scholarly journals Sertoliform Endometrioid Tumor of Ovary Presenting as Torsion

2016 ◽  
Vol 8 (02) ◽  
pp. 112-115
Author(s):  
Prathiksha Pai ◽  
Meena N Jadhav ◽  
Rashmi K Patil ◽  
Shreekant K Kittur
Keyword(s):  
Good Prognosis ◽  
Interesting Case ◽  
Low Grade ◽  
Endometrioid Carcinoma ◽  
Ovarian Mass ◽  
Apical Cytoplasm ◽  
Grade Malignancy ◽  
Well Differentiated ◽  
Columnar Cells ◽  
Carcinoma Of The Ovary

ABSTRACTSertoliform endometrioid carcinoma of the ovary (SEC) is an uncommon variant that bears histologic similarity to sertoli and sertoli-leydig cell tumors. We report an interesting case of SEC in a 55-year-old female with a left ovarian mass with torsion. Histology revealed an SEC, featuring foci of typical endometrioid carcinoma, and areas composed of uniform, small, hollow tubules lined by columnar cells with apical cytoplasm. Tumor cells were strongly immunoreactive for EMA and cytokeratin but negative for inhibin; thus, confirming the diagnosis of SEC ovary. Recognition of this tumor is important as it is a well-differentiated, low-grade malignancy that displays good prognosis when confined to the ovary.

Sertoliform Endometrioid Carcinoma of the Ovary: A Potential Diagnostic Pitfall

2007 ◽  
Vol 131 (6) ◽  
pp. 979-981
Author(s):  
Anil Misir ◽  
Monalisa Sur
Keyword(s):  
Tumor Cells ◽  
Leydig Cell ◽  
Good Prognosis ◽  
Endometrioid Carcinoma ◽  
Older Population ◽  
Diagnostic Pitfall ◽  
Well Differentiated ◽  
Carcinoma Of The Ovary ◽  
Leydig Cell Tumors ◽  
Usual Pattern

Abstract Sertoliform endometrioid carcinoma of the ovary (SEC) is an uncommon variant that bears histologic similarity to Sertoli and Sertoli-Leydig cell tumors (SLTs). Clinically, SEC affects an older population (60–70 years), while patients with SLT have an average age of 25 years and may exhibit endocrine manifestations. A number of histologic features can be used to distinguish the 2 entities, the most important ones being (1) the presence of areas with the usual pattern of endometrioid carcinoma, and (2) the presence of mucin at the apical borders of the tumor cells. Cytokeratin stains positively, while inhibin and calretinin stain negatively in SEC; the converse is true for SLTs. Based on the clinicopathologic behavior of this entity, SEC should be considered a well-differentiated carcinoma with relatively good prognosis if limited to the ovary.

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

scholarly journals Well-Differentiated Liposarcoma of The Larynx: A Case Report and Review of Literature

2016 ◽  
Vol 9 (1) ◽  
pp. 85-89
Author(s):  
Svetlana A. Mateva ◽  
Margarita R. Nikolova ◽  
Alexandar V. Valkov ◽  
Margarita R. Nikolova
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
World Health ◽  
Low Grade ◽  
Review Of Literature ◽  
Grade Malignancy ◽  
Well Differentiated ◽  
Health Organization ◽  
Histologic Types

Summary Liposarcoma is one of the most common soft tissue sarcomas in adults with a relative incidence amongst other sarcomas ranging from 9.8% to 16%. It usually locates in the limbs and retroperitoneum. Primary liposarcomas of the larynx and hypopharynx are rare, comprising less than 20% of all head and neck liposarcomas. According to World Health Organization, these tumors are divided into four histologic types, and well-differentiated liposarcoma is the most common one. It is a tumor of low-grade malignancy that may recur locally, but does not metastasize. We present a case of laryngopharyngeal well- differentiated liposarcoma in an old patient with two previous removals. We also discuss recently published cases with this unusual location of liposarcoma.

Low-Grade Intraosseous Osteosarcoma With Prominent Lymphoid Infiltrate

2000 ◽  
Vol 124 (6) ◽  
pp. 868-871
Author(s):  
Mary L. Ostrowski ◽  
Mark E. Johnson ◽  
Paula D. Smith ◽  
Patricia Chevez-Barrios ◽  
Harlan J. Spjut
Keyword(s):  
Malignant Lymphoma ◽  
Limb Salvage ◽  
Salvage Surgery ◽  
Good Prognosis ◽  
Initial Diagnosis ◽  
Limb Salvage Surgery ◽  
Low Grade ◽  
Lymphoid Infiltrate ◽  
Flow Cytometric ◽  
Well Differentiated

Abstract Low-grade intraosseous osteosarcoma is an uncommon and well-differentiated osteosarcoma with a good prognosis. We report a proximal tibial low-grade intraosseous osteosarcoma with a prominent intratumoral lymphoid infiltrate, which led to an initial diagnosis of probable malignant lymphoma. The importance of this infiltrate, which exhibited reactive features on flow cytometric studies, is not known. Our patient is free of tumor 1 year after limb salvage surgery, without hematologic or lymphoid abnormalities.

scholarly journals Grade 1 Endometrioid Endometrial Carcinoma Presenting with Pelvic Bone Metastasis: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
My-Linh T. Nguyen ◽  
Christopher J. LaFargue ◽  
Tarah L. Pua ◽  
Sean S. Tedjarati
Keyword(s):  
Endometrial Carcinoma ◽  
Uterine Cancer ◽  
Treatment Options ◽  
Good Prognosis ◽  
Pelvic Bone ◽  
Low Grade ◽  
Endometrioid Endometrial Carcinoma ◽  
Endometrial Cancers ◽  
Well Differentiated ◽  
The Right

Most grade 1 endometrioid endometrial cancers are confined to the uterus at the time of diagnosis and confer a good prognosis. Rarely will a grade 1 endometrioid endometrial carcinoma present with distant metastasis, especially to the bone. We present the case of a 56-year-old woman with postmenopausal bleeding and right hip pain due to metastatic grade 1 endometrioid uterine cancer invading into the right ischium. We discuss treatment options as well as provide a review of prior published reports on bony metastasis in grade 1 endometrioid endometrial cancers. To date, this case is one of 10 others which demonstrates that even a well-differentiated, low-grade endometrioid endometrial carcinoma can progress in a highly aggressive manner.

scholarly journals Invasive basal cell carcinoma: A case report

2018 ◽  
Vol 7 (3) ◽  
Author(s):  
Ernani Canuto Figueirêdo Júnior ◽  
Maria do Socorro Vieira Pereira ◽  
Henrique Cezar Coutinho Barsi Filho ◽  
Jadeilson de Moura Ferreira ◽  
Myllena Alves Xavier ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Surgical Excision ◽  
Good Prognosis ◽  
Low Grade ◽  
Epithelial Tumor ◽  
Maxillofacial Abnormalities ◽  
Grade Malignancy ◽  
Nodular Sclerosing

Basal cell carcinoma (BCC) is an epithelial tumor of low-grade malignancy, recurrent, with capacity for local invasion and destruction of adjacent bone or cartilage, yet rare metastasis. It presents as superficial, fibro-epithelial, nodular, sclerosing or pigmented. The best treatment is surgical excision; and frequently the cancer has a good prognosis. The purpose of this article is to study and discuss the clinical, histopathological and treatment of BCC.Descriptors: Maxillofacial Abnormalities; Neoplasms; Carcinoma, Basal Cell; Diagnosis; Therapeutics.

Immunotherapy and potential predictive biomarkers in the treatment of neuroendocrine neoplasia

2020 ◽  
Author(s):  
Guanghui Xu ◽  
Yuhao Wang ◽  
Hushan Zhang ◽  
Xueke She ◽  
Jianjun Yang
Keyword(s):  
Current Knowledge ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Predictive Biomarkers ◽  
The Body ◽  
Low Grade ◽  
Ablative Therapies ◽  
Cancer Types ◽  
New Treatment ◽  
Well Differentiated

Neuroendocrine neoplasias (NENs) are a heterogeneous group of rare tumors scattered throughout the body. Surgery, locoregional or ablative therapies as well as maintenance treatments are applied in well-differentiated, low-grade NENs, whereas cytotoxic chemotherapy is usually applied in high-grade neuroendocrine carcinomas. However, treatment options for patients with advanced or metastatic NENs are limited. Immunotherapy has provided new treatment approaches for many cancer types, including neuroendocrine tumors, but predictive biomarkers of immune checkpoint inhibitors (ICIs) in the treatment of NENs have not been fully reported. By reviewing the literature and international congress abstracts, we summarize the current knowledge of ICIs, potential predicative biomarkers in the treatment of NENs, implications and efficacy of ICIs as well as biomarkers for NENs of gastroenteropancreatic system, lung NENs and Merkel cell carcinoma in clinical practice.

scholarly journals MDM2 Amplified Sarcomas: A Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 496
Author(s):  
Raf Sciot
Keyword(s):  
Suppressor Gene ◽  
Negative Regulator ◽  
Low Grade ◽  
P53 Mutations ◽  
Lipomatous Tumor ◽  
Double Minute ◽  
Genetic Features ◽  
Murine Double Minute ◽  
Well Differentiated ◽  
Mdm2 Amplification

Murine Double Minute Clone 2, located at 12q15, is an oncogene that codes for an oncoprotein of which the association with p53 was discovered 30 years ago. The most important function of MDM2 is to control p53 activity; it is in fact the best documented negative regulator of p53. Mutations of the tumor suppressor gene p53 represent the most frequent genetic change in human cancers. By overexpressing MDM2, cancer cells have another means to block p53. The sarcomas in which MDM2 amplification is a hallmark are well-differentiated liposarcoma/atypical lipomatous tumor, dedifferentiated liposarcoma, intimal sarcoma, and low-grade osteosarcoma. The purpose of this review is to summarize the typical clinical, histopathological, immunohistochemical, and genetic features of these tumors.

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