scholarly journals Antibacterial resistance patterns of Acinetobacter baumannii complex: The results of Isfahan Antimicrobial Resistance Surveillance-1 Program

2021 ◽  
Vol 14 (7) ◽  
pp. 316
Author(s):  
Soodabeh Rostami ◽  
SayedNassereddin Mostafavi ◽  
Zary Nokhodian ◽  
Behrooz Ataei ◽  
Azam Cheraghi ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Acinetobacter Baumannii ◽  
Antibacterial Resistance ◽  
Antimicrobial Resistance Surveillance ◽  
Resistance Patterns ◽  
Acinetobacter Baumannii Complex

scholarly journals The epidemiology of carbapenem resistance in Acinetobacter baumannii complex in Germany (2014–2018): an analysis of data from the national Antimicrobial Resistance Surveillance system

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Dunja Said ◽  
Niklas Willrich ◽  
Olaniyi Ayobami ◽  
Ines Noll ◽  
Tim Eckmanns ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Acinetobacter Baumannii ◽  
Respiratory Infections ◽  
Tertiary Care ◽  
Carbapenem Resistance ◽  
Infection Prevention And Control ◽  
Antimicrobial Resistance Surveillance ◽  
Carbapenem Resistant ◽  
Acinetobacter Baumannii Complex ◽  
Epidemiological Trends

Abstract Background Carbapenem-resistant Acinetobacter baumannii complex (CRABC) has globally emerged as a serious public health challenge. This study aimed to describe epidemiological trends and risk factors of carbapenem resistance in A. baumannii complex isolates in Germany between 2014 and 2018. Methods We analysed 43,948 clinical A. baumannii complex isolates using 2014 to 2018 data from the German Antimicrobial Resistance Surveillance system. We applied descriptive statistics and uni- and multivariable regression analyses to investigate carbapenem resistance in A. baumannii complex isolates. Results The proportion of carbapenem resistance in clinical A. baumannii complex isolates declined from 7.6% (95% confidence interval [95% CI] 4.4–12.7%) in 2014 to 3.5% (95% CI 2.5–4.7%) in 2018 (adjusted OR [aOR] 0.85 [95% CI 0.79–0.93, p ≤ 0.001]). Higher mean CRABC proportions for 2014 to 2018 were observed in secondary care hospitals (4.9% [95% CI 3.2–7.5%], aOR 3.6 [95% CI 2.4–5.3, p ≤ 0.001]) and tertiary care hospitals (5.9% [95% CI 3.0–11.2%], aOR 5.4 [95% CI 2.9–10.0, p ≤ 0.001) compared to outpatient clinics (1.3% [95% CI 1.1–1.6%]). CRABC proportions in hospitals varied between German regions and ranged between 2.4% (95% CI 1.6–3.5%) in the Southeast and 8.8% (95% CI 4.2–17.3%) in the Northwest. Lower CRABC proportions were observed in younger patients (< 1 year: 0.6% [95% CI 0.2–1.3%]; 1–19 years: 1.3% [95% CI 0.7–2.5%]) than adults (20–39 years: 7.7% [95% CI 4.4–13.0%]; 40–59 years: 6.2% [4.2–8.9%]; 60–79 years: 5.8% [95% CI 4.0–8.3%]). In the 20–39 year old patient age group, CRABC proportions were significantly higher for men than for women (14.6% [95% CI 8.6–23.6%] vs. 2.5% [95% CI 1.3–4.5%]). A. baumannii complex isolates from lower respiratory infections were more likely to be carbapenem-resistant than isolates from upper respiratory infections (11.4% [95% CI 7.9–16.2%] vs. 4.0% [95% CI 2.7–6.0%]; adjusted OR: 1.5 [95% CI 1.2–1.9, p ≤ 0.001]). Conclusions In contrast to many other regions worldwide, carbapenem resistance proportions among clinical A. baumannii complex isolates are relatively low in Germany and have declined in the last few years. Ongoing efforts in antibiotic stewardship and infection prevention and control are needed to prevent the spread of carbapenem-resistant A. baumannii complex in Germany.

scholarly journals Molecular Detection of blaOXA-type Carbapenemase Genes and Antimicrobial Resistance Patterns among Clinical Isolates of Acinetobacter baumannii

2021 ◽  
Author(s):  
Maghsoud Kafshnouchi ◽  
Marzieh Safari ◽  
Amir Khodavirdipour ◽  
Abbas Bahador ◽  
Seyed Hamid Hashemi ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Acinetobacter Baumannii ◽  
Dominant Gene ◽  
Diffusion Method ◽  
Phylogenetic Tree Analysis ◽  
Disk Diffusion Method ◽  
Treatment Regimens ◽  
Class D ◽  
Resistance Patterns ◽  
New Treatment

Abstract Acinetobacter baumannii is a bacterium found in most places, especially in clinics and hospitals, and an important agent of nosocomial infections. The presence of class D enzymes such as OXA-type carbapenemases in A. baumannii is proven to have a key function in resistance to carbapenem. The aim of the current study is to determine the blaOXA-type carbapenemase genes and antimicrobial resistance among clinically isolated samples of A. baumannii. We assessed 100 clinically isolated specimens of A. baumannii from patients in intensive care units of educational hospitals of Hamadan, West of Iran. The A. baumannii isolates' susceptibility to antibiotics was performed employing disk diffusion method. Multiplex polymerase chain reaction was used to identify the blaOXA-24-like , blaOXA-23-like , blaOXA-58-like , and blaOXA-51-like genes. The blaOXA-23-like , blaOXA-24-like , and blaOXA-58-like genes' prevalence were found to be 84, 58, and 3%, respectively. The highest coexistence of the genes was for blaOXA-51/23 (84%) followed by blaOXA-51/24-like (58%). The blaOXA-51/23- like pattern of genes is a sort of dominant gene in resistance in A. baumannii from Hamadan hospitals. The highest resistance to piperacillin (83%) and ciprofloxacin (81%) has been observed in positive isolates of blaOXA-23-like . The A. baumannii isolates with blaOXA-58-like genes did not show much resistance to antibiotics. Based on the results of the phylogenetic tree analysis, all isolates have shown a high degree of similarity. This study showed the high frequency of OXA-type carbapenemase genes among A. baumannii isolates from Hamadan hospitals, Iran. Thus, applying an appropriate strategy to limit the spreading of these strains and also performing new treatment regimens are necessary.

scholarly journals Antimicrobial resistance patterns and their encoding genes among clinical isolates of Acinetobacter baumannii in Ahvaz, Southwest Iran

MethodsX ◽  
2020 ◽  
Vol 7 ◽  
pp. 101031
Author(s):  
Mojtaba Moosavian ◽  
Khadijeh Ahmadi ◽  
Saeed Shoja ◽  
Jalal Mardaneh ◽  
Fatemeh Shahi ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Acinetobacter Baumannii ◽  
Clinical Isolates ◽  
Resistance Patterns ◽  
Southwest Iran ◽  
Encoding Genes

scholarly journals MECHANISMS OF ANTIMICROBIAL RESISTANCE SPECIFIC FOR PSEUDOMONAS AERUGINOSA AND ACINETOBACTER BAUMANNII

InterConf ◽  
2021 ◽  
pp. 266-274
Author(s):  
Greta Balan ◽  
Emilia Behta ◽  
Olga Brînza ◽  
Livia Ţapu ◽  
Olga Burduniuc
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Resistance ◽  
Acinetobacter Baumannii ◽  
Single Agent ◽  
Mechanisms Of Resistance ◽  
Development Of Resistance ◽  
Resistance Patterns

The exposure of bacteria to antibiotics has led to the development of resistance againstevery single agent utilized. Through a understanding the mechanisms of resistance, the clinician can better comprehend and predict resistance patterns even to antibioticsnot reported on the antibiogram, and subsequently select the most appropriate antibiotic for the pathogen in question.

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