Heart rate in patients with or without hypertension: A retrospective study

Objective This study evaluated the role of cetirizine compared to diphenhydramine as premedications for patients receiving paclitaxel, cetuximab, and rituximab infusions. Historically, diphenhydramine has been linked with more sedation in comparison to cetirizine; however, it is unknown if cetirizine can replace diphenhydramine in the prevention of hypersensitivity reactions in patients receiving chemotherapy. Methods This is a retrospective study designed to assess infusion reactions occurring in patients receiving diphenhydramine or cetirizine premedication for rituximab, paclitaxel, or cetuximab therapies. Infusion reactions were defined as various symptoms such as flushing, itching, alterations in heart rate and blood pressure, and dyspnea plus the clinical setting of a concurrent or very recent infusion. Results A total of 207 patients were evaluated in this study with 83 patients receiving cetirizine and 124 diphenhydramine patients. Overall, the percentage of patients with at least one chemotherapy-related infusion event in the cetirizine group was 19.3% (95% CI 11.4–29.4) compared to diphenhydramine group 24.2% (95% CI 17.0–32.7), P = 0.40. Of the patients who received cetirizine and then experienced an event in the first cycle, 41.7% (95% CI 13.7–74.3) of the events were due to paclitaxel, 50.0% (95% CI 19.4–80.6) were due to rituximab, and 8.3% (95% CI 0.1–43.6) were due to cetuximab. Of the patients who received diphenhydramine and then experienced an event in the first cycle, 26.1% (95% CI 5.7–51.4) were due to paclitaxel, 73.9% (95% CI 48.6–94.3) were due to rituximab and none due to cetuximab. Conclusion Cetirizine appears to be a viable substitute for diphenhydramine for the prevention of infusions reactions with cetuximab, paclitaxel, and rituximab infusions in adults. Prospective studies are needed to determine the efficacy and safety of cetirizine compared with diphenhydramine in the prevention of chemotherapy-related infusion reactions.

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Combined Neurofeedback and Heart Rate Variability Training for Individuals with Symptoms of Anxiety and Depression: A Retrospective Study

NeuroRegulation ◽

10.15540/nr.4.1.37 ◽

2017 ◽

Vol 4 (1) ◽

pp. 37-55 ◽

Cited By ~ 5

Author(s):

Elyse Kemmerer White ◽

Kayleah Michelle Groeneveld ◽

Rachel Kelly Tittle ◽

Nicholas Abram Bolhuis ◽

Rachel E. Martin ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Retrospective Study ◽

Anxiety And Depression

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Prediction model for thyrotoxic atrial fibrillation: a retrospective study.

10.21203/rs.3.rs-428694/v1 ◽

2021 ◽

Author(s):

Daria Aleksandrovna Ponomartseva ◽

Ilia Vladislavovich Derevitskii ◽

Sergey Valerevich Kovalchuk ◽

Alina Yurevna Babenko

Keyword(s):

Machine Learning ◽

Atrial Fibrillation ◽

Heart Rate ◽

Retrospective Study ◽

Prediction Model ◽

Performance Metrics ◽

Premature Ventricular Contraction ◽

Ventricular Contraction ◽

Atrial Contraction ◽

Premature Atrial Contraction

Abstract Background: Thyrotoxic atrial fibrillation (TAF) is a recognized significant complication of hyperthyroidism. Early identification of the individuals predisposed to TAF would improve thyrotoxic patients’ management. However, to our knowledge, an instrument that establishes an individual risk of the condition is unavailable. Therefore, the aim of this study is to build a TAF prediction model and rank TAF predictors in order of importance. Methods: In this retrospective study, we have investigated 36 demographic and clinical features for 420 patients with overt hyperthyroidism, 30% of which had TAF. At first, the association of these features with TAF was evaluated by classical statistical methods. Then, we developed several TAF prediction models with eight different machine learning classifiers and compared them by performance metrics. The models included ten features that were selected based on their clinical effectuality and importance for model output. Finally, we ranked TAF predictors, elicited from the optimal final model, by the machine learning tehniques. Results: The best performance metrics prediction model was built with the extreme gradient boosting classifier. It had the reasonable accuracy of 84% and AUROC of 0.89 on the test set. The model confirmed such well-known TAF risk factors as age, sex, hyperthyroidism duration, heart rate and some concomitant cardiovascular diseases (arterial hypertension and conjestive heart rate). We also identified premature atrial contraction and premature ventricular contraction as new TAF predictors. The top five TAF predictors, elicited from the model, included (in order of importance) PAC, PVC, hyperthyroidism duration, heart rate during hyperthyroidism and age. Conclusions: We developed a machine learning model for TAF prediction. It seems to be the first available analytical tool for TAF risk assessment. In addition, we defined five most important TAF predictors, including premature atrial contraction and premature ventricular contraction as the new ones. These results have contributed to TAF prediction investigation and may serve as a basis for further research focused on TAF prediction improvement and facilitation of thyrotoxic patients’ management.

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2 Systemic glucocorticoids and bradycardia in critically ill children: a retrospective study

Paediatrics & Child Health ◽

10.1093/pch/pxaa068.001 ◽

2020 ◽

Vol 25 (Supplement_2) ◽

pp. e1-e1

Author(s):

Camille Maltais-Bilodeau ◽

Maryse Frenette ◽

Geneviève Morissette ◽

Dennis Bailey ◽

Karine Cloutier ◽

...

Keyword(s):

Intensive Care Unit ◽

Heart Rate ◽

Intensive Care ◽

Retrospective Study ◽

Critically Ill ◽

Medical Staff ◽

Pediatric Population ◽

Critically Ill Children ◽

Rate Variation ◽

The Impact

Abstract Background Glucocorticoids are widely used in the pediatric population. They are associated with numerous side effects including repercussions on the cardiovascular system. The impact on heart rate is not well known, but bradycardia has been reported, mostly with high doses. Objectives We described the occurrence of bradycardias and the variation of heart rate in critically ill children receiving glucocorticoids. Design/Methods We conducted a retrospective study including 1 month old to 18 year old children admitted to the Pediatric Intensive Care Unit between 2014 and 2017, who received a glucocorticoid dose equivalent to 1 to 15 mg/kg/day of prednisone. We collected data on exposition to glucocorticoids, heart rate before, during and after the exposition, and interventions from the medical staff in response to bradycardia. The primary outcome was the occurrence of bradycardia and the secondary outcomes were the magnitude of heart rate variation and the clinical management of bradycardias. Results We included 92 admissions (85 patients). The median dose of glucocorticoid used was 2.80 mg/kg/day of prednisone (2.08—3.80). We found 70 cases (76%) with at least one bradycardia. Before treatment, all patients had a mean heart rate higher than the 5th percentile for age. During exposition to glucocorticoids, 8 patients (10%, n = 83) had a median heart rate ≤ 5th percentile. We noted 46 cases of bradycardia (50%) that led to an intervention from the medical staff, but no patient had a major event associated to bradycardia. We found a significant association between bradycardia and age (estimate -0.136, 95% CI -0.207—-0.065, p < 0.001), glucocorticoid dose (estimate 4.820, 95% CI 2.048—7.592, p < 0.001) and intravenous administration (estimate 8.709, 95% CI 1.893—15.524, p = 0.012). Conclusion In our study, most children hospitalized at the intensive care unit receiving standard doses of glucocorticoid experienced bradycardia. The majority of episodes led to an intervention from the medical staff. Presence of bradycardia was associated with younger age, higher dose and IV administration of glucocorticoids.

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Cardiovascular Safety of Clonidine and Dexmedetomidine in Critically Ill Patients after Cardiac Surgery

Critical Care Research and Practice ◽

10.1155/2020/4750615 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Angelina Grest ◽

Judith Kurmann ◽

Markus Müller ◽

Victor Jeger ◽

Bernard Krüger ◽

...

Keyword(s):

Heart Rate ◽

Cardiac Surgery ◽

Retrospective Study ◽

Mean Arterial Pressure ◽

Critically Ill ◽

Critically Ill Patients ◽

Low Cost ◽

Cardiovascular Safety ◽

Drug Infusion ◽

Saps Ii

Purpose. The aim of this retrospective study was to assess the haemodynamic adverse effects of clonidine and dexmedetomidine in critically ill patients after cardiac surgery. Methods. 2769 patients were screened during the 30-month study period. Heart rate (HR), mean arterial pressure (MAP), and norepinephrine requirements were assessed 3-hourly during the first 12 hours of the continuous drug infusion. Results are given as median (interquartile range) or numbers (percentages). Results. Patients receiving clonidine (n = 193) were younger (66 (57–73) vs 70 (63–77) years, p=0.003) and had a lower SAPS II (35 (27–48) vs 41 (31–54), p=0.008) compared with patients receiving dexmedetomidine (n = 141). At the start of the drug infusion, HR (90 (75–100) vs 90 (80–105) bpm, p=0.028), MAP (70 (65–80) vs 70 (65–75) mmHg, p=0.093), and norepinephrine (0.05 (0.00–0.11) vs 0.12 (0.03–0.19) mcg/kg/min, p<0.001) were recorded in patients with clonidine and dexmedetomidine. Bradycardia (HR < 60 bpm) developed in 7.8% with clonidine and 5.7% with dexmedetomidine (p=0.51). Between baseline and 12 hours, norepinephrine remained stable in the clonidine group (0.00 (−0.04–0.02) mcg/kg/min) and decreased in the dexmedetomidine group (−0.03 (−0.10–0.02) mcg/kg/min, p=0.007). Conclusions. Dexmedetomidine and the low-cost drug clonidine can both be used safely in selected patients after cardiac surgery.

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Combined spinal epidural analgesia for labor using sufentanil epidurally versus intrathecally: a retrospective study on the influence on fetal heart trace

Journal of Perinatal Medicine ◽

10.1515/jpm-2014-0077 ◽

2015 ◽

Vol 43 (4) ◽

Cited By ~ 1

Author(s):

Nele Everaert ◽

Marc Coppens ◽

Peter Vlerick ◽

Geert Braems ◽

Patrick Wouters ◽

...

Keyword(s):

Heart Rate ◽

Retrospective Study ◽

Epidural Analgesia ◽

Fetal Heart Rate ◽

Neonatal Outcome ◽

Fetal Heart ◽

Uterine Activity ◽

Combined Spinal Epidural ◽

Spinal Epidural ◽

Intrathecal Space

AbstractWe retrospectively compared a protocol using sufentanil and ropivacaine intrathecally with a protocol in which only ropivacaine was administered intrathecally and sufentanil was used epidurally to evaluate whether banning sufentanil from the intrathecal space results in a decreased incidence of adverse fetal heart rate changes.Some 520 cardiotocographic tracings were examined for changes in fetal heart rate and uterine activity following two different protocols of combined spinal epidural analgesia. Charts were consulted for neonatal and labor outcome.When sufentanil was used epidurally instead of intrathecally, the incidence of adverse changes in fetal heart trace was less, demonstrated by a higher percentage of normal reassuring tracings (74.5% vs. 60.4% when sufentanil was used intrathecally; P=0.007), less tracings showing bradycardia (7.5% vs. 14.1%; P=0.035), and more tracings displaying 3 or more accelerations in fetal heart rate in 45 min (93.5% vs. 83.9%; P=0.003) together with less episodes of tachycardia (3.5% vs. 11.4%; P=0.005). There were no differences in labor and neonatal outcome.Based on fetal heart tracing, it seems favorable to ban sufentanil from the intrathecal compartment.

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Ethnic analogies and differences in fetal heart rate variability signal: A retrospective study

Journal of Obstetrics and Gynaecology Research ◽

10.1111/jog.13213 ◽

2016 ◽

Vol 43 (2) ◽

pp. 281-290 ◽

Cited By ~ 4

Author(s):

Salvatore Tagliaferri ◽

Francesca Giovanna Esposito ◽

Rosa Fagioli ◽

Marco Di Cresce ◽

Lucia Sacchi ◽

...

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Retrospective Study ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Fetal Heart Rate Variability

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Retrospective study of allometric relationship between heart rate, electrocardiographic parameters and bodyweight in dogs

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-10407 ◽

2019 ◽

Vol 71 (6) ◽

pp. 1800-1804

Author(s):

A.S.C. Aleixo ◽

A. Alfonso ◽

M.G. Fillippi ◽

S.B. Chiacchio ◽

M.L.G. Lourenço

Keyword(s):

Heart Rate ◽

Retrospective Study ◽

The Body ◽

Weak Correlation ◽

Allometric Relationship ◽

Domestic Species ◽

Electrocardiographic Parameters ◽

The Relationship ◽

Weight Groups

ABSTRACT The allometric relationship between bodyweight (BW) and heart rate (HR) has been described as inversely proportional in domestic species, but that has been refuted. The relationship between HR and electrocardiographic variables is described in literature. However, studies about the variation and influence of factors on the hemodynamic and electrocardiographic parameters in dogs are not abundant. As the metabolic rate is defined as the production and dissipation of heat by the body surface area (BSA) in m², it is essential to define that relationship. A retrospective study was conducted to analyze the correlation between HR, ECG parameters and BW in dogs. One thousand electrocardiographic tracings were analyzed in addition to the ECG parameters and clinical data such as gender, age and bodyweight. The determination of BSA was performed as follows: BSA (m2) = (10.1 x bodyweight 0.67) X 10-4. When the unified groups were analyzed, there was a negative but weak correlation (r= -0.14, P< 0.0001) between bodyweight and HR. There were differences between weight groups regarding electrocardiographic variables. There is no allometric relationship between BW and HR in dogs. Weight was associated with changes in ECG variables.

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Identifying predictive factors of rapid response/code blue: A retrospective study using logistic regression analysis

10.21203/rs.3.rs-35696/v1 ◽

2020 ◽

Author(s):

Brittany Thomas ◽

Herschel Knapp ◽

Frances Patmon

Keyword(s):

Heart Rate ◽

Logistic Regression ◽

Regression Analysis ◽

Retrospective Study ◽

Logistic Regression Analysis ◽

Medical Records ◽

Community Hospital ◽

Rapid Response ◽

Care Providers ◽

Single Centre

Abstract Background: Rapid response calls and cardiac arrests are often preceded by observable signs of clinical deterioration often hours prior to the adverse event.Objectives: The purpose of this retrospective study was to identify risk factors that provide predictive value in determining the likelihood of a Rapid Response Call on adult telemetry patients at a single-centre community hospital.Design: This was a retrospective study based on secondary data analysis. After approval by the Institutional Review Board was obtained (CANV DHIRB-2018-362), we utilized the electronic medical record system to extract de-identified quantitative data from patient medical records.Setting: This study utilized medical records from patients on the Telemetry unit at a single-centre, 230-bed community hospital.Participants: The sample consisted of 250 randomized de-identified medical records from both patients who did and did not require a rapid response between January and December, 2018. Patients who were less than 18 years of age and those who were transferred to another facility or to another hospital were excluded from the analyses.Methods: The variables that were collected included age, gender, race, primary admitting medical diagnosis, hemoglobin, potassium, magnesium, creatinine, lactic acid, and urine output. Additional variables collected in four-hour increments included the vital signs: temperature, heart rate, oxygen saturation, respirations, systolic and diastolic blood pressure, and level of consciousness which was scored using the adult Glasgow Coma Scale. Logistic regression analysis was used to identify which of these variables were statistically significant in predicting patient deterioration.Results: The following predictors were statistically significant (a = 0.05 with 95% Confidence Intervals [CI]): For every one beat increase in heart rate 4 hours prior to a RRT, the odds of a RRT increased by 4.9% (p=0.003) (CI=95% 1.016, 1.084). For every one increase in respirations, the odds of a RRT increased by 42.8% (p=0.004) (95% CI 1.11, 1.82), 8 hours before the RRT, and by 47% (p=0.002) (95% CI 1.15, 1.87), 12 hours before a RRT. African Americans had 20.6 times the odds of experiencing an RRT compared to Caucasians (p<0.001) (95% CI 3.4, 124.6), Hispanics had 56.6 times the odds of experiencing a RRT compared to Caucasians (p<0.001) (95% CI 11.4, 280.4), and other races had 6.3 times the odds of a RRT compared to Caucasians (p=0.044) (95% CI 1.05, 38.5).Conclusions: Such predictors can be used to identify early signs of deterioration that can alert health care providers to early intervention.

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An Observational Retrospective Study Investigating Changes in Seizure Adequacy Parameters of Electroconvulsive Therapy and Their Relationships to Clinical Outcome in Schizophrenia and Schizoaffective Disorder

Clinical EEG and Neuroscience ◽

10.1177/1550059420932076 ◽

2020 ◽

pp. 155005942093207

Author(s):

Onur Durmaz ◽

Tuba Öcek Baş

Keyword(s):

Heart Rate ◽

Retrospective Study ◽

Clinical Outcome ◽

Electroconvulsive Therapy ◽

Schizoaffective Disorder ◽

Predictor Variable ◽

Peak Heart Rate ◽

Syndrome Scale ◽

Scale Scores ◽

Negative Syndrome

The aim of the current study was to investigate a possible relationship between electroconvulsive therapy (ECT) seizure adequacy parameters and clinical outcome as well as differences between ECT responders and nonresponders in terms of ECT seizure parameters in patients diagnosed with schizophrenia and schizoaffective disorder. First and last ECT records data, sociodemographic variables, and baseline and post ECT Positive and Negative Syndrome Scale scores were obtained. Maximum sustained power was higher in last ECT in favor of responders while peak heart rate was higher in ECT nonresponders than responders in first ECT. Stimulus doses were higher in last ECT than in the first ECT in both groups. No predictor variable was observed among baseline ECT seizure parameters for clinical improvement. Study was insufficient to yield a precise finding pointing a relationship between electrophysiological seizure parameters and clinical outcome in schizophrenia and schizoaffective disorder.

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