Aim. To evaluate intima-media thickness, interadventitial diameter of common carotid arteries and their ratio in patients with type 2 diabetes mellitus as well as in combination with metabolic syndrome, previously not receiving statins.
Methods. The results of Doppler ultrasound of common carotid arteries of 233 patients were analyzed. 73 of them were diagnosed with type 2 diabetes (49 males, 24 females, average age 59.2±9.13 years), 74 - in combination with metabolic syndrome (38 males, 36 females, average age 61.38±9.16 years), and 86 did not have neither type 2 diabetes nor metabolic syndrome (52 males and 34 females, average age 58.99±7.23 years). For variables with normal distribution, mean value (M) and error of mean (m) were used, and when comparing nonparametric parameters, distribution in contingency table and χ2 was used.
Results. Mean values of intima-media thickness of common carotid arteries and the ratio of intima-media thickness to interadventitial diameter were significantly higher (p <0.05), and interadventitial diameter was significantly lower (p <0.05) in the subgroups of patients with type 2 diabetes alone and in combination with metabolic syndrome compared to patients without these diseases. Significantly more frequently the cases of increased intima-media thickness and decreased interadventitial diameter of common carotid arteries were revealed on both sides in the subgroups with type 2 diabetes alone and combined with metabolic syndrome (p <0.001), that resulted in increased ratio of intima-media thickness to interadventitial diameter being indicative of general increase of arterial wall stiffness and decreased ability to compensatory remodeling in these categories of patients.
Conclusion. In patients with type 2 diabetes mellitus and its combination with metabolic syndrome previously not receiving statins, the values of intima-media thickness, interadventitial diameter and their ratio statistically significantly differ frome those in patients without type 2 diabetes and metabolic syndrome; the presence of metabolic syndrome does not influence values of intima-media thickness, interadventitial diameter and their ratio in patients with type 2 diabetes mellitus.
Risk Factors for the Progression of Intima-Media Thickness of Carotid Arteries: A 2-Year Follow-Up Study in Patients with Newly Diagnosed Type 2 Diabetes
