scholarly journals Noninvasive assessment of peripheral skeletal muscle weakness in idiopathic pulmonary fibrosis: a pilot study with multiparametric MRI of the rectus femoris muscle

2020 ◽  
Vol 15 ◽  
Author(s):  
Wagner Diniz de Paula ◽  
Marcelo Palmeira Rodrigues ◽  
Nathali Mireise Costa Ferreira ◽  
Viviane Vieira Passini ◽  
César Augusto Melo-Silva
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Idiopathic Pulmonary Fibrosis ◽  
Rectus Femoris ◽  
Cross Sectional ◽  
Quadriceps Femoris Muscle ◽  
Fat Fraction ◽  
Rectus Femoris Muscle ◽  
Quadriceps Femoris Muscle Strength ◽  
Femoris Muscle

Background: To investigate differences in magnetic resonance imaging (MRI) features of rectus femoris muscle between idiopathic pulmonary fibrosis (IPF) patients and healthy volunteers.Methods: Thirteen IPF patients with GAP Index stage II disease were subjected to pulmonary function tests, 6-minute walk test (6MWT), quadriceps femoris muscle strength measurement and MRI of the thigh at rest. At MRI, muscle cross-sectional areas, T2 and T2* relaxometry, and 3-point Dixon fat fraction were measured. The results were compared to those of eight healthy sedentary volunteers.Results: IPF patients had significantly lower %predicted FVC, FEV1 and DLCO (p<0.001 for the three variables) and walked significantly less in the 6MWT (p=0.008). Mean quadriceps femoris muscle strength also was significantly lower in IPF patients (p=0.041). Rectus femoris muscle T2* measurements were significantly shorter in IPF patients (p=0.027). No significant intergroup difference was found regarding average muscle cross-sectional areas (p=0.790 for quadriceps and p=0.816 for rectus femoris) or rectus femoris fat fraction (p=0.901). Rectus femoris T2 values showed a non-significant trend to be shorter in IPF patients (p=0.055).Conclusions: Our preliminary findings suggest that, besides disuse atrophy, other factors such as hypoxia (but not inflammation) may play a role in the peripheral skeletal muscle dysfunction observed in IPF patients. This might impact the rehabilitation strategies for IPF patients and warrants further investigation.

EFICÁCIA DA CORRENTE AUSSIE NA MELHORA DA FORÇA DO QUADRÍCEPS EM INDIVÍDUOS RESTRITOS AO LEITO

2019 ◽  
Vol 22 (2) ◽  
pp. 112
Author(s):  
Filipe Abdalla dos Reis ◽  
Carolina Palma ◽  
Patrícia Isabel Machry Barbosa ◽  
Filipe Abdalla dos Reis ◽  
Daniel Martins Pereira
Keyword(s):  
Muscle Strength ◽  
Rectus Femoris ◽  
Treated Group ◽  
Quadriceps Muscle ◽  
Control Group ◽  
Cross Sectional ◽  
Significant Strength ◽  
The Right ◽  
Rectus Femoris Muscle ◽  
Femoris Muscle

O imobilismo acomete diversos sistemas tais como o gastrointestinal, urinário, cardiovascular, respiratório, cutâneo e musculoesqueléticoe intervenções precoces são necessárias para reduzir os problemas físicos e psicológicos. Objetivo: analisar a eficácia da corrente Aussie namelhora da força muscular do quadríceps em indivíduos restritos ao leito. Métodos: Participaram do estudo 12 indivíduos, sendo 7 homens e5 mulheres, distribuídos aleatoriamente em grupo controle (GC) e grupo tratado (GT). Utilizou-se a dinamometria isométrica (handheld) paraavaliação da força e, também, o ultrassom diagnóstico para avaliar a área de secção transversa do músculo reto femoral. Todos os participantes foram avaliados em dois períodos denominados de pré e pós. Resultados: Verificou-se redução significativa de força no GC coxa direita 2,5 N (p=0,047) e esquerda 3,8 N (p=0,008) nos momentos pré e pós. O GT apresentou ganho de força não significativa na coxa direita 4,9 N (p=0,117) e esquerda 3,2 N (p=0,107). Na ultrassonografia verificou-se no GC, redução não significativa na área da coxa direita 0,04 cm (p=0,283) e significativa na esquerda 0,06 cm (p=0,037). No GT houve redução não significativa coxa direita 0,13 cm (p=0,099) e significativa esquerda 0,22 cm (p=0,002). Conclusão: Pode-se inferir que a associação entre exercícios isométricos e corrente Aussie contribuiu para aumentar a força muscular do quadríceps em indivíduos com imobilidade ao leito.Palavras-chave: Força Muscular. Resposta de Imobilidade Tônica. Músculo Quadriceps.AbstractImmobilism affects several systems such as the gastrointestinal, urinary, cardiovascular, respiratory, cutaneous and musculoskeletal and earlyinterventions are necessary to reduce physical and psychological problems. Objective: to analyze the effectiveness of the Aussie current in the improvement of quadriceps muscle strength in bed restricted individuals. Methods: Twelve individuals, 7 males and 5 females, were randomly assigned to the control group (CG) and treated group (TG). The use of isometric dynamometry (handheld) for strength evaluation and also the diagnostic ultrasound to evaluate the cross-sectional area of the rectus femoris muscle. All participants were evaluated in two periods called pre and post. Results: There was a significant reduction of strength in the right thigh in CG 2.5 N (p = 0.047) and left 3.8 N (p = 0.008) in the pre and post moments. TG presented a non-significant strength gain in the right thigh 4.9 N (p = 0.117) and left 3.2 N (p = 0.107). Ultrasonography showed no significant reduction in the right thigh area 0.04 cm (p = 0.283) and significant at the left (0.06 cm) (p = 0.037). In the TG there was no significant reduction in the right thigh 0.13 cm (p = 0.099) and significant in the left one 0.22 cm (p = 0.002). Conclusion: It can be inferred that the association between isometric exercises and current Aussie contributed to increase the muscular strength of the quadriceps in individuals with immobility to bed.Keywords: Muscle Strength. Tonic Immobility Response. Quadriceps Muscle.

VALIDATION STUDY OF CADAVER RECTUS FEMORIS MUSCLE MEASUREMENT BY ULTRASONOGRAPHY AND ANATOMICAL PLANIMETRY

2008 ◽  
Vol 11 (04) ◽  
pp. 173-179 ◽  
Author(s):  
Wolfram Weinrebe ◽  
Dietmar Stippler ◽  
Sara Doll ◽  
Kurt Zahr ◽  
Ekkehart Jenetzky ◽  
...  
Keyword(s):  
Validation Study ◽  
Rectus Femoris ◽  
The Elderly ◽  
Accurate Method ◽  
Mean Difference ◽  
Muscle Size ◽  
Cross Sectional ◽  
Significant Difference ◽  
Rectus Femoris Muscle ◽  
Femoris Muscle

Ultrasonography is frequently used to measure the rectus femoris muscle cross-section area, and has been suggested to associate with poor health condition. However, no validation studies have been performed to compare rectus femoris muscle ultrasonography (RFMS) with anatomical planimetry when measuring the muscle cross-sectional area (CSA). This validation study compared the two methods of CSA measurement of unfixed (frozen) and fixed (unfrozen) rectus femoris muscle specimens obtained from elderly human cadavers. Agreement between tests was studied by Bland–Altman analysis. We found a significant difference between planimetry and RFMS of unfixed (frozen) muscle specimens (mean difference, -0.389 cm2; 95% CI, -0.144 to -0.634), p = 0.022. No significant difference was observed between the two methods when measuring fixed (unfrozen) muscle specimens (mean difference, 0.032 cm2, 95% CI, -0.007 to -0.070), p = 0.107. In fixed specimens, the 95% limit of agreement between the two methods ranged between 0.12 cm2 and -0.06 cm2 (<10% deviation); while in unfixed muscle specimens, the range was between 0.28 cm2 and -1.06 cm2 (~50% deviation). In light of the similar results obtained in fixed specimens, ultrasound is a safe and accurate method of rectus femoris muscle size assessment. In clinical practice, RFMS may be used to detect a decrease in rectus femoris muscle mass, typically associated with malnutrition of the elderly, and may therefore be a simple and practical tool for the screening of malnutrition.

scholarly journals Muscle-Skeletal Abnormalities and Muscle Oxygenation during Isokinetic Strength Exercise in Heart Failure with Preserved Ejection Fraction Phenotype: A Cross-Sectional Study

2022 ◽  
Vol 19 (2) ◽  
pp. 709
Author(s):  
Amanda Vale-Lira ◽  
Natália Turri-Silva ◽  
Kenneth Verboven ◽  
João Luiz Quagliotti Durigan ◽  
Alexandra Corrêa de Lima ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Muscle Strength ◽  
Rectus Femoris ◽  
Cross Sectional Study ◽  
Exercise Intolerance ◽  
Strength Exercise ◽  
Echo Intensity ◽  
Sectional Study ◽  
Cross Sectional

Exercise intolerance, a hallmark of patients with heart failure (HF), is associated with muscle weakness. However, its causative microcirculatory and muscle characteristics among those with preserved or reduced ejection fraction (HFpEF or HFrEF) phenotype is unclear. The musculoskeletal abnormalities that could result in impaired peripheral microcirculation are sarcopenia and muscle strength reduction in HF, implying lowered oxidative capacity and perfusion affect transport and oxygen utilization during exercise, an essential task from the microvascular muscle function. Besides that, skeletal muscle microcirculatory abnormalities have also been associated with exercise intolerance in HF patients who also present skeletal muscle myopathy. This cross-sectional study aimed to compare the muscle microcirculation dynamics via near-infrared spectroscopy (NIRS) response during an isokinetic muscle strength test and ultrasound-derived parameters (echo intensity was rectus femoris muscle, while the muscle thickness parameter was measured on rectus femoris and quadriceps femoris) in heart failure patients with HFpEF and HFrEF phenotypes and different functional severities (Weber Class A, B, and C). Twenty-eight aged-matched patients with HFpEF (n = 16) and HFrEF (n = 12) were assessed. We found phenotype differences among those with Weber C severity, with HFrEF patients reaching lower oxyhemoglobin (O2Hb, μM) (−10.9 ± 3.8 vs. −23.7 ± 5.7, p = 0.029) during exercise, while HFpEF reached lower O2Hb during the recovery period (−3.0 ± 3.4 vs. 5.9 ± 2.8, p = 0.007). HFpEF with Weber Class C also presented a higher echo intensity than HFrEF patients (29.7 ± 8.4 vs. 15.1 ± 6.8, p = 0.017) among the ultrasound-derived variables. Our preliminary study revealed more pronounced impairments in local microcirculatory dynamics in HFpEF vs. HFrEF patients during a muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging, which may help explain the commonly observed exercise intolerance in HFpEF patients.

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