scholarly journals Post COVID-19 tuberculosis: An emerging threat of pandemic

2021 ◽  
Author(s):  
Aqusa Zahid ◽  
Nousheen Iqbal ◽  
Sarosh Moeen ◽  
Muhammad Irfan
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Severe Acute Respiratory Syndrome ◽  
Opportunistic Infection ◽  
Immunocompetent Patient ◽  
Young Female ◽  
High Index ◽  
The World ◽  
High Index Of Suspicion

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) pandemic has hit the world hard. Millions of people have died due to the infection and several have suffered with what are now known as post COVID-19 squeal. Among these squeals one is immunosuppression which leaves patients prone to severe opportunistic infection. We here report a case of young female who was infected by COVID-19 and later developed cavitary pneumonia which upon investigation turned out to be due to mycobacterium tuberculosis.  Through this report we aim to highlight the importance of high index of suspicion for infection like Mycobacterium tuberculosis after COVID-19 infection which developed in a healthy immunocompetent patient.

scholarly journals COVID-19 and Pulmonary Mycobacterium Tuberculosis Coinfection

2021 ◽  
Vol 36 (5) ◽  
pp. e298-e298
Author(s):  
Redha Al Lawati ◽  
Nasser Al Busaidi ◽  
Rashid Al Umairi ◽  
Merah Al Busaidy ◽  
Hanan Hamed Al Naabi ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Case Reports ◽  
World Health ◽  
Delay In Diagnosis ◽  
Global Pandemic ◽  
First Case ◽  
Appropriate Treatment ◽  
The World ◽  
Health Organization ◽  
High Index Of Suspicion

The Coronavirus disease-2019 (COVID-19) outbreak was classified as a global pandemic by the World Health Organization on 11 March 2020. It is caused by the novel severe acute respiratory syndrome coronavirus 2. The virus affects mainly the human respiratory system. Mycobacterium tuberculosis (TB) is another respiratory infection known to affect humans and may share joint clinical presentations and risk factors with COVID-19 infection. Therefore, clinicians must have a high index of suspicion that the two infections might coexist so that there is no delay in diagnosis and starting the appropriate treatment. There are few case reports about TB and COVID-19 coinfection. The first case report ever was from China and there have been a few others around the world. Here, we report two cases of coexisting COVID-19 and newly diagnosed pulmonary TB infection in Oman.

scholarly journals Isolated Mycobacterium Tuberculosis Tenosynovitis and Osteomyelitis of the Foot in an Immunocompetent Patient

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Elgazzar A ◽  
◽  
Cecchini A ◽  
Elmezayen RI ◽  
◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Delayed Diagnosis ◽  
Pulmonary Involvement ◽  
Immunocompetent Patient ◽  
Complete Healing ◽  
Radiological Findings ◽  
Intravenous Antibiotics ◽  
Healing Wounds ◽  
High Index Of Suspicion ◽  
Immunocompetent Patients

Tubercular osteomyelitis must be considered in the differential diagnosis of immunocompetent patients who present with non-healing wounds with underlying osteomyelitis. Clinical and radiological findings may be indistinguishable from typical bacteria osteomyelitis. A high index of suspicion may prevent delayed diagnosis, and early treatment may prevent subsequent complications. This is a case report of an immunocompetent patient who presented with a chronic non-healing foot wound complicated by abscess and osteomyelitis that did not improve with an appropriate course of intravenous antibiotics. Wound cultures subsequently grew Mycobacterium tuberculosis without evidence of pulmonary involvement. The patient was treated with an initial two-month regimen of rifampin, isoniazid, pyridoxine, pyrazinamide and ethambutol, followed by a tenmonth regimen of rifampin, isoniazid and pyridoxine. The patient experienced significant improvement and complete healing of the foot wound after approximately the first two months of therapy.

scholarly journals Pericardial Effusion - Melioidosis or Tuberculosis

2012 ◽  
Vol 13 (2) ◽  
pp. 230-232
Author(s):  
Smitha Bhat ◽  
Jayaprakash Alva ◽  
Mohammad Ashraf ◽  
Sourab Hiremath ◽  
Shishir Duble
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pericardial Effusion ◽  
East Asia ◽  
High Index ◽  
South East Asia ◽  
Northern Australia ◽  
High Index Of Suspicion

Melioidosis which is endemic in South East Asia and Northern Australia is now being reported from the Indian subcontinents as well. Meliodosis rarely presents as pericardial effusion. We report a case of B. pseudomallei causing pericardial effusion from India, where the most common infective cause of pericardial effusion is Mycobacterium tuberculosis. The chronic presentation of melioidosis is not unlike tuberculosis, and the clinician must have a high index of suspicion to diagnose meliodosis, especially in geographical areas where both tuberculosis and melioidosis are prevalent.DOI: http://dx.doi.org/10.3329/jom.v13i2.9368 J Medicine 2012; 13 : 230-232

scholarly journals Fibrocalculous pancreatic diabetes (FCPD)presenting as regression of puberty–a rare presentation of a rare disease

2021 ◽  
Vol 8 (1) ◽  
pp. 44-45
Author(s):  
Suman Sarkar ◽  
Nikhil Sonthalia ◽  
Sukanya Saha ◽  
Nirmalya Roy ◽  
Ankan Pathak ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Rare Disease ◽  
Young Female ◽  
High Index ◽  
Rare Presentation ◽  
Pancreatic Diabetes ◽  
Secondary Amenorrhea ◽  
Fibrocalculous Pancreatic Diabetes ◽  
High Index Of Suspicion

Here we present a case of young female who presented to us with secondary amenorrhea causing regression of puberty which is quite uncommon as a presentation of FCPD which is occasionally encountered in our day to day clinical practice. The aim of this communication is to keep a high index of suspicion and to keep FCPD as a possible aetiology which can lead to regression of puberty.

scholarly journals Extrapulmonary Tuberculosis masquerading as chest wall malignancy: It just never ceases to surprise us!

2021 ◽  
Author(s):  
Mousa Hussein ◽  
Abdalhadi Ahmed ◽  
Anam Elarabi ◽  
Ibrahim Rasheed ◽  
Abbas Alabbas ◽  
...  
Keyword(s):  
Chest Wall ◽  
Acquired Immunodeficiency Syndrome ◽  
Extrapulmonary Tuberculosis ◽  
Immunocompetent Patient ◽  
High Index ◽  
Diagnostic Challenge ◽  
Acquired Immunodeficiency ◽  
High Index Of Suspicion ◽  
Immunodeficiency Syndrome

With the emergence of the acquired immunodeficiency syndrome, we witnessed a higher incidence of disseminated and extrapulmonary tuberculosis. It poses a significant diagnostic challenge for the physicians; therefore, a high index of suspicion should be maintained. Here we present a case of isolated chest wall tuberculosis in an immunocompetent patient.

Fungal laryngitis in immunocompetent patients

2004 ◽  
Vol 118 (5) ◽  
pp. 379-381 ◽  
Author(s):  
Hisham M. Mehanna ◽  
Tony Kuo ◽  
John Chaplin ◽  
Graeme Taylor ◽  
Randall P. Morton
Keyword(s):  
Immunocompetent Patient ◽  
Predisposing Factors ◽  
High Index ◽  
Mucosal Barrier ◽  
Prolonged Treatment ◽  
Steroid Use ◽  
Disease Eradication ◽  
High Index Of Suspicion ◽  
Immunocompetent Patients ◽  
Do So

The diagnosis of fungal laryngitis is often overlooked in systemically immunocompetent patients because it is commonly considered a disease of the immunocompromised, and because it often mimics, clinically and histologically, more common and more serious conditions e.g. leukoplakia. A high index of suspicion is required to make the diagnosis, and should be considered in any immunocompetent patient with persistent or refractory laryngitis and factors predisposing to local mucosal barrier impairment e.g. gastropharyngeal reflux, smoking or inhaled steroid use. In such cases, demonstration of hyperkeratosis, particularly if associated with intraepithelial neutrophils, on biopsy should trigger a search for fungal elements using specialized stains. Prolonged treatment by systemic antimycotics is required. Treatment should also include the elimination of any predisposing factors, as failure to do so may result in difficulty with disease eradication or recurrence of the condition.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

Neurobrucellosis associated with feral swine hunting in the southern United States

2020 ◽  
Vol 13 (12) ◽  
pp. e238216
Author(s):  
Harry Ross Powers ◽  
Jared R Nelson ◽  
Salvador Alvarez ◽  
Julio C Mendez
Keyword(s):  
United States ◽  
At Risk ◽  
High Index ◽  
Southern United States ◽  
Endemic Country ◽  
Feral Swine ◽  
Neurological Sequelae ◽  
Initial Symptoms ◽  
The Usa ◽  
High Index Of Suspicion

Although uncommon, Brucella infection can occur outside the areas of high endemicity, such as the USA. In the southern USA, hunters of wild swine are at risk for brucellosis. We present a case of a patient with fever, headache and constitutional symptoms that were ongoing for 11 months. He was diagnosed with neurobrucellosis. The patient was treated successfully with intravenous ceftriaxone, oral doxycycline and oral rifampin therapy. He had persistent neurological sequelae after completing treatment. This case illustrates the high index of suspicion needed to diagnose neurobrucellosis in a non-endemic country because initial symptoms can be subtle. The disease can be treated successfully, but long-lasting neurological sequelae are common.

scholarly journals Deepening of In Silico Evaluation of SARS-CoV-2 Detection RT-qPCR Assays in the Context of New Variants

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 565
Author(s):  
Mathieu Gand ◽  
Kevin Vanneste ◽  
Isabelle Thomas ◽  
Steven Van Gucht ◽  
Arnaud Capron ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Severe Acute Respiratory Syndrome ◽  
In Silico ◽  
The Other ◽  
Viral Rna ◽  
Potential Threat ◽  
The World

For 1 year now, the world is undergoing a coronavirus disease-2019 (COVID-19) pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most widely used method for COVID-19 diagnosis is the detection of viral RNA by RT-qPCR with a specific set of primers and probe. It is important to frequently evaluate the performance of these tests and this can be done first by an in silico approach. Previously, we reported some mismatches between the oligonucleotides of publicly available RT-qPCR assays and SARS-CoV-2 genomes collected from GISAID and NCBI, potentially impacting proper detection of the virus. In the present study, 11 primers and probe sets investigated during the first study were evaluated again with 84,305 new SARS-CoV-2 unique genomes collected between June 2020 and January 2021. The lower inclusivity of the China CDC assay targeting the gene N has continued to decrease with new mismatches detected, whereas the other evaluated assays kept their inclusivity above 99%. Additionally, some mutations specific to new SARS-CoV-2 variants of concern were found to be located in oligonucleotide annealing sites. This might impact the strategy to be considered for future SARS-CoV-2 testing. Given the potential threat of the new variants, it is crucial to assess if they can still be correctly targeted by the primers and probes of the RT-qPCR assays. Our study highlights that considering the evolution of the virus and the emergence of new variants, an in silico (re-)evaluation should be performed on a regular basis. Ideally, this should be done for all the RT-qPCR assays employed for SARS-CoV-2 detection, including also commercial tests, although the primer and probe sequences used in these kits are rarely disclosed, which impedes independent performance evaluation.

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