Trend in asthma severity in steroid naive asthmatic children in Benin city, Nigeria

2013 ◽  
Vol 16 (3) ◽  
pp. 371 ◽  
Author(s):  
O Oviawe ◽  
WO Osarogiagbon
Keyword(s):  
Asthma Severity ◽  
Asthmatic Children ◽  
Benin City

THE DECREASE IN SEVERITY OF ASTHMA IN CHILDREN OF PARENTS WHO SMOKE SINCE THE PARENTS HAVE BEEN EXPOSING THEM TO LESS CIGARETTE SMOKE

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 255-255
Author(s):  
Martin I. Sachs
Keyword(s):  
Cigarette Smoke ◽  
Secondhand Smoke ◽  
Marked Reduction ◽  
Asthma Severity ◽  
Asthmatic Children ◽  
Asthma In Children ◽  
Harmful Effects

Since 1986 an increasing awareness of the harmful effects of secondhand smoke has caused parents to smoke fewer cigarettes in the presence of their asthmatic children. This has been associated with a marked reduction in asthma severity of the smokers' children.

scholarly journals Assessment and prediction of asthma and its severity in the pediatric community

1990 ◽  
Vol 24 (6) ◽  
pp. 437-444 ◽  
Author(s):  
Julio Cesar R. Pereira ◽  
Fleming Carswell ◽  
Anthony O. Hughes
Keyword(s):  
Severe Disease ◽  
Asthma Severity ◽  
Positive Skin ◽  
Asthmatic Children ◽  
Multiplicative Effect ◽  
Skin Allergy ◽  
Single Positive ◽  
Laboratory Investigations ◽  
Response To Exercise

Seventy four asthmatic children aged 7 to 11 years were examined along with controls matched by age and sex. Clinical and laboratory investigations preceded a 28-day follow-up where data about morning and evening peak expiratory flow rate (PEF), symptoms and treatment were recorded. The coefficient of variation of PEF was found to be an objective measurement of asthma severity that has statistically significant correlation with both symptoms (r s= .36) and treatment (r s= .60). Moreover, it separates mild and severe asthmatics, as confirmed by statistically significant differences (p= .008 or less) in symptoms, treatment, skin allergy and airways response to exercise. Skin allergy and airways responsiveness to exercise were found to be predictors of both disease and severity. By means of logistic regression analysis it was possible to establish the probabilities for both asthma and severe asthma when children presenting and not presenting these characteristics are compared. One single positive skin test represent a probability of 88% for the development of asthma and a probability of 70% for severe disease. A PEF reduction of 10% after an exercise test implies a probability of 73% for disease and a probability of 64% for severe disease. Increases in these variables imply geometrically increased risks and their presence together have a multiplicative effect in the final risk.

scholarly journals Relationship of Oxidant and Antioxidant Markers to Asthma Severity in Egyptian Asthmatic Children

2017 ◽  
Vol 5 (5) ◽  
pp. 645-650 ◽  
Author(s):  
Inas R. EL-Alameey ◽  
Gihan A. Fathy ◽  
Mones M. Abu Shady ◽  
Alaa Ali ◽  
Hanan A. Fathy ◽  
...  
Keyword(s):  
Asymmetric Dimethylarginine ◽  
Strong Predictor ◽  
Predictive Biomarker ◽  
Asthma Severity ◽  
Healthy Children ◽  
Serum Concentrations ◽  
Asthmatic Children ◽  
Paraoxonase Activity ◽  
Asthmatic Patients ◽  
Anti Oxidant

BACKGROUND: Asthma is a chronic airway disease which is characterized by oxidant antioxidant imbalance with the generation of oxidative stress related mediators.AIM: The study aimed to evaluate the role of asymmetric dimethylarginine, and malondialdehyde as oxidant markers and serum paraoxonase activity as an antioxidant marker in asthma, and to determine their relationship to the asthma severity and lung function among asthmatic children in Egypt.PATIENTS AND METHODS: This case control study was conducted on sixty patients with asthma compared with sixty apparently healthy children of matched age and sex.RESULTS: Serum concentrations of oxidant markers as asymmetric dimethylarginine and malondialdehyde were significantly increased in asthmatic patients while anti-oxidant marker as paraoxonase activity was significantly decreased compared to healthy controls (P < 0.05). ANOVA test revealed highly significant elevation of the serum concentrations of oxidant markers while anti-oxidant marker was significantly decreased in severe asthmatic patients (P < 0.001) compared to the patients with moderate and mild asthma respectively. Serum malondialdehyde concentration was a strong predictor of asthma severity by multiple regression analysis (P < 0.05).CONCLUSION: The study revealed an imbalance between oxidative and antioxidant defence systems in asthmatic children. Serum concentration of malondialdehyde was the most predictive biomarker having a significant association with asthma severity.

Cardiovascular Fitness in Children With Asthma Correlates With Psychologic Functioning of the Child

PEDIATRICS ◽  
1989 ◽  
Vol 84 (3) ◽  
pp. 460-464 ◽  
Author(s):  
Robert C. Strunk ◽  
David A. Mrazek ◽  
Jolene T. Fukuhara ◽  
Jim Masterson ◽  
Susan K. Ludwick ◽  
...  
Keyword(s):  
Global Assessment ◽  
Child Behavior Checklist ◽  
Asthma Severity ◽  
Forced Expiratory Volume ◽  
Cardiovascular Fitness ◽  
Assessment Scale ◽  
Bicycle Ergometry ◽  
Global Assessment Scale ◽  
Asthmatic Children ◽  
Children With Asthma

Abnormalities in fitness in asthmatic children are assumed to derive from illness severity. We studied 90 children with moderately severe to severe but stable asthma for (1) fitness levels using bicycle ergometry, (2) measures of asthma severity, (3) clinician's impression of child (Child Global Assessment Scale), and (4) mother's rating of child's behavior (Child Behavior Checklist). Fitness values ranged from 15% to 120% of normal values for age, sex, and body surface area: 48% were abnormal (&lt;2 SD below mean) and 5% were borderline (1 to 2 SD below mean). Associations between levels of fitness and medical and psychologic criteria were tested using regression analyses. Of the 11 medical variables used to define the severity of asthma, recent exacerbation of disease, forced expiratory volume in 1 second, and specific airway conductance together accounted for 8.1% of the variability in the workload ratios (ie, R2 = 0.081). The importance of the psychologic factors in determining the variability in the workload ratios was tested after the importance of the medical variables had been considered: Child Global Assessment Scale accounted for a significant amount of variability, improving the R2 to 0.180 (an increase to 0.100, P = .003). These data suggest that, within the spectrum of disease presented by the patients in this study, adjustment to the disease is at least as important as severity of disease in determining fitness.

scholarly journals Serum vitamin D status and biochemical parameters of asthmatic children in Sokoto Metropolis, North-western Nigeria

2019 ◽  
Vol 11 (2) ◽  
pp. 64-70
Author(s):  
Mohammed Haruna Yeldu ◽  
Mohammed Danjuma ◽  
Mainasara Abdullahi Sulaiman ◽  
Jiya Nma Muhammad ◽  
Garba Balkisu Illah ◽  
...  
Keyword(s):  
Vitamin D ◽  
Biochemical Parameters ◽  
Immunoglobulin E ◽  
Airflow Obstruction ◽  
Serum Vitamin ◽  
Hypovitaminosis D ◽  
Asthma Severity ◽  
Vitamin D Status ◽  
Asthmatic Children ◽  
Serum Vitamin D

Background: Asthma is a common chronic disorder of the airways that is complex and characterized by variable and recurring symptoms. It is characterized by the occurrence of bronchial hyper responsiveness, airflow obstruction and an underlying inflammation. Several studies have proposed the association of vitamin D with increased incidence of asthma symptoms. Aims and Objectives: This study aimed at determining the serum vitamin D status and biochemical parameters among asthmatic children in Sokoto-Nigeria. Materials and Methods: The study population consisted of 120 subjects including 80 asthmatic children and 40 age-and sex-matched apparently healthy controls from two tertiary Hospitals in Sokoto Metropolis. Serum vitamin D, calcium, parathyroid hormone (PTH), immunoglobulin E (IgE) and magnesium were measured using standard techniques. Results: Mean serum vitamin D and magnesium were significantly (p ˂ 0.05) lower, while serum PTH and IgE were significantly higher (p˂0.001) in asthmatic children than in controls. Vitamin D insufficiency was found to be prevalent among the asthmatic children. There was no significant relationship between the low level of vitamin D and asthma severity. Conclusion: This study observed that, hypovitaminosis D and hypomagnesaemia occurred among asthmatic children, and asthma was more prone in the younger children than in their older counterpart. It is recommended that in order to avoid or limit the rate of children having asthmatic episodes, vitamin D and magnesium supplements should be used in the management of asthmatic children.

scholarly journals Obesity May Provide Pro-ILC3 Development Inflammatory Environment in Asthmatic Children

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Yumin Wu ◽  
Jiawei Yue ◽  
Juncheng Wu ◽  
Wei Zhou ◽  
Dapeng Li ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Messenger Rna ◽  
Mrna Level ◽  
Asthma Severity ◽  
Lymphoid Cells ◽  
Mrna Levels ◽  
Asthmatic Children ◽  
Prevalence Of Obesity ◽  
Elevated Frequency ◽  
Relative Mrna Expression

The prevalence of obesity in children has dramatically increased in the last few decades, and obesity has also emerged as an important risk factor for asthma. Innate mechanisms have been shown to be involved in both diseases, particularly through the recently described innate lymphoid cells (ILCs), in which ILC3s have been linked to obesity both in human and in murine models. The aim of this study was to explore whether being overweight in asthmatic children was associated with elevated circulating ILC3 or elevated messenger RNA (mRNA) levels of RORC, IL-17A, and IL-22. Our results showed significantly elevated ILC3 frequencies in overweight asthmatic children compared with nonoverweight controls based on the detection of Lin+CD127+IL-23R+ cells by flow cytometry. Moreover, elevated ILC3 frequencies positively correlated with the mRNA expression of RORC which has been identified as a transcription factor of ILC3s. The relative mRNA expression level of IL-17A was also upregulated in overweight compared to nonoverweight children, as was the relative mRNA level of IL-22. However, there were no correlations between ILC3 frequencies or the expressions of RORC, IL-17A, and IL-22 and asthma severity. These results suggested that childhood obesity is an independent factor that is associated with an elevated frequency of circulating ILC3s and higher expressions of RORC, IL-22, and IL-17A.

The improvement in asthma severity and pulmonary functions after laser acupuncture application in asthmatic children

2014 ◽  
Vol 13 (2) ◽  
pp. 93-99 ◽  
Author(s):  
Nagwa H. Mohamed ◽  
Hala H. Shaaba ◽  
Mona M. Soliman ◽  
Ola A. Dabbous ◽  
Inas E. M. Ahmed Kamel
Keyword(s):  
Asthma Severity ◽  
Laser Acupuncture ◽  
Asthmatic Children ◽  
Pulmonary Functions

scholarly journals Impact of inaccuracy of peak flowmeters with Wright scale on asthma severity assessment in children

2008 ◽  
Vol 61 (7-8) ◽  
pp. 354-358 ◽  
Author(s):  
Dragana Stamatovic ◽  
Nada Bokan-Erdeljan ◽  
Milan Gajic ◽  
Zorica Vujnovic-Zivkovic
Keyword(s):  
European Union ◽  
Asthma Management ◽  
Asthma Severity ◽  
Study Group ◽  
Severity Assessment ◽  
Objective Method ◽  
Predictive Equation ◽  
Asthmatic Children ◽  
Before And After ◽  
Daily Variability

Introduction Measurement of daily variability of peak expiratory flow (PEF) is widely accepted as an objective method to assess asthma severity. Recent investigations have proved nonlinearity of original Wright scale of peak flowmeter. All country members of European Union have been obliged to implement a new scale according to standard EN 13826 since 2005. This study examined whether the correction of PEF values for the inaccuracy of the scale would affect asthma management based on their daily variability. Material and methods We analyzed PEF values (2352) in 34 children, aged 5-16, during 3-5 weeks of monitoring in order to establish the diagnosis of asthma by using peak flowmeters with Write scale. The correction of measured values for inaccuracy was managed with original Dr M. Miller's predictive equation. The daily variability of PEF (amplitude percent mean) up to 20% was considered as 'normal', 20-29.9% as 'raised', and 30% and above as 'high'. The assessment of daily variability was performed before and after correction. Results There was no significant change in the number of days with airway liability as regarding the assessed whole study group (p=0.475). However, 22 (64.7%) of children had at least one false clinical message about daily variability during the monitoring. It was overestimated in 12 (7%) days in younger (6.6?0.8 years) or of shorter stature (122.6?3.6cm) and underestimated in 13 (4%) days in older (11.1?2.7) or taller ones (150.9?12.5 cm) (p<0.001). Conclusion Usage of peak flowmeters with Wright scale may lead to an error in asthma severity assessment based on daily variability of PEF. It may cause overtreatment or undertreatment of asthmatic children.

scholarly journals Relation of Asthma Control with Quality of Life among a Sample of Egyptian Asthmatic School Children

2019 ◽  
Vol 7 (17) ◽  
pp. 2780-2785
Author(s):  
Hala G. Elnady ◽  
Lobna S. Sherif ◽  
Rania N. Sabry ◽  
Dina Abu Zeid ◽  
Hanan Atta ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Asthma Severity ◽  
Physical Symptoms ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Asthmatic Children ◽  
Asthmatic Patients ◽  
Egyptian Children

BACKGROUND: Asthma is considered a chronic health illness that not only resulted in physical symptoms but also emotional effects. It is; therefore, so important to assess the quality of life of asthmatic patients besides their level of disease control. AIM: To determine the correlation of asthma control with the health-related quality of life (HRQOL) of asthmatic children in Egypt. METHODS: One hundred and twenty-eight asthmatic Egyptian children were enrolled in the study. They were subjected to asthma severity grading, asthma control questionnaire (ACQ) and pediatric asthma quality of life questionnaire (PAQLQ). Studied cases were taken from 6 primary and preparatory schools, Giza governorate. RESULTS: The mean child control score was significantly higher in not well-controlled asthmatics compared to well-controlled asthmatics (p < 0.005). The not well controlled asthmatic children showed significantly lower activity limitation score, symptoms score, and overall asthmatic score compared to controlled asthmatic children (p < 0.05). The severity of asthma shows significant positive correlation with symptoms score, emotional function score and overall asthmatic score (p < 0.05). CONCLUSION: The quality of life for the asthmatic children is strongly correlated with the level of asthma control and severity.

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