FMD and CIMT: Surrogate markers of atherosclerosis in subclinical and overt hypothyroidism in sub Himalyan Region

ABSTRACT Serum thyrotrophin (TSH) was determined by the double-antibody radioimmunoassay in 58 patients with primary hypothyroidism and was found to be elevated in all but 2 patients, one of whom had overt and one clinically borderline hypothyroidism. Six (29%) out of 21 subjects with symptomless autoimmune thyroiditis (SAT) had an elevated serum TSH level. There was little correlation between the severity of the disease and the serum TSH values in individual cases. However, the mean serum TSH value in overt hypothyroidism (93.4 μU/ml) was significantly higher than the mean value both in clinically borderline hypothyroidism (34.4 μU/ml) and in SAT (8.8 μU/ml). The response to the thyrotrophin-releasing hormone (TRH) was increased in all 39 patients with overt or borderline hypothyroidism and in 9 (43 %) of the 21 subjects with SAT. The individual TRH response in these two groups showed a marked overlap, but the mean response was significantly higher in overt (149.5 μU/ml) or clinically borderline hypothyroidism (99.9 μU/ml) than in SAT (35.3 μU/ml). Thus a normal basal TSH level in connection with a normal response to TRH excludes primary hypothyroidism, but nevertheless not all patients with elevated TSH values or increased responses to TRH are clinically hypothyroid.

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Faculty Opinions recommendation of Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1027039.326557 ◽

2005 ◽

Author(s):

Jacqueline Upcroft

Keyword(s):

Helicobacter Pylori ◽

Helicobacter Pylori Infection ◽

Surrogate Markers

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Overt and subclinical hypothyroidism among Bangladeshi pregnant women and its effect on fetomaternal outcome

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v40i2.25183 ◽

2015 ◽

Vol 40 (2) ◽

pp. 52-57 ◽

Cited By ~ 5

Author(s):

M Sharmeen ◽

PA Shamsunnahar ◽

TR Laita ◽

SB Chowdhury

Keyword(s):

Adverse Effects ◽

Pregnant Women ◽

Subclinical Hypothyroidism ◽

Thyroid Dysfunction ◽

Perinatal Outcomes ◽

Fetal Outcome ◽

Thyroid Stimulating Hormone ◽

Overt Hypothyroidism ◽

Adequate Treatment ◽

In Pregnancy

Objectives: Thyroid disorders are among the common endocrine problems in pregnant women. It is now well established that not only overt but subclinical thyroid dysfunction also has adverse effects on maternal and fetal outcome. There are few data from Bangladesh about the prevalence of thyroid dysfunction in pregnancy. With this background, this study aims to find out thyroid dysfunction (both overt and subclinical hypothyroidism) in pregnancy and its impact on obstetrical outcome.Methods: We studied the evaluation of 50 admitted pregnancies corresponding to 29 women with subclinical hypothyroidism and rest 21 was overt hypothyroidism. Detailed history and examination were performed. Apart from routine obstetrical investigations, Thyroid Stimulating Hormone (TSH) estimation was done. Their obstetrical and perinatal outcomes were noted.Results: Overt hypothyroidism was significantly (p<0.05) higher in 25 to 44 years age group. However two and three abortions were significantly (p<0.05) higher in overt hypothyroidism patients. In sub clinical hypothyroidism 86.2% conceived firstly within 2 years and 66.7% in overt hypothyroidism patients conceived firstly in between 3 to 5 years after marriage. Overt hypothyroids were prone to have pregnancy-induced hypertension 42.9%, intrauterine growth restriction (P=0.001) and gestational diabetes (38.1%) as compared to subclinical cases. Neonatal complications were significantly more in overt hypothyroidism group. Mean TSH level was significantly (p<0.05) higher in overt hypothyroidism patients but mean FT4 level was almost similar in both groups. Majority of the patient underwent caesarean section in both groups due to associated medical and obstetrical complications. None of the babies showed hypothyroidism by cord blood tests. In this analysis our results showed that overt hypothyroidism among Bangladeshi pregnant women are associated with more maternal complication & adverse parental outcome than subclinical hypothyroidism. The adequate treatment of hypothyroidism during gestation minimizes risks and generally, makes it possible for pregnancies to be carried to term without complications. Significant adverse effects on maternal and fetal outcome were seen emphasizing the importance of routine antenatal thyroid screening.Bangladesh Med Res Counc Bull 2014; 40 (2): 52-57

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Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers

Human Pathology ◽

10.1016/j.humpath.2014.09.012 ◽

2015 ◽

Vol 46 (1) ◽

pp. 94-103 ◽

Cited By ~ 61

Author(s):

Makoto Urano ◽

Toshitaka Nagao ◽

Satoru Miyabe ◽

Kenichiro Ishibashi ◽

Kayoko Higuchi ◽

...

Keyword(s):

Salivary Gland ◽

Surrogate Markers ◽

Secretory Carcinoma ◽

Mammary Analogue Secretory Carcinoma

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Evolution of Hashimoto thyroiditis in children with type 1 diabetes mellitus (TIDM)

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0222 ◽

2020 ◽

Vol 33 (12) ◽

pp. 1525-1531

Author(s):

Feneli Karachaliou ◽

Nikitas Skarakis ◽

Evangelia Bountouvi ◽

Theodora Spyropoulou ◽

Eleni Tsintzou ◽

...

Keyword(s):

Diabetes Mellitus ◽

Randomized Trials ◽

Elevated Serum ◽

Hashimoto Thyroiditis ◽

Diabetes Mellitus Type 1 ◽

Overt Hypothyroidism ◽

Normal Ranges ◽

Serum Tsh

AbstractObjectivesTreatment of children with Hashimoto thyroiditis (HT) and particularly of those with coexistent diabetes mellitus type 1 (TIDM) and normal/mildly elevated serum TSH is controversial. The aim of the study was to evaluate the natural course of HT in children with TIDM compared with children with no other coexistent autoimmunity and investigate for possible predictive factors of thyroid function deterioration.MethodsData from 96 children with HT, 32 with T1DM (23 girls, nine boys) mean (sd) age: 10.6 (2.3) years, and 64 age and sex-matched without T1DΜ (46 girls, 18 boys), mean (sd) age: 10.2 (2.9) years were evaluated retrospectively. They all had fT4 and TSH values within normal ranges and available data for at least three years’ follow-up.ResultsDuring the follow-up period, 11 children (34.4%) with TIDM exhibited subclinical hypothyroidism and two children (6.2%) progressed to overt hypothyroidism compared to 12 (18.8%) and two (3.1%) among children without TIDM, respectively. Among children with HT, a higher percentage (40.6%) of children with T1DM progressed to subclinical or overt hypothyroidism, compared with children (21.9%) with similar characteristics but without TIDM or other coexistent autoimmunity.ConclusionsThe annual conversion rate from euthyroidism to hypothyroidism in children with T1DM was significantly higher compared to sex and age-matched children without TIDM. Prospective randomized trials are needed to support the view of an earlier intervention therapy even in milder degrees of thyroid failure in these children.

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CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

The Journal of Pathology Clinical Research ◽

10.1002/cjp2.211 ◽

2021 ◽

Author(s):

Dafné Moreno Lorenzana ◽

María del Rocío Juárez Velázquez ◽

Adriana Reyes León ◽

Daniel Martínez Anaya ◽

Adrián Hernández Monterde ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Signaling Pathways ◽

Lymphoblastic Leukemia ◽

Surrogate Markers ◽

Gene Fusions ◽

Mexican Children ◽

Recurrent Gene Fusions

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Weight Cycling in Women: Adaptation or Risk?

Seminars in Reproductive Medicine ◽

10.1055/s-0040-1721418 ◽

2020 ◽

Author(s):

Katelyn J. Carey ◽

Wendy Vitek

Keyword(s):

Weight Loss ◽

Body Composition ◽

Weight Gain ◽

Pregnancy Complications ◽

Weight Regain ◽

Reproductive Age ◽

Cardiometabolic Health ◽

Surrogate Markers ◽

Weight Cycling ◽

Gut Peptides

AbstractObesity, dieting, and weight cycling are common among reproductive-age women. Weight cycling refers to intentional weight loss followed by unintentional weight regain. Weight loss is accompanied by changes in gut peptides, adipose hormones, and energy expenditure that promote weight regain to a tightly regulated set point. While weight loss can improve body composition and surrogate markers of cardiometabolic health, it is hypothesized that the weight regain can result in an overshoot effect, resulting in excess weight gain, altered body composition, and negative effects on surrogate markers of cardiometabolic health. Numerous observational studies have examined the association of weight cycling and health outcomes. There appears to be modest association between weight cycling with type 2 diabetes mellitus and dyslipidemia in women, but no association with hypertension, cardiovascular events, and overall cancer risk. Interestingly, mild weight cycling may be associated with a decreased risk of overall and cardiovascular mortality. Little is known about the effects of weight cycling in the preconception period. Although obesity and weight gain are associated with pregnancy complications, preconception weight loss does not appear to mitigate the risk of most pregnancy complications related to obesity. Research on preconception weight cycling may provide insight into this paradox.

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