scholarly journals Cancer relapse in surgical patients who received perioperative transfusion of blood and blood products: A case-control study

2019 ◽  
Vol 63 (1) ◽  
pp. 31
Author(s):  
R Subha ◽  
Kurian Cherian ◽  
Archana Nair ◽  
RachelCherian Koshy ◽  
Jagathnath Krishna
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
Blood Products ◽  
Cancer Relapse ◽  
Control Study

scholarly journals 1185. Association Between Blood Product Transfusion and Development of Hospital Acquired Infections or Mortality in Patients Admitted to the Hospital Wards. A Retrospective Case-Control Study

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S617-S617
Author(s):  
Arunmozhi S Aravagiri ◽  
Ayutyanont Napatkamon ◽  
Sabhyata Sharma ◽  
Timothy Collins ◽  
Chimezie Ubbaonu ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Secondary Outcome ◽  
Blood Products ◽  
Multivariable Model ◽  
Retrospective Case ◽  
Hospital Acquired Infections ◽  
Hospital Acquired ◽  
Hospital Wards ◽  
Control Study

Abstract Background Transfusion of blood products has been shown to be associated with increased mortality and risk of infections in critically ill patients and following cardiac surgery [1-2]. However, there is scarce data evaluating this association in patients admitted to hospital wards. Here we seek to see if transfusion of blood products carries the same risk of infection and mortality in more stable patients. Methods This was a retrospective case-control study of patients admitted to the internal medicine wards who received packed red blood cells (PRBC), fresh frozen plasma (FFP) or platelet transfusions, using data from the HCA Healthcare administrative database from 2016 to 2019. Patients admitted with an infection, on steroids or other immunosuppressant medications were excluded. ICD-10 codes at discharge were used to determine hospital acquired infections (HAI). The presence of HAI was the dependent variable. A multivariable logistic regression was used to determine the effects of the independent variables on development of HAI after adjusting for age and Carlson’s Comorbidity Index. Odds ratios and 95% confidence intervals were calculated. Primary outcome of study was presence of HAI, while secondary outcome was mortality in transfused vs. non-transfused patients. Results A total of 1952 subjects were included in the study analysis. Of these, 653 or 33.4% had a HAI during their admission. Adjusted multivariable model showed transfusion of PRBC (OR 1.14, 95%CI 0.85-1.52), platelets (OR 1.41, 95% CI 0.93-2.10) or FFP (OR 1.27 95%CI 0.90-1.75) was not associated with increased odds of having a HAI. The multivariable model however, did show an increase in odds of mortality in patients who were transfused with PRBC (OR 2.51, 95%CI 1.78-3.54), platelets (OR 3.17, 95%CI 2.01-5.0) or FFP (OR 2.78, 95% CI 1.89-4.08) compared to non-transfused. Conclusion Our data failed to show association between transfusion of blood products and HAI. However, it showed there was significant increase in mortality in patients that had received blood products during their admission. Disclosures All Authors: No reported disclosures

scholarly journals KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Mark Terrelonge ◽  
Sara C. LaHue ◽  
Christopher Tang ◽  
Irina Movsesyan ◽  
Clive R. Pullinger ◽  
...  
Keyword(s):  
Older Adults ◽  
Postoperative Delirium ◽  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
Primary Study ◽  
Diverse Populations ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Control Study

AbstractDespite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperative delirium, compared with those with postoperative delirium, are more likely to have specific single nucleotide polymorphisms (SNPs) in the FKBP5, KIBRA, KLOTHO, MTNR1B, and SIRT1 genes known to be associated with cognition or delirium. This prospective nested matched exploratory case–control study included 94 older adults who underwent orthopedic surgery and screened for postoperative delirium. Forty-seven subjects had incident delirium, and 47 age-matched controls were not delirious. The primary study outcome was genotype frequency for the five SNPs. Compared with participants with delirium, those without delirium had higher adjusted odds of KIBRA SNP rs17070145 CT/TT [vs. CC; adjusted odds ratio (aOR) 2.80, 95% confidence interval (CI) 1.03, 7.54; p = 0.04] and MTNR1B SNP rs10830963 CG/GG (vs. CC; aOR 4.14, 95% CI 1.36, 12.59; p = 0.01). FKBP5 SNP rs1360780 CT/TT (vs. CC) demonstrated borderline increased adjusted odds of not developing delirium (aOR 2.51, 95% CI 1.00, 7.34; p = 0.05). Our results highlight the relevance of KIBRA, MTNR1B, and FKBP5 in understanding the complex relationship between delirium, cognition, and sleep, which warrant further study in larger, more diverse populations.

scholarly journals The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Blood ◽  
2011 ◽  
Vol 117 (16) ◽  
pp. 4218-4225 ◽  
Author(s):  
Alexander P. J. Vlaar ◽  
Jorrit J. Hofstra ◽  
Rogier M. Determann ◽  
Denise P. Veelo ◽  
Frederique Paulus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiac Surgery ◽  
Acute Lung Injury ◽  
Case Control Study ◽  
Case Control ◽  
Blood Products ◽  
Bioactive Lipids ◽  
Related Risk ◽  
Nested Case Control ◽  
Control Study

Abstract Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related morbidity and mortality. Both antibodies and bioactive lipids that have accumulated during storage of blood have been implicated in TRALI pathogenesis. In a single-center, nested, case-control study, patients were prospectively observed for onset of TRALI according to the consensus definition. Of 668 patients, 16 patients (2.4%) developed TRALI. Patient-related risk factors for onset of TRALI were age and time on the cardiopulmonary bypass. Transfusion-related risk factors were total amount of blood products (odds ratio [OR] = 1.2; 95% confidence interval [CI], 1.03-1.44), number of red blood cells stored more than 14 days (OR = 1.6; 95% CI, 1.04-2.37), total amount of plasma (OR = 1.2; 95% CI, 1.03-1.44), presence of antibodies in donor plasma (OR = 8.8; 95% CI, 1.8-44), and total amount of transfused bioactive lipids (OR = 1.0; 95% CI, 1.00-1.07). When adjusted for patient risk factors, only the presence of antibodies in the associated blood products remained a risk factor for TRALI (OR = 14.2; 95% CI, 1.5-132). In-hospital mortality of TRALI was 13% compared with 0% and 3% in transfused and nontransfused patients, respectively (P < .05). In conclusion, the incidence of TRALI is high in cardiac surgery patients and associated with adverse outcome. Our results suggest that cardiac surgery patients may benefit from exclusion of blood products containing HLA/HNA antibodies.

The cost of infection in surgical patients: a case-control study

1993 ◽  
Vol 25 (4) ◽  
pp. 239-250 ◽  
Author(s):  
R. Coello ◽  
H. Glenister ◽  
J. Fereres ◽  
C. Bartlett ◽  
D. Leigh ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
The Cost ◽  
Control Study

Reducing preoperative fasting in elective adult surgical patients: a case–control study

2011 ◽  
Vol 181 (1) ◽  
pp. 99-104 ◽  
Author(s):  
S. Power ◽  
D. O. Kavanagh ◽  
G. McConnell ◽  
K. Cronin ◽  
C. Corish ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
Preoperative Fasting ◽  
Control Study

Are lower preoperative serum sodium levels associated with postoperative surgical site infection? Results from a propensity matched case-control study

2020 ◽  
pp. 100-104
Author(s):  
N Naidoo ◽  
TE Madiba ◽  
Y Moodley
Keyword(s):  
Serum Sodium ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Surgical Patients ◽  
Site Infection ◽  
Preoperative Serum ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Background: We previously reported a statistical trend toward a harmful association between lower preoperative serum sodium levels and surgical site infection (SSI) in South African (SA) laparotomy patients. Serum sodium tests are widely available and could serve as a cost-effective method for preoperatively identifying patients at risk for SSI who might benefit from additional preventative strategies. We sought to investigate the possible association between lower serum sodium levels and SSI further, in a larger sample of SA patients undergoing various surgical procedures. Objective: To determine if lower preoperative serum sodium levels are associated with SSI in SA surgical patients. Method: This was a propensity matched case-control study involving data from 729 surgical patients who attended a quaternary SA hospital between 01 January 2012 and 31 July 2016. Cases were defined as patients who developed SSI. Controls were defined as patients who did not develop SSI. Multivariate logistic regression was used to investigate the association between preoperative serum sodium levels (in mmol/L) and SSI. Results: Lower preoperative serum sodium levels were associated with a higher risk of SSI (odds ratio per 1.0 mmol/L decrease in serum sodium: 1.051, 95% confidence interval: 1.007–1.097; p = 0.026). Conclusion: Although we report a statistically significant association between lower preoperative serum sodium levels and a higher risk of SSI, the magnitude of this effect size (odds ratio) is minimal and clinically insignificant. Preoperative serum sodium levels are unlikely to be useful for SSI risk stratification in our setting.

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