scholarly journals Pedunculated solitary fibrous tumours arising from the pleura

2016 ◽  
Vol 65 (3) ◽  
Author(s):  
A. Poyraz ◽  
D. Kilic ◽  
A. Hatipoglu ◽  
T. Bakirci ◽  
B. Bilezikci
Keyword(s):  
Surgical Resection ◽  
Late Recurrence ◽  
Complete Resection ◽  
Solitary Fibrous Tumour ◽  
Clinical Entity ◽  
Visceral Pleura ◽  
Solitary Fibrous Tumours ◽  
Distinct Clinical Entity ◽  
Rare Tumours

Solitary fibrous tumour (SFT) is one of the rare tumours which arise from visceral pleura. Klemperer and Rabin first described SFT as a distinct clinical entity among primary pleural tumoUrs in 1931. Approximately 820 cases have been reported in literature to date. The management of patients with SFT is complete resection of the tumour and follow up of the patient to detect any possible late recurrence. In the present paper, we report two cases of pedunculated solitary fibrous tumours of the pleura that appeared as a wandering chest nodule to which surgical resection undertaken at our hospital. The aim is to summarise our experience in the management of solitary fibrous tumour.

scholarly journals Solitary Fibrous Tumour of the Pleura: A Case Report

2010 ◽  
Vol 17 (3) ◽  
pp. 113-114 ◽  
Author(s):  
George Rakovich ◽  
Maxime Laflamme ◽  
Denise Ouellette ◽  
Gilles Beauchamp
Keyword(s):  
Case Report ◽  
Surgical Resection ◽  
Complete Resection ◽  
Solitary Fibrous Tumour ◽  
Pathological Features ◽  
Benign Lesions ◽  
Solitary Fibrous Tumours ◽  
Large Size ◽  
Hypertrophic Pulmonary Osteoarthropathy ◽  
Pleural Neoplasms

Solitary fibrous tumours of the pleura are rare pleural neoplasms that are distinct from mesothelioma. Most of them are benign, although some behave aggressively; morphological and pathological features are important in distinguishing them from mesothelioma and in predicting clinical behaviour. Solitary fibrous tumours often grow to a large size before causing symptoms, and are characteristically associated with hypertrophic pulmonary osteoarthropathy in up to 20% of cases. In cases of benign lesions, complete resection is usually curative. A case involving a 62-year-old woman who underwent surgical resection of a solitary fibrous tumour of the pleura measuring 25 cm in size is described.

scholarly journals Giant solitary fibrous tumour of the pleura. Case report and review of the literature

2015 ◽  
Vol 49 (4) ◽  
pp. 395-401 ◽  
Author(s):  
Anton Crnjac ◽  
Bojan Veingerl ◽  
Damjan Vidovic ◽  
Rajko Kavalar ◽  
Aljaz Hojski
Keyword(s):  
Case Report ◽  
Pleural Cavity ◽  
Vena Cava ◽  
Lower Lobe ◽  
Disease Recurrence ◽  
Solitary Fibrous Tumour ◽  
Diagnostic Radiology ◽  
Lobe Bronchus ◽  
Solitary Fibrous Tumours ◽  
Rare Tumours

Abstract Background. Solitary fibrous tumours of the pleura (SFTP) are rare tumours. They are mostly benign. Only around 12% of them are malignant. In the initial stage they are mostly asymptomatic and by growing they cause chest pain, irritating cough and dyspnoea on account of the pressure created on the surrounding structures. Rare giant tumours have compression symptoms on the mediastinal structures. The condition requires tiered diagnostic radiology. Preoperative biopsy is not successful in most cases. The therapy of choice is radical surgical tumour removal. Malignant or non-radically removed benign solitary fibrous tumours of the pleura additionally require neoadjuvant therapy. Case report. A 68-year old patient was hospitalized for giant solitary fibrous tumour of the pleura in the right pleural cavity. With its expansive growth the tumour caused the shift of the mediastinum by compressing the lower vena cava, right cardiac auricle as well as the intermediate and lower lobe bronchus. Due to cardiac inflow obstruction and right lung collapse, the patient’s life was endangered with signs of cardio-respiratory failure. After preoperative diagnostic radiology, the tumour was surgically removed. Postoperatively, the patient’s condition improved. No disease recurrence was diagnosed after a year. Conclusions. Giant solitary fibrous tumour of the pleura may cause serious and life-threatening conditions by causing compression of the pleural cavity with its expansive growth. Early diagnosis of the condition enables less aggressive as well as video-assisted thoracic surgery in patients with significantly better state of health. Large tumour surgeries in cardio-respiratory affected patients are highly risk-associated procedures.

scholarly journals Predictive Factors of Surgical Outcome in Frontal Lobe Epilepsy Explored with Stereoelectroencephalography

Neurosurgery ◽  
2017 ◽  
Vol 83 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Francesca Bonini ◽  
Aileen McGonigal ◽  
Didier Scavarda ◽  
Romain Carron ◽  
Jean Régis ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Surgical Resection ◽  
Complete Resection ◽  
Conditional Inference ◽  
Prognostic Indicators ◽  
Frontal Lobe Epilepsy ◽  
Seizure Outcome ◽  
Seizure Freedom ◽  
Epileptogenic Zone

Abstract BACKGROUND Resective surgery established treatment for pharmacoresistant frontal lobe epilepsy (FLE), but seizure outcome and prognostic indicators are poorly characterized and vary between studies. OBJECTIVE To study long-term seizure outcome and identify prognostic factors. METHODS We retrospectively analyzed 42 FLE patients having undergone surgical resection, mostly preceded by invasive recordings with stereoelectroencephalography (SEEG). Postsurgical outcome up to 10-yr follow-up and prognostic indicators were analyzed using Kaplan–Meier analysis and multivariate and conditional inference procedures. RESULTS At the time of last follow-up, 57.1% of patients were seizure-free. The estimated chance of seizure freedom was 67% (95% confidence interval [CI]: 54-83) at 6 mo, 59% (95% CI: 46-76) at 1 yr, 53% (95% CI: 40-71) at 2 yr, and 46% (95% CI: 32-66) at 5 yr. Most relapses (83%) occurred within the first 12 mo. Multivariate analysis showed that completeness of resection of the epileptogenic zone (EZ) as defined by SEEG was the main predictor of seizure outcome. According to conditional inference trees, in patients with complete resection of the EZ, focal cortical dysplasia as etiology and focal EZ were positive prognostic indicators. No difference in outcome was found in patients with positive vs negative magnetic resonance imaging. CONCLUSION Surgical resection in drug-resistant FLE can be a successful therapeutic approach, even in the absence of neuroradiologically visible lesions. SEEG may be highly useful in both nonlesional and lesional FLE cases, because complete resection of the EZ as defined by SEEG is associated with better prognosis.

The Role of Radiation Therapy after Surgical Resection of Nonfunctional Pituitary Macroadenomas

Neurosurgery ◽  
2004 ◽  
Vol 55 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Paul Park ◽  
William F. Chandler ◽  
Ariel L. Barkan ◽  
John J. Orrego ◽  
John A. Cowan ◽  
...  
Keyword(s):  
High Resolution ◽  
Surgical Resection ◽  
Postoperative Radiotherapy ◽  
Tumor Resection ◽  
Complete Resection ◽  
High Resolution Imaging ◽  
Recurrence Rates ◽  
Number Of Patients ◽  
Resolution Imaging

Abstract OBJECTIVE: Radiotherapy after aggressive surgical resection of nonfunctional macroadenoma (NFA) of the pituitary remains controversial. Historically, immediate postoperative radiotherapy has been recommended to decrease risk of recurrence. With the availability of high-resolution imaging, most neurosurgeons now withhold radiation until recurrence. There is relatively little evidence to support this practice, however. This study reviews postoperative results in a large number of patients with NFA, the majority of whom did not undergo prophylactic radiation. METHODS: Of the 258 patients who underwent surgery from 1979 to 1999 for NFA, medical records were available for 176. Forty-four patients were treated with immediate postoperative radiotherapy after tumor resection, and the remaining 132 patients were followed up with serial imaging studies and treated with radiotherapy only when a recurrence was documented by follow-up imaging. RESULTS: Patients in the group that received immediate postoperative radiotherapy at time of initial diagnosis and surgery did not differ significantly with respect to age or sex from those in the group that was observed. Five- and 10-year recurrence rates were 2.3 and 2.3%, respectively, for patients who received immediate postoperative radiotherapy, as compared with 15.2 and 50.5%, respectively, for patients who were followed up and did not receive radiotherapy unless there was evidence of recurrence or progression. No patient had symptomatic recurrence in the group that was observed if consistent follow-up was performed. Of the 26 patients who received radiotherapy at time of tumor recurrence or progression, 18 had adequate follow-up, and in all cases, the tumors either remained stable or regressed. CONCLUSION: Withholding radiotherapy after a high-percentage resection of NFA leads to a higher recurrence rate, but it avoids exposing all patients to the risks of radiation. Deferring radiotherapy for patients with complete or near-complete resection seems to be a safe and prudent approach, as our data suggest that recurrences may be detected early with high-resolution imaging and treated effectively with radiation at time of recurrence. Therefore, immediate postoperative radiotherapy may be eliminated for patients with complete or near complete resection of NFA and who agree to undergo close follow-up for a long period.

scholarly journals Outcome of surgical management of hemophilic pseudotumor: Review of 9 Cases from single-center

2020 ◽  
Author(s):  
Yunfeng Yao ◽  
Chenxi Xue ◽  
Wang Fang ◽  
Jingcai Niu ◽  
Pengde Kang ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Soft Tissues ◽  
Bone Destruction ◽  
Coagulation Factor ◽  
Perioperative Period ◽  
Clinical Results ◽  
Complete Resection ◽  
Long Term Effects ◽  
Iliac Vessel

Abstract Background: Pseudotumours are a rare and serious complication of haemophilia, A slowly growing pseudotumour frequently destroys structures of bone and soft tissues. Surgical resection is the primary method for treatment of proximal pseudotumours. The purpose of this retrospective study was to evaluate the operative methods and clinical results of surgical treatment for those rare cases.Methods: We reviewed nine patients with hemophilic pseudotumours, who received surgical resection treatment in our hospital. The age range was 20-51 years. All operations were performed by one group surgeons. The method of operation depends on the origin and the extent of pseudotumor involvement. With the supplementary of recombinant coagulation factor VIII, six cases received complete resection; one received cytoreduction surgery as the pseudotumor closing to iliac vessel and nerve; two cases received complete resection and construction as bone destruction. Factor substitution was maintained for 14 days. Results: In our series, the average intraoperative blood loss volume was 710±35 ml(range ,240-2100ml). Six patients received blood transfusion during perioperative period. All wounds healed smoothly, no infection or chronic sinus formation. There is no iatrogenic vascular nerve injury in our series. Complete follow-up was performed in all patients. Mean follow-up duration was 14.5months (range, 6–26months). One patient with pseudotumor in the thigh had a recurrence of one year after operation, then secondary operation was performed, Conclusions: Surgical resection for haemophilic pseudotumours is an effctive and safe method . The choice of surgical procedure must be individualized according to the localization and the progress of pseudotumor. However, as relatively few cases and shorter follow-up time in our series. The long-term effects of these patients need further follow-up.

570 Solitary Fibrous Tumours of the Pleura: Case Series

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
L Ishak ◽  
N Kostoulas
Keyword(s):  
Risk Factors ◽  
Thoracoscopic Surgery ◽  
Pulmonary Function Tests ◽  
Geographical Area ◽  
Case Series ◽  
Excision Biopsy ◽  
Presenting Symptoms ◽  
Solitary Fibrous Tumours ◽  
Rare Tumours

Abstract Introduction Solitary fibrous tumours of the pleura (SFTP) are rare tumours with poorly recognised presentations and aetiology. Aim to evaluate the presentations, risk factors, investigations, management and follow up for 4 cases of SFTP Method retrospective review of medical records of 4 patients diagnosed with SFTP at the Golden Jubilee National Hospital between January-October 2020. Data was collated on presenting signs and symptoms, co-morbidities, risk factors, investigations, management and follow. A literature review was conducted, and findings discussed. Results All cases were males aged 62-85. All were referred from the same geographical area. Pre-disposing risk factors included exposure to cold-dust (1), asbestos (1) and smoking (1). Presenting symptoms were cough (3), shortness of breath (1), weight loss and fatigue (1). Associated co-morbidities were coagulopathy(2) and hyperglycaemia (1). Patients were investigated pre-operatively with chest x-ray (4), pulmonary function tests (4), PET-CT scan (4) and CT biopsy (3). One patient had genetic studies for chromosome 18 translocation. Three out of 4 patients were managed surgically with wedge resection (3) via video-assisted thoracoscopic surgery (2) or open thoracotomy(1), followed by excision biopsy studies (3). Tumours originated from the visceral (1), mediastinal (1) and parietal (1) pleura. Recurrence risk for all patients was deemed to be 20%. Follow up was with 6 monthly CT scans for 5 years (1). Conclusions SFTP is a rare tumour which presents with non-specific symptoms. Better understanding of the aetiology, presentation and investigations is needed to aid definitive diagnosis and tailored management

Activity of chemotherapy in inflammatory myofibroblastic tumor (IMT): A retrospective analysis within the Italian Rare Tumours Network (RTR).

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e22545-e22545 ◽  
Author(s):  
Giacomo Giulio Baldi ◽  
Alessandro Gronchi ◽  
Bruno Vincenzi ◽  
Tommaso Martino De Pas ◽  
Maria A. Pantaleo ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Medical Therapy ◽  
Advanced Disease ◽  
Locally Advanced ◽  
Soft Tissue Tumour ◽  
Complete Surgical Resection ◽  
Rare Tumours ◽  
Best Responses ◽  
Disease Free

e22545 Background: IMT is a rare soft tissue tumour often curable with surgical resection. Nonetheless, in advanced cases a medical therapy is needed. Few data are available on the role of conventional chemotherapy. We report on a retrospective study on the activity of cytotoxic chemotherapy in pts with IMT treated within the RTR. Methods: Patients (pts) of any age with a centrally confirmed diagnosis of IMT treated with anthracycline-based or methotrexate (MTX) and vinorelbine/vinblastine-based regimens between 2008 and 2018 were reviewed. ALK status was evaluated by immunohistochemistry and FISH. Response was assessed by RECIST 1.1. Results: Twenty pts were retrospectively identified (ALK positive = 12, under assessment = 8); median age at the time of treatment start = 38, range = 5-77; disease extent: local disease = 2, locally advanced = 9, metastatic disease = 9. Thirteen pts (65%) received an anthracycline-based regimen, 7 (35%) MTX and vinorelbine/vinblastine. In the anthracycline-based group, 6 (46%) and 7 (54%) pts were treated for localized and advanced disease, respectively. Twelve pts were evaluable for response. Best responses were: 1 CR (8%), 6 PR (50%), 2 SD (17%), 3 PD (25%), for an ORR = 58%. 8 pts received a complete surgical resection at the end of the medical treatment and 6 are disease free. At 39 mos median follow-up, mPFS for 7 pts treated for advanced disease was 5.4 mos (IQR: 1.9-18.8). In the MTX and vinorelbine/vinblastine group, 2 (28%) and 5 (72%) pts were treated for localized disease and advanced disease, respectively. All pts were evaluable for response. Best responses were: 5 PR (50%), 3 SD (30%), 2 PD (20%), for an ORR = 50%. Two pts received a complete surgical resection after the end of chemotherapy and both are disease free. At 56.4 mos median follow-up, mPFS for pts with advanced disease was not reached, with disease progression reported only in 1 pt. Conclusions: Chemotherapy is an option in localised IMT when tumour shrinkage is needed as well as for tumour control in advanced disease. Clearly, its efficacy should be compared with ALK inhibitors, although of course both groups of agents may be resorted to stepwisely in advanced cases in need for medical therapy.

scholarly journals Solitary fibrous tumour of the sigmoid colon mesentery

2019 ◽  
Vol 12 (5) ◽  
pp. e228774
Author(s):  
Gabriel Mekel ◽  
Eli Balshan ◽  
Frank Traupman
Keyword(s):  
Sigmoid Colon ◽  
Surgical Excision ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Solitary Fibrous Tumour ◽  
The Body ◽  
En Bloc ◽  
Solitary Fibrous Tumours ◽  
Rare Tumours ◽  
Benign Nature

Solitary fibrous tumours (SFTs) are rare tumours arising from mesenchymal tissues. Despite of their more frequent occurrence in the pleura, SFT can present anywhere in the body. Only a few cases have been described arising from the mesentery. Most tumours have a benign nature; however, up to 20% of them can spread, most commonly to liver, lung and bone. Surgical excision including all surrounding tissues remains the treatment of choice; however, there is no consensus regarding the need for adjuvant therapies. We present a 79-year-old man with abdominal pain who was found to have a SFT in the mesentery of the sigmoid colon, treated with en bloc resection. A multidisciplinary team including surgeons, medical and radiation oncologists is recommended in the care of these patients.

scholarly journals Perioperative strategy and outcome in giant retroperitoneal dedifferentiated liposarcoma—results of a retrospective cohort study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Robert Bachmann ◽  
Franziska Eckert ◽  
Daniel Gelfert ◽  
Jens Strohäker ◽  
Christian Beltzer ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Soft Tissue Sarcomas ◽  
Radical Resection ◽  
Complete Resection ◽  
Neoadjuvant Radiochemotherapy ◽  
En Bloc ◽  
Free Survival ◽  
Retroperitoneal Liposarcoma ◽  
Median Diameter

Abstract Background and objectives Retroperitoneal liposarcoma (RPLS) are common soft tissue sarcomas of adulthood. The aim of this study is to show resectability of even giant liposarcomas and to identify factors associated with recurrence and survival in primary retroperitoneal liposarcomas. Methods We retrospectively reviewed the records of patients with retroperitoneal liposarcoma. Seventy-seven patients met inclusion criteria. Out of these 10 patients with primary giant, dedifferentiated retroperitoneal liposarcomas were operated with en bloc compartment resection with intention of radical resection. Treatment consisted of neoadjuvant radiochemotherapy and surgical resection or surgical resection. Results In 6 patients, neoadjuvant radiochemotherapy was performed; 3 patients were treated with surgical resection alone and 1 patient received adjuvant chemotherapy. The median diameter of tumor size was 360 mm (300 to 440 mm). Operative outcome showed complete resection in all 10 patients. Local tumor free survival was in median 19 month. Tumor recurrence was seen in 3 of 4 patients (75%) without neoadjuvant radiochemotherapy, and in 2 of 6 patients (33%) after neoadjuvant radiochemotherapy in 2 years follow-up. Conclusion Even in case of giant retroperitoneal liposarcoma, complete resection is possible and remains the principal treatment. The rate of recurrence was improved in patients with neoadjuvant radiochemotherapy.

scholarly journals Management of solitary fibrous tumours of the pleura: a systematic review and meta-analysis

2020 ◽  
Vol 6 (3) ◽  
pp. 00055-2020
Author(s):  
Rachel M. Mercer ◽  
Charlotte Wigston ◽  
Radhika Banka ◽  
Giuseppe Cardillo ◽  
Rachel Benamore ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Meta Analysis ◽  
Case Series ◽  
R0 Resection ◽  
Recurrence Rates ◽  
Solitary Fibrous Tumours ◽  
Rare Tumours ◽  
First Recurrence ◽  
Evidence Based Guidelines

BackgroundSolitary fibrous tumours of the pleura (SFTP), or pleural fibromas, are rare tumours that generally, but not universally, follow a benign course. Surgical resection is the standard treatment, but there are no evidence-based guidelines regarding the management of these tumours.MethodsFive databases were searched from inception to April 1, 2019 for studies reporting on SFTP management.ResultsTwenty-seven studies met the inclusion criteria (1542 patients, all non-comparative case series); 98% of these patients underwent resection and all SFTP included were pathologically diagnosed. 394 out of 1299 cases (30.5%, 95% CI 27.8–32.8%) were malignant with recurrence rates of between 0% and 42.9%. A pleural effusion was always associated with a negative outcome, but no other features were consistently reported to have negative associations. Preoperative biopsies incorrectly reported malignant histology in two studies. Over 25% of cases of recurrence occurred when a complete (R0) resection had been achieved. The first recurrence occurred >5 years after the initial resection in at least 23% of cases.ConclusionsThere is strong evidence to support long-term surveillance after surgical resection of SFTP, even where a complete (R0) resection has been achieved; however, there is no clear evidence to inform clinicians regarding the selection of patients who should undergo resection. The rates of malignant SFTP and SFTP recurrence are higher than previously reported. Only those that were pathologically diagnosed or resected were included, which may bias the data towards more aggressive tumours. Data collection on radiologically diagnosed SFTP is required to draw conclusions regarding the timing and need for intervention.

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