scholarly journals Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis

2019 ◽  
Vol 91 (3) ◽  
Author(s):  
Gianpaolo Perletti ◽  
Vittorio Magri ◽  
Anne Vral ◽  
Konstantinos Stamatiou ◽  
Alberto Trinchieri
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Binary Data ◽  
Meta Analysis ◽  
Intraepithelial Neoplasia ◽  
Pooled Analysis ◽  
Protective Role ◽  
Tea Catechins ◽  
Prostate Intraepithelial Neoplasia ◽  
Green Tea Catechins

A focused, single outcome meta-analysis on the protective role of extracts of green tea catechins against prostate cancer. Randomized, placebo-controlled studies enrolling patients with a histologically confirmed diagnosis of high-grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar proliferation but no prostate cancer were included. Meta-analysis for binary data was performed using Mantel-Haenszel statistics, using a random-effects model. Heterogeneity was investigated by calculating the I2. Four studies matched the inclusion criteria for the review. The pooled population was 223 patients; 114 and 109 patients were randomized to catechin and placebo groups, respectively. Nine cases of prstate cancer occurred in the catechin arm (7.9%), and 24 cases were reported in the placebo arm (22%). Pooled analysis resulted in a significant reduction of cancer risk in favor of the catechin arm (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0). In conclusion, our data suggest that the intake of concentrated green tea catechin preparations may confer a significant protective effect to carriers of early neoplastic lesions in the prostate. The quality of the evidence is moderate, and additional, largescale studies are warranted to substantiate these preliminary findings.

scholarly journals CHEMOPREVENTION OF HUMAN PROSTATE CANCER BY ORAL ADMINISTRATION OF GREEN TEA CATECHINS: A TRANSLATIONAL RESEARCH STORY

2008 ◽  
Vol 65 (1) ◽  
Author(s):  
S Bettuzzi ◽  
F Rizzi
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Cell Transformation ◽  
Treatment Options ◽  
Intraepithelial Neoplasia ◽  
Clinical Progression ◽  
Elderly Men ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Tumour Activity

Clinical progression of Prostate Cancer (CaP) is variable: some tumours are indolent, others rapidly progress. Because, diagnosis is usually in elderly men, CaP is an ideal target for chemoprevention. We showed that Green Tea Catechins (GTC) possess anti-tumour activity, suggesting that it might be beneficial in the early stages of cell transformation. But an experimental confirmation in a real clinical setting was needed. High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) is a pre-invasive stage of CaP for which no treatment options are available until CaP is diagnosed.

scholarly journals Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4014
Author(s):  
Anchalee Rawangkan ◽  
Kirati Kengkla ◽  
Sukrit Kanchanasurakit ◽  
Acharaporn Duangjai ◽  
Surasak Saokaew
Keyword(s):  
Systematic Review ◽  
Green Tea ◽  
Viral Infections ◽  
Influenza Infection ◽  
Meta Analysis ◽  
Influenza Virus Infection ◽  
Control Group ◽  
Tea Consumption ◽  
Tea Catechins ◽  
Green Tea Catechins

Influenza is one of the most serious respiratory viral infections worldwide. Although several studies have reported that green tea catechins (GTCs) might prevent influenza virus infection, this remains controversial. We performed a systematic review and meta-analysis of eight studies with 5,048 participants that examined the effect of GTC administration on influenza prevention. In a random-effects meta-analysis of five RCTs, 884 participants treated with GTCs showed statistically significant effects on the prevention of influenza infection compared to the control group (risk ratio (RR) 0.67, 95%CIs 0.51–0.89, P = 0.005) without evidence of heterogeneity (I2= 0%, P = 0.629). Similarly, in three cohort studies with 2,223 participants treated with GTCs, there were also statistically significant effects (RR 0.52, 95%CIs 0.35–0.77, P = 0.001) with very low evidence of heterogeneity (I2 = 3%, P = 0.358). Additionally, the overall effect in the subgroup analysis of gargling and orally ingested items (taking capsules and drinking) showed a pooled RR of 0.62 (95% CIs 0.49–0.77, P = 0.003) without heterogeneity (I2= 0%, P = 0.554). There were no obvious publication biases (Egger’s test (P = 0.138) and Begg’s test (P = 0.103)). Our analysis suggests that green tea consumption is effective in the prophylaxis of influenza infections. To confirm the findings before implementation, longitudinal clinical trials with specific doses of green tea consumption are warranted.

Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials

2014 ◽  
Vol 53 (6) ◽  
pp. 1299-1311 ◽  
Author(s):  
Saman Khalesi ◽  
Jing Sun ◽  
Nicholas Buys ◽  
Arash Jamshidi ◽  
Elham Nikbakht-Nasrabadi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Green Tea ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Tea Catechins ◽  
Green Tea Catechins ◽  
Randomised Controlled

scholarly journals Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis

2009 ◽  
Vol 91 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Olivia J Phung ◽  
William L Baker ◽  
Leslie J Matthews ◽  
Michael Lanosa ◽  
Alicia Thorne ◽  
...  
Keyword(s):  
Systematic Review ◽  
Green Tea ◽  
Meta Analysis ◽  
Anthropometric Measures ◽  
Tea Catechins ◽  
Green Tea Catechins

The role of circulating adiponectin in prostate cancer: a meta-analysis

2015 ◽  
Vol 30 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Qiaofang Liao ◽  
Chan Long ◽  
Zhuojuan Deng ◽  
Xiaoxia Bi ◽  
Jun Hu
Keyword(s):  
Prostate Cancer ◽  
Early Diagnosis ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Protective Role ◽  
Biological Mechanisms ◽  
Extensive Search ◽  
Standard Mean Difference ◽  
Potential Biomarker

Purpose Emerging evidence suggests that adiponectin may play a protective role in tumor progression and prognosis. However, available evidence in prostate cancer is conflicting. Therefore, we carried out a meta-analysis to evaluate the role of circulating adiponectin and prostate cancer. Methods and results An extensive search was performed on Google, PubMed, Elsevier Science and Springer from the date of the inception of those services to December 2013. Eleven studies with 2,504 patients and 3,565 controls concerning this association were included in our analysis. Standard mean difference (SMD) with 95% confidence intervals (95% CIs) was used to estimate this association. The pooled analysis showed that circulating adiponectin concentrations were lower in patients with prostate cancer than controls, with a pooled SMD of -0.893 μg/mL (95% CI, -1.345 to -0.440, p=0.000). Dose-response relationships between concentrations of adiponectin and risk of prostate cancer were evaluated. We found that decreased concentrations of adiponectin were associated with a significantly greater risk of prostate cancer (p for nonlinearity = 0.043). Conclusions The results of our analysis indicated that concentration of adiponectin in cancer patients was significantly lower than in controls. Thus, adiponectin may serve as a potential biomarker for early diagnosis of this disease. We also found that decreased concentration of adiponectin was associated with a significantly greater risk of prostate cancer. However, more studies in future, especially larger, prospective studies, are needed to confirm this association with underlying biological mechanisms.

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