Bone marrow aspiration diagnostic findings in adults at the Lagos University Teaching Hospital: A 10-year review (2005-2014).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e18563-e18563
Author(s):  
Yusuf Adetomiwa Adelabu ◽  
Uche Maureen Amaechi ◽  
Sampson Omagbemi Owhin ◽  
Folasade Adebisi Adelekan ◽  
Oluwole Olugbenga Banjoko ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Bone Marrow Aspiration ◽  
University Teaching

scholarly journals Bone marrow aspiration cytology in Abubakar Tafawa Balewa University Teaching Hospital, Bauchi State, Nigeria: Indications and diagnostic utility

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Rufai Abdu Dachi ◽  
Falmata Grema Mustapha ◽  
Saleh Yuguda ◽  
Modu Baba Kagu ◽  
Ali Adamu Gwaram ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Megaloblastic Anemia ◽  
Bone Marrow Aspiration ◽  
University Teaching ◽  
Anatomical Site ◽  
Diagnostic Utility ◽  
Monitoring Tool ◽  
Aspiration Cytology ◽  
Hematological Diseases

Bone Marrow Aspiration (BMA) cytology is an important diagnostic and monitoring tool where cytological details of the marrow elements are examined using light microscopy. Various hematological diseases are diagnosed and monitored by using BMA. This study aimed at reporting a 3-year BMA experience of Department of Hematology and Blood Transfusion of Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) Bauchi. This was a retrospective study that involved the use of records of the bone marrow aspirates done from January 1st, 2016 to December 31st, 2018. The age, sex, indications for BMA, anatomical site and final bone marrow diagnosis were collated. The data was analyzed using SPSS Version 23.0 software. One hundred and three (103) bone marrow aspirations were performed during the period under review. Two third of the participants were males, with the median age of 40.0 years and a range of 5 months to 92 years. The commonest indication for BMA was recurrent anemia 45.6%, followed by splenomegaly, fever and lymphadenopathy with 11.7% each. While, the commonest diagnosis by BMA was megaloblastic anemia (28.2%). Mixed nutritional deficiency and Bone Marrow (BM) metastasis are the commoner BMA diagnoses with 12.6% each. Recurrent anemia is the commonest indication for BMA and nutritional anemias (megaloblastic and combined nutrients deficiency) are the commonest BMA diagnoses in Bauchi. Proper evaluation of patients by the clinicians before referral is recommended to ensure that only those that really need the procedure are subjected to it.

scholarly journals Bone Marrow Examination in Cases of Pancytopenia

2008 ◽  
Vol 47 (169) ◽  
Author(s):  
Abhimanyu Jha ◽  
G Sayami ◽  
R C Adhikari ◽  
A D Panta ◽  
R Jha
Keyword(s):  
Bone Marrow ◽  
Megaloblastic Anemia ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Pure Red Cell Aplasia ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Cross Sectional ◽  
Erythroid Hyperplasia ◽  
Niemann Pick

This study was carried to identify the causes of pancytopenia and to fi nd out the bone marrowmorphology in cases of pancytopenia.It was a cross sectional study conducted over a period of two years in the Department of Pathology,Tribhuvan University Teaching Hospital. Bone marrow aspiration smears of patients fulfi lling thecriteria of pancytopenia were examined. The data obtained were analyzed using measures of centraltendency.One hundred and forty eight cases underwent bone marrow aspiration and it constituted 15.74% oftotal cases. Mean age was 30 years (range, 1-79 years). 42 cases were children (28.37%). Male: femaleratio was 1.5:1. The commonest cause was hypoplastic bone marrow seen in 43 cases (29%) followedby megaloblastic anemia in 35 cases (23.64%), and hematological malignancy in 32 cases (21.62%).Erythroid hyperplasia was seen in 29 cases (19.6%) and normal bone marrow was seen in 5 cases(3.38%). There was one case each of Niemann-Pick disease and metastatic neuroblastoma in childrenand chronic pure red cell aplasia and leishmaniasis in adults. Acute leukemia was the commonesthematological malignancy. In children, commonest fi nding was hypoplastic bone marrow (38.1%)while in adults megaloblastic anemia (30.18%) was commonest fi nding followed by hypoplasticanemia (25.47%).In present study bone marrow examination was able to establish diagnosis in 77% of cases. Hypoplasticmarrow was the commonest diagnosis, followed by megaloblastic anemia, and hematologicalmalignancies.Key Words: Bone marrow aspiration, hypoplastic anemia, leukemia, megaloblastic anemia,pancytopenia

MORPHOLOGICAL FEATURES OF BONE MARROW ASPIRATES IN VARIOUS TYPES OF CYTOPENIA(S) AT SAIDU TEACHING HOSPITAL, SWAT

1969 ◽  
Vol 4 (2) ◽  
pp. 550-554
Author(s):  
SAADIA HAROON DURRANI ◽  
AMREEK LAL ◽  
ZUFISHAN BATOOL ◽  
MUHAMMAD SAYYAR ◽  
ASHHAD HALIMI
Keyword(s):  
Bone Marrow ◽  
Teaching Hospital ◽  
Megaloblastic Anemia ◽  
Age Groups ◽  
Bone Marrow Aspiration ◽  
Sampling Procedure ◽  
Morphological Features ◽  
Teaching Hospitals ◽  
Deficiency Anemia ◽  
Malignant Neoplasms

OBJECTIVES: To find and document clinico-hematological features of bone marrow aspirates inpatients presenting with various forms of cytopenia(s) at Saidu Teaching Hospitals Swat.STUDY DESIGN: Descriptive study.PLACE AND DURATION OF STUDY: This study was carried out over a period of one year (1stJanuary 2013 to 31st December 2013) at Pathology department, Saidu Medical College, Saidu Sharif,Swat.METHODS AND MATERIALS: Total 200 patients of both genders and all age groups withcytopenias referred from Saidu Teaching Hospital for bone marrow cytology were included for bonemarrow aspiration and assessment.RESULTS: Two hundred patients underwent bone marrow sampling procedure. Patient’s age rangedfrom 6 months to 90 years. There were 56% male and 44% female at the ratio of 1.5:1. The mostcommon non malignant hematological condition was megaloblastic anemia 28%, mixed nutritionaldeficiency anemia 16%, hypoplasia 8%, hemolytic anemia 7%, iron deficiency anemia was present in6% cases, visceral leishmaniasis 4%, thrombocytopenia due to any cause (immune thrombocytopenicpurpura (ITP)) 2%, anemia of chronic illness was present in 2% cases, malaria and sepsis leading tocytopenia were 1% each. Malignant neoplasms in our study were 50 cases (25%), which were comprisedof; ALL 10%, AML 5%, CML 4%, MDS 3%, multiple myeloma 1.5% and lymphoproliferativedisorders in 1% cases.CONCLUSION: This study showed the pattern of morphological features on bone marrow aspiration,which was found to be different from pattern seen in European and Middle East regions and similar tothat found in Asian subcontinent.KEY WORDS: Cytopenias, pancytopenia, bicytopenia, anemia, thrombocytopenia, megaloblasticanemia, acute leukemia, myelodysplastic syndrome.

scholarly journals Prevalence and Nature of Adult Hematological Malignancies Using Bone Marrow Aspiration Cytology in a Tertiary Health Facility: A Seven Year Retrospective Review

2021 ◽  
Vol 2 (1) ◽  
pp. 39-45
Author(s):  
AM Onoja ◽  
SA Otene ◽  
AT Onoja ◽  
IN Ibrahim ◽  
A Mke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Retrospective Review ◽  
Hodgkin’S Lymphoma ◽  
Treatment Options ◽  
Bone Marrow Aspiration ◽  
University Teaching ◽  
Hodgkin's Lymphoma ◽  
State University ◽  
Haematological Disorders ◽  
Clinic Medical

Bone Marrow Aspiration (BMA) is a procedure that is often used to evaluate patients with haematological disorders including haematological malignancies (HMs) which account for about 6.5% of all cancers worldwide. There is paucity of data on the prevalence and pattern of HMs from BMA cytology in Nigeria. We carried out a retrospective review to determine the prevalence and distribution of HMs among adult patients who had BMA cytology at Benue State University Teaching Hospital (BSUTH) from June 2012 to July 2019. A total of 158 BMA reports extracted from the marrow and clinic medical records were reviewed. Out of 158 adult BMA cytology reports, HMs accounted for 78(49.4%) of all haematological disorders. There was no significant gender difference. The Male 38(48.7%) to Female 40(51.3%) ratio (M:F) was 1:1.1. Their ages ranged from 16 to 85 years with the median age of 54.0 years. Out of the 78 HMs, Lymphoid neoplasms were the most prevalent 47(60.3%), the leukaemias were higher 53/78(67.9%) compared to the non-leukaemic neoplasms. Of the 53 leukaemias, those of chronic lymphoid types were more 24/53(45.3%), followed by the chronic myeloid 15/53(28.3%). Chronic lymphocytic leukaemia (CLL) was the predominant leukaemia 24/53(45.3%) as well as the most prevalent HM 24/78(30.8%), followed by chronic myeloid leukaemia (CML) 19.2%(15/78). Others were myelodysplastic syndrome (MDS) 11.5%(9/78), acute lymphoblastic leukaemia (ALL) 10.3% (8/78), multiple myeloma (MM) 10.3%(8/78), acute myeloblastic leukaemia (AML) 7.7%(6/78), non-Hodgkin's lymphoma (NHL) 6.4%(5/78), Small lymphocytic lymphoma (SLL) 2.6%(2/78) and Hodgkin's lymphoma (HL) 1.3%(1/78). In conclusion, we established high prevalence of HMs among patients who had BMA cytology evaluation at BSUTH with the preponderance of lymphoid malignancies. We advocate for inclusion of HMs in the National Health Insurance Scheme (NHIS) for full implementation and to prioritise provision of modern diagnostic equipment and treatment options for quality and optimal management of leukaemias in the center.

scholarly journals Megakaryocytic alterations in bone marrow aspiration smears in thrombocytopenia

2019 ◽  
Vol 9 (2) ◽  
pp. 1523-1529
Author(s):  
Anuja Bhandari ◽  
Anil Dev Pant ◽  
Anjan Shrestha ◽  
Jiwan Thapa
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndromes ◽  
Statistical Evaluation ◽  
Morphological Changes ◽  
Bone Marrow Aspiration ◽  
University Teaching ◽  
Hematological Parameter ◽  
One Year ◽  
A Prospective Study ◽  
Dysplastic Change

Background: Thrombocytopenia can be seen in any patients irrespective of age and the causes are diverse. This study was done to determine the frequency of various conditions associated with thrombocytopenia and to assess the number and morphology of megakaryocytes in various cases of thrombocytopenia. Megakaryocytic alterations in myelodysplastic versus non-myelodysplastic conditions were also evaluated in this study. Materials and methods: This was a prospective study conducted on 132 cases of bone marrow aspirates of thrombocytopenia over a duration of one year from 14th April 2017 to 13th April 2018 in Tribhuvan University Teaching Hospital, Kathmandu. All the statistical evaluation was done by using SPSS version 24. Results: In this study of 132 cases, megakaryocytic thrombocytopenia was the most common cause of thrombocytopenia for which bone marrow aspiration was done. The most common dysplastic change observed in megakaryocytes was micro megakaryocyte which was more commonly seen in MDS. Nondysplastic changes frequently observed were immature forms followed by bare nuclei and were more frequently seen in megakaryocytic thrombocytopenia followed by in myelodysplastic syndromes. Conclusions: Many similar morphological changes were observed in megakaryocytes among different hematological diseases. So, the presence of dysplastic megakaryocyte should not prompt an interpretation of myelodysplastic syndromes and should always be correlated with patient’s clinical and hematological parameter.

Ultrasound guided thyroid FNA with cytopathology in-attendance significantly improved accuracy in a university teaching hospital

2015 ◽  
Author(s):  
Mohamed Ahmed ◽  
Michael Jeffers ◽  
John Feeney ◽  
Pardeep Govender ◽  
Mark Sherlock ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
University Teaching ◽  
Ultrasound Guided ◽  
Thyroid Fna ◽  
Improved Accuracy

Is one benign thyroid FNA cytology sufficient to out rule malignancy? A university teaching hospital experience

2015 ◽  
Author(s):  
Mohamed Ahmed ◽  
Michael Jeffers ◽  
John Feeney ◽  
Pardeep Govender ◽  
Mark Sherlock ◽  
...  
Keyword(s):  
Teaching Hospital ◽  
University Teaching ◽  
Hospital Experience ◽  
Thyroid Fna ◽  
Benign Thyroid

Vitamin B12 Deficiency an Unusual Cause of Fever: A Case Report

2019 ◽  
Vol 4 (02) ◽  
Author(s):  
Shyama . ◽  
P. Kumar ◽  
Surabhi .
Keyword(s):  
Bone Marrow ◽  
Vitamin B12 ◽  
Unusual Case ◽  
Vitamin B12 Deficiency ◽  
Bone Marrow Aspiration ◽  
Microcytic Anemia ◽  
Peripheral Smear ◽  
Erythroid Hyperplasia ◽  
B12 Deficiency ◽  
Vitamin B12 Supplementation

Introduction: An unusual case of a 19 year old female, presenting with fever, pallor and hepatosplenomegaly for one month. She had microcytic anemia on peripheral smear examination but her bone marrow aspiration & biopsy revealed a hypercelluar marrow with megaloblastic erythroid hyperplasia. Resolution of fever within 48 hours of Vitamin B12 supplementation, initiated in view of the megaloblastic bone marrow picture & low serumVitamin B12 level, suggests a causal association. Conclusion: Vitamin B12 deficiency seems to be an unusual cause of PUO (Pyrexia of unkown origin) which should be ruled out in every case of PUO.

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