scholarly journals Prevalence of fungal hyphae in potentially malignant lesions and conditions-does its occurrence play a role in epithelial dysplasia?

2015 ◽  
Vol 19 (1) ◽  
pp. 10 ◽  
Author(s):  
BhagyalaxmiPraveen Hongal ◽  
VenkateshV Kulkarni ◽  
PriyaShirish Joshi ◽  
PrasadPrakash Karande ◽  
AdilS Shroff ◽  
...  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Karin Berria Tomazelli ◽  
Filipe Modolo ◽  
Elena Riet Correa Rivero

Oral squamous cell carcinoma (OSCC) is usually preceded by detectable mucosal changes, as leukoplakias and erythroplakia. Histologically, these lesions can range from hyperkeratosis and acanthosis to epithelial dysplasia and even OSCC. The aim of this study was to investigate the proliferative activity, using AgNORs quantification proteins, in low- and high-risk oral epithelial dysplasia, OSCC, and nondysplastic epithelium (inflammatory fibrous hyperplasia). The sample was divided into 4 groups: G1: 10 cases of inflammatory fibrous hyperplasia (IFH), G2: 11 cases of low-risk epithelial dysplasia (LD), G3: 10 cases of high-risk epithelial dysplasia (HD), and G4: 11 cases of OSCC. The quantitative analysis was performed using an image processing software in photomicrographs at 1000x magnification. The one-way ANOVA was used for comparison of the mean AgNORs counts between the study groups. The mean AgNORs count was significantly higherP≤0.01in OSCC when compared to IFH and the LD; however, it was not statistically different from HD. The mean number of LD was significantly lower than the HD and OSCC, with no difference related to IFH. AgNORs quantification can be an important and cheap method to help in the determination of the degree of epithelial dysplasia and, consequently, in the analysis of their potential for malignant transformation.


Author(s):  
M. Reyes ◽  
G. Rojas-Alcayaga ◽  
A. Maturana ◽  
JP. Aitken ◽  
C. Rojas ◽  
...  

Author(s):  
ACIR JOSÉ DIRSCHNABEL ◽  
JANAINA PITT ◽  
FRANCIELLE KAFER ◽  
CAMILA PEZZINI ◽  
LEA MARIA FRANCESCHI DALLANORA ◽  
...  

2021 ◽  
pp. 1-7
Author(s):  
Vasudha Singh ◽  
Mudita Bhargava ◽  
Kachnar Varma ◽  
Vatsala Misra ◽  
Richa Singh

<b><i>Introduction:</i></b> Incidence of oral epithelial dysplasia and oral squamous cell carcinoma (SCC) is very high in south Asian countries as compared to western population owing to a greater use of tobacco in these regions. While visual examination and exfoliative cytology are the most common screening and diagnostic modalities at present, it is a subjective analysis. Quantitative analyses such as nuclear size, cell size, and nuclear-to-cytoplasmic ratio may provide an accurate diagnosis and improve reproducibility. The aim of the study was to evaluate the role of morphometry as a diagnostic adjunct to exfoliative cytology and to derive a significant cutoff to identify the population at risk for development of SCC among chronic tobacco users. <b><i>Material and Methods:</i></b> This was an outpatient-based prospective study done in a tertiary hospital over a period of 2 years. Hundred and fifty cases with a history of chronic tobacco use for a minimum period of 5 years were evaluated. Visual inspection using acetic acid was done. Oral scrapes were taken for cytological and morphometric analysis followed by incision biopsy for histopathological evaluation, wherever possible. <b><i>Results:</i></b> On morphometrical analysis, mean nuclear area and nuclear:cytoplasmic (N:C) ratio increased, while the cytoplasmic area decreased from smears with normal cytology to oral dysplasia to SCC. Analysis of variance and post hoc Tukey’s honest significant difference test showed a statistically significant difference among the 3 groups (<i>p</i> value &#x3c;0.05). A cutoff value for a significant N:C ratio was calculated as ≥0.08 using Youden’s index with a sensitivity and a specificity of 88% and 94%, respectively. <b><i>Conclusion:</i></b> In high-risk cases, morphometry can be a useful adjunct to exfoliative cytology and visual examination for an early and accurate diagnosis and timely intervention in oral potentially malignant and malignant lesions, thereby improving the prognosis.


2008 ◽  
Vol 37 (6) ◽  
pp. 358-363 ◽  
Author(s):  
Roberto Navone ◽  
Monica Pentenero ◽  
Isabella Rostan ◽  
Paola Burlo ◽  
Andrea Marsico ◽  
...  

2020 ◽  
pp. 2797-2827
Author(s):  
John Gibson ◽  
Douglas Robertson

Many systemic diseases are associated with oral symptoms or signs, hence thorough examination of the lips, gums, teeth, tongue, and oropharynx should be part of any complete physical examination of a patient. Dental caries, caused by bacterial action, is one of the commonest human diseases and a cause of considerable misery. Chronic periodontal disease is the most important cause of dental loss in adults. In addition to describing these conditions, this chapter also covers potentially malignant lesions of the oral mucosa and oral cancer; viral, fungal, and bacterial infections; oral ulceration; oral manifestations of dermatological, gastroenterological, haematological, and multisystem disorders; orofacial pain syndromes; and salivary gland disorders.


2008 ◽  
Vol 74 (8) ◽  
pp. 739-742 ◽  
Author(s):  
Vincent E. Mortellaro ◽  
Julia Marshall ◽  
Steven E. Harms ◽  
Steven N. Hochwald ◽  
Edward M. Copeland ◽  
...  

Pathologic nipple discharge often presents a diagnostic and therapeutic dilemma for clinicians. We present two patients with pathologic nipple discharge in whom breast MR facilitated preoperative identification of and management of otherwise occult index lesions. Breast MR should be considered in the toolbox for evaluation of occult nipple discharge when other available strategies have failed to demonstrate an underlying etiology for the pathologic discharge. The use of breast MR in this setting may permit directed evaluation and management of potentially malignant lesions.


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