scholarly journals Idiopathic granulomatous mastitis

2011 ◽  
Vol 15 (1) ◽  
pp. 4
Author(s):  
Grace Rubin ◽  
Debra Ardath Meerkotter
Keyword(s):  
Breast Carcinoma ◽  
Medical Treatment ◽  
Immunosuppressive Therapy ◽  
Core Biopsy ◽  
Fungal Infections ◽  
Rare Condition ◽  
Surgical Excision ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Ultrasound Features

The rare condition of idiopathic granulomatous mastitis (IGM) is presented here, unusually, in a 54-year-old woman. IGM mimics breast carcinoma and further differentials include tuberculosis and fungal infections of the breast together with other chronic granulomatous conditions. Of note is its characteristic ultrasound features that can suggest the diagnosis. Diagnosis is made by core biopsy and histology. Patients have been shown to respond to steroid and other immunosuppressive therapy, with surgical excision reserved for those whose condition is recurrent and unresponsive to medical treatment.

scholarly journals Out Come of Wide Local Excision with and without Corticosteroid Therapy in Management of Idiopathic Granulomatous Mastitis

2021 ◽  
Vol 107 (1_suppl) ◽  
pp. 13-13
Author(s):  
R Amira Maher ◽  
Ahmed Gamal Eldin Osman ◽  
K Fahmy ◽  
Shinamwi M ◽  
Osama Al Atarash
Keyword(s):  
Recurrence Rate ◽  
Corticosteroid Therapy ◽  
Surgical Excision ◽  
Cosmetic Outcome ◽  
Systemic Steroid ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Palpable Mass ◽  
Group A ◽  
Group B

Introduction: Idiopathic granulomatous mastitis is a rare benign breast disease. Initial reports from hospitals in Egypt from Departments of Pathology at Cancer Institutes of Cairo, Tanta and Mansoura Universities; indicate that the disease is not as rare as that in the developed countries. It often mimics breast carcinoma both clinically and radiologically. Histological examination is the gold standard for diagnosis. Management of Idiopathic granulomatous mastitis is still debatable. In our study, we aimed to evaluate the addition of corticosteroid therapy to surgical excision in management of idiopathic granulomatous mastitis. Patients and Methods: This is a comparative study was conducted at Ain-Shams University Hospital’s breast clinic on patients with idiopathic granulomatous mastitis from to August 2015 till September 2018. Thirty patients were divided into 2 groups. Group (A) includes patients who underwent surgical management only. Group (B) includes patients who received corticosteroid therapy according to the severity of the cases then surgical Excision was done for the residual lesion. Follow up of all cases up to 1-2 years was done to document the recurrence rate and compare the cosmetic outcome of both groups. Informed consent was obtained from all patients included in the study. Results: The mean age of the affected women was 38.80 and 33.13 in group (A) and group (B), respectively and it wasn’t statistically different (p value = 0.099). The most common presenting symptom was a palpable mass in the breast (66.7% and 93.3%) in group (A) and group (B) respectively. Recurrence rate was higher in group (A) (40%) with no recurrence documented in group (B) however 2 cases were omitted from the study due to steroid noncompliance and complications. Cosmetic outcome was excellent in 76.9% of group (B) and good in 53.3% of group (A). Conclusion: Systemic steroid therapy with surgical resection is the recommended as first-line treatment strategy for IGM as it shows less recurrence rate and surgical scarring. Increased awareness of IGM will increase their understanding and improve their management.

scholarly journals Idiopathic granulomatous mastitis: challenges of treatment in iranian women

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Leyla Shojaee ◽  
Nasrin Rahmani ◽  
Siavash Moradi ◽  
Asieh Motamedi ◽  
Gholamali Godazandeh
Keyword(s):  
Recurrence Rate ◽  
Low Dose ◽  
Unknown Origin ◽  
Surgical Excision ◽  
Chronic Inflammatory Disease ◽  
High Dose ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Results Of Treatment ◽  
Information Treatment

Abstract Background and objective As a chronic inflammatory disease of an unknown origin, the treatment of granulomatous mastitis has always been controversial. According to some researchers, surgical treatment and certain medications, especially steroids, are more effective in treating the disease. This study aimed at evaluating the results of treatment in a group of patients with granulomatous mastitis. Materials and methods This longitudinal cohort study evaluated the treatment outcomes of 87 patients with pathology-confirmed granulomatous mastitis referred to the surgical clinic of Central Hospital in Sari, Iran. Demographic, clinical, and pathological information, treatment methods and results, and the recurrence rate were analyzed. Findings A total of 87 female patients with granulomatous mastitis aged 22–52 years with a mean age of 34 years were evaluated. All patients had palpable masses; the breast masses were painful in 48.3% of patients, and 55.2% of patients suffered from erythema and inflammation, and8% had fistulas and ulcers at the inflammation site. The patients were followed-up for an average duration of 26 months (8–48 months) after treatment and recovery. The overall recurrence rate was 24.1%, and the recurrence rate was 29.4% in patients underwent surgery, 34.8% in patients received high-dose prednisolone, and 17% in those received low-dose prednisolone together with drainage (p < 0.001). Conclusions According to the results, the low-dose prednisolone plus drainage was more effective with a lower recurrence rate than only surgical excision or high-dose prednisolone. In fact, the use of minimally invasive methods such as drainage plus low-dose steroids is a more effective method with fewer side effects than the other two methods.

scholarly journals Granulomatous Mastitis: A Rare Cause of Male Breast Lump

2016 ◽  
Vol 9 (2) ◽  
pp. 516-519 ◽  
Author(s):  
Abdel Rahman A. Al Manasra ◽  
Mohammad F. Al-Hurani
Keyword(s):  
Breast Tissue ◽  
Nipple Discharge ◽  
Surgical Excision ◽  
Male Breast ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Radiologic Findings ◽  
Female Breast ◽  
The Right ◽  
Histopathologic Findings

Background: Mastitis is a common benign disorder of the female breast. It is frequently associated with tenderness, swelling and nipple discharge. We are describing an extremely rare case of an idiopathic granulomatous mastitis in the male breast. Only 1 previous case was reported. Case Report: A 29-year-old male patient presented with a hard, painless lump in the right breast of 2 weeks duration. The patient underwent surgical excision with margin. The histopathologic findings were consistent with granulomatous mastitis. The case was reported as idiopathic granulomatous mastitis after exclusion of all known causes of the disease. Conclusion: Granulomatous mastitis is rare in females and extremely rare in male breast tissue. Since this disease mimics breast cancer in its clinical picture and radiologic findings are usually not conclusive, surgical excision is recommended in all cases.

scholarly journals Idiopathic Granulomatous Mastitis Presenting in a Patient With Hypothyroidism and Recent Hospitalization for Myxedema Coma: A Rare Case Report and Review of Literature

2020 ◽  
Vol 8 ◽  
pp. 232470962094932
Author(s):  
Stephen Bell ◽  
Ricardo Villasmil ◽  
Natalia Lattanzio ◽  
Qassem Abdelal ◽  
Alan King ◽  
...  
Keyword(s):  
Rare Condition ◽  
Inflammatory Disorder ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Myxedema Coma ◽  
Inflammatory Conditions ◽  
Noticeable Improvement ◽  
Rare Case Report ◽  
Ulcerative Lesions ◽  
Breast Inflammation

Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast. Clinical features may include painful breasts, erythema, subcutaneous nodules, and ulcerative lesions. It can mimic various other breast pathologies, and it is a diagnosis of exclusion after infection, malignancy, and other inflammatory conditions have been ruled out. In this article, we present a case of IGM developing in a 40-year-old female 3 months after hospitalization for myxedema coma. A contrast-enhanced magnetic resonance imaging of the breasts showed bilateral edema, and a biopsy was negative for malignancy or infection. She was started on prednisone and had noticeable improvement of ulcerations within several weeks. IGM is a rare condition that requires a multimodal treatment approach. Often recalcitrant disease is encountered and requires surgical intervention, immunosuppression, and antimicrobial therapy. The diagnosis should be entertained in patients with bilateral breast inflammation to avoid unnecessary surgical resection early on.

Corticosteroid treatment and timing of surgery in idiopathic granulomatous mastitis confusing with breast carcinoma

2010 ◽  
Vol 123 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Fazilet Erozgen ◽  
Yeliz E. Ersoy ◽  
Murat Akaydin ◽  
Naim Memmi ◽  
Aysun Simsek Celik ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Corticosteroid Treatment ◽  
Timing Of Surgery ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

A clinicopthologic study of a rare clinical entity mimicking breast carcinoma: idiopathic granulomatous mastitis

The Breast ◽  
2000 ◽  
Vol 9 (1) ◽  
pp. 52-56 ◽  
Author(s):  
Y. Erhan ◽  
A. Veral ◽  
E. Kara ◽  
N. Özdemir ◽  
M. Kapkac ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Clinical Entity ◽  
Rare Clinical Entity ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

scholarly journals Management of Idiopathic Granulomatous Mastitis Diagnosed by Core Biopsy: A Retrospective Multicenter Study

2013 ◽  
Vol 19 (4) ◽  
pp. 411-418 ◽  
Author(s):  
Ebru Şen Oran ◽  
Sibel Özkan Gürdal ◽  
Yücel Yankol ◽  
Meltem Öznur ◽  
Zerrin Calay ◽  
...  
Keyword(s):  
Multicenter Study ◽  
Core Biopsy ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Retrospective Multicenter Study

Treatment Modality of Idiopathic Granulomatous Mastitis with Surgery Alone or in Combination with Steroid

2021 ◽  
Vol 7 (1) ◽  
pp. 924-926
Author(s):  
Nilufar Shabnam ◽  
Md Iqbal Mahmud Choudhury ◽  
Tazin Ahsan
Keyword(s):  
Wide Spectrum ◽  
Surgical Excision ◽  
Disease Diagnosis ◽  
Chronic Inflammatory Disease ◽  
Fistula Formation ◽  
Controlled Clinical Trial ◽  
Granulomatous Mastitis ◽  
Inflammatory Mass ◽  
Idiopathic Granulomatous Mastitis ◽  
Therapeutic Modalities

Background: Idiopathic Granulomatous Mastitis (IGM) is a rare chronic inflammatory disease. Diagnosis and treatment is still a challenge because of obscure etiology and rareness. Owing to wide spectrum of IGM it is difficult to standardize and optimize the treatment. The aim of our study was to evaluate the outcome of surgical excision or in combination with steroid in treating IGM. Methodology: A randomized controlled clinical trial was done in BIRDEM (Bangladesh Institute of Research and Rehabilitation of Diabetic, Endocrine and Metabolic Disorder) Hospital, Dhaka, Bangladesh from July’2008 to June’2018. Overall 82 patients met the inclusion criteria. We analyzed therapeutic modalities and compared the patients’ outcomes based on treatment. Results: All patients underwent wide excision with clear margin under general anesthesia. Post operatively steroid was given in 41 patients. Duration of steroid therapy was 6 months after surgery. We have seen that recovery time was short in steroid group (Gr-II) average 167.07 days in compared without steroid (Gr l) average 253.28 days. Patients who underwent surgery only (GR-I) about 49.90% patients experienced recurrence (e.g. fistula formation and inflammatory mass etc.) On the other hand, 12.1% patients developed recurrences that were treated with steroid following surgery (Gr-II). Conclusion: Surgery with steroid is more effective in treatment of idiopathic granulomatous mastitis than surgery alone. Bioresearch Commu. 7(1): 924-926, 2021 (January)

scholarly journals Idiopathic granulomatous mastitis mimicking inflammatory breast carcinoma: What are the odds?

IDCases ◽  
2016 ◽  
Vol 6 ◽  
pp. 83-84 ◽  
Author(s):  
B. Zulfiqar ◽  
U. Appalaneni ◽  
B. Ahmed ◽  
A. Hassan ◽  
P. Boddu ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Inflammatory Breast Carcinoma

Surgical outcome of lobular neoplasia diagnosed in core biopsy: Prospective study of 316 cases.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 4-4 ◽  
Author(s):  
Barbara Susnik ◽  
Deborah Day ◽  
Janet Krueger ◽  
Ellen Abeln ◽  
Tara Bowman ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Prospective Study ◽  
Core Biopsy ◽  
Lobular Carcinoma ◽  
Positive Family History ◽  
Surgical Excision ◽  
Lobular Neoplasia ◽  
Group I ◽  
Atypical Lobular Hyperplasia ◽  
Mass Lesions

4 Background: Recommendations for management of lobular neoplasia (LN) including lobular carcinoma in situ (LCIS) or atypical lobular hyperplasia (ALH) diagnosed in core biopsy specimens (CB) are controversial. The aim of our prospective study is to identify subset of patients with LN diagnosed in CB who do not require subsequent surgical excision (SE). Methods: All patients with a diagnosis of ALH or LCIS on CB were referred for SE. Cases with coexistent DCIS or invasive breast carcinoma were excluded. Cases with coexistent ductal atypia including FEA or ADH (LN-DA) and LCIS variants including pleomorphic or necrotic LCIS (LN-V) were separated from classic LN (LN-C). Dedicated breast pathologists and radiologists reviewed all cases with careful imaging/pathology (IP) correlation. Results: From June 2008 to December 2013, 13,772 percutaneous breast CB procedures were performed. A total of 370 patients with LN diagnosed on CB were referred to SE. 302 (82%) patients with 316 lesions underwent SE within 2 months after initial diagnosis. Average age was 55.3, 27% had positive family history and 4% had previous breast carcinoma. After patients with synchronous ipsilateral CB showing cancer were excluded (20 patients) from upgrade analysis, the diagnostic groups included 228 LN-C, 15 LN-V and 53 LN-DA. In the LN-C group I/P discordance represented 6/228 cases (2.6%). Upgrade to carcinoma of LN-C varied between discordant (6/6) and concordant cases (8/222=3.6%). In comparison, upgrades were seen in 26.7% LN-V (4/15), and 28.3% LN-DA (15/53). For concordant LN-C, the imaging target was calcifications in 176/222 cases (81%); 7 were associated with upgrade (3.9%). Upgrades were rare for MRI targeted lesions (0/14) and mass lesions (1/32). Overall, upgrades were similar for ALH and LCIS (3.4% vs. 4.5 %). Conclusions: While LN with nonclassic morphology or with associated ductal atypia requires SE, this can be avoided in classic LN diagnosed on CB targeting calcifications when careful imaging/pathology correlation is applied; the likelihood of unsuspected cancer diagnosis is minimal and limited to coincidental cases. Until larger numbers are studied, excising classic LN diagnosed as masses or MRI detected lesions may be prudent.

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