570 Solitary Fibrous Tumours of the Pleura: Case Series

Abstract Introduction Solitary fibrous tumours of the pleura (SFTP) are rare tumours with poorly recognised presentations and aetiology. Aim to evaluate the presentations, risk factors, investigations, management and follow up for 4 cases of SFTP Method retrospective review of medical records of 4 patients diagnosed with SFTP at the Golden Jubilee National Hospital between January-October 2020. Data was collated on presenting signs and symptoms, co-morbidities, risk factors, investigations, management and follow. A literature review was conducted, and findings discussed. Results All cases were males aged 62-85. All were referred from the same geographical area. Pre-disposing risk factors included exposure to cold-dust (1), asbestos (1) and smoking (1). Presenting symptoms were cough (3), shortness of breath (1), weight loss and fatigue (1). Associated co-morbidities were coagulopathy(2) and hyperglycaemia (1). Patients were investigated pre-operatively with chest x-ray (4), pulmonary function tests (4), PET-CT scan (4) and CT biopsy (3). One patient had genetic studies for chromosome 18 translocation. Three out of 4 patients were managed surgically with wedge resection (3) via video-assisted thoracoscopic surgery (2) or open thoracotomy(1), followed by excision biopsy studies (3). Tumours originated from the visceral (1), mediastinal (1) and parietal (1) pleura. Recurrence risk for all patients was deemed to be 20%. Follow up was with 6 monthly CT scans for 5 years (1). Conclusions SFTP is a rare tumour which presents with non-specific symptoms. Better understanding of the aetiology, presentation and investigations is needed to aid definitive diagnosis and tailored management

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Treatment and therapeutic strategies for pituitary apoplexy in pregnancy: a case series

Journal of Medical Case Reports ◽

10.1186/s13256-021-02892-5 ◽

2021 ◽

Vol 15 (1) ◽

Author(s):

Yuya Kato ◽

Yoshikazu Ogawa ◽

Teiji Tominaga

Keyword(s):

Pituitary Apoplexy ◽

Clinical Symptoms ◽

Case Series ◽

Optimal Timing ◽

Presenting Symptoms ◽

Pathological Evaluation ◽

Mother And Child ◽

Life Threatening ◽

In Pregnancy

Abstract Background Pregnancy is a known risk factor for pituitary apoplexy, which is life threatening for both mother and child. However, very few clinical interventions have been proposed for managing pituitary apoplexy in pregnancy. Case presentation We describe the management of three cases of pituitary apoplexy during pregnancy and review available literature. Presenting symptoms in our case series were headache and/or visual disturbances, and the etiology in all cases was hemorrhage. Conservative therapy was followed until 34 weeks of gestation, after which babies were delivered by cesarean section with prophylactic bolus hydrocortisone supplementation. Tumor removal was only electively performed after delivery using the transsphenoidal approach. All three patients and their babies had a good clinical course, and postoperative pathological evaluation revealed that all tumors were functional and that they secreted prolactin. Conclusions Although the mechanism of pituitary apoplexy occurrence remains unknown, the most important treatment strategy for pituitary apoplexy in pregnancy remains adequate hydrocortisone supplementation and frequent hormonal investigation. Radiological follow-up should be performed only if clinical symptoms deteriorate, and optimal timing for surgical resection should be discussed by a multidisciplinary team that includes obstetricians and neonatologists.

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Bilateral ocular surface squamous neoplasia: A study of 25 patients and review of literature

European Journal of Ophthalmology ◽

10.1177/11206721211007109 ◽

2021 ◽

pp. 112067212110071

Author(s):

Vijitha S Vempuluru ◽

Monalisha Pattnaik ◽

Neha Ghose ◽

Swathi Kaliki

Keyword(s):

Risk Factors ◽

Ocular Surface ◽

Histopathological Examination ◽

Topical Steroid ◽

Case Series ◽

Intraepithelial Neoplasia ◽

Excisional Biopsy ◽

Ocular Surface Squamous Neoplasia ◽

Retrospective Case

Purpose: To describe the risk factors, clinical presentation, management, and outcomes of patients with bilateral ocular surface squamous neoplasia (OSSN). Methods: Retrospective case series. Results: Of the 25 patients with bilateral OSSN, the mean age at diagnosis of OSSN was 31 years (median, 24 years; range, 2–60 years). Risk factors for bilateral OSSN included xeroderma pigmentosum ( n = 15, 60%), human immunodeficiency virus infection ( n = 3, 12%), conjunctival xerosis ( n = 1, 4%), and topical steroid use ( n = 1, 4%). There were no identifiable ocular or systemic risk factors in 7 (28%) patients. Presentation was synchronous in 14 (56%) and metachronous in 11 (44%) patients. Tumor morphology was bilaterally similar in 12 (48%) patients. Histopathological examination ( n = 36) revealed conjunctival intraepithelial neoplasia (CIN) grade 1 in 4 (8%); grade 2 in 7 (14%); carcinoma in situ in 5 (10%), and invasive carcinoma in 20 (40%). Primary management of OSSN ( n = 49) included excisional biopsy ( n = 31, 62%), topical immunotherapy (IFN α2B) ( n = 11; 22%), topical Mitomycin C (MMC) ( n = 3, 6%), enucleation ( n = 1, 2%), orbital exenteration ( n = 2, 4%), and plaque brachytherapy (PBT) ( n = 1, 2%). One patient was lost to follow-up after detection of tumor in the second eye. Recurrent tumors were noted in 16 (32%) eyes and binocular globe salvage was achieved in 16 (64%) patients at a mean follow up of 41 months (median 30 months; range, 1–164 months). Conclusion: OSSN occurrence can be synchronous or metachronous. Meticulous examination of the fellow eye is important for an early diagnosis of OSSN.

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Abstract W P21: Should We Perform Thrombectomy In Patients With Wake-up Strokes? A Case Series Using Ct Perfusion For Patient Selection

Stroke ◽

10.1161/str.46.suppl_1.wp21 ◽

2015 ◽

Vol 46 (suppl_1) ◽

Author(s):

Gabriel Vidal ◽

James Milburn ◽

Garrett Bennett ◽

Vivek Sabharwal ◽

Mustafa Al Hasan

Keyword(s):

Risk Factors ◽

Ct Perfusion ◽

Medical Center ◽

Case Series ◽

Stroke Severity ◽

Vessel Occlusion ◽

Single Center Experience ◽

Aspiration Technique ◽

Group 2

Background and objectives: Approximately 25% of patients who present with acute ischemic stroke are wake-up strokes. These patients are often not treated with IV thrombolytics because of unclear onset of symptoms. Little data exists on endovascular therapy as acute treatment for this population, particularly with an aspiration technique. The objective of this study is to compare outcomes of patients who presented with wake-up strokes due to large vessel occlusion treated with neuroendovascular procedures versus those who received conservative treatment, based on a 2-year (2012-2013), single center experience at Ochsner Medical Center in New Orleans, LA. Method: 24 consecutive patients, who presented with wake-up strokes, were outside the IV tPA window, and had both CTA confirmed intracranial LVO and CT-perfusion data upon arrival to our institution were retrospectively studied. Patients with hemorrhages, tandem lesions, or high-grade carotid stenosis were excluded from this analysis. Decision to perform endovascular treatment was made by the vascular neurologist and neuro-interventionalist based on stroke severity and CTA/perfusion data. Patients in group 1 (n = 8) underwent endovascular revascularization procedures; patients in group 2 (n = 16) were treated conservatively (medical management alone). Presentation NIHSS, risk factors, mortality, discharge NIHSS, discharge mRS, and follow up mRS were compared. Results: There were no statistical differences in patient population regarding age, gender, and risk factors. There was no statistical difference in their initial NIHSS (16.8 vs. 21.8, p=0.05162), or mortality (0% vs 21%, pr=0.262). The two groups were statistically different in their discharge NIHSS (7.25 vs 21.81, p<0.00045), discharge mRS (2 vs 5, p<0.00001), clinic follow up mRS (1.37 vs 4.94, p<0.00001), and good outcome at discharge (mRS 0-2)(75% vs 0%, pr<0.0002). Conclusion: Patients with wake-up strokes, LVO, and favorable CT-perfusion data who underwent neuroendovascular reperfusion treatment had significantly better outcomes in our population, despite similar stroke severity at presentation. This suggests that with careful selection, neuroendovascular therapy for wake-up strokes may lead to improved outcomes.

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Transnasal endoscopic approach for pediatric skull base lesions: a case series

Journal of Neurosurgery Pediatrics ◽

10.3171/2019.4.peds18693 ◽

2019 ◽

Vol 24 (3) ◽

pp. 246-257 ◽

Cited By ~ 1

Author(s):

Jennifer L. Quon ◽

Lily H. Kim ◽

Peter H. Hwang ◽

Zara M. Patel ◽

Gerald A. Grant ◽

...

Keyword(s):

Skull Base ◽

Pediatric Population ◽

Case Series ◽

Length Of Hospital Stay ◽

Skull Base Tumors ◽

Presenting Symptoms ◽

Institutional Experience ◽

Transnasal Endoscopic Approach ◽

Skull Base Lesions

OBJECTIVETransnasal endoscopic transsphenoidal approaches constitute an essential technique for the resection of skull base tumors in adults. However, in the pediatric population, sellar and suprasellar lesions have historically been treated by craniotomy. Transnasal endoscopic approaches are less invasive and thus may be preferable to craniotomy, especially in children. In this case series, the authors present their institutional experience with transnasal endoscopic transsphenoidal approaches for pediatric skull base tumors.METHODSThe authors retrospectively reviewed pediatric patients (age ≤ 18 years) who had undergone transnasal endoscopic transsphenoidal approaches for either biopsy or resection of sellar or suprasellar lesions between 2007 and 2016. All operations were performed jointly by a team of pediatric neurosurgeons and skull base otolaryngologists, except for 8 cases performed by one neurosurgeon.RESULTSThe series included 42 patients between 4 and 18 years old (average 12.5 years) who underwent 51 operations. Headache (45%), visual symptoms (69%), and symptoms related to hormonal abnormalities (71%) were the predominant presenting symptoms. Improvement in preoperative symptoms was seen in 92% of cases. Most patients had craniopharyngiomas (n = 16), followed by pituitary adenomas (n = 12), Rathke cleft cysts (n = 4), germinomas (n = 4), chordomas (n = 2), and other lesion subtypes (n = 4). Lesions ranged from 0.3 to 6.2 cm (median 2.5 cm) in their greatest dimension. Gross-total resection was primarily performed (63% of cases), with 5 subsequent recurrences. Nasoseptal flaps were used in 47% of cases, fat grafts in 37%, and lumbar drains in 47%. CSF space was entered intraoperatively in 15 cases, and postoperative CSF was observed only in lesions with suprasellar extension. There were 8 cases of new hormonal deficits and 3 cases of new cranial nerve deficits. Length of hospital stay ranged from 1 to 61 days (median 5 days). Patients were clinically followed up for a median of 46 months (range 1–120 months), accompanied by a median radiological follow-up period of 45 months (range 3.8–120 months). Most patients (76%) were offered adjuvant therapy.CONCLUSIONSIn this single-institution report of the transnasal endoscopic transsphenoidal approach, the authors demonstrated that this technique is generally safe and effective for different types of pediatric skull base lesions. Favorable effects of surgery were sustained during a follow-up period of 4 years. Further refinement in technology will allow for more widespread use in the pediatric population.

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Chondrosarcomas of the skull base and temporal bone

The Journal of Laryngology & Otology ◽

10.1017/s0022215107006081 ◽

2007 ◽

Vol 121 (8) ◽

pp. 725-735 ◽

Cited By ~ 25

Author(s):

L R Lustig ◽

J Sciubba ◽

M J Holliday

Keyword(s):

Radiation Therapy ◽

Skull Base ◽

Temporal Bone ◽

Histological Grade ◽

Tumour Control ◽

Presenting Symptoms ◽

Rare Tumours ◽

Temporal Bones ◽

Symptoms And Signs

AbstractObjective:To evaluate the clinical presentation and outcomes of treatment for patients with chondrosarcomas involving the skull base and temporal bone.Study design:Retrospective review.Setting:Tertiary medical centre.Patients:Cases of histologically confirmed chondrosarcoma involving the skull base and temporal bones.Intervention:Surgery.Main outcome measures:Demographic features of presenting patients; presenting symptoms and signs; surgical approach employed; use of post-operative radiation therapy; histological grade of tumour; and interval of post-operative follow up.Results: Twelve patients were identified with chondrosarcomas involving the skull base, with post-operative follow up ranging from three to 33 years. The average age at presentation was 42 years. The most common presenting symptoms were diplopia, decreased visual acuity and headaches. Five of the 12 patients required multiple surgical procedures.Conclusions:Patients with chondrosarcoma involving the skull base and temporal bone may present in a variety of ways. Surgical resection, even subtotal, in combination with radiation therapy, can often provide good tumour control over many years for these rare tumours.

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Pedunculated solitary fibrous tumours arising from the pleura

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2006.563 ◽

2016 ◽

Vol 65 (3) ◽

Author(s):

A. Poyraz ◽

D. Kilic ◽

A. Hatipoglu ◽

T. Bakirci ◽

B. Bilezikci

Keyword(s):

Surgical Resection ◽

Late Recurrence ◽

Complete Resection ◽

Solitary Fibrous Tumour ◽

Clinical Entity ◽

Visceral Pleura ◽

Solitary Fibrous Tumours ◽

Distinct Clinical Entity ◽

Rare Tumours

Solitary fibrous tumour (SFT) is one of the rare tumours which arise from visceral pleura. Klemperer and Rabin first described SFT as a distinct clinical entity among primary pleural tumoUrs in 1931. Approximately 820 cases have been reported in literature to date. The management of patients with SFT is complete resection of the tumour and follow up of the patient to detect any possible late recurrence. In the present paper, we report two cases of pedunculated solitary fibrous tumours of the pleura that appeared as a wandering chest nodule to which surgical resection undertaken at our hospital. The aim is to summarise our experience in the management of solitary fibrous tumour.

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Thoracoscopic Lobectomy for Congenital Pulmonary Airway Malformation: Where Are We in 2019?

European Journal of Pediatric Surgery ◽

10.1055/s-0040-1702221 ◽

2020 ◽

Vol 30 (02) ◽

pp. 146-149

Author(s):

Arnaud Bonnard

Keyword(s):

Fast Track ◽

Thoracoscopic Surgery ◽

Pulmonary Function Tests ◽

Congenital Pulmonary Airway Malformation ◽

Adequate Treatment ◽

The Past ◽

Track Management ◽

Pulmonary Airway ◽

Tomography Scan

AbstractThoracoscopic surgery for congenital pulmonary airway malformation (CPAM) is still a matter of debate and used by approximately 50% of the surgeons in Europe. Several questions need to be addressed about CPAM. The adequate treatment, the surgical approach, and the follow-up are few of them. A review of recent articles published in the literature over the past 5 years is done in trying to respond to these questions. A multidisciplinary team is required to follow these patients since approximately 10 to 15% will develop a chronic lung disease and asthma. In the case of conservative management, computed tomography scan should be perform to monitor the evolution of the CPAM. Minimally invasive surgery should be used whenever possible, although the advantages of pulmonary function tests are not clearly defined, allowing a postoperative fast-track management.

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GIANT CELL TUMOURS OF TENDON SHEATH OF HAND: CAUSES AND STRATEGIES TO PREVENT RECURRENCE

Hand Surgery ◽

10.1142/s0218810411005242 ◽

2011 ◽

Vol 16 (02) ◽

pp. 149-154 ◽

Cited By ~ 11

Author(s):

Azal Jalgaonkar ◽

Baljinder Dhinsa ◽

Howard Cottam ◽

Ganapathyraman Mani

Keyword(s):

Risk Factors ◽

Local Recurrence ◽

Giant Cell ◽

Recurrence Rate ◽

Case Series ◽

Tendon Sheath ◽

Giant Cell Tumours ◽

High Incidence ◽

The Mean

Giant cell tumours of tendon sheath of hand present a surgical dilemma due to their high incidence of local recurrence. We present a case series of 46 patients with 47 histologically confirmed giant cell tumours of tendon sheath over a ten-year period from 1998 to 2008. The mean follow-up was 47 months (range 25–124 months). We identified tumours with bony erosions and piecemeal resections as predictors of recurrence. Our recurrence rate of 9% was at the lower end of spectrum of previously published reports (range 7%–44%). We recommend "en-masse" excision of these tumours. All the patients with suspicion of these tumours should have preoperative radiographs to identify erosions. A thorough curettage of the bone should be done in cases with osseous erosion to prevent recurrence. Patients with these risk factors should be followed up annually for five years and be warned about recurrence.

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Development of invasive disease in 433 women treated for vulvar, vaginal or perianal intraepithelial neoplasia

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.5043 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 5043-5043

Author(s):

M. K. Fehr ◽

K. J. Dedes ◽

S. Heinzl ◽

M. D. Mueller ◽

M. Baumann ◽

...

Keyword(s):

Risk Factors ◽

Multivariate Analysis ◽

Case Series ◽

Intraepithelial Neoplasia ◽

Invasive Disease ◽

Malignant Potential ◽

Initial Diagnosis ◽

Laser Evaporation ◽

High Grade

5043 Background: The incidence of intraepithelial neoplasia (IN) of the lower anogenital tract is increasing. Due to small case-series, the malignant potential of treated high-grade IN is not well defined and risk factors for progression are not established. Methods: Patients with IN of the vulva (VIN), vagina (VAIN) and perianal skin (PAIN) were identified in the electronic databases of three university colposcopy clinics. Inclusion criteria were biopsy proven IN grade 2–3 (high-grade) and no history of vaginal, vulvar or anorectal cancer. Excluded were patients with the diagnosis of invasive disease within one year from initial diagnosis of IN. Results: 442 patients were identified from 1977 to 2005 with a mean follow up of 69.9 ± 56.1 months. Initial diagnosis was VIN III in 75.3%, VIN II in 17.2%, VAIN II in 4.3%, VAIN III in 2%, and PAIN II/III in 1.1% of patients. Mean age at initial diagnosis was 47.1 ± 14.1 (range, 18–102). Initial treatment was biopsy and laser evaporation in 61.5%, surgical excision in 32.8%, and other locally destructive methods in 3.1% of patients. 9 patients refused any treatment (2.0%). In the 433 treated patients, recurrent disease (e.g. diagnosed >1 year after initial diagnosis) occurred in 32.2%. In patients with a follow up longer than 5 years, 14.4 % were still experiencing recurrences. In multivariate analysis, immunosuppression (OR: 2.33, 95% CI 1.06–5.06, p = 0.035) was associated with recurrence but not smoking, age or histological grade. Progression to invasive disease occurred in 3.8% of treated patients within a mean time of 7.9 ± 6.8 years (range, 1.3–24.5). In multivariate analysis, immunosuppression (OR:3.31, 95% CI 1.01–10.93, p = 0.049) and smoking (OR:3.12, 95% CI 1.07–9.08, p = 0.037) were independent risk factors for progression. Conclusions: Anogenital IN is a chronic disease in a substantial proportion of patients. The malignant potential is remarkably high despite repeated treatments. Therefore, long lasting surveillance is mandatory, especially in immunosuppressed or smoking patients. No significant financial relationships to disclose.

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