesions were identified in 1.2% of scans. They were more prevalent in abdomen CT and MRI scans (3.0% and 0.6%, respectively). Scans performed increased 7.7% year-on-year from 2015-19, with a more pronounced rise in the number with AI lesions (14.7% pa). Only 394/4097 patients (9.6%) had a documented endocrinology referral code within 90 days, with medical (11.8%) more likely to refer than surgical (7.2%) specialties (p<0.001). Despite prevalence increasing with age, older patients were less likely to be referred (p<0.001). Conclusions While overall AI prevalence appeared low, scan numbers are large and rising; the number with identified AI are increasing still further. The poor AI referral rates, even in centres such as ours where dedicated AI multi-disciplinary team meetings and digital management systems are used, highlights the need for new streamlined, clinically-effective systems and processes to appropriately manage the AI workload.

A comparative study of bone marrow aspirate with trephine biopsy in pancytopenia disorders

2021 ◽  
Vol 6 (3) ◽  
pp. 201-206
Author(s):  
Kavya J ◽  
Kalpana Kumari MK
Keyword(s):  
Bone Marrow ◽  
Sensitivity And Specificity ◽  
Megaloblastic Anemia ◽  
Tertiary Care ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Care Hospital ◽  
Trephine Biopsy ◽  
Hematological Disorders ◽  
Hematoxylin And Eosin

Pancytopenia is commonly reported in clinical hematology practice. Due to its varied marrow pathology and underlying ailments, diagnosis is often misleading and delayed. Bone marrow examination would provide a comprehensive diagnosis of both blood and bone marrow, since aspirate investigates the cytological morphology and biopsy evaluates the cellularity, architecture, and compact marrows.To compare bone marrow aspiration and trephine biopsy results in the diagnosis of pancytopenia, and to determine the sensitivity and specificity of aspirate examination in pancytopenia diagnosis.This prospective study was conducted at a tertiary care hospital from July 2014 to June 2016. A total of 320 samples were received at the department of pathology for bone marrow examination (aspirate and biopsy). Romanowsky (Leishman) stain was used to investigate aspirate samples. All biopsy samples were processed into 3-5 μ blocks and stained using hematoxylin and eosin after decalcification with 5.5% EDTA. Data analysis was performed using SPSS19.Pancytopenia constituted 56 (18.7%) cases with the mean age of 41.79 years. Of the total pancytopenia cases, hematological disorders constituted 50 (89.3%) cases and 6 (10.7%) were non-hematological cases. Aspirate and biopsy diagnosis positively correlated in 76.79% of cases. A 100% sensitivity and specificity of aspirate diagnosis was observed in, acute myeloid leukemia, hypersplenism, myelodysplastic syndrome, megaloblastic anemia, hematological malignancy in remission and negative for lymphoma infiltrate. Aspirate had no role in diagnosis of uremic osteodystrophy and myelofibrosis, whereas leishmaniasis was diagnosed on aspirate alone.Pancytopenia includes multiple underlying ailments which requires a differential diagnosis approach. Combining both aspirate and biopsy for diagnosis would benefit the patient in prognosis as they are complementary to each other.

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