Chronic Periodontal Disease and COVID – 19 Complications: Mechanistic Links Through Increase of CD14+ CD16+ Monocytes Blood Count

Many people in the world are affected by hyperlipidemia, which is a known risk factor for atherosclerotic disease. On the other hand, periodontitis, a prevalent oral disease, has been connected to several systemic health changes, including an altered lipid metabolism. Transient and recurrent bacteremias, which may be caused by periodontal infection, induce an intense local and systemic inflammatory response, leading to changes in the whole body. The aim of the present study was to verify the relationship between severe and moderate periodontal disease and blood lipid levels. Sixty individuals seen at the clinics of the University of Taubaté, São Paulo, over 20 years old, were divided into two groups, with and without periodontitis, and paired according to sex and age. Their levels of total cholesterol, tryglicerides and fractions were determined. Variables related to high cholesterol levels, including age, sex and body mass index, were evaluated. The values recommended by the Brazilian Society of Cardiology were considered to classify lipidemia. The results showed that mean levels of cholesterol (192.1 mg/dl ± 40.9) and triglycerides (153.5 mg/dl ± 105.6) in individuals with periodontitis were higher than, but not statistically different from, those of individuals without periodontitis (186.1 mg/dl ± 35.4 and 117.5 mg/dl ± 68, respectively). Therefore, this study has demonstrated that there is no significant relationship between periodontal disease, regardless of its intensity, and blood lipid levels in the studied population.

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Association between chronic periodontal disease and cardiovascular risk factor hyperlipidemia

Journal of Dr NTR University of Health Sciences ◽

10.4103/2277-8632.146628 ◽

2014 ◽

Vol 3 (4) ◽

pp. 249 ◽

Cited By ~ 1

Author(s):

Anitha Akkaloori ◽

Parthasarathi Parthasarathi ◽

MohammadShakeel Anjum ◽

Praveen Gadde ◽

Monica Mocherla ◽

...

Keyword(s):

Risk Factor ◽

Cardiovascular Risk ◽

Periodontal Disease ◽

Cardiovascular Risk Factor ◽

Chronic Periodontal Disease

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Subgingival microbiota and chronic periodontal disease: Culpability in causation of systemic pathologies

Astrocyte ◽

10.4103/2349-0977.137853 ◽

2014 ◽

Vol 1 (2) ◽

pp. 100 ◽

Cited By ~ 1

Author(s):

Anuj Aggarwal ◽

Ankur Aggarwal ◽

SP Aggarwal

Keyword(s):

Periodontal Disease ◽

Chronic Periodontal Disease ◽

Subgingival Microbiota

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Reactive pocket epithelium in untreated chronic periodontal disease: possible derivation from developmental remnants of the enamel organ and root sheath

Journal of Oral Pathology and Medicine ◽

10.1034/j.1600-0714.2001.300308.x ◽

2001 ◽

Vol 30 (3) ◽

pp. 178-186 ◽

Cited By ~ 16

Author(s):

Neil Hunter ◽

Brent Nicholls ◽

Mukesh Srivastava ◽

Cheryl C. Chapple ◽

Hans F. Zoellner ◽

...

Keyword(s):

Periodontal Disease ◽

Enamel Organ ◽

Root Sheath ◽

Chronic Periodontal Disease

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Genetic susceptibility to chronic periodontal disease

Microbes and Infection ◽

10.1016/s1286-4579(02)01642-8 ◽

2002 ◽

Vol 4 (11) ◽

pp. 1157-1167 ◽

Cited By ~ 28

Author(s):

Pamela J. Baker ◽

Derry C. Roopenian

Keyword(s):

Periodontal Disease ◽

Genetic Susceptibility ◽

Chronic Periodontal Disease

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Oxidative stress in chronic periodontitis patients with type II diabetes mellitus

European Journal of Dentistry ◽

10.4103/ejd.ejd_244_17 ◽

2018 ◽

Vol 12 (02) ◽

pp. 225-231 ◽

Cited By ~ 4

Author(s):

Ruby Ramya Vincent ◽

Devapriya Appukuttan ◽

Dhayanand John Victor ◽

Aruna Balasundaram

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Periodontal Disease ◽

Diabetic Patients ◽

Clinical Parameters ◽

Type Ii ◽

Chronic Periodontal Disease ◽

Significant Difference ◽

The Mean ◽

Group 1

ABSTRACT Objective: Oxidative stress (OS) refers to the disequilibrium between free radicals and antioxidant defense mechanisms and is significantly implicated in the pathogenesis of chronic degenerative and inflammatory diseases such as chronic periodontal disease (CP) and diabetes mellitus (DM). This study aimed to evaluate the total antioxidants capacity (TAOC) and total oxidants status (TOS) in the gingival crevicular fluid (GCF) in CP participants with type II DM. Materials and Methods: A total of 80 participants were allotted into four groups as follows: Group 1: Generalized CP (GCP) without type II DM (n = 20); Group 2: GCP with type II DM (n = 20); Group 3: Type II DM without CP (n = 20); and Group 4: Systemically and periodontally healthy (PH) (n = 20). Clinical parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level were recorded. Pooled GCF was collected followed by the estimation of TAOC, TOS, and OS index (OSI) using Erel O Colorimetric analysis. Results: The clinical parameters recorded showed the statistically significant difference (P < 0.001) between the groups. The mean TAOC value was the highest in PH group. The mean TOS and OSI were higher in Group 1, 2, and 3 participants when compared to the PH participants. All the biochemical parameters evaluated showed a statistically significant difference (P < 0.001) between groups. Conclusions: The study further validates the use of OSI as a marker for periodontal disease activity and emphasizes the role of OS in the pathogenesis of Type II diabetic patients with the chronic periodontal disease.

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