A Clinically Useful Self-Report Measure of theDSM-5Anxious Distress Specifier for Major Depressive Disorder

Agreement has not been achieved across symptom factor studies of major depressive disorder, and no studies have identified characteristic postdisaster depressive symptom structures. This study examined the symptom structure of major depression across two databases of 1181 survivors of 11 disasters studied using consistent research methods and full diagnostic assessment, addressing limitations of prior self-report symptom-scale studies. The sample included 808 directly-exposed survivors of 10 disasters assessed 1–6 months post disaster and 373 employees of 8 organizations affected by the September 11, 2001 terrorist attacks assessed nearly 3 years after the attacks. Consistent symptom patterns identifying postdisaster major depression were not found across the 2 databases, and database factor analyses suggested a cohesive grouping of depression symptoms. In conclusion, this study did not find symptom clusters identifying postdisaster major depression to guide the construction and validation of screeners for this disorder. A full diagnostic assessment for identification of postdisaster major depressive disorder remains necessary.

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Cognitive Therapy for Major Depressive Disorder in Primary Care

The British Journal of Psychiatry ◽

10.1192/bjp.144.4.400 ◽

1984 ◽

Vol 144 (4) ◽

pp. 400-406 ◽

Cited By ~ 159

Author(s):

John D. Teasdale ◽

Melanie J. V. Fennell ◽

George A. Hibbert ◽

Peter L Amies

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Cognitive Therapy ◽

Comparison Group ◽

Psychological Treatment ◽

Antidepressant Medication ◽

Self Report ◽

Major Depressive ◽

Treatment As Usual ◽

Severity Of Depression

SummaryCognitive therapy for depression is a psychological treatment designed to train patients to identify and correct the negative depressive thinking which, it has been hypothesised, contributes to the maintenance of depression. General practice patients meeting Research Diagnostic Criteria for primary major depressive disorder were randomly allocated either to continue with the treatment they would normally receive (which in the majority of cases included antidepressant medication) or to receive, in addition, sessions of cognitive therapy. At completion of treatment, patients receiving cognitive therapy were significantly less depressed than the comparison group, both on blind ratings of symptom severity made by psychiatric assessors and on a self-report measure of severity of depression. At three-month follow-up cognitive therapy patients no longer differed from patients receiving treatment-as-usual, but this was mainly as a result of continuing improvement in the comparison group.

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The Inventory to Diagnose Depression (IDD): A self-report scale to diagnose major depressive disorder.

Journal of Consulting and Clinical Psychology ◽

10.1037/0022-006x.55.1.55 ◽

1987 ◽

Vol 55 (1) ◽

pp. 55-59 ◽

Cited By ~ 137

Author(s):

Mark Zimmerman ◽

William Coryell

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Self Report ◽

Major Depressive

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The effectiveness of intravenous ketamine in adults with treatment-resistant major depressive disorder and bipolar disorder presenting with prominent anxiety: Results from the Canadian Rapid Treatment Center of Excellence

Journal of Psychopharmacology ◽

10.1177/0269881120954048 ◽

2020 ◽

pp. 026988112095404

Author(s):

Roger S McIntyre ◽

Nelson B Rodrigues ◽

Orly Lipsitz ◽

Flora Nasri ◽

Hartej Gill ◽

...

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Depressive Symptomatology ◽

Rapid Onset ◽

Anxiety Symptoms ◽

Self Report ◽

Treatment Center ◽

Treatment Resistant ◽

Major Depressive

Background: Individuals meeting criteria for treatment-resistant depression (TRD) are differentially affected by high levels of anxiety symptoms. Aims: There is a need to identify the efficacy of novel rapid-onset treatments in adults with mood disorders and comorbid anxious-distress. Methods: This study included patients with treatment-resistant major depressive disorder (MDD) or bipolar disorder (BD) who were receiving intravenous (IV) ketamine treatment at a community-based clinic.Anxious-distress was proxied using items from the Quick Inventory of Depressive Symptomatology–Self Report 16-item (QIDS-SR16) and Generalized Anxiety Disorder 7-item (GAD7) scales. The difference in QIDS-SR16 total score, QIDS-SR16 suicidal ideation (SI) item and GAD7 score were analyzed between groups. Results: A total of 209 adults with MDD ( n = 177) and BD ( n = 26) were included in this analysis. From this sample, 94 patients (mean = 45 ± 13.9 years) met the criteria for anxious-distress. Individuals meeting the criteria for anxious-distress exhibited a significantly greater reduction in QIDS-SR16 total score following four infusions ( p = 0.02) when compared with patients not meeting the anxious-distress criteria. Both anxious-distressed and low-anxiety patients exhibited a significant reduction in SI ( p < 0.0001) following four infusions.Finally, there was a significantly greater reduction in anxiety symptoms in the anxious-distress group compared with the non–anxious distress group following three ( p = 0.02) and four infusions ( p < 0.001). Conclusion: Patients with TRD and prominent anxiety receiving IV ketamine exhibited a significant reduction in depressive, SI and anxiety symptoms.

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The effects of the interplay of genetics and early environmental risk on the course of internalizing symptoms from late childhood through adolescence

Development and Psychopathology ◽

10.1017/s0954579415000401 ◽

2015 ◽

Vol 28 (1) ◽

pp. 225-237 ◽

Cited By ~ 6

Author(s):

Rashelle J. Musci ◽

Katherine E. Masyn ◽

Kelly Benke ◽

Brion Maher ◽

George Uhl ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Internalizing Symptoms ◽

Latent Trait ◽

Self Report ◽

Health Concern ◽

Environment Interaction ◽

Major Depressive ◽

Polygenic Score ◽

Gene Environment

AbstractInternalizing symptoms during adolescence and beyond is a major public health concern, particularly because severe symptoms can lead to the diagnosis of a number of serious psychiatric conditions. This study utilizes a unique sample with a complex statistical method in order to explore Gene × Environment interactions found in internalizing symptoms during adolescence. Data for this study were drawn from a longitudinal prevention intervention study (n = 798) of Baltimore city school children. Internalizing symptom data were collected using self-report and blood or saliva samples genotyped using Affymetrix 6.0 microarrays. A major depression polygenic score was created for each individual using information from the major depressive disorder Psychiatric Genetics Consortium and used as a predictor in a latent trait–state–occasion model. The major depressive disorder polygenic score was a significant predictor of the stable latent trait variable, which captures time-independent phenotypic variability. In addition, an early childhood stressor of death or divorce was a significant predictor of occasion-specific variables. A Gene × Environment interaction was not a significant predictor of the latent trait or occasion variables. These findings support the importance of genetics on the stable latent trait portion of internalizing symptoms across adolescence.

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Sociodemographic Predictors of Response to Antidepressant Treatment

The International Journal of Psychiatry in Medicine ◽

10.2190/1td6-7nlx-nf5x-kv91 ◽

1997 ◽

Vol 27 (2) ◽

pp. 129-136 ◽

Cited By ~ 16

Author(s):

Maya Spillmann ◽

Joseph S. Borus ◽

Katharine G. Davidson ◽

John J. Worthington ◽

Joyce R. Tedlow ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Marital Status ◽

Employment Status ◽

Antidepressant Treatment ◽

Self Report ◽

Study Entry ◽

Major Depressive ◽

Sociodemographic Variables ◽

Level Of Education

Objective: Our goal was to assess whether sociodemographic variables such as gender, marital status, level of education, and employment status are related to the changes in social functioning that have been reported after drug treatment in outpatients with major depressive disorder. Method: Eligible subjects were 166 depressed outpatients participating in a study involving open treatment with fluoxetine 20 mg/day for eight weeks. Diagnosis of major depressive disorder was made with the use of the Structured Clinical Interview for DSM-III-R-Patient Edition (SCID-P), and patients were required to have a seventeen-item Hamilton Rating Scale for Depression (HAM-D-17) score ⩾ 16 at study entry. All subjects were administered the HAM-D-17 and the Social Adjustment Scale-Self-Report (SAS-SR) before and after treatment with fluoxetine. Results: We found that SAS-SR scores decreased significantly following treatment with fluoxetine from a mean score at baseline of 2.6 ± 0.7 to a mean score at endpoint of 2.3 ± 0.6. After adjusting for the degree of change in HAM-D-17 scores, we found a significant relationship between degree of change in SAS-SR and level of education. No statistically significant relationships were observed between SAS-SR change and age, gender, marital status, and employment status. Conclusion: The degree of improvement in psychosocial functioning observed in depressed outpatients following antidepressant treatment appears to be related to the level of education at study entry, but not to other sociodemographic variables. Further studies need to investigate the nature of this relationship.

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The Diagnostic Inventory for Depression: A self-report scale to diagnose DSM-IV major depressive disorder

Journal of Clinical Psychology ◽

10.1002/jclp.10207 ◽

2003 ◽

Vol 60 (1) ◽

pp. 87-110 ◽

Cited By ~ 74

Author(s):

Mark Zimmerman ◽

Thomas Sheeran ◽

Diane Young

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Self Report ◽

Major Depressive ◽

Dsm Iv

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Efficacy of brief dynamic interpersonal therapy in patients with major depressive disorder: a prospective, multicenter randomized controlled trial protocol

10.21203/rs.2.24389/v1 ◽

2020 ◽

Author(s):

Lanlan Wang ◽

Qian Wang ◽

Wenhui Jiang ◽

Jianfeng Luo ◽

Jun Tong ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Controlled Trial ◽

Self Report ◽

Hamilton Depression Scale ◽

Major Depressive ◽

Interpersonal Therapy ◽

Randomized Controlled ◽

Multicenter Randomized Controlled Trial

Abstract Background : Dynamic Interpersonal Psychotherapy (DIT) is a brief manualized depression-focused intervention. This paper describes a study protocol of a multi-site, three-arm randomized controlled trial comparing medication plus DIT to medication alone and medication plus an active control psychotherapy in the treatment of major depressive disorder (MDD). Methods : 240 patients with MDD will be randomly allocated on a 1:1:1 basis to the treatment conditions, with 80 patients in each group. Patients will be assessed pre-and post-intervention and at 6- and 12-months follow-up with the 17-item Hamilton Depression Scale (HAMD-17) and Hamilton Anxiety Scale (HAMA-14) administered by blind evaluators, and the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder-7-item scale(GAD-7), side effect reaction scale (TESS), and The Self-Assessment Scale of the Overall Efficacy and Satisfaction of Patients (SASE). The primary outcome is change from baseline in HAMD-17 scores. Secondary outcomes include rates of response, remission and relapse, change from baseline in self-report depression and measures of anxious symptomatology, and subjective satisfaction of patients. Discussion: This will be the first multicentered RCT in China to assess the potential efficacy of psychotherapy for MDD. The study has the potential to inform clinical treatment guidelines for the treatment of MDD in China. Trial registration : ChiCTR，ChiCTR1800016970， Registered on July 5 th 2018 - Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=28786 . Key words : Depression; Dynamic Interpersonal Therapy; Multicenter randomized controlled trial,

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Contribution of Religion/spirituality and Major Depressive Disorder to Altruism

10.31219/osf.io/ts9vn ◽

2020 ◽

Author(s):

Richard Neugebauer ◽

Priya Wickramaratne ◽

Connie Svob ◽

Clayton McClintock ◽

Marc J. Gameroff ◽

...

Keyword(s):

Major Depressive Disorder ◽

High Risk ◽

Depressive Disorder ◽

Posttraumatic Growth ◽

Risk Group ◽

Statistical Significance ◽

Positive Association ◽

High Risk Group ◽

Self Report ◽

Major Depressive

Background. In most studies, religiosity and spirituality (R/S) are positively associated with altruism, whereas depression is negatively associated. However, the cross-sectional designs of these studies limit their epidemiological value. We examine the association of R/S and major depressive disorder (MDD) with altruism in a five year longitudinal study nested in a larger prospective study.Methods. Depressed and non-depressed individuals and their first- and second-generation offspring were assessed over several decades. At Year30 after baseline, R/S was measured using participants’ self-report; MDD, by clinical interview. At Year35, participants completed a measure of altruism. Adjusted odds ratios (AOR) were calculated using multivariate logistic regression; statistical significance, set at p<.05. two-tailed.Results. In the overall sample, both R/S and MDD were significantly associated with altruism, AOR 2.52 (95% CI 1.15-5.49) and AOR 2.43 (95% CI 1.05-5.64), respectively; in the High Risk group alone, the corresponding AORs were 4.69 (95% CI 1.39-15.84) and 4.74 (95% CI 1.92-11.72). Among highly R/S people in the High Risk group, the AOR for MDD with altruism was 22.55 (95% CI 1.23-414.60) p<.04; among the remainder, it was 3.12 (95% CI 0.63-15.30), a substantial but non-significant difference.Limitations. Altruism is based on self-report, not observation, hence, vulnerable to bias.Conclusions. MDD’s positive association with elevated altruism concurs with studies of posttraumatic growth in finding developmental growth from adversity. The conditions that foster MDD’s positive association with altruism and the contribution of R/S to this process requires further study.

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