Wound-healing activity of ethanolic and aqueous extracts of Ficus benghalensis

Wounds are nothing but any damage to the tissue or skin that can be healed. The wound healing process is usually built in the human body to self heal many wounds. When there is an injury in the body, there is an inflammatory response that is generated in the body, and the cells begin to raise the collagen levels in the skin which enables to increase the healing process. Ficus species of plants are famous for their potency to treat diseases in various Indian systems of medicine and the tree is commonly called as a banyan. Especially the plant in the species benghalensis is used to treat rheumatism, wounds and other skin related problems like an ulcer. The herbal gels were prepared using the incorporation of the aqueous extracts of the plant Ficus benghalensis into carbopol gel. They were investigated for the wound healing potential compared to the betadine drug standard. The gels at a concentration 200mg/g of the gel showed better activity compared to the gel at 100mg/g and the standard drug, betadine.

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Evaluation of Wound Healing Activity of Aerial Parts of Ocimum Basilicum Linn and Bark of Ficus Benghalensis Linn and Their Polyherbal Formulation in Wound Healing Models

IOSR Journal of Pharmacy and Biological Sciences ◽

10.9790/3008-1204015056 ◽

2017 ◽

Vol 12 (04) ◽

pp. 50-56

Author(s):

Gaurav Dubey ◽

Satkar Prasad ◽

Sailesh Kumar Ghatuary ◽

Anil Sarathe ◽

Kalpana Prajapati ◽

...

Keyword(s):

Wound Healing ◽

Ocimum Basilicum ◽

Polyherbal Formulation ◽

Ficus Benghalensis ◽

Aerial Parts ◽

Wound Healing Activity

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Wound healing activity of Cleome rutidosperma DC. roots

International Current Pharmaceutical Journal ◽

10.3329/icpj.v1i6.10536 ◽

2012 ◽

Vol 1 (6) ◽

pp. 151-154 ◽

Cited By ~ 5

Author(s):

Sumanta Mondal ◽

Padilam Suresh

Keyword(s):

Wound Healing ◽

Petroleum Ether ◽

Petroleum Ether Extract ◽

Pharmaceutical Journal ◽

Chloroform Extract ◽

Aqueous Extracts ◽

Chloroform Methanol ◽

Activity Comparison ◽

Cleome Rutidosperma ◽

Wound Healing Activity

The petroleum ether, chloroform, methanol and aqueous extracts of Cleome rutidosperma DC (Family: Capparidaceae) roots were evaluated for their wound healing activities in rats using excision and incision wound models respective-ly. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation and wound breaking strength. Nitrofurazone (0.2% w/w) in simple ointment I.P. was used as reference standard for the activity comparison. The results of the study revealed that the animals treated with methanol and aqueous extracts of C. rutidosperma showed faster rate of wound healing compared to other extracts under study. The chloroform extract of the selected plant also produced promising results but the effects are seen to be of lesser extent than the corresponding methanol and aqueous extracts. The petroleum ether extract did not produce significant results. The present work justifies the use of C. rutidosperma roots for wound healing activity as claimed in the folklore literature. DOI: http://dx.doi.org/10.3329/icpj.v1i6.10536 International Current Pharmaceutical Journal 2012, 1(6): 151-154

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Studies on Wound Healing Activity of Heliotropium indicum Linn. Leaves on Rats

ISRN Pharmacology ◽

10.5402/2011/847980 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 14

Author(s):

G. K. Dash ◽

P. N. Murthy

Keyword(s):

Wound Healing ◽

Granulation Tissue ◽

Dead Space ◽

Methanol Extract ◽

Infection Model ◽

Aqueous Extracts ◽

Reference Standard ◽

Wound Model ◽

Heliotropium Indicum ◽

Wound Healing Activity

The petroleum ether, chloroform, methanol, and aqueous extracts of Heliotropium indicum Linn. (Family: Boraginaceae) were separately evaluated for their wound healing activity in rats using excision (normal and infected), incision, and dead space wound models. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound breaking strength, weights of the granulation tissue, determination of hydroxyproline, super oxide dismutase (SOD), catalase, and histopathology of the granulation tissues. Nitrofurazone (0.2% w/w) in simple ointment I. P. was used as reference standard for the activity comparison. The results revealed significant promotion of wound healing with both methanol and aqueous extracts with more promising activity with the methanol extract compared to other extracts under study. In the wound infection model (with S. aureus and P. aeruginosa), the methanol extract showed significant healing activity similar to the reference standard nitrofurazone. Significant increase in the granulation tissue weight, increased hydroxyproline content, and increased activity of SOD and catalase level with the animals treated with methanol extract in dead space wound model further augmented the wound healing potential of H. indicum. The present work substantiates its validity of the folklore use.

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Development of wound healing hydrogels using bio synthesized silver nano particles and its antibacterial activity of Major Wound pathogens

Journal of University of Shanghai for Science and Technology ◽

10.51201/jusst/21/06442 ◽

2021 ◽

Vol 23 (06) ◽

pp. 1346-1362

Author(s):

Reetha K ◽

◽

Suganya K ◽

Karkuvelraja R ◽

Sanjay Prasad S ◽

...

Keyword(s):

Wound Healing ◽

Antibacterial Activity ◽

Inhibitory Concentration ◽

Color Change ◽

Nano Particles ◽

Aqueous Extracts ◽

Agno3 Solution ◽

Methanolic Extracts ◽

Vis Spectroscopy ◽

Wound Healing Activity

In this present study, biosynthesis of AgNp’s from methanolic extracts of H. Colorata and its wound healing activity was documented. The synthesis of AgNp’s was done by treating AgNO3 solution with an aqueous extract of H. colorata. The production of AgNp’s was confirmed by a color change of the solution from clear to brown color. The reduced AgNp’s were characterized by Scanning Electron Microscope (SEM), UV–vis spectroscopy. From UV analysis peak was observed at 415nm and spherical shaped AgNp’s were observed. The antibacterial activity and Minimum inhibitory Concentration (MIC) of the silver nanoparticles were determined. The results suggest that biosynthesized AgNp’s from aqueous extracts ofH.coloratashowed a significant antibacterial activity against wound pathogens.

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Assessment of Wound Healing Activity of the Aqueous Extracts ofColutea cilicicaBoiss. & Bal. Fruits and Leaves

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nep190 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 4

Author(s):

Ipek Peşin Süntar ◽

Ufuk Koca ◽

Esra Küpeli Akkol ◽

Demet Yılmazer ◽

Murat Alper

Keyword(s):

Wound Healing ◽

Histopathological Examination ◽

Healing Process ◽

Wound Healing Process ◽

Aqueous Extracts ◽

Reference Drug ◽

Excision Wound ◽

Wound Model ◽

Incision Wound ◽

Wound Healing Activity

The fruiting branches ofColutea cilicicaBoiss. & Bal., along with leaves and fruits, have been used to heal inflammatory wounds at traditional medicine in various parts of Turkey. In order to evaluate the wound healing activity of the plant, aqueous extracts were prepared from the flowering parts and fruits ofColutea cilicicaBoiss. & Bal. by using 40°C distilled water. Incision wound healing models by using tensiometer on rats and excision wound healing models on mice were employed to assess the activity. Significant wound healing activity was observed when ointment formulation of the aqueous extract at 1% concentration was applied on the mentioned models. The fruit extract treated the groups of animals, showing a 78.1% contraction in wounds, which was close to the contraction value of the reference drug Madecassol (100%). On the other hand, the same extract used on the incision wound model demonstrated a significant increase (42%) in wound tensile strength, compared to the flowering aerial parts. Histopathological examination also supported the results shown in both the incision and excision wound models. The wound healing effect was evaluated and compared with the reference ointment Madecassol. Moreover, zinc and vitamin C levels in the fruit (9480 ± 0 mcg g−1; 389 mg g−1) and flowering aerial part (6609 ± 1 mcg g−1; 404 mg g−1) extracts, which might have contributed to the wound healing process, were determined. The experimental data confirmed the traditional usage ofC. cilicicaBoiss.& Bal.

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