scholarly journals Thyroid Hormone Levels in Apparently Euthyroid Subjects with Essential Hypertension in a Tertiary Hospital in Nigeria

2013 ◽  
Vol 5 (01) ◽  
pp. 26-29 ◽  
Author(s):  
Abiodun Mathias Emokpae ◽  
Aliyu Abdu ◽  
Humphrey Benedo Osadolor
Keyword(s):  
Essential Hypertension ◽  
Thyroid Hormone ◽  
Medical Information ◽  
Young Patients ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Thyroid Disorder ◽  
Major Health Problem ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

ABSTRACT Background: High blood pressure (BP) is a major health problem in Nigeria and the involvement of thyroid hormones in this condition has not been evaluated in this center. Objective: The objective of this study was to evaluate the proportion of patients with an essential hypertension who had abnormal thyroid hormone levels and the type of thyroid disorders commonly observed in this group of patients. Materials and Methods: A retrospective study of 94 patients (30 males, aged 30.4 ± 2 years and 64 females, aged 43.4 ± 1.3 years) with essential hypertension was carried out between January 2005 and December 2007. Demographic and other medical information were obtained from the health records. Analysis of laboratory results of triiodothyronine (T3), Thyroxine (T4), and thyroid stimulating hormone (TSH) were made. Results: Of the 94 patients evaluated, 26 (27.7%) had abnormal thyroid hormone levels, with 23.4% having hyperthyroidism, 4.3% had sub-clinical hypothyroidism and none had overt hypothyroidism. Of the 26 subjects with abnormal thyroid hormone levels, 18 (69.2%) were females while 8 (30.8%) were males. Out of the 18 female subjects with abnormal thyroid hormone levels, 16 had hyperthyroid levels while 2 had sub-clinical hypothyroid levels. Out of the 8 male patients, 6 had hyperthyroid hormone levels while 2 had sub-clinical hypothyroid levels. Conclusion: Thyroid hormone abnormalities are common in patients with essential hypertension. Hyperthyroidism was the most common thyroid disorder observed. Young patients presenting with essential hypertension should be screened for thyroid hormone abnormalities since they can best be managed by treating the underlying causes.

scholarly journals Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester

2017 ◽  
Vol 21 (1) ◽  
pp. 17-21
Author(s):  
Nandita Hazra ◽  
Binay Mitra ◽  
Reetika Pal
Keyword(s):  
Thyroid Hormone ◽  
Pregnant Women ◽  
Reference Intervals ◽  
Thyroid Stimulating Hormone ◽  
Specific Reference ◽  
Indian Women ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Maternal Thyroid ◽  
Stimulating Hormone

ABSTRACT Aim Maternal thyroid hormone levels during pregnancy are vital for the health of the mother as well as the developing child. Fetal growth is affected by maternal thyroid levels. Various physiological changes like alterations of thyroxine-binding globulins, human chorionic gonadotropin level, and changes in iodide metabolism affect maternal thyroid hormone levels. Therefore, reference intervals (RIs) for thyroid hormones in pregnant population require to be established separately from the general population. Materials and methods The RIs of serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were determined in healthy pregnant women by enzyme-linked immunosorbent assay (ELISA) technique after segregating them into three trimesters. This study was conducted in a 492-bedded zonal-level hospital. The reference population was chosen from a study population of pregnant women by strict inclusion and exclusion criteria. The assays were done by the most-commonly used, economical ELISA method employing standard kits. Tests were done using accurate and precise methods with proper quality control measures. Results The RIs were calculated from the central 95% of distribution of total T3, total T4, and TSH values located between 2.5 and 97.5 percentile values. The 0.90 confidence intervals for the upper and lower reference limits were calculated. The values thus obtained were different from those provided by the manufacturer kit literature. Conclusion It is recommended to determine one's own laboratory-specific, method-specific, trimester-wise RIs for maternal thyroid hormone status and use them for screening of pregnant women. How to cite this article Chakrabarty BK, Mitra B, Pal R, Hazra N. Specific Reference Intervals of Serum Triiodothyronine, Thyroxine, and Thyroid-stimulating Hormone in Normal Pregnant Indian Women as per Trimester. Indian J Med Biochem 2017;21(1):17-21.

Suppressed Serum TSH with Normal Free Thyroid Hormone Levels in Patients with No History of Thyroid Disorder

1989 ◽  
Vol 76 (s20) ◽  
pp. 45P-45P
Author(s):  
DJ Stott ◽  
J Finlayson ◽  
AR McLellan ◽  
P Chu ◽  
WD Alexander
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Disorder ◽  
Hormone Levels ◽  
Free Thyroid Hormone ◽  
History Of ◽  
Thyroid Hormone Levels ◽  
Serum Tsh

scholarly journals Association of High Vitamin D Status with Low Circulating Thyroid-Stimulating Hormone Independent of Thyroid Hormone Levels in Middle-Aged and Elderly Males

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Qingqing Zhang ◽  
Zhixiao Wang ◽  
Min Sun ◽  
Mengdie Cao ◽  
Zhenxin Zhu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Hormone ◽  
Smoking Status ◽  
Thyroid Stimulating Hormone ◽  
Vitamin D Status ◽  
Middle Aged ◽  
Hormone Levels ◽  
Elderly Males ◽  
Thyroid Hormone Levels ◽  
Tsh Levels

Background. A recent study has reported that high circulating 25-hydroxyvitamin D [25(OH)D] is associated with low circulating thyroid-stimulating hormone (TSH) levels, but only in younger individuals. The goal of the present study was to explore the relationship between vitamin D status and circulating TSH levels with thyroid autoimmunity and thyroid hormone levels taken into consideration in a population-based health survey of middle-aged and elderly individuals.Methods. A total of 1,424 Chinese adults, aged 41–78 years, were enrolled in this cross-sectional study. Serum levels of 25(OH)D, TSH, thyroid hormones, and thyroid autoantibodies were measured.Results. The prevalence of vitamin D insufficiency was 94.29% in males and 97.22% in females, and the prevalence of vitamin D deficiency was 55.61% in males and 69.64% in females. Vitamin D status was not associated with positive thyroid autoantibodies after controlling for age, gender, body mass index, and smoking status. Higher 25(OH)D levels were associated with lower TSH levels after controlling for age, FT4 and FT3 levels, thyroid volume, the presence of thyroid nodule(s), and smoking status in males.Conclusion. High vitamin D status in middle-aged and elderly males was associated with low circulating TSH levels independent of thyroid hormone levels.

scholarly journals DIAGNOSIS OF ENDOCRINE DISEASE: How reliable are free thyroid and total T3 hormone assays?

2016 ◽  
Vol 175 (6) ◽  
pp. R255-R263 ◽  
Author(s):  
Kerry J Welsh ◽  
Steven J Soldin
Keyword(s):  
Thyroid Hormone ◽  
Reference Method ◽  
Reference Interval ◽  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Disease States ◽  
Number Of Patients ◽  
Liquid Chromatography Tandem Mass ◽  
Thyroid Hormone Levels

Hypothyroidism is a very common disorder worldwide, for which the usual treatment is monotherapy with levothyroxine (L-T4). However, a number of patients treated with L-T4 continue to report symptoms of hypothyroidism despite seemingly normal levels of thyroid-stimulating hormone (TSH), free-T3 (FT3) and free-T4 (FT4) measured by immunoassay. This review summarizes the limitations of the immunoassays commonly used to measure thyroid hormone levels and emphasizes the advantages of the role of liquid chromatography-tandem mass spectrometry (LC-MS/MS). Immunoassays for free thyroid hormone are affected by alterations in serum binding proteins that occur in many physiological and disease states. Multiple studies show falsely normal values for T3, FT3 and FT4 by immunoassay that are below the reference interval when measured by (ultrafiltration) LC-MS/MS, a reference method. We suggest evaluation of thyroid hormone levels by ultrafiltration LC-MS/MS for patients who continue to experience hypothyroid symptoms on LT-4. This may help identify the approximately 20% subset of patients who would benefit from addition of T3 to their treatment regimen (combination therapy).

Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression

2019 ◽  
Vol 108 (3) ◽  
pp. 232-243 ◽  
Author(s):  
Shuming Zhong ◽  
Guanmao Chen ◽  
Lianping Zhao ◽  
Yanbin Jia ◽  
Feng Chen ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Frequency Band ◽  
Thyroid Stimulating Hormone ◽  
Intrinsic Activity ◽  
Frequency Bands ◽  
Hormone Levels ◽  
Bipolar Ii ◽  
Serum Thyroid Hormone ◽  
Thyroid Hormone Levels ◽  
The Right

Background/Aims: Although abnormalities of amplitude of low-frequency fluctuations (ALFF) and hormone levels of hypothalamus-pituitary-thyroid axis have been reported in patients with bipolar disorder (BD), the association between abnormal ALFF and serum thyroid hormone levels remains unknown. Method: A total of 90 patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging, and then routine band (0.01–0.1 Hz), slow-5 band (0.01–0.027 Hz), and slow-4 band (0.027–0.073 Hz) ALFF analysis were performed. Additionally, serum thyroid hormone levels including free tri-iodothyronine (FT3), total tri-iodothyronine (TT3), free thyroxin (FT4), total thyroxin (TT4), and thyroid-stimulating hormone (TSH) were detected. The correlation between abnormal serum thyroid hormone levels and ALFF values in patients with BD II depression was calculated. Results: Compared with the HCs, patients with BD II depression showed decreased ALFF in bilateral precuneus (PCu)/posterior cingulate cortex (PCC) in routine and slow-4 frequency bands, decreased ALFF in the right PCu, and increased ALFF in the right middle occipital gyrus (MOG) in the slow-5 frequency band. Additionally, patients with BD II depression showed lower TSH level than HCs, and TSH level was positively correlated with ALFF values in the bilateral PCu/PCC in the routine frequency band. Conclusions: These findings suggest that patients with BD II depression display intrinsic activity abnormalities, mainly in the PCu/PCC and MOG, which are associated with specific frequency bands. Moreover, altered intrinsic activity in the PCu/PCC may be related to TSH levels in bipolar II depression.

Delivery factors and neonatal thyroid hormone levels: a systematic review

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Fahimeh Ramezani Tehrani ◽  
Sima Nazarpour
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Mode Of Delivery ◽  
Thyroid Stimulating Hormone ◽  
Labor Pain ◽  
Elective Cesarean Section ◽  
Postnatal Life ◽  
Hormone Levels ◽  
Vaginal Deliveries ◽  
Thyroid Hormone Levels

Abstract Postnatal thyroid hormone changes enable the neonate to be adapted for postnatal life. Several factors can affect this adaption. In this review, we summarized the studies that reported the association among the delivery factors and neonatal thyroid hormones and thyroid stimulating hormone. A comprehensive literature search was performed in PubMed, Web of Science, and Scopus up to March 2020, to identify the studies investigating the relationship between delivery factors, especially the mode of delivery and labor pain, and neonatal thyroid hormones and TSH. Finally, in this review study, of 157 articles obtained in the initial search, 25 eligible studies were reviewed. Various maternal, fetal/neonatal, and obstetric factors affected neonatal TSH and thyroid hormones. Among various influencing factors, mode of delivery, labor pains, and duration of labor have a strong relationship with neonatal thyroid hormones and need to be considered for interpretation of neonatal thyroid status. The majority of the studies revealed that vaginal deliveries (instrumental or natural) lead to higher levels of cord TSH compared to elective cesarean section. This can be explained by the increased secretion of catecholamine during labor. It has been suggested that blood TSH and thyroid hormone levels are affected by perinatal stress events such as maternal anxiety, labor pains, fetal distress, and other stimulants of the catecholamine response. These changes may act as the trigger to increase thyroid hormone levels for adapting of neonates in the first hours after birth. This assumption needs to be re-evaluated by performing comprehensive and well-designed studies.

scholarly journals Assessment of Thyroid Hormone Levels in Diabetes Mellitus Subjects Resident in Port Harcourt Metropolis

2021 ◽  
pp. 40-46
Author(s):  
T. Neebee–Sordum ◽  
D. G. Tamuno-emine ◽  
D. Onwuli
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Hormone ◽  
Cross Sectional Study ◽  
Thyroid Stimulating Hormone ◽  
University Teaching ◽  
Cross Sectional ◽  
Hormone Levels ◽  
Port Harcourt ◽  
Thyroid Hormone Levels ◽  
Rivers State

Aim: The aim of this study was to assess thyroid hormone levels in among diabetics in Port- Harcourt  of Rivers State in Nigeria Study Design: This study is a cross-sectional study. Place and Duration of Study: This study was conducted at Chemical Pathology Department, Rivers State University Teaching Hospital, Port Harcourt, Nigeria, between December, 2019 and February, 2020. Methodology: A total of 224 subjects were recruited for the study, diabetic parents (132 subjects), non-diabetic parents (112 subjects. Five (5) ml of blood sample was collected and used to analyse for serum thyroxine (T4), tri-iodothyronine (T­­3) and thyroid stimulating hormone (TSH) using Enzyme-linked immunoasorbent assay. Data were analyzed statistically with SPSS version 22.0 and values considered significant at p< 0.05. Results: The mean ± S.D of serum TSH were 1.28± 0.6u/ml (control) and 1.84±1.05 u/ml (subject), (p=0.023). T4 value were 2.49 ± 0.86u/ml (control) (p=0.024) and 3.90 ±1,62u/ml (subjects) and T3 values were 1.89±0.41u/ml (p=0.0001). Conclusion: The evaluation of thyroid hormones (TSH, T4 and T3) among diabetes with the age ranges of population studied shows that there was altered thyroid hormone in diabetes mellitus individuals.

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