Evaluation of continuous ambulatory peritoneal dialysis fluid C-reactive protein in patients with peritonitis

Objective To evaluate the predictive value of a single baseline serum C-reactive protein (sCRP) as a marker of mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. Design A review of prospectively collected data in a 2-year follow-up study. Setting Tertiary medical center. Patients The study included 106 patients who were stable and had been on CAPD for a minimum of 3 months. Main Outcome Measures Patient survival rate was the main outcome measure of this study. Other outcome measures were technique survival rate, peritonitis rate, and hospitalized days. Covariables used in the survival analysis were age, sex, the presence of cardiovascular disease or diabetes mellitus, sCRP, serum albumin, hematocrit, cholesterol, HDL-cholesterol, malnutrition by subjective global assessment (SGA), weekly Kt/V urea, and weekly standardized creatinine clearance (SCCr). Results The 2-year patient survival rate was significantly lower in the increased sCRP group than in the normal sCRP group (66.7% vs 94.1%, p = 0.001), although there was no significant difference in technique failure, peritonitis rate, and hospitalized days between the two groups. By Cox proportional hazards analysis, independent predictors of mortality were: cardiovascular disease (relative risk, RR = 8.96, p < 0.005); increased sCRP level (RR = 1.19, p < 0.05); and high hematocrit (RR = 1.18, p < 0.05). ← Conclusion Serum CRP at enrollment is an independent predictor of 2-year patient survival in CAPD patients.

Download Full-text

A high performance liquid chromatography (HPLC) assay for linezolid in continuous ambulatory peritoneal dialysis fluid (CAPDF)

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkg177 ◽

2003 ◽

Vol 51 (4) ◽

pp. 1041-1042 ◽

Cited By ~ 10

Author(s):

C. M. Tobin

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

High Performance ◽

Hplc Assay ◽

Dialysis Fluid ◽

Peritoneal Dialysis Fluid

Download Full-text

Growth of Bacterial Clinical Isolates in Continuous Ambulatory Peritoneal Dialysis Fluid

Peritoneal Dialysis International ◽

10.1177/089686088300300311 ◽

1983 ◽

Vol 3 (3) ◽

pp. 144-145 ◽

Cited By ~ 4

Author(s):

Dayl J. Flournoy ◽

Fred A. Perryman ◽

Syed M.H. Qadri

Keyword(s):

Peritoneal Dialysis ◽

Continuous Ambulatory Peritoneal Dialysis ◽

Chemical Constituent ◽

Pseudomonas Sp ◽

Bacterial Isolates ◽

Proteus Vulgaris ◽

Dialysis Fluid ◽

Colony Forming Units ◽

Peritoneal Dialysis Fluid ◽

Group D

Clinical bacterial isolates (105 colony forming units/mi) were inoculated into sterile unused and used continuous ambulatory peritoneal dialysis (CAPD) fluid, incubated for 24 hours at 3SOC and observed for growth as evidenced by turbidity. The CAPD fluids also were tested for selected chemical constituent concentrations. The main differences in sterile unused and used fluids were: pH, 5.25 (unused) vs 7.60–8.62 (used); glucose, 1350–3680 vs 407–1227 mg/dl; potassium, 0 vs 2.0–4.2 mEq/l and phosphorous, 0 and 2.5–5.5 mg/dl respectively. When isolates of Candido albicans (10 strains), Enterobacter sp. (2), Escherichia coli (2), Group D Enterococci (2), Klebsiella pneumoniae (2), Proteus vulgaris (2), Pseudomonas aeruginosa (30), Pseudomonas sp. (2), Serratia marcescens (2), Staphylococcus aureus (2), S. epidermidis (2) and alphahemolytic streptococci (10) were tested against the fluids, none of the isolates grew in unused fluid but all grew in used fluid, which had been in the peritoneal cavity for as little as one and one-halfhours. Although the organisms did not grow in unused fluid, they were still viable at their original concentrations as deterrnined by quantitative subcultures.

Download Full-text